Summary statistics and tables

Reference: This article was used as a reference — CDISC Pilot NCA Analysis

Package Imports and Setup

Load Packages

using DataFrames
using CategoricalArrays
using DataFramesMeta
using ReadStatTables
using SummaryTables
using Printf
using HypothesisTests
using ReadStat
using StatsModels, StatsPlots, Statistics

include("con-fun.jl")

find_next_nominal_time (generic function with 1 method)

Data Loading

Read the datasets

path = joinpath(@__DIR__, "..", "Datasets") |> normpath
pc = @chain readstat(joinpath(path, "pc.xpt")) DataFrame convert_blanks_to_missing
ex = @chain readstat(joinpath(path, "ex.xpt")) DataFrame convert_blanks_to_missing
vs = @chain readstat(joinpath(path, "vs.xpt")) DataFrame convert_blanks_to_missing
lb = @chain readstat(joinpath(path, "lb.xpt")) DataFrame convert_blanks_to_missing
adsl = @chain readstat(joinpath(path, "adsl.xpt")) DataFrame convert_blanks_to_missing
adsl_orig = @chain readstat(joinpath(path, "adsl_orig.xpt")) DataFrame convert_blanks_to_missing
adqsadas_orig = @chain readstat(joinpath(path, "adqsadas_orig.xpt")) DataFrame convert_blanks_to_missing
adqscibc_orig = @chain readstat(joinpath(path, "adqscibc_orig.xpt")) DataFrame convert_blanks_to_missing
adae_orig = @chain readstat(joinpath(path, "adae_orig.xpt")) DataFrame convert_blanks_to_missing
adlbh = @chain readstat(joinpath(path, "adlbh.xpt")) DataFrame convert_blanks_to_missing
adlbc = @chain readstat(joinpath(path, "adlbc.xpt")) DataFrame convert_blanks_to_missing
adlbh_orig = @chain readstat(joinpath(path, "adlbh_orig.xpt")) DataFrame convert_blanks_to_missing
adlbc_orig = @chain readstat(joinpath(path, "adlbc_orig.xpt")) DataFrame convert_blanks_to_missing
adlbhy_orig = @chain readstat(joinpath(path, "adlbhy_orig.xpt")) DataFrame convert_blanks_to_missing

9954×43 DataFrame

9929 rows omitted

Row	STUDYID	SUBJID	USUBJID	TRTP	TRTPN	TRTA	TRTAN	TRTSDT	TRTEDT	AGE	AGEGR1	AGEGR1N	RACE	RACEN	SEX	COMP24FL	DSRAEFL	SAFFL	AVISIT	AVISITN	ADY	ADT	VISIT	VISITNUM	PARAMTYP	PARAM	PARAMCD	PARAMN	PARCAT1	AVAL	BASE	A1LO	A1HI	R2A1LO	R2A1HI	BR2A1LO	BR2A1HI	ABLFL	SHIFT1	SHIFT1N	CRIT1	CRIT1FL	CRIT1FN
	String15	String7	String15	String31	Float64	String31	Float64	Date	Date	Float64	String7	Float64	String	Float64	String3	String3	String3?	String3	String31	Float64	Float64?	Date?	String15?	Float64?	String7?	String	String7	Float64	String7	Float64?	Float64?	Float64?	Float64?	Float64?	Float64?	Float64?	Float64?	String3?	String31?	Float64?	String15?	String3?	Float64?
1	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y	missing	Y	Baseline	0.0	-7.0	2013-12-26	SCREENING 1	1.0	missing	Alanine Aminotransferase (U/L)	ALT	1.0	CHEM	27.0	27.0	6.0	34.0	4.5	0.794118	4.5	0.794118	Y	missing	missing	R2A1HI > 1.5	N	0.0
2	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y	missing	Y	Baseline	0.0	-7.0	2013-12-26	SCREENING 1	1.0	missing	Aspartate Aminotransferase (U/L)	AST	2.0	CHEM	40.0	40.0	9.0	34.0	4.44444	1.17647	4.44444	1.17647	Y	missing	missing	R2A1HI > 1.5	N	0.0
3	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y	missing	Y	Baseline	0.0	-7.0	2013-12-26	SCREENING 1	1.0	missing	Bilirubin (umol/L)	BILI	3.0	CHEM	10.26	10.26	3.0	21.0	3.42	0.488571	3.42	0.488571	Y	missing	missing	R2A1HI > 1.5	N	0.0
4	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y	missing	Y	Baseline	0.0	missing	missing	missing	missing	DERIVED	Bilirubin 1.5 x ULN	BILIHY	4.0	HYLAW	0.0	0.0	missing	missing	missing	missing	missing	missing	Y	Normal to Normal	1.0	missing	missing	missing
5	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y	missing	Y	Baseline	0.0	missing	missing	missing	missing	DERIVED	Transaminase 1.5 x ULN	TRANSHY	5.0	HYLAW	0.0	0.0	missing	missing	missing	missing	missing	missing	Y	Normal to Normal	1.0	missing	missing	missing
6	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y	missing	Y	Baseline	0.0	missing	missing	missing	missing	DERIVED	Total Bili 1.5 x ULN and Transaminase 1.5 x ULN	HYLAW	6.0	HYLAW	0.0	0.0	missing	missing	missing	missing	missing	missing	Y	Normal to Normal	1.0	missing	missing	missing
7	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y	missing	Y	Week 2	2.0	15.0	2014-01-16	WEEK 2	4.0	missing	Alanine Aminotransferase (U/L)	ALT	1.0	CHEM	41.0	27.0	6.0	34.0	6.83333	1.20588	4.5	0.794118	missing	missing	missing	R2A1HI > 1.5	N	0.0
8	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y	missing	Y	Week 2	2.0	15.0	2014-01-16	WEEK 2	4.0	missing	Aspartate Aminotransferase (U/L)	AST	2.0	CHEM	33.0	40.0	9.0	34.0	3.66667	0.970588	4.44444	1.17647	missing	missing	missing	R2A1HI > 1.5	N	0.0
9	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y	missing	Y	Week 2	2.0	15.0	2014-01-16	WEEK 2	4.0	missing	Bilirubin (umol/L)	BILI	3.0	CHEM	8.55	10.26	3.0	21.0	2.85	0.407143	3.42	0.488571	missing	missing	missing	R2A1HI > 1.5	N	0.0
10	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y	missing	Y	Week 2	2.0	missing	missing	missing	missing	DERIVED	Bilirubin 1.5 x ULN	BILIHY	4.0	HYLAW	0.0	0.0	missing	missing	missing	missing	missing	missing	missing	Normal to Normal	1.0	missing	missing	missing
11	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y	missing	Y	Week 2	2.0	missing	missing	missing	missing	DERIVED	Transaminase 1.5 x ULN	TRANSHY	5.0	HYLAW	0.0	0.0	missing	missing	missing	missing	missing	missing	missing	Normal to Normal	1.0	missing	missing	missing
12	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y	missing	Y	Week 2	2.0	missing	missing	missing	missing	DERIVED	Total Bili 1.5 x ULN and Transaminase 1.5 x ULN	HYLAW	6.0	HYLAW	0.0	0.0	missing	missing	missing	missing	missing	missing	missing	Normal to Normal	1.0	missing	missing	missing
13	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y	missing	Y	Week 4	4.0	29.0	2014-01-30	WEEK 4	5.0	missing	Alanine Aminotransferase (U/L)	ALT	1.0	CHEM	18.0	27.0	6.0	34.0	3.0	0.529412	4.5	0.794118	missing	missing	missing	R2A1HI > 1.5	N	0.0
⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮
9943	CDISCPILOT01	1427	01-718-1427	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	N	missing	Y	Week 6	6.0	43.0	2013-01-28	WEEK 6	7.0	missing	Alanine Aminotransferase (U/L)	ALT	1.0	CHEM	16.0	14.0	6.0	32.0	2.66667	0.5	2.33333	0.4375	missing	missing	missing	R2A1HI > 1.5	N	0.0
9944	CDISCPILOT01	1427	01-718-1427	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	N	missing	Y	Week 6	6.0	43.0	2013-01-28	WEEK 6	7.0	missing	Aspartate Aminotransferase (U/L)	AST	2.0	CHEM	30.0	29.0	9.0	34.0	3.33333	0.882353	3.22222	0.852941	missing	missing	missing	R2A1HI > 1.5	N	0.0
9945	CDISCPILOT01	1427	01-718-1427	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	N	missing	Y	Week 6	6.0	43.0	2013-01-28	WEEK 6	7.0	missing	Bilirubin (umol/L)	BILI	3.0	CHEM	8.55	8.55	3.0	21.0	2.85	0.407143	2.85	0.407143	missing	missing	missing	R2A1HI > 1.5	N	0.0
9946	CDISCPILOT01	1427	01-718-1427	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	N	missing	Y	Week 6	6.0	missing	missing	missing	missing	DERIVED	Bilirubin 1.5 x ULN	BILIHY	4.0	HYLAW	0.0	0.0	missing	missing	missing	missing	missing	missing	missing	Normal to Normal	1.0	missing	missing	missing
9947	CDISCPILOT01	1427	01-718-1427	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	N	missing	Y	Week 6	6.0	missing	missing	missing	missing	DERIVED	Transaminase 1.5 x ULN	TRANSHY	5.0	HYLAW	0.0	0.0	missing	missing	missing	missing	missing	missing	missing	Normal to Normal	1.0	missing	missing	missing
9948	CDISCPILOT01	1427	01-718-1427	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	N	missing	Y	Week 6	6.0	missing	missing	missing	missing	DERIVED	Total Bili 1.5 x ULN and Transaminase 1.5 x ULN	HYLAW	6.0	HYLAW	0.0	0.0	missing	missing	missing	missing	missing	missing	missing	Normal to Normal	1.0	missing	missing	missing
9949	CDISCPILOT01	1427	01-718-1427	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	N	missing	Y	Week 8	8.0	57.0	2013-02-11	WEEK 8	8.0	missing	Alanine Aminotransferase (U/L)	ALT	1.0	CHEM	12.0	14.0	6.0	32.0	2.0	0.375	2.33333	0.4375	missing	missing	missing	R2A1HI > 1.5	N	0.0
9950	CDISCPILOT01	1427	01-718-1427	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	N	missing	Y	Week 8	8.0	57.0	2013-02-11	WEEK 8	8.0	missing	Aspartate Aminotransferase (U/L)	AST	2.0	CHEM	23.0	29.0	9.0	34.0	2.55556	0.676471	3.22222	0.852941	missing	missing	missing	R2A1HI > 1.5	N	0.0
9951	CDISCPILOT01	1427	01-718-1427	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	N	missing	Y	Week 8	8.0	57.0	2013-02-11	WEEK 8	8.0	missing	Bilirubin (umol/L)	BILI	3.0	CHEM	6.84	8.55	3.0	21.0	2.28	0.325714	2.85	0.407143	missing	missing	missing	R2A1HI > 1.5	N	0.0
9952	CDISCPILOT01	1427	01-718-1427	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	N	missing	Y	Week 8	8.0	missing	missing	missing	missing	DERIVED	Bilirubin 1.5 x ULN	BILIHY	4.0	HYLAW	0.0	0.0	missing	missing	missing	missing	missing	missing	missing	Normal to Normal	1.0	missing	missing	missing
9953	CDISCPILOT01	1427	01-718-1427	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	N	missing	Y	Week 8	8.0	missing	missing	missing	missing	DERIVED	Transaminase 1.5 x ULN	TRANSHY	5.0	HYLAW	0.0	0.0	missing	missing	missing	missing	missing	missing	missing	Normal to Normal	1.0	missing	missing	missing
9954	CDISCPILOT01	1427	01-718-1427	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	N	missing	Y	Week 8	8.0	missing	missing	missing	missing	DERIVED	Total Bili 1.5 x ULN and Transaminase 1.5 x ULN	HYLAW	6.0	HYLAW	0.0	0.0	missing	missing	missing	missing	missing	missing	missing	Normal to Normal	1.0	missing	missing	missing

TABLE 1

Data Preparation - Table 1

adsl_prep = @chain adsl_orig begin
    @transform :TRT01P = categorical(:TRT01P,
        levels = ["Placebo", "Xanomeline Low Dose", "Xanomeline High Dose"],
        ordered = true)
    @transform :TRT01P = recode(:TRT01P,
        "Xanomeline Low Dose" => "Low Dose",
        "Xanomeline High Dose" => "High Dose")
    
    @select :USUBJID :TRT01P :ITTFL :SAFFL :EFFFL :COMP24FL :DCDECOD 

end

254×7 DataFrame

229 rows omitted

Row	USUBJID	TRT01P	ITTFL	SAFFL	EFFFL	COMP24FL	DCDECOD
	String15	Cat…	String3	String3	String3	String3	String31
1	01-701-1015	Placebo	Y	Y	Y	Y	COMPLETED
2	01-701-1023	Placebo	Y	Y	Y	N	ADVERSE EVENT
3	01-701-1028	High Dose	Y	Y	Y	Y	COMPLETED
4	01-701-1033	Low Dose	Y	Y	Y	N	STUDY TERMINATED BY SPONSOR
5	01-701-1034	High Dose	Y	Y	Y	Y	COMPLETED
6	01-701-1047	Placebo	Y	Y	Y	N	ADVERSE EVENT
7	01-701-1097	Low Dose	Y	Y	Y	Y	COMPLETED
8	01-701-1111	Low Dose	Y	Y	Y	N	ADVERSE EVENT
9	01-701-1115	Low Dose	Y	Y	Y	N	ADVERSE EVENT
10	01-701-1118	Placebo	Y	Y	Y	Y	COMPLETED
11	01-701-1130	Placebo	Y	Y	Y	Y	COMPLETED
12	01-701-1133	High Dose	Y	Y	Y	Y	COMPLETED
13	01-701-1146	High Dose	Y	Y	Y	N	ADVERSE EVENT
⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮
243	01-718-1079	Low Dose	Y	Y	Y	N	ADVERSE EVENT
244	01-718-1101	High Dose	Y	Y	Y	Y	STUDY TERMINATED BY SPONSOR
245	01-718-1139	Placebo	Y	Y	Y	Y	COMPLETED
246	01-718-1150	Placebo	Y	Y	Y	Y	COMPLETED
247	01-718-1170	Low Dose	Y	Y	Y	N	ADVERSE EVENT
248	01-718-1172	Placebo	Y	Y	Y	N	WITHDRAWAL BY SUBJECT
249	01-718-1250	Low Dose	Y	Y	Y	N	ADVERSE EVENT
250	01-718-1254	Low Dose	Y	Y	Y	Y	COMPLETED
251	01-718-1328	High Dose	Y	Y	Y	N	WITHDRAWAL BY SUBJECT
252	01-718-1355	Placebo	Y	Y	Y	Y	COMPLETED
253	01-718-1371	High Dose	Y	Y	Y	N	ADVERSE EVENT
254	01-718-1427	High Dose	Y	Y	Y	N	LACK OF EFFICACY

		XANOMELINE
	Total (n=254)	Placebo (n=86)	Low Dose (n=84)	High Dose (n=84)	P-Value	Test
INTENT-TO-TREAT
Y	254 (100%)	86 (100%)	84 (100%)	84 (100%)
SAFETY
Y	254 (100%)	86 (100%)	84 (100%)	84 (100%)
EFFICACY
N	20 (7.87%)	7 (8.14%)	3 (3.57%)	10 (11.9%)
Y	234 (92.1%)	79 (91.9%)	81 (96.4%)	74 (88.1%)
COMPLETE WEEK 24
N	136 (53.5%)	26 (30.2%)	56 (66.7%)	54 (64.3%)
Y	118 (46.5%)	60 (69.8%)	28 (33.3%)	30 (35.7%)
Complete Study
ADVERSE EVENT	92 (36.2%)	8 (9.3%)	44 (52.4%)	40 (47.6%)
COMPLETED	110 (43.3%)	58 (67.4%)	25 (29.8%)	27 (32.1%)
DEATH	3 (1.18%)	2 (2.33%)	1 (1.19%)	0 (0%)
LACK OF EFFICACY	4 (1.57%)	3 (3.49%)	0 (0%)	1 (1.19%)
LOST TO FOLLOW-UP	2 (0.787%)	1 (1.16%)	1 (1.19%)	0 (0%)
PHYSICIAN DECISION	3 (1.18%)	1 (1.16%)	0 (0%)	2 (2.38%)
PROTOCOL VIOLATION	6 (2.36%)	2 (2.33%)	1 (1.19%)	3 (3.57%)
STUDY TERMINATED BY SPONSOR	7 (2.76%)	2 (2.33%)	2 (2.38%)	3 (3.57%)
WITHDRAWAL BY SUBJECT	27 (10.6%)	9 (10.5%)	10 (11.9%)	8 (9.52%)

TABLE 2

Data Preparation - Table 2

adsl_prep = @chain adsl_orig begin
    @transform :TRT01P = categorical(:TRT01P,
        levels = ["Placebo", "Xanomeline Low Dose", "Xanomeline High Dose"],
        ordered = true)
    @transform :TRT01P = recode(:TRT01P,
        "Xanomeline Low Dose" => "Low Dose",
        "Xanomeline High Dose" => "High Dose")
    
    @rtransform :COMP24FL = ifelse(:COMP24FL == "Y", 
        "Completed Week 24", 
        ifelse(:COMP24FL == "N", "Early Termination (prior to Week 24)", missing))

    @rtransform :DCDECOD = ifelse(:COMP24FL == "Completed Week 24" && :DCDECOD != "Complete",
        "Completed", :DCDECOD)
end

254×48 DataFrame

229 rows omitted

Row	STUDYID	USUBJID	SUBJID	SITEID	SITEGR1	ARM	TRT01P	TRT01PN	TRT01A	TRT01AN	TRTSDT	TRTEDT	TRTDUR	AVGDD	CUMDOSE	AGE	AGEGR1	AGEGR1N	AGEU	RACE	RACEN	SEX	ETHNIC	SAFFL	ITTFL	EFFFL	COMP8FL	COMP16FL	COMP24FL	DISCONFL	DSRAEFL	DTHFL	BMIBL	BMIBLGR1	HEIGHTBL	WEIGHTBL	EDUCLVL	DISONSDT	DURDIS	DURDSGR1	VISIT1DT	RFSTDTC	RFENDTC	VISNUMEN	RFENDT	DCDECOD	DCREASCD	MMSETOT
	String15	String15	String7	String3	String3	String31	Cat…	Float64	String31	Float64	Date	Date	Float64	Float64	Float64	Float64	String7	Float64	String7	String	Float64	String3	String31	String3	String3	String3	String3	String3	String	String3?	String3?	String3?	Float64?	String7	Float64	Float64?	Float64	Date	Float64	String7	Date	String15	String15	Float64	Date	Abstract…	String31	Float64
1	CDISCPILOT01	01-701-1015	1015	701	701	Placebo	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	182.0	0.0	0.0	63.0	<65	1.0	YEARS	WHITE	1.0	F	HISPANIC OR LATINO	Y	Y	Y	Y	Y	Completed Week 24	missing	missing	missing	25.1	25-<30	147.3	54.4	16.0	2010-04-30	43.9	>=12	2013-12-26	2014-01-02	2014-07-02	12.0	2014-07-02	Completed	Completed	23.0
2	CDISCPILOT01	01-701-1023	1023	701	701	Placebo	Placebo	0.0	Placebo	0.0	2012-08-05	2012-09-01	28.0	0.0	0.0	64.0	<65	1.0	YEARS	WHITE	1.0	M	HISPANIC OR LATINO	Y	Y	Y	N	N	Early Termination (prior to Week 24)	Y	Y	missing	30.4	>=30	162.6	80.3	14.0	2006-03-11	76.4	>=12	2012-07-22	2012-08-05	2012-09-02	5.0	2012-09-02	ADVERSE EVENT	Adverse Event	23.0
3	CDISCPILOT01	01-701-1028	1028	701	701	Xanomeline High Dose	High Dose	81.0	Xanomeline High Dose	81.0	2013-07-19	2014-01-14	180.0	77.7	13986.0	71.0	65-80	2.0	YEARS	WHITE	1.0	M	NOT HISPANIC OR LATINO	Y	Y	Y	Y	Y	Completed Week 24	missing	missing	missing	31.4	>=30	177.8	99.3	16.0	2009-12-16	42.8	>=12	2013-07-11	2013-07-19	2014-01-14	12.0	2014-01-14	Completed	Completed	23.0
4	CDISCPILOT01	01-701-1033	1033	701	701	Xanomeline Low Dose	Low Dose	54.0	Xanomeline Low Dose	54.0	2014-03-18	2014-03-31	14.0	54.0	756.0	74.0	65-80	2.0	YEARS	WHITE	1.0	M	NOT HISPANIC OR LATINO	Y	Y	Y	N	N	Early Termination (prior to Week 24)	Y	missing	missing	28.8	25-<30	175.3	88.5	12.0	2009-08-02	55.3	>=12	2014-03-10	2014-03-18	2014-04-14	5.0	2014-04-14	STUDY TERMINATED BY SPONSOR	Sponsor Decision	23.0
5	CDISCPILOT01	01-701-1034	1034	701	701	Xanomeline High Dose	High Dose	81.0	Xanomeline High Dose	81.0	2014-07-01	2014-12-30	183.0	76.9	14067.0	77.0	65-80	2.0	YEARS	WHITE	1.0	F	NOT HISPANIC OR LATINO	Y	Y	Y	Y	Y	Completed Week 24	missing	missing	missing	26.1	25-<30	154.9	62.6	9.0	2011-09-29	32.9	>=12	2014-06-24	2014-07-01	2014-12-30	12.0	2014-12-30	Completed	Completed	21.0
6	CDISCPILOT01	01-701-1047	1047	701	701	Placebo	Placebo	0.0	Placebo	0.0	2013-02-12	2013-03-09	26.0	0.0	0.0	85.0	>80	3.0	YEARS	WHITE	1.0	F	NOT HISPANIC OR LATINO	Y	Y	Y	N	N	Early Termination (prior to Week 24)	Y	Y	missing	30.4	>=30	148.6	67.1	8.0	2009-07-26	42.0	>=12	2013-01-22	2013-02-12	2013-03-29	6.0	2013-03-29	ADVERSE EVENT	Adverse Event	23.0
7	CDISCPILOT01	01-701-1097	1097	701	701	Xanomeline Low Dose	Low Dose	54.0	Xanomeline Low Dose	54.0	2014-01-01	2014-07-09	190.0	54.0	10260.0	68.0	65-80	2.0	YEARS	WHITE	1.0	M	NOT HISPANIC OR LATINO	Y	Y	Y	Y	Y	Completed Week 24	missing	missing	missing	27.3	25-<30	168.9	78.0	18.0	2005-09-22	99.1	>=12	2013-12-23	2014-01-01	2014-07-09	12.0	2014-07-09	Completed	Completed	10.0
8	CDISCPILOT01	01-701-1111	1111	701	701	Xanomeline Low Dose	Low Dose	54.0	Xanomeline Low Dose	54.0	2012-09-07	2012-09-16	10.0	54.0	540.0	81.0	>80	3.0	YEARS	WHITE	1.0	F	NOT HISPANIC OR LATINO	Y	Y	Y	N	N	Early Termination (prior to Week 24)	Y	Y	missing	23.9	<25	158.2	59.9	22.0	2009-04-04	40.7	>=12	2012-08-25	2012-09-07	2012-09-17	4.0	2012-09-17	ADVERSE EVENT	Adverse Event	23.0
9	CDISCPILOT01	01-701-1115	1115	701	701	Xanomeline Low Dose	Low Dose	54.0	Xanomeline Low Dose	54.0	2012-11-30	2013-01-23	55.0	54.0	2970.0	84.0	>80	3.0	YEARS	WHITE	1.0	M	NOT HISPANIC OR LATINO	Y	Y	Y	Y	N	Early Termination (prior to Week 24)	Y	Y	missing	23.9	<25	181.6	78.9	12.0	2004-05-28	101.9	>=12	2012-11-23	2012-11-30	2013-01-23	8.0	2013-01-23	ADVERSE EVENT	Adverse Event	20.0
10	CDISCPILOT01	01-701-1118	1118	701	701	Placebo	Placebo	0.0	Placebo	0.0	2014-03-12	2014-09-09	182.0	0.0	0.0	52.0	<65	1.0	YEARS	WHITE	1.0	M	NOT HISPANIC OR LATINO	Y	Y	Y	Y	Y	Completed Week 24	missing	missing	missing	21.9	<25	180.3	71.2	14.0	2010-06-24	44.2	>=12	2014-02-27	2014-03-12	2014-09-09	12.0	2014-09-09	Completed	Completed	20.0
11	CDISCPILOT01	01-701-1130	1130	701	701	Placebo	Placebo	0.0	Placebo	0.0	2014-02-15	2014-08-16	183.0	0.0	0.0	84.0	>80	3.0	YEARS	WHITE	1.0	M	NOT HISPANIC OR LATINO	Y	Y	Y	Y	Y	Completed Week 24	missing	missing	missing	27.6	25-<30	169.7	79.4	12.0	2010-05-22	44.7	>=12	2014-02-09	2014-02-15	2014-08-16	12.0	2014-08-16	Completed	Completed	19.0
12	CDISCPILOT01	01-701-1133	1133	701	701	Xanomeline High Dose	High Dose	81.0	Xanomeline High Dose	81.0	2012-10-28	2013-04-28	183.0	77.2	14121.0	81.0	>80	3.0	YEARS	WHITE	1.0	F	NOT HISPANIC OR LATINO	Y	Y	Y	Y	Y	Completed Week 24	missing	missing	missing	28.1	25-<30	162.6	74.4	10.0	2010-03-11	31.5	>=12	2012-10-23	2012-10-28	2013-04-29	12.0	2013-04-29	Completed	Completed	21.0
13	CDISCPILOT01	01-701-1146	1146	701	701	Xanomeline High Dose	High Dose	81.0	Xanomeline High Dose	81.0	2013-05-20	2013-06-26	38.0	70.3	2673.0	75.0	65-80	2.0	YEARS	WHITE	1.0	F	NOT HISPANIC OR LATINO	Y	Y	Y	N	N	Early Termination (prior to Week 24)	Y	Y	missing	24.9	<25	147.3	54.0	16.0	2009-11-17	41.7	>=12	2013-05-07	2013-05-20	2013-06-30	7.0	2013-06-30	ADVERSE EVENT	Adverse Event	22.0
⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮
243	CDISCPILOT01	01-718-1079	1079	718	718	Xanomeline Low Dose	Low Dose	54.0	Xanomeline Low Dose	54.0	2012-09-19	2012-10-31	43.0	54.0	2322.0	67.0	65-80	2.0	YEARS	WHITE	1.0	F	NOT HISPANIC OR LATINO	Y	Y	Y	N	N	Early Termination (prior to Week 24)	Y	Y	missing	20.0	<25	158.8	50.4	16.0	2005-06-27	86.5	>=12	2012-09-11	2012-09-19	2012-11-06	7.0	2012-11-06	ADVERSE EVENT	Adverse Event	17.0
244	CDISCPILOT01	01-718-1101	1101	718	718	Xanomeline High Dose	High Dose	81.0	Xanomeline High Dose	81.0	2013-02-17	2013-07-31	165.0	78.5	12960.0	82.0	>80	3.0	YEARS	BLACK OR AFRICAN AMERICAN	2.0	M	NOT HISPANIC OR LATINO	Y	Y	Y	Y	Y	Completed Week 24	Y	missing	missing	23.2	<25	186.2	80.3	12.0	2008-04-14	57.7	>=12	2013-02-01	2013-02-17	2013-08-02	12.0	2013-08-02	Completed	Sponsor Decision	13.0
245	CDISCPILOT01	01-718-1139	1139	718	718	Placebo	Placebo	0.0	Placebo	0.0	2013-05-19	2013-11-17	183.0	0.0	0.0	77.0	65-80	2.0	YEARS	WHITE	1.0	M	NOT HISPANIC OR LATINO	Y	Y	Y	Y	Y	Completed Week 24	missing	missing	missing	22.4	<25	171.5	65.8	14.0	2008-03-29	61.2	>=12	2013-05-03	2013-05-19	2013-11-17	12.0	2013-11-17	Completed	Completed	16.0
246	CDISCPILOT01	01-718-1150	1150	718	718	Placebo	Placebo	0.0	Placebo	0.0	2013-01-19	2013-07-29	192.0	0.0	0.0	73.0	65-80	2.0	YEARS	WHITE	1.0	F	NOT HISPANIC OR LATINO	Y	Y	Y	Y	Y	Completed Week 24	missing	missing	missing	22.5	<25	156.2	54.9	16.0	2012-03-11	10.1	<12	2013-01-12	2013-01-19	2013-07-31	12.0	2013-07-31	Completed	Completed	22.0
247	CDISCPILOT01	01-718-1170	1170	718	718	Xanomeline Low Dose	Low Dose	54.0	Xanomeline Low Dose	54.0	2013-09-16	2013-10-12	27.0	54.0	1458.0	80.0	65-80	2.0	YEARS	WHITE	1.0	F	NOT HISPANIC OR LATINO	Y	Y	Y	N	N	Early Termination (prior to Week 24)	Y	Y	missing	21.8	<25	162.6	57.6	12.0	2012-08-25	12.0	>=12	2013-08-25	2013-09-16	2013-11-03	5.0	2013-11-03	ADVERSE EVENT	Adverse Event	19.0
248	CDISCPILOT01	01-718-1172	1172	718	718	Placebo	Placebo	0.0	Placebo	0.0	2013-09-21	2013-11-29	70.0	0.0	0.0	74.0	65-80	2.0	YEARS	WHITE	1.0	M	NOT HISPANIC OR LATINO	Y	Y	Y	Y	N	Early Termination (prior to Week 24)	Y	missing	missing	21.9	<25	174.0	66.2	21.0	2011-10-01	23.5	>=12	2013-09-15	2013-09-21	2013-11-29	9.0	2013-11-29	WITHDRAWAL BY SUBJECT	Withdrew Consent	10.0
249	CDISCPILOT01	01-718-1250	1250	718	718	Xanomeline Low Dose	Low Dose	54.0	Xanomeline Low Dose	54.0	2013-09-21	2014-01-31	133.0	54.0	7182.0	82.0	>80	3.0	YEARS	WHITE	1.0	F	HISPANIC OR LATINO	Y	Y	Y	Y	Y	Early Termination (prior to Week 24)	Y	Y	missing	23.6	<25	157.5	58.5	21.0	2008-08-20	60.1	>=12	2013-08-21	2013-09-21	2014-02-08	11.0	2014-02-08	ADVERSE EVENT	Adverse Event	18.0
250	CDISCPILOT01	01-718-1254	1254	718	718	Xanomeline Low Dose	Low Dose	54.0	Xanomeline Low Dose	54.0	2013-07-10	2014-01-09	184.0	54.0	9936.0	78.0	65-80	2.0	YEARS	WHITE	1.0	M	HISPANIC OR LATINO	Y	Y	Y	Y	Y	Completed Week 24	missing	missing	missing	28.3	25-<30	170.2	82.1	18.0	2011-09-12	21.6	>=12	2013-06-28	2013-07-10	2014-01-09	12.0	2014-01-09	Completed	Completed	16.0
251	CDISCPILOT01	01-718-1328	1328	718	718	Xanomeline High Dose	High Dose	81.0	Xanomeline High Dose	81.0	2013-02-01	2013-04-18	77.0	76.1	5859.0	86.0	>80	3.0	YEARS	WHITE	1.0	M	NOT HISPANIC OR LATINO	Y	Y	Y	Y	N	Early Termination (prior to Week 24)	Y	missing	missing	21.9	<25	170.2	63.5	12.0	2010-01-11	36.6	>=12	2013-01-28	2013-02-01	2013-05-01	9.0	2013-05-01	WITHDRAWAL BY SUBJECT	Withdrew Consent	13.0
252	CDISCPILOT01	01-718-1355	1355	718	718	Placebo	Placebo	0.0	Placebo	0.0	2013-02-28	2013-08-29	183.0	0.0	0.0	79.0	65-80	2.0	YEARS	WHITE	1.0	M	NOT HISPANIC OR LATINO	Y	Y	Y	Y	Y	Completed Week 24	missing	missing	missing	20.8	<25	167.6	58.5	15.0	2008-12-05	50.3	>=12	2013-02-12	2013-02-28	2013-08-29	12.0	2013-08-29	Completed	Completed	16.0
253	CDISCPILOT01	01-718-1371	1371	718	718	Xanomeline High Dose	High Dose	81.0	Xanomeline High Dose	81.0	2013-04-26	2013-08-01	98.0	77.4	7587.0	69.0	65-80	2.0	YEARS	WHITE	1.0	F	NOT HISPANIC OR LATINO	Y	Y	Y	Y	N	Early Termination (prior to Week 24)	Y	Y	missing	27.8	25-<30	154.9	66.7	10.0	2013-02-04	2.2	<12	2013-04-11	2013-04-26	2013-08-08	9.0	2013-08-08	ADVERSE EVENT	Adverse Event	16.0
254	CDISCPILOT01	01-718-1427	1427	718	718	Xanomeline High Dose	High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	57.0	73.9	4212.0	74.0	65-80	2.0	YEARS	BLACK OR AFRICAN AMERICAN	2.0	F	NOT HISPANIC OR LATINO	Y	Y	Y	Y	N	Early Termination (prior to Week 24)	Y	missing	missing	20.5	<25	158.8	51.7	16.0	2010-05-03	31.4	>=12	2012-12-13	2012-12-17	2013-02-18	8.0	2013-02-18	LACK OF EFFICACY	Lack of Efficacy	19.0

Data wrangling

dcdecod_map = Dict(
    "Withdrawal By Subject" => "Subject decided to withdraw",
    "Study Terminated By Sponsor" => "Sponsor decision",
    "Physician Decision" => "Physician decided to withdraw subject",
    "Protocol Violation" => missing
)

adsl = @chain adsl_orig begin
    @rtransform :DCDECOD = get(dcdecod_map, titlecase(strip(:DCDECOD)), titlecase(strip(:DCDECOD)))
end

254×48 DataFrame

229 rows omitted

Row	STUDYID	USUBJID	SUBJID	SITEID	SITEGR1	ARM	TRT01P	TRT01PN	TRT01A	TRT01AN	TRTSDT	TRTEDT	TRTDUR	AVGDD	CUMDOSE	AGE	AGEGR1	AGEGR1N	AGEU	RACE	RACEN	SEX	ETHNIC	SAFFL	ITTFL	EFFFL	COMP8FL	COMP16FL	COMP24FL	DISCONFL	DSRAEFL	DTHFL	BMIBL	BMIBLGR1	HEIGHTBL	WEIGHTBL	EDUCLVL	DISONSDT	DURDIS	DURDSGR1	VISIT1DT	RFSTDTC	RFENDTC	VISNUMEN	RFENDT	DCDECOD	DCREASCD	MMSETOT
	String15	String15	String7	String3	String3	String31	String31	Float64	String31	Float64	Date	Date	Float64	Float64	Float64	Float64	String7	Float64	String7	String	Float64	String3	String31	String3	String3	String3	String3	String3	String3	String3?	String3?	String3?	Float64?	String7	Float64	Float64?	Float64	Date	Float64	String7	Date	String15	String15	Float64	Date	String?	String31	Float64
1	CDISCPILOT01	01-701-1015	1015	701	701	Placebo	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	182.0	0.0	0.0	63.0	<65	1.0	YEARS	WHITE	1.0	F	HISPANIC OR LATINO	Y	Y	Y	Y	Y	Y	missing	missing	missing	25.1	25-<30	147.3	54.4	16.0	2010-04-30	43.9	>=12	2013-12-26	2014-01-02	2014-07-02	12.0	2014-07-02	Completed	Completed	23.0
2	CDISCPILOT01	01-701-1023	1023	701	701	Placebo	Placebo	0.0	Placebo	0.0	2012-08-05	2012-09-01	28.0	0.0	0.0	64.0	<65	1.0	YEARS	WHITE	1.0	M	HISPANIC OR LATINO	Y	Y	Y	N	N	N	Y	Y	missing	30.4	>=30	162.6	80.3	14.0	2006-03-11	76.4	>=12	2012-07-22	2012-08-05	2012-09-02	5.0	2012-09-02	Adverse Event	Adverse Event	23.0
3	CDISCPILOT01	01-701-1028	1028	701	701	Xanomeline High Dose	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2013-07-19	2014-01-14	180.0	77.7	13986.0	71.0	65-80	2.0	YEARS	WHITE	1.0	M	NOT HISPANIC OR LATINO	Y	Y	Y	Y	Y	Y	missing	missing	missing	31.4	>=30	177.8	99.3	16.0	2009-12-16	42.8	>=12	2013-07-11	2013-07-19	2014-01-14	12.0	2014-01-14	Completed	Completed	23.0
4	CDISCPILOT01	01-701-1033	1033	701	701	Xanomeline Low Dose	Xanomeline Low Dose	54.0	Xanomeline Low Dose	54.0	2014-03-18	2014-03-31	14.0	54.0	756.0	74.0	65-80	2.0	YEARS	WHITE	1.0	M	NOT HISPANIC OR LATINO	Y	Y	Y	N	N	N	Y	missing	missing	28.8	25-<30	175.3	88.5	12.0	2009-08-02	55.3	>=12	2014-03-10	2014-03-18	2014-04-14	5.0	2014-04-14	Sponsor decision	Sponsor Decision	23.0
5	CDISCPILOT01	01-701-1034	1034	701	701	Xanomeline High Dose	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2014-07-01	2014-12-30	183.0	76.9	14067.0	77.0	65-80	2.0	YEARS	WHITE	1.0	F	NOT HISPANIC OR LATINO	Y	Y	Y	Y	Y	Y	missing	missing	missing	26.1	25-<30	154.9	62.6	9.0	2011-09-29	32.9	>=12	2014-06-24	2014-07-01	2014-12-30	12.0	2014-12-30	Completed	Completed	21.0
6	CDISCPILOT01	01-701-1047	1047	701	701	Placebo	Placebo	0.0	Placebo	0.0	2013-02-12	2013-03-09	26.0	0.0	0.0	85.0	>80	3.0	YEARS	WHITE	1.0	F	NOT HISPANIC OR LATINO	Y	Y	Y	N	N	N	Y	Y	missing	30.4	>=30	148.6	67.1	8.0	2009-07-26	42.0	>=12	2013-01-22	2013-02-12	2013-03-29	6.0	2013-03-29	Adverse Event	Adverse Event	23.0
7	CDISCPILOT01	01-701-1097	1097	701	701	Xanomeline Low Dose	Xanomeline Low Dose	54.0	Xanomeline Low Dose	54.0	2014-01-01	2014-07-09	190.0	54.0	10260.0	68.0	65-80	2.0	YEARS	WHITE	1.0	M	NOT HISPANIC OR LATINO	Y	Y	Y	Y	Y	Y	missing	missing	missing	27.3	25-<30	168.9	78.0	18.0	2005-09-22	99.1	>=12	2013-12-23	2014-01-01	2014-07-09	12.0	2014-07-09	Completed	Completed	10.0
8	CDISCPILOT01	01-701-1111	1111	701	701	Xanomeline Low Dose	Xanomeline Low Dose	54.0	Xanomeline Low Dose	54.0	2012-09-07	2012-09-16	10.0	54.0	540.0	81.0	>80	3.0	YEARS	WHITE	1.0	F	NOT HISPANIC OR LATINO	Y	Y	Y	N	N	N	Y	Y	missing	23.9	<25	158.2	59.9	22.0	2009-04-04	40.7	>=12	2012-08-25	2012-09-07	2012-09-17	4.0	2012-09-17	Adverse Event	Adverse Event	23.0
9	CDISCPILOT01	01-701-1115	1115	701	701	Xanomeline Low Dose	Xanomeline Low Dose	54.0	Xanomeline Low Dose	54.0	2012-11-30	2013-01-23	55.0	54.0	2970.0	84.0	>80	3.0	YEARS	WHITE	1.0	M	NOT HISPANIC OR LATINO	Y	Y	Y	Y	N	N	Y	Y	missing	23.9	<25	181.6	78.9	12.0	2004-05-28	101.9	>=12	2012-11-23	2012-11-30	2013-01-23	8.0	2013-01-23	Adverse Event	Adverse Event	20.0
10	CDISCPILOT01	01-701-1118	1118	701	701	Placebo	Placebo	0.0	Placebo	0.0	2014-03-12	2014-09-09	182.0	0.0	0.0	52.0	<65	1.0	YEARS	WHITE	1.0	M	NOT HISPANIC OR LATINO	Y	Y	Y	Y	Y	Y	missing	missing	missing	21.9	<25	180.3	71.2	14.0	2010-06-24	44.2	>=12	2014-02-27	2014-03-12	2014-09-09	12.0	2014-09-09	Completed	Completed	20.0
11	CDISCPILOT01	01-701-1130	1130	701	701	Placebo	Placebo	0.0	Placebo	0.0	2014-02-15	2014-08-16	183.0	0.0	0.0	84.0	>80	3.0	YEARS	WHITE	1.0	M	NOT HISPANIC OR LATINO	Y	Y	Y	Y	Y	Y	missing	missing	missing	27.6	25-<30	169.7	79.4	12.0	2010-05-22	44.7	>=12	2014-02-09	2014-02-15	2014-08-16	12.0	2014-08-16	Completed	Completed	19.0
12	CDISCPILOT01	01-701-1133	1133	701	701	Xanomeline High Dose	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2012-10-28	2013-04-28	183.0	77.2	14121.0	81.0	>80	3.0	YEARS	WHITE	1.0	F	NOT HISPANIC OR LATINO	Y	Y	Y	Y	Y	Y	missing	missing	missing	28.1	25-<30	162.6	74.4	10.0	2010-03-11	31.5	>=12	2012-10-23	2012-10-28	2013-04-29	12.0	2013-04-29	Completed	Completed	21.0
13	CDISCPILOT01	01-701-1146	1146	701	701	Xanomeline High Dose	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2013-05-20	2013-06-26	38.0	70.3	2673.0	75.0	65-80	2.0	YEARS	WHITE	1.0	F	NOT HISPANIC OR LATINO	Y	Y	Y	N	N	N	Y	Y	missing	24.9	<25	147.3	54.0	16.0	2009-11-17	41.7	>=12	2013-05-07	2013-05-20	2013-06-30	7.0	2013-06-30	Adverse Event	Adverse Event	22.0
⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮
243	CDISCPILOT01	01-718-1079	1079	718	718	Xanomeline Low Dose	Xanomeline Low Dose	54.0	Xanomeline Low Dose	54.0	2012-09-19	2012-10-31	43.0	54.0	2322.0	67.0	65-80	2.0	YEARS	WHITE	1.0	F	NOT HISPANIC OR LATINO	Y	Y	Y	N	N	N	Y	Y	missing	20.0	<25	158.8	50.4	16.0	2005-06-27	86.5	>=12	2012-09-11	2012-09-19	2012-11-06	7.0	2012-11-06	Adverse Event	Adverse Event	17.0
244	CDISCPILOT01	01-718-1101	1101	718	718	Xanomeline High Dose	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2013-02-17	2013-07-31	165.0	78.5	12960.0	82.0	>80	3.0	YEARS	BLACK OR AFRICAN AMERICAN	2.0	M	NOT HISPANIC OR LATINO	Y	Y	Y	Y	Y	Y	Y	missing	missing	23.2	<25	186.2	80.3	12.0	2008-04-14	57.7	>=12	2013-02-01	2013-02-17	2013-08-02	12.0	2013-08-02	Sponsor decision	Sponsor Decision	13.0
245	CDISCPILOT01	01-718-1139	1139	718	718	Placebo	Placebo	0.0	Placebo	0.0	2013-05-19	2013-11-17	183.0	0.0	0.0	77.0	65-80	2.0	YEARS	WHITE	1.0	M	NOT HISPANIC OR LATINO	Y	Y	Y	Y	Y	Y	missing	missing	missing	22.4	<25	171.5	65.8	14.0	2008-03-29	61.2	>=12	2013-05-03	2013-05-19	2013-11-17	12.0	2013-11-17	Completed	Completed	16.0
246	CDISCPILOT01	01-718-1150	1150	718	718	Placebo	Placebo	0.0	Placebo	0.0	2013-01-19	2013-07-29	192.0	0.0	0.0	73.0	65-80	2.0	YEARS	WHITE	1.0	F	NOT HISPANIC OR LATINO	Y	Y	Y	Y	Y	Y	missing	missing	missing	22.5	<25	156.2	54.9	16.0	2012-03-11	10.1	<12	2013-01-12	2013-01-19	2013-07-31	12.0	2013-07-31	Completed	Completed	22.0
247	CDISCPILOT01	01-718-1170	1170	718	718	Xanomeline Low Dose	Xanomeline Low Dose	54.0	Xanomeline Low Dose	54.0	2013-09-16	2013-10-12	27.0	54.0	1458.0	80.0	65-80	2.0	YEARS	WHITE	1.0	F	NOT HISPANIC OR LATINO	Y	Y	Y	N	N	N	Y	Y	missing	21.8	<25	162.6	57.6	12.0	2012-08-25	12.0	>=12	2013-08-25	2013-09-16	2013-11-03	5.0	2013-11-03	Adverse Event	Adverse Event	19.0
248	CDISCPILOT01	01-718-1172	1172	718	718	Placebo	Placebo	0.0	Placebo	0.0	2013-09-21	2013-11-29	70.0	0.0	0.0	74.0	65-80	2.0	YEARS	WHITE	1.0	M	NOT HISPANIC OR LATINO	Y	Y	Y	Y	N	N	Y	missing	missing	21.9	<25	174.0	66.2	21.0	2011-10-01	23.5	>=12	2013-09-15	2013-09-21	2013-11-29	9.0	2013-11-29	Subject decided to withdraw	Withdrew Consent	10.0
249	CDISCPILOT01	01-718-1250	1250	718	718	Xanomeline Low Dose	Xanomeline Low Dose	54.0	Xanomeline Low Dose	54.0	2013-09-21	2014-01-31	133.0	54.0	7182.0	82.0	>80	3.0	YEARS	WHITE	1.0	F	HISPANIC OR LATINO	Y	Y	Y	Y	Y	N	Y	Y	missing	23.6	<25	157.5	58.5	21.0	2008-08-20	60.1	>=12	2013-08-21	2013-09-21	2014-02-08	11.0	2014-02-08	Adverse Event	Adverse Event	18.0
250	CDISCPILOT01	01-718-1254	1254	718	718	Xanomeline Low Dose	Xanomeline Low Dose	54.0	Xanomeline Low Dose	54.0	2013-07-10	2014-01-09	184.0	54.0	9936.0	78.0	65-80	2.0	YEARS	WHITE	1.0	M	HISPANIC OR LATINO	Y	Y	Y	Y	Y	Y	missing	missing	missing	28.3	25-<30	170.2	82.1	18.0	2011-09-12	21.6	>=12	2013-06-28	2013-07-10	2014-01-09	12.0	2014-01-09	Completed	Completed	16.0
251	CDISCPILOT01	01-718-1328	1328	718	718	Xanomeline High Dose	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2013-02-01	2013-04-18	77.0	76.1	5859.0	86.0	>80	3.0	YEARS	WHITE	1.0	M	NOT HISPANIC OR LATINO	Y	Y	Y	Y	N	N	Y	missing	missing	21.9	<25	170.2	63.5	12.0	2010-01-11	36.6	>=12	2013-01-28	2013-02-01	2013-05-01	9.0	2013-05-01	Subject decided to withdraw	Withdrew Consent	13.0
252	CDISCPILOT01	01-718-1355	1355	718	718	Placebo	Placebo	0.0	Placebo	0.0	2013-02-28	2013-08-29	183.0	0.0	0.0	79.0	65-80	2.0	YEARS	WHITE	1.0	M	NOT HISPANIC OR LATINO	Y	Y	Y	Y	Y	Y	missing	missing	missing	20.8	<25	167.6	58.5	15.0	2008-12-05	50.3	>=12	2013-02-12	2013-02-28	2013-08-29	12.0	2013-08-29	Completed	Completed	16.0
253	CDISCPILOT01	01-718-1371	1371	718	718	Xanomeline High Dose	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2013-04-26	2013-08-01	98.0	77.4	7587.0	69.0	65-80	2.0	YEARS	WHITE	1.0	F	NOT HISPANIC OR LATINO	Y	Y	Y	Y	N	N	Y	Y	missing	27.8	25-<30	154.9	66.7	10.0	2013-02-04	2.2	<12	2013-04-11	2013-04-26	2013-08-08	9.0	2013-08-08	Adverse Event	Adverse Event	16.0
254	CDISCPILOT01	01-718-1427	1427	718	718	Xanomeline High Dose	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	57.0	73.9	4212.0	74.0	65-80	2.0	YEARS	BLACK OR AFRICAN AMERICAN	2.0	F	NOT HISPANIC OR LATINO	Y	Y	Y	Y	N	N	Y	missing	missing	20.5	<25	158.8	51.7	16.0	2010-05-03	31.4	>=12	2012-12-13	2012-12-17	2013-02-18	8.0	2013-02-18	Lack Of Efficacy	Lack of Efficacy	19.0

Data wrangling

allowed_levels = [
    "Adverse Event",
    "Death",
    "Lack Of Efficacy",
    "Lost To Follow-Up",
    "Subject decided to withdraw"
]

adsl = @chain adsl begin
    @rtransform :DCDECOD = get(
        Dict(
            "Adverse Event" => "Adverse Event",
            "Death" => "Death",
            "Lack Of Efficacy" => "Lack Of Efficacy",
            "Lost To Follow-Up" => "Lost To Follow-Up",
            "Subject decided to withdraw" => "Subject decided to withdraw"
        ),
        :DCDECOD,
        missing
    )
end

adsl.DCDECOD = categorical(adsl.DCDECOD, levels=allowed_levels, ordered=true)

254-element CategoricalArrays.CategoricalArray{Union{Missing, String},1,UInt32}:
 missing
 "Adverse Event"
 missing
 missing
 missing
 "Adverse Event"
 missing
 "Adverse Event"
 "Adverse Event"
 missing
 ⋮
 missing
 "Adverse Event"
 "Subject decided to withdraw"
 "Adverse Event"
 missing
 "Subject decided to withdraw"
 missing
 "Adverse Event"
 "Lack Of Efficacy"

Data wrangling

p_loefl = @chain adsl begin
    @rtransform :loefl = if ismissing(:DCDECOD)
        0
    else
        :DCDECOD == "Lack Of Efficacy" ? 1 : 0
    end
    groupby(:TRT01P)
    combine(_, :loefl => sum => :count)
end

3×2 DataFrame

Row	TRT01P	count
	String31	Int64
1	Placebo	3
2	Xanomeline High Dose	1
3	Xanomeline Low Dose	0

		XANOMELINE
	Total (n=254)	Placebo (n=86)	Xanomeline High Dose (n=84)	Xanomeline Low Dose (n=84)	P-Value	Test
Completion Status
N	136 (53.5%)	26 (30.2%)	54 (64.3%)	56 (66.7%)
Y	118 (46.5%)	60 (69.8%)	30 (35.7%)	28 (33.3%)
Reason for Early Termination (prior to Week 24)					0.001	ChisqTest
Adverse Event	92 (36.2%)	8 (9.3%)	40 (47.6%)	44 (52.4%)
Death	3 (1.18%)	2 (2.33%)	0 (0%)	1 (1.19%)
Lack Of Efficacy	4 (1.57%)	3 (3.49%)	1 (1.19%)	0 (0%)
Lost To Follow-Up	2 (0.787%)	1 (1.16%)	0 (0%)	1 (1.19%)
Subject decided to withdraw	27 (10.6%)	9 (10.5%)	8 (9.52%)	10 (11.9%)
Missing	126 (49.6%)	63 (73.3%)	35 (41.7%)	28 (33.3%)

TABLE 3

Data Preparation - Table 3

adsl_l = @chain adsl_orig begin
    @select :USUBJID :SITEGR1 :SITEID :TRT01P :ITTFL :EFFFL :COMP24FL
    @transform :SITE = string(:SITEGR1, " — ", :SITEID)
    stack(Not([:USUBJID, :SITEGR1, :SITEID, :TRT01P, :SITE]), variable_name = :DESC, value_name = :YN)
    @rtransform :YN = :YN == "Y" ? 1 : 0
    @rsubset :YN == 1
    @rtransform :DESC = ifelse(:DESC == "ITTFL", "ITT",
                         :DESC == "EFFFL" ? "Eff" :
                         :DESC == "COMP24FL" ? "Com" : missing)
end

606×7 DataFrame

581 rows omitted

Row	USUBJID	SITEGR1	SITEID	TRT01P	SITE	DESC	YN
	String15	String3	String3	String31	String	String	Int64
1	01-701-1015	701	701	Placebo	InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "900", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "900", "900", "900", "900", "900", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "900", "900", "900", "900", "713", "713", "713", "713", "713", "713", "713", "713", "713", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "900", "900", "900", "900", "900", "900", "900", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"] — InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "702", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "706", "706", "706", "707", "707", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "711", "711", "711", "711", "713", "713", "713", "713", "713", "713", "713", "713", "713", "714", "714", "714", "714", "714", "714", "715", "715", "715", "715", "715", "715", "715", "715", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "717", "717", "717", "717", "717", "717", "717", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"]	ITT	1
2	01-701-1023	701	701	Placebo	InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "900", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "900", "900", "900", "900", "900", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "900", "900", "900", "900", "713", "713", "713", "713", "713", "713", "713", "713", "713", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "900", "900", "900", "900", "900", "900", "900", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"] — InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "702", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "706", "706", "706", "707", "707", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "711", "711", "711", "711", "713", "713", "713", "713", "713", "713", "713", "713", "713", "714", "714", "714", "714", "714", "714", "715", "715", "715", "715", "715", "715", "715", "715", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "717", "717", "717", "717", "717", "717", "717", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"]	ITT	1
3	01-701-1028	701	701	Xanomeline High Dose	InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "900", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "900", "900", "900", "900", "900", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "900", "900", "900", "900", "713", "713", "713", "713", "713", "713", "713", "713", "713", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "900", "900", "900", "900", "900", "900", "900", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"] — InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "702", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "706", "706", "706", "707", "707", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "711", "711", "711", "711", "713", "713", "713", "713", "713", "713", "713", "713", "713", "714", "714", "714", "714", "714", "714", "715", "715", "715", "715", "715", "715", "715", "715", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "717", "717", "717", "717", "717", "717", "717", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"]	ITT	1
4	01-701-1033	701	701	Xanomeline Low Dose	InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "900", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "900", "900", "900", "900", "900", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "900", "900", "900", "900", "713", "713", "713", "713", "713", "713", "713", "713", "713", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "900", "900", "900", "900", "900", "900", "900", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"] — InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "702", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "706", "706", "706", "707", "707", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "711", "711", "711", "711", "713", "713", "713", "713", "713", "713", "713", "713", "713", "714", "714", "714", "714", "714", "714", "715", "715", "715", "715", "715", "715", "715", "715", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "717", "717", "717", "717", "717", "717", "717", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"]	ITT	1
5	01-701-1034	701	701	Xanomeline High Dose	InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "900", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "900", "900", "900", "900", "900", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "900", "900", "900", "900", "713", "713", "713", "713", "713", "713", "713", "713", "713", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "900", "900", "900", "900", "900", "900", "900", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"] — InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "702", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "706", "706", "706", "707", "707", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "711", "711", "711", "711", "713", "713", "713", "713", "713", "713", "713", "713", "713", "714", "714", "714", "714", "714", "714", "715", "715", "715", "715", "715", "715", "715", "715", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "717", "717", "717", "717", "717", "717", "717", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"]	ITT	1
6	01-701-1047	701	701	Placebo	InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "900", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "900", "900", "900", "900", "900", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "900", "900", "900", "900", "713", "713", "713", "713", "713", "713", "713", "713", "713", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "900", "900", "900", "900", "900", "900", "900", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"] — InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "702", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "706", "706", "706", "707", "707", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "711", "711", "711", "711", "713", "713", "713", "713", "713", "713", "713", "713", "713", "714", "714", "714", "714", "714", "714", "715", "715", "715", "715", "715", "715", "715", "715", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "717", "717", "717", "717", "717", "717", "717", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"]	ITT	1
7	01-701-1097	701	701	Xanomeline Low Dose	InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "900", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "900", "900", "900", "900", "900", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "900", "900", "900", "900", "713", "713", "713", "713", "713", "713", "713", "713", "713", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "900", "900", "900", "900", "900", "900", "900", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"] — InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "702", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "706", "706", "706", "707", "707", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "711", "711", "711", "711", "713", "713", "713", "713", "713", "713", "713", "713", "713", "714", "714", "714", "714", "714", "714", "715", "715", "715", "715", "715", "715", "715", "715", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "717", "717", "717", "717", "717", "717", "717", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"]	ITT	1
8	01-701-1111	701	701	Xanomeline Low Dose	InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "900", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "900", "900", "900", "900", "900", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "900", "900", "900", "900", "713", "713", "713", "713", "713", "713", "713", "713", "713", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "900", "900", "900", "900", "900", "900", "900", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"] — InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "702", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "706", "706", "706", "707", "707", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "711", "711", "711", "711", "713", "713", "713", "713", "713", "713", "713", "713", "713", "714", "714", "714", "714", "714", "714", "715", "715", "715", "715", "715", "715", "715", "715", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "717", "717", "717", "717", "717", "717", "717", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"]	ITT	1
9	01-701-1115	701	701	Xanomeline Low Dose	InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "900", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "900", "900", "900", "900", "900", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "900", "900", "900", "900", "713", "713", "713", "713", "713", "713", "713", "713", "713", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "900", "900", "900", "900", "900", "900", "900", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"] — InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "702", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "706", "706", "706", "707", "707", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "711", "711", "711", "711", "713", "713", "713", "713", "713", "713", "713", "713", "713", "714", "714", "714", "714", "714", "714", "715", "715", "715", "715", "715", "715", "715", "715", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "717", "717", "717", "717", "717", "717", "717", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"]	ITT	1
10	01-701-1118	701	701	Placebo	InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "900", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "900", "900", "900", "900", "900", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "900", "900", "900", "900", "713", "713", "713", "713", "713", "713", "713", "713", "713", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "900", "900", "900", "900", "900", "900", "900", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"] — InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "702", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "706", "706", "706", "707", "707", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "711", "711", "711", "711", "713", "713", "713", "713", "713", "713", "713", "713", "713", "714", "714", "714", "714", "714", "714", "715", "715", "715", "715", "715", "715", "715", "715", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "717", "717", "717", "717", "717", "717", "717", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"]	ITT	1
11	01-701-1130	701	701	Placebo	InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "900", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "900", "900", "900", "900", "900", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "900", "900", "900", "900", "713", "713", "713", "713", "713", "713", "713", "713", "713", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "900", "900", "900", "900", "900", "900", "900", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"] — InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "702", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "706", "706", "706", "707", "707", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "711", "711", "711", "711", "713", "713", "713", "713", "713", "713", "713", "713", "713", "714", "714", "714", "714", "714", "714", "715", "715", "715", "715", "715", "715", "715", "715", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "717", "717", "717", "717", "717", "717", "717", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"]	ITT	1
12	01-701-1133	701	701	Xanomeline High Dose	InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "900", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "900", "900", "900", "900", "900", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "900", "900", "900", "900", "713", "713", "713", "713", "713", "713", "713", "713", "713", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "900", "900", "900", "900", "900", "900", "900", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"] — InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "702", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "706", "706", "706", "707", "707", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "711", "711", "711", "711", "713", "713", "713", "713", "713", "713", "713", "713", "713", "714", "714", "714", "714", "714", "714", "715", "715", "715", "715", "715", "715", "715", "715", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "717", "717", "717", "717", "717", "717", "717", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"]	ITT	1
13	01-701-1146	701	701	Xanomeline High Dose	InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "900", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "900", "900", "900", "900", "900", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "900", "900", "900", "900", "713", "713", "713", "713", "713", "713", "713", "713", "713", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "900", "900", "900", "900", "900", "900", "900", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"] — InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "702", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "706", "706", "706", "707", "707", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "711", "711", "711", "711", "713", "713", "713", "713", "713", "713", "713", "713", "713", "714", "714", "714", "714", "714", "714", "715", "715", "715", "715", "715", "715", "715", "715", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "717", "717", "717", "717", "717", "717", "717", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"]	ITT	1
⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮
595	01-716-1441	716	716	Placebo	InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "900", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "900", "900", "900", "900", "900", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "900", "900", "900", "900", "713", "713", "713", "713", "713", "713", "713", "713", "713", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "900", "900", "900", "900", "900", "900", "900", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"] — InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "702", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "706", "706", "706", "707", "707", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "711", "711", "711", "711", "713", "713", "713", "713", "713", "713", "713", "713", "713", "714", "714", "714", "714", "714", "714", "715", "715", "715", "715", "715", "715", "715", "715", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "717", "717", "717", "717", "717", "717", "717", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"]	Com	1
596	01-716-1447	716	716	Xanomeline High Dose	InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "900", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "900", "900", "900", "900", "900", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "900", "900", "900", "900", "713", "713", "713", "713", "713", "713", "713", "713", "713", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "900", "900", "900", "900", "900", "900", "900", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"] — InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "702", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "706", "706", "706", "707", "707", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "711", "711", "711", "711", "713", "713", "713", "713", "713", "713", "713", "713", "713", "714", "714", "714", "714", "714", "714", "715", "715", "715", "715", "715", "715", "715", "715", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "717", "717", "717", "717", "717", "717", "717", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"]	Com	1
597	01-717-1004	900	717	Xanomeline Low Dose	InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "900", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "900", "900", "900", "900", "900", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "900", "900", "900", "900", "713", "713", "713", "713", "713", "713", "713", "713", "713", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "900", "900", "900", "900", "900", "900", "900", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"] — InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "702", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "706", "706", "706", "707", "707", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "711", "711", "711", "711", "713", "713", "713", "713", "713", "713", "713", "713", "713", "714", "714", "714", "714", "714", "714", "715", "715", "715", "715", "715", "715", "715", "715", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "717", "717", "717", "717", "717", "717", "717", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"]	Com	1
598	01-717-1109	900	717	Xanomeline High Dose	InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "900", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "900", "900", "900", "900", "900", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "900", "900", "900", "900", "713", "713", "713", "713", "713", "713", "713", "713", "713", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "900", "900", "900", "900", "900", "900", "900", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"] — InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "702", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "706", "706", "706", "707", "707", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "711", "711", "711", "711", "713", "713", "713", "713", "713", "713", "713", "713", "713", "714", "714", "714", "714", "714", "714", "715", "715", "715", "715", "715", "715", "715", "715", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "717", "717", "717", "717", "717", "717", "717", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"]	Com	1
599	01-717-1174	900	717	Xanomeline High Dose	InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "900", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "900", "900", "900", "900", "900", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "900", "900", "900", "900", "713", "713", "713", "713", "713", "713", "713", "713", "713", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "900", "900", "900", "900", "900", "900", "900", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"] — InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "702", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "706", "706", "706", "707", "707", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "711", "711", "711", "711", "713", "713", "713", "713", "713", "713", "713", "713", "713", "714", "714", "714", "714", "714", "714", "715", "715", "715", "715", "715", "715", "715", "715", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "717", "717", "717", "717", "717", "717", "717", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"]	Com	1
600	01-717-1357	900	717	Xanomeline High Dose	InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "900", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "900", "900", "900", "900", "900", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "900", "900", "900", "900", "713", "713", "713", "713", "713", "713", "713", "713", "713", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "900", "900", "900", "900", "900", "900", "900", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"] — InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "702", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "706", "706", "706", "707", "707", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "711", "711", "711", "711", "713", "713", "713", "713", "713", "713", "713", "713", "713", "714", "714", "714", "714", "714", "714", "715", "715", "715", "715", "715", "715", "715", "715", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "717", "717", "717", "717", "717", "717", "717", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"]	Com	1
601	01-717-1446	900	717	Xanomeline Low Dose	InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "900", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "900", "900", "900", "900", "900", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "900", "900", "900", "900", "713", "713", "713", "713", "713", "713", "713", "713", "713", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "900", "900", "900", "900", "900", "900", "900", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"] — InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "702", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "706", "706", "706", "707", "707", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "711", "711", "711", "711", "713", "713", "713", "713", "713", "713", "713", "713", "713", "714", "714", "714", "714", "714", "714", "715", "715", "715", "715", "715", "715", "715", "715", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "717", "717", "717", "717", "717", "717", "717", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"]	Com	1
602	01-718-1101	718	718	Xanomeline High Dose	InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "900", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "900", "900", "900", "900", "900", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "900", "900", "900", "900", "713", "713", "713", "713", "713", "713", "713", "713", "713", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "900", "900", "900", "900", "900", "900", "900", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"] — InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "702", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "706", "706", "706", "707", "707", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "711", "711", "711", "711", "713", "713", "713", "713", "713", "713", "713", "713", "713", "714", "714", "714", "714", "714", "714", "715", "715", "715", "715", "715", "715", "715", "715", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "717", "717", "717", "717", "717", "717", "717", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"]	Com	1
603	01-718-1139	718	718	Placebo	InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "900", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "900", "900", "900", "900", "900", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "900", "900", "900", "900", "713", "713", "713", "713", "713", "713", "713", "713", "713", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "900", "900", "900", "900", "900", "900", "900", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"] — InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "702", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "706", "706", "706", "707", "707", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "711", "711", "711", "711", "713", "713", "713", "713", "713", "713", "713", "713", "713", "714", "714", "714", "714", "714", "714", "715", "715", "715", "715", "715", "715", "715", "715", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "717", "717", "717", "717", "717", "717", "717", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"]	Com	1
604	01-718-1150	718	718	Placebo	InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "900", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "900", "900", "900", "900", "900", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "900", "900", "900", "900", "713", "713", "713", "713", "713", "713", "713", "713", "713", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "900", "900", "900", "900", "900", "900", "900", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"] — InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "702", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "706", "706", "706", "707", "707", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "711", "711", "711", "711", "713", "713", "713", "713", "713", "713", "713", "713", "713", "714", "714", "714", "714", "714", "714", "715", "715", "715", "715", "715", "715", "715", "715", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "717", "717", "717", "717", "717", "717", "717", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"]	Com	1
605	01-718-1254	718	718	Xanomeline Low Dose	InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "900", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "900", "900", "900", "900", "900", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "900", "900", "900", "900", "713", "713", "713", "713", "713", "713", "713", "713", "713", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "900", "900", "900", "900", "900", "900", "900", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"] — InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "702", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "706", "706", "706", "707", "707", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "711", "711", "711", "711", "713", "713", "713", "713", "713", "713", "713", "713", "713", "714", "714", "714", "714", "714", "714", "715", "715", "715", "715", "715", "715", "715", "715", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "717", "717", "717", "717", "717", "717", "717", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"]	Com	1
606	01-718-1355	718	718	Placebo	InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "900", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "900", "900", "900", "900", "900", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "900", "900", "900", "900", "713", "713", "713", "713", "713", "713", "713", "713", "713", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "900", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "900", "900", "900", "900", "900", "900", "900", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"] — InlineStrings.String3["701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "701", "702", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "703", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "704", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "705", "706", "706", "706", "707", "707", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "708", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "709", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "710", "711", "711", "711", "711", "713", "713", "713", "713", "713", "713", "713", "713", "713", "714", "714", "714", "714", "714", "714", "715", "715", "715", "715", "715", "715", "715", "715", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "716", "717", "717", "717", "717", "717", "717", "717", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718", "718"]	Com	1

Data wrangling

adsl_l = @chain adsl_orig begin
    @select :SUBJID :SITEID :TRT01P :ITTFL :EFFFL :COMP24FL
    @rtransform :SITE = string(:SITEID)
    stack([:ITTFL, :EFFFL, :COMP24FL], 
          [:SUBJID, :SITEID, :TRT01P, :SITE], 
          variable_name = :DESC, value_name = :YN)

    @rtransform :YN = :YN == "Y" ? 1 : 0
    @rsubset :YN == 1

    @rtransform :DESC = if :DESC == "ITTFL"
        "ITT"
    elseif :DESC == "EFFFL"
        "Eff"
    elseif :DESC == "COMP24FL"
        "Com"
    else
        missing
    end

    @transform :DESC = categorical(:DESC, levels = ["ITT", "Eff", "Com"])
    @transform :TRT01P = categorical(:TRT01P,
        levels = ["Placebo", "Xanomeline Low Dose", "Xanomeline High Dose"],
        ordered = true)
    @transform :TRT01P = recode(:TRT01P,
        "Xanomeline Low Dose" => "Low Dose",
        "Xanomeline High Dose" => "High Dose")
    
end

606×6 DataFrame

581 rows omitted

Row	SUBJID	SITEID	TRT01P	SITE	DESC	YN
	String7	String3	Cat…	String3	Cat…	Int64
1	1015	701	Placebo	701	ITT	1
2	1023	701	Placebo	701	ITT	1
3	1028	701	High Dose	701	ITT	1
4	1033	701	Low Dose	701	ITT	1
5	1034	701	High Dose	701	ITT	1
6	1047	701	Placebo	701	ITT	1
7	1097	701	Low Dose	701	ITT	1
8	1111	701	Low Dose	701	ITT	1
9	1115	701	Low Dose	701	ITT	1
10	1118	701	Placebo	701	ITT	1
11	1130	701	Placebo	701	ITT	1
12	1133	701	High Dose	701	ITT	1
13	1146	701	High Dose	701	ITT	1
⋮	⋮	⋮	⋮	⋮	⋮	⋮
595	1441	716	Placebo	716	Com	1
596	1447	716	High Dose	716	Com	1
597	1004	717	Low Dose	717	Com	1
598	1109	717	High Dose	717	Com	1
599	1174	717	High Dose	717	Com	1
600	1357	717	High Dose	717	Com	1
601	1446	717	Low Dose	717	Com	1
602	1101	718	High Dose	718	Com	1
603	1139	718	Placebo	718	Com	1
604	1150	718	Placebo	718	Com	1
605	1254	718	Low Dose	718	Com	1
606	1355	718	Placebo	718	Com	1

		Dose
		Placebo (n=225)			Low Dose (n=193)			High Dose (n=188)
		Desc			Desc			Desc
	Total (n=606)	ITT (n=86)	Eff (n=79)	Com (n=60)	ITT (n=84)	Eff (n=81)	Com (n=28)	ITT (n=84)	Eff (n=74)	Com (n=30)
Pooled-SITEID
701	105 (17.3%)	14 (16.3%)	14 (17.7%)	11 (18.3%)	13 (15.5%)	13 (16%)	5 (17.9%)	14 (16.7%)	14 (18.9%)	7 (23.3%)
702	2 (0.33%)	0 (0%)	0 (0%)	0 (0%)	1 (1.19%)	1 (1.23%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)
703	40 (6.6%)	6 (6.98%)	5 (6.33%)	4 (6.67%)	6 (7.14%)	5 (6.17%)	1 (3.57%)	6 (7.14%)	5 (6.76%)	2 (6.67%)
704	57 (9.41%)	9 (10.5%)	9 (11.4%)	5 (8.33%)	8 (9.52%)	7 (8.64%)	3 (10.7%)	8 (9.52%)	8 (10.8%)	0 (0%)
705	34 (5.61%)	5 (5.81%)	3 (3.8%)	2 (3.33%)	5 (5.95%)	5 (6.17%)	3 (10.7%)	6 (7.14%)	4 (5.41%)	1 (3.33%)
706	7 (1.16%)	1 (1.16%)	1 (1.27%)	1 (1.67%)	1 (1.19%)	1 (1.23%)	0 (0%)	1 (1.19%)	1 (1.35%)	0 (0%)
707	5 (0.825%)	1 (1.16%)	1 (1.27%)	1 (1.67%)	1 (1.19%)	1 (1.23%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)
708	58 (9.57%)	9 (10.5%)	9 (11.4%)	7 (11.7%)	8 (9.52%)	8 (9.88%)	2 (7.14%)	8 (9.52%)	5 (6.76%)	2 (6.67%)
709	51 (8.42%)	7 (8.14%)	7 (8.86%)	5 (8.33%)	7 (8.33%)	6 (7.41%)	2 (7.14%)	7 (8.33%)	7 (9.46%)	3 (10%)
710	70 (11.6%)	11 (12.8%)	8 (10.1%)	6 (10%)	10 (11.9%)	10 (12.3%)	2 (7.14%)	10 (11.9%)	8 (10.8%)	5 (16.7%)
711	8 (1.32%)	1 (1.16%)	1 (1.27%)	1 (1.67%)	1 (1.19%)	1 (1.23%)	0 (0%)	2 (2.38%)	1 (1.35%)	0 (0%)
713	24 (3.96%)	3 (3.49%)	3 (3.8%)	3 (5%)	3 (3.57%)	3 (3.7%)	2 (7.14%)	3 (3.57%)	2 (2.7%)	2 (6.67%)
714	16 (2.64%)	2 (2.33%)	2 (2.53%)	2 (3.33%)	2 (2.38%)	2 (2.47%)	1 (3.57%)	2 (2.38%)	2 (2.7%)	1 (3.33%)
715	18 (2.97%)	3 (3.49%)	2 (2.53%)	2 (3.33%)	3 (3.57%)	3 (3.7%)	1 (3.57%)	2 (2.38%)	2 (2.7%)	0 (0%)
716	61 (10.1%)	8 (9.3%)	8 (10.1%)	7 (11.7%)	8 (9.52%)	8 (9.88%)	3 (10.7%)	8 (9.52%)	8 (10.8%)	3 (10%)
717	19 (3.14%)	2 (2.33%)	2 (2.53%)	0 (0%)	2 (2.38%)	2 (2.47%)	2 (7.14%)	3 (3.57%)	3 (4.05%)	3 (10%)
718	31 (5.12%)	4 (4.65%)	4 (5.06%)	3 (5%)	5 (5.95%)	5 (6.17%)	1 (3.57%)	4 (4.76%)	4 (5.41%)	1 (3.33%)

TABLE 4

Data Preparation - Table 4

adsl_demo = @chain adsl_orig begin
    @transform :TRT01P = categorical(:TRT01P,
        levels = ["Placebo", "Xanomeline Low Dose", "Xanomeline High Dose"],
        ordered = true)
    @transform :TRT01P = recode(:TRT01P,
        "Xanomeline Low Dose" => "Low Dose",
        "Xanomeline High Dose" => "High Dose")
    @transform :SEX = recode(categorical(:SEX), "F" => "Female", "M" => "Male")
    @transform :SEX = categorical(:SEX, levels = ["Female", "Male"], ordered = true)
    @transform :AGEGR1 = recode(categorical(:AGEGR1),
        "<65" => "<65 yrs",
        "65-80" => "65-80 yrs",
        ">80" => ">80 yrs")
    @transform :RACE = titlecase.(strip.(:RACE))
    @transform :BMIBLGR1 = categorical(:BMIBLGR1,
        levels = ["<25", "25-<30", ">=30"], ordered = true)
    @transform :DURDSGR1 = recode(categorical(:DURDSGR1),
        "<12 Months" => "<12 months",
        ">=12 Months" => ">=12 months")
end

254×48 DataFrame

229 rows omitted

Row	STUDYID	USUBJID	SUBJID	SITEID	SITEGR1	ARM	TRT01P	TRT01PN	TRT01A	TRT01AN	TRTSDT	TRTEDT	TRTDUR	AVGDD	CUMDOSE	AGE	AGEGR1	AGEGR1N	AGEU	RACE	RACEN	SEX	ETHNIC	SAFFL	ITTFL	EFFFL	COMP8FL	COMP16FL	COMP24FL	DISCONFL	DSRAEFL	DTHFL	BMIBL	BMIBLGR1	HEIGHTBL	WEIGHTBL	EDUCLVL	DISONSDT	DURDIS	DURDSGR1	VISIT1DT	RFSTDTC	RFENDTC	VISNUMEN	RFENDT	DCDECOD	DCREASCD	MMSETOT
	String15	String15	String7	String3	String3	String31	Cat…	Float64	String31	Float64	Date	Date	Float64	Float64	Float64	Float64	Cat…	Float64	String7	String	Float64	Cat…	String31	String3	String3	String3	String3	String3	String3	String3?	String3?	String3?	Float64?	Cat…	Float64	Float64?	Float64	Date	Float64	Cat…	Date	String15	String15	Float64	Date	String31	String31	Float64
1	CDISCPILOT01	01-701-1015	1015	701	701	Placebo	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	182.0	0.0	0.0	63.0	<65 yrs	1.0	YEARS	White	1.0	Female	HISPANIC OR LATINO	Y	Y	Y	Y	Y	Y	missing	missing	missing	25.1	25-<30	147.3	54.4	16.0	2010-04-30	43.9	>=12	2013-12-26	2014-01-02	2014-07-02	12.0	2014-07-02	COMPLETED	Completed	23.0
2	CDISCPILOT01	01-701-1023	1023	701	701	Placebo	Placebo	0.0	Placebo	0.0	2012-08-05	2012-09-01	28.0	0.0	0.0	64.0	<65 yrs	1.0	YEARS	White	1.0	Male	HISPANIC OR LATINO	Y	Y	Y	N	N	N	Y	Y	missing	30.4	>=30	162.6	80.3	14.0	2006-03-11	76.4	>=12	2012-07-22	2012-08-05	2012-09-02	5.0	2012-09-02	ADVERSE EVENT	Adverse Event	23.0
3	CDISCPILOT01	01-701-1028	1028	701	701	Xanomeline High Dose	High Dose	81.0	Xanomeline High Dose	81.0	2013-07-19	2014-01-14	180.0	77.7	13986.0	71.0	65-80 yrs	2.0	YEARS	White	1.0	Male	NOT HISPANIC OR LATINO	Y	Y	Y	Y	Y	Y	missing	missing	missing	31.4	>=30	177.8	99.3	16.0	2009-12-16	42.8	>=12	2013-07-11	2013-07-19	2014-01-14	12.0	2014-01-14	COMPLETED	Completed	23.0
4	CDISCPILOT01	01-701-1033	1033	701	701	Xanomeline Low Dose	Low Dose	54.0	Xanomeline Low Dose	54.0	2014-03-18	2014-03-31	14.0	54.0	756.0	74.0	65-80 yrs	2.0	YEARS	White	1.0	Male	NOT HISPANIC OR LATINO	Y	Y	Y	N	N	N	Y	missing	missing	28.8	25-<30	175.3	88.5	12.0	2009-08-02	55.3	>=12	2014-03-10	2014-03-18	2014-04-14	5.0	2014-04-14	STUDY TERMINATED BY SPONSOR	Sponsor Decision	23.0
5	CDISCPILOT01	01-701-1034	1034	701	701	Xanomeline High Dose	High Dose	81.0	Xanomeline High Dose	81.0	2014-07-01	2014-12-30	183.0	76.9	14067.0	77.0	65-80 yrs	2.0	YEARS	White	1.0	Female	NOT HISPANIC OR LATINO	Y	Y	Y	Y	Y	Y	missing	missing	missing	26.1	25-<30	154.9	62.6	9.0	2011-09-29	32.9	>=12	2014-06-24	2014-07-01	2014-12-30	12.0	2014-12-30	COMPLETED	Completed	21.0
6	CDISCPILOT01	01-701-1047	1047	701	701	Placebo	Placebo	0.0	Placebo	0.0	2013-02-12	2013-03-09	26.0	0.0	0.0	85.0	>80 yrs	3.0	YEARS	White	1.0	Female	NOT HISPANIC OR LATINO	Y	Y	Y	N	N	N	Y	Y	missing	30.4	>=30	148.6	67.1	8.0	2009-07-26	42.0	>=12	2013-01-22	2013-02-12	2013-03-29	6.0	2013-03-29	ADVERSE EVENT	Adverse Event	23.0
7	CDISCPILOT01	01-701-1097	1097	701	701	Xanomeline Low Dose	Low Dose	54.0	Xanomeline Low Dose	54.0	2014-01-01	2014-07-09	190.0	54.0	10260.0	68.0	65-80 yrs	2.0	YEARS	White	1.0	Male	NOT HISPANIC OR LATINO	Y	Y	Y	Y	Y	Y	missing	missing	missing	27.3	25-<30	168.9	78.0	18.0	2005-09-22	99.1	>=12	2013-12-23	2014-01-01	2014-07-09	12.0	2014-07-09	COMPLETED	Completed	10.0
8	CDISCPILOT01	01-701-1111	1111	701	701	Xanomeline Low Dose	Low Dose	54.0	Xanomeline Low Dose	54.0	2012-09-07	2012-09-16	10.0	54.0	540.0	81.0	>80 yrs	3.0	YEARS	White	1.0	Female	NOT HISPANIC OR LATINO	Y	Y	Y	N	N	N	Y	Y	missing	23.9	<25	158.2	59.9	22.0	2009-04-04	40.7	>=12	2012-08-25	2012-09-07	2012-09-17	4.0	2012-09-17	ADVERSE EVENT	Adverse Event	23.0
9	CDISCPILOT01	01-701-1115	1115	701	701	Xanomeline Low Dose	Low Dose	54.0	Xanomeline Low Dose	54.0	2012-11-30	2013-01-23	55.0	54.0	2970.0	84.0	>80 yrs	3.0	YEARS	White	1.0	Male	NOT HISPANIC OR LATINO	Y	Y	Y	Y	N	N	Y	Y	missing	23.9	<25	181.6	78.9	12.0	2004-05-28	101.9	>=12	2012-11-23	2012-11-30	2013-01-23	8.0	2013-01-23	ADVERSE EVENT	Adverse Event	20.0
10	CDISCPILOT01	01-701-1118	1118	701	701	Placebo	Placebo	0.0	Placebo	0.0	2014-03-12	2014-09-09	182.0	0.0	0.0	52.0	<65 yrs	1.0	YEARS	White	1.0	Male	NOT HISPANIC OR LATINO	Y	Y	Y	Y	Y	Y	missing	missing	missing	21.9	<25	180.3	71.2	14.0	2010-06-24	44.2	>=12	2014-02-27	2014-03-12	2014-09-09	12.0	2014-09-09	COMPLETED	Completed	20.0
11	CDISCPILOT01	01-701-1130	1130	701	701	Placebo	Placebo	0.0	Placebo	0.0	2014-02-15	2014-08-16	183.0	0.0	0.0	84.0	>80 yrs	3.0	YEARS	White	1.0	Male	NOT HISPANIC OR LATINO	Y	Y	Y	Y	Y	Y	missing	missing	missing	27.6	25-<30	169.7	79.4	12.0	2010-05-22	44.7	>=12	2014-02-09	2014-02-15	2014-08-16	12.0	2014-08-16	COMPLETED	Completed	19.0
12	CDISCPILOT01	01-701-1133	1133	701	701	Xanomeline High Dose	High Dose	81.0	Xanomeline High Dose	81.0	2012-10-28	2013-04-28	183.0	77.2	14121.0	81.0	>80 yrs	3.0	YEARS	White	1.0	Female	NOT HISPANIC OR LATINO	Y	Y	Y	Y	Y	Y	missing	missing	missing	28.1	25-<30	162.6	74.4	10.0	2010-03-11	31.5	>=12	2012-10-23	2012-10-28	2013-04-29	12.0	2013-04-29	COMPLETED	Completed	21.0
13	CDISCPILOT01	01-701-1146	1146	701	701	Xanomeline High Dose	High Dose	81.0	Xanomeline High Dose	81.0	2013-05-20	2013-06-26	38.0	70.3	2673.0	75.0	65-80 yrs	2.0	YEARS	White	1.0	Female	NOT HISPANIC OR LATINO	Y	Y	Y	N	N	N	Y	Y	missing	24.9	<25	147.3	54.0	16.0	2009-11-17	41.7	>=12	2013-05-07	2013-05-20	2013-06-30	7.0	2013-06-30	ADVERSE EVENT	Adverse Event	22.0
⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮
243	CDISCPILOT01	01-718-1079	1079	718	718	Xanomeline Low Dose	Low Dose	54.0	Xanomeline Low Dose	54.0	2012-09-19	2012-10-31	43.0	54.0	2322.0	67.0	65-80 yrs	2.0	YEARS	White	1.0	Female	NOT HISPANIC OR LATINO	Y	Y	Y	N	N	N	Y	Y	missing	20.0	<25	158.8	50.4	16.0	2005-06-27	86.5	>=12	2012-09-11	2012-09-19	2012-11-06	7.0	2012-11-06	ADVERSE EVENT	Adverse Event	17.0
244	CDISCPILOT01	01-718-1101	1101	718	718	Xanomeline High Dose	High Dose	81.0	Xanomeline High Dose	81.0	2013-02-17	2013-07-31	165.0	78.5	12960.0	82.0	>80 yrs	3.0	YEARS	Black Or African American	2.0	Male	NOT HISPANIC OR LATINO	Y	Y	Y	Y	Y	Y	Y	missing	missing	23.2	<25	186.2	80.3	12.0	2008-04-14	57.7	>=12	2013-02-01	2013-02-17	2013-08-02	12.0	2013-08-02	STUDY TERMINATED BY SPONSOR	Sponsor Decision	13.0
245	CDISCPILOT01	01-718-1139	1139	718	718	Placebo	Placebo	0.0	Placebo	0.0	2013-05-19	2013-11-17	183.0	0.0	0.0	77.0	65-80 yrs	2.0	YEARS	White	1.0	Male	NOT HISPANIC OR LATINO	Y	Y	Y	Y	Y	Y	missing	missing	missing	22.4	<25	171.5	65.8	14.0	2008-03-29	61.2	>=12	2013-05-03	2013-05-19	2013-11-17	12.0	2013-11-17	COMPLETED	Completed	16.0
246	CDISCPILOT01	01-718-1150	1150	718	718	Placebo	Placebo	0.0	Placebo	0.0	2013-01-19	2013-07-29	192.0	0.0	0.0	73.0	65-80 yrs	2.0	YEARS	White	1.0	Female	NOT HISPANIC OR LATINO	Y	Y	Y	Y	Y	Y	missing	missing	missing	22.5	<25	156.2	54.9	16.0	2012-03-11	10.1	<12	2013-01-12	2013-01-19	2013-07-31	12.0	2013-07-31	COMPLETED	Completed	22.0
247	CDISCPILOT01	01-718-1170	1170	718	718	Xanomeline Low Dose	Low Dose	54.0	Xanomeline Low Dose	54.0	2013-09-16	2013-10-12	27.0	54.0	1458.0	80.0	65-80 yrs	2.0	YEARS	White	1.0	Female	NOT HISPANIC OR LATINO	Y	Y	Y	N	N	N	Y	Y	missing	21.8	<25	162.6	57.6	12.0	2012-08-25	12.0	>=12	2013-08-25	2013-09-16	2013-11-03	5.0	2013-11-03	ADVERSE EVENT	Adverse Event	19.0
248	CDISCPILOT01	01-718-1172	1172	718	718	Placebo	Placebo	0.0	Placebo	0.0	2013-09-21	2013-11-29	70.0	0.0	0.0	74.0	65-80 yrs	2.0	YEARS	White	1.0	Male	NOT HISPANIC OR LATINO	Y	Y	Y	Y	N	N	Y	missing	missing	21.9	<25	174.0	66.2	21.0	2011-10-01	23.5	>=12	2013-09-15	2013-09-21	2013-11-29	9.0	2013-11-29	WITHDRAWAL BY SUBJECT	Withdrew Consent	10.0
249	CDISCPILOT01	01-718-1250	1250	718	718	Xanomeline Low Dose	Low Dose	54.0	Xanomeline Low Dose	54.0	2013-09-21	2014-01-31	133.0	54.0	7182.0	82.0	>80 yrs	3.0	YEARS	White	1.0	Female	HISPANIC OR LATINO	Y	Y	Y	Y	Y	N	Y	Y	missing	23.6	<25	157.5	58.5	21.0	2008-08-20	60.1	>=12	2013-08-21	2013-09-21	2014-02-08	11.0	2014-02-08	ADVERSE EVENT	Adverse Event	18.0
250	CDISCPILOT01	01-718-1254	1254	718	718	Xanomeline Low Dose	Low Dose	54.0	Xanomeline Low Dose	54.0	2013-07-10	2014-01-09	184.0	54.0	9936.0	78.0	65-80 yrs	2.0	YEARS	White	1.0	Male	HISPANIC OR LATINO	Y	Y	Y	Y	Y	Y	missing	missing	missing	28.3	25-<30	170.2	82.1	18.0	2011-09-12	21.6	>=12	2013-06-28	2013-07-10	2014-01-09	12.0	2014-01-09	COMPLETED	Completed	16.0
251	CDISCPILOT01	01-718-1328	1328	718	718	Xanomeline High Dose	High Dose	81.0	Xanomeline High Dose	81.0	2013-02-01	2013-04-18	77.0	76.1	5859.0	86.0	>80 yrs	3.0	YEARS	White	1.0	Male	NOT HISPANIC OR LATINO	Y	Y	Y	Y	N	N	Y	missing	missing	21.9	<25	170.2	63.5	12.0	2010-01-11	36.6	>=12	2013-01-28	2013-02-01	2013-05-01	9.0	2013-05-01	WITHDRAWAL BY SUBJECT	Withdrew Consent	13.0
252	CDISCPILOT01	01-718-1355	1355	718	718	Placebo	Placebo	0.0	Placebo	0.0	2013-02-28	2013-08-29	183.0	0.0	0.0	79.0	65-80 yrs	2.0	YEARS	White	1.0	Male	NOT HISPANIC OR LATINO	Y	Y	Y	Y	Y	Y	missing	missing	missing	20.8	<25	167.6	58.5	15.0	2008-12-05	50.3	>=12	2013-02-12	2013-02-28	2013-08-29	12.0	2013-08-29	COMPLETED	Completed	16.0
253	CDISCPILOT01	01-718-1371	1371	718	718	Xanomeline High Dose	High Dose	81.0	Xanomeline High Dose	81.0	2013-04-26	2013-08-01	98.0	77.4	7587.0	69.0	65-80 yrs	2.0	YEARS	White	1.0	Female	NOT HISPANIC OR LATINO	Y	Y	Y	Y	N	N	Y	Y	missing	27.8	25-<30	154.9	66.7	10.0	2013-02-04	2.2	<12	2013-04-11	2013-04-26	2013-08-08	9.0	2013-08-08	ADVERSE EVENT	Adverse Event	16.0
254	CDISCPILOT01	01-718-1427	1427	718	718	Xanomeline High Dose	High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	57.0	73.9	4212.0	74.0	65-80 yrs	2.0	YEARS	Black Or African American	2.0	Female	NOT HISPANIC OR LATINO	Y	Y	Y	Y	N	N	Y	missing	missing	20.5	<25	158.8	51.7	16.0	2010-05-03	31.4	>=12	2012-12-13	2012-12-17	2013-02-18	8.0	2013-02-18	LACK OF EFFICACY	Lack of Efficacy	19.0

		Treatment Arm
	Overall (n=254)	Placebo (n=86)	Low Dose (n=84)	High Dose (n=84)	P-Value	Test
Age (y)					0.628	UnequalVarianceTTest
n	254	86	84	84
Mean	75.1	75.2	75.7	74.4
SD	8.25	8.59	8.29	7.89
Median	77	76	77.5	76
Min	51	52	51	56
Max	89	89	88	88
					0.144	ChisqTest
<65 yrs	33 (13%)	14 (16.3%)	8 (9.52%)	11 (13.1%)
65-80 yrs	144 (56.7%)	42 (48.8%)	47 (56%)	55 (65.5%)
>80 yrs	77 (30.3%)	30 (34.9%)	29 (34.5%)	18 (21.4%)
Sex					0.141	ChisqTest
Female	143 (56.3%)	53 (61.6%)	50 (59.5%)	40 (47.6%)
Male	111 (43.7%)	33 (38.4%)	34 (40.5%)	44 (52.4%)
Race (Origin)
American Indian Or Alaska Native	1 (0.394%)	0 (0%)	0 (0%)	1 (1.19%)
Black Or African American	23 (9.06%)	8 (9.3%)	6 (7.14%)	9 (10.7%)
White	230 (90.6%)	78 (90.7%)	78 (92.9%)	74 (88.1%)
MMSE					0.643	UnequalVarianceTTest
n	254	86	84	84
Mean	18.1	18	17.9	18.5
SD	4.21	4.27	4.22	4.16
Median	19	19.5	18	20
Min	10	10	10	10
Max	24	23	24	24
Duration of disease					0.118	UnequalVarianceTTest
n	254	86	84	84
Mean	43.9	42.6	48.7	40.5
SD	28.4	30.2	29.6	24.7
Median	36.2	35.3	40.2	36
Min	2.2	7.2	7.8	2.2
Max	183	183	131	135
					NaN	ChisqTest
<12	12 (4.72%)	5 (5.81%)	3 (3.57%)	4 (4.76%)
>=12	242 (95.3%)	81 (94.2%)	81 (96.4%)	80 (95.2%)
<12 months	0 (0%)	0 (0%)	0 (0%)	0 (0%)
>=12 months	0 (0%)	0 (0%)	0 (0%)	0 (0%)
Baseline BMI					0.004	UnequalVarianceTTest
Mean (SD)	24.7 (4.09)	23.6 (3.67)	25.1 (4.27)	25.3 (4.16)
Median [Min, Max]	24.2 [13.7, 40.1]	23.4 [15.1, 33.3]	24.3 [17.7, 40.1]	24.8 [13.7, 34.5]
Missing	1 (0.394%)	0 (0%)	1 (1.19%)	0 (0%)
					0.233	ChisqTest
<25	150 (59.1%)	59 (68.6%)	47 (56%)	44 (52.4%)
25-<30	76 (29.9%)	21 (24.4%)	27 (32.1%)	28 (33.3%)
>=30	28 (11%)	6 (6.98%)	10 (11.9%)	12 (14.3%)

TABLE 5

Data Preparation - Table 5

adqsadas = @chain adqsadas_orig begin
    @rsubset :EFFFL == "Y" && :ITTFL == "Y" && :PARAMCD == "ACTOT" && :ANL01FL == "Y"
    @rsubset :AVISITN in (0, 24)
    dropmissing(:CHG)
    @transform :TRTP = recode(categorical(:TRTP),
        "Xanomeline Low Dose" => "Low Dose",
        "Xanomeline High Dose" => "High Dose"
    )
    @transform :TRTP = categorical(:TRTP, levels=["Placebo", "Low Dose", "High Dose"], ordered=true)
end

234×40 DataFrame

209 rows omitted

Row	STUDYID	SITEID	SITEGR1	USUBJID	TRTSDT	TRTEDT	TRTP	TRTPN	AGE	AGEGR1	AGEGR1N	RACE	RACEN	SEX	ITTFL	EFFFL	COMP24FL	AVISIT	AVISITN	VISIT	VISITNUM	ADY	ADT	PARAM	PARAMCD	PARAMN	AVAL	BASE	CHG	PCHG	ABLFL	ANL01FL	DTYPE	AWRANGE	AWTARGET	AWTDIFF	AWLO	AWHI	AWU	QSSEQ
	String15	String3	String3	String15	Date	Date	Cat…	Float64	Float64	String7	Float64	String	Float64	String3	String3	String3	String3	String15	Float64	String31	Float64	Float64	Date	String	String7	Float64	Float64?	Float64?	Float64	Float64?	String3?	String3?	String7?	String7	Float64	Float64	Float64?	Float64?	String7	Float64
1	CDISCPILOT01	701	701	01-701-1015	2014-01-02	2014-07-02	Placebo	0.0	63.0	<65	1.0	WHITE	1.0	F	Y	Y	Y	Week 24	24.0	WEEK 24	12.0	168.0	2014-06-18	Adas-Cog(11) Subscore	ACTOT	15.0	8.0	13.0	-5.0	-38.4615	missing	Y	missing	>140	168.0	0.0	141.0	missing	DAYS	5060.0
2	CDISCPILOT01	701	701	01-701-1023	2012-08-05	2012-09-01	Placebo	0.0	64.0	<65	1.0	WHITE	1.0	M	Y	Y	N	Week 24	24.0	RETRIEVAL	201.0	198.0	2013-02-18	Adas-Cog(11) Subscore	ACTOT	15.0	12.0	13.0	-1.0	-7.69231	missing	Y	missing	>140	168.0	30.0	141.0	missing	DAYS	5045.0
3	CDISCPILOT01	701	701	01-701-1028	2013-07-19	2014-01-14	High Dose	81.0	71.0	65-80	2.0	WHITE	1.0	M	Y	Y	Y	Week 24	24.0	WEEK 24	12.0	172.0	2014-01-06	Adas-Cog(11) Subscore	ACTOT	15.0	3.0	3.0	0.0	0.0	missing	Y	missing	>140	168.0	4.0	141.0	missing	DAYS	5060.0
4	CDISCPILOT01	701	701	01-701-1033	2014-03-18	2014-03-31	Low Dose	54.0	74.0	65-80	2.0	WHITE	1.0	M	Y	Y	N	Week 24	24.0	RETRIEVAL	201.0	182.0	2014-09-15	Adas-Cog(11) Subscore	ACTOT	15.0	7.0	7.0	0.0	0.0	missing	Y	missing	>140	168.0	14.0	141.0	missing	DAYS	5045.0
5	CDISCPILOT01	701	701	01-701-1034	2014-07-01	2014-12-30	High Dose	81.0	77.0	65-80	2.0	WHITE	1.0	F	Y	Y	Y	Week 24	24.0	WEEK 24	12.0	170.0	2014-12-17	Adas-Cog(11) Subscore	ACTOT	15.0	11.0	11.0	0.0	0.0	missing	Y	missing	>140	168.0	2.0	141.0	missing	DAYS	5060.0
6	CDISCPILOT01	701	701	01-701-1047	2013-02-12	2013-03-09	Placebo	0.0	85.0	>80	3.0	WHITE	1.0	F	Y	Y	N	Week 24	24.0	RETRIEVAL	201.0	167.0	2013-07-28	Adas-Cog(11) Subscore	ACTOT	15.0	19.0	10.0	9.0	90.0	missing	Y	missing	>140	168.0	1.0	141.0	missing	DAYS	5045.0
7	CDISCPILOT01	701	701	01-701-1097	2014-01-01	2014-07-09	Low Dose	54.0	68.0	65-80	2.0	WHITE	1.0	M	Y	Y	Y	Week 24	24.0	WEEK 24	12.0	169.0	2014-06-18	Adas-Cog(11) Subscore	ACTOT	15.0	51.0	56.7241	-5.72414	-10.0912	missing	Y	missing	>140	168.0	1.0	141.0	missing	DAYS	5060.0
8	CDISCPILOT01	701	701	01-701-1111	2012-09-07	2012-09-16	Low Dose	54.0	81.0	>80	3.0	WHITE	1.0	F	Y	Y	N	Week 24	24.0	RETRIEVAL	201.0	169.0	2013-02-22	Adas-Cog(11) Subscore	ACTOT	15.0	9.0	7.0	2.0	28.5714	missing	Y	missing	>140	168.0	1.0	141.0	missing	DAYS	5045.0
9	CDISCPILOT01	701	701	01-701-1115	2012-11-30	2013-01-23	Low Dose	54.0	84.0	>80	3.0	WHITE	1.0	M	Y	Y	N	Week 24	24.0	RETRIEVAL	201.0	172.0	2013-05-20	Adas-Cog(11) Subscore	ACTOT	15.0	10.0	10.0	0.0	0.0	missing	Y	missing	>140	168.0	4.0	141.0	missing	DAYS	5045.0
10	CDISCPILOT01	701	701	01-701-1118	2014-03-12	2014-09-09	Placebo	0.0	52.0	<65	1.0	WHITE	1.0	M	Y	Y	Y	Week 24	24.0	WEEK 24	12.0	169.0	2014-08-27	Adas-Cog(11) Subscore	ACTOT	15.0	15.0	26.0	-11.0	-42.3077	missing	Y	missing	>140	168.0	1.0	141.0	missing	DAYS	5060.0
11	CDISCPILOT01	701	701	01-701-1130	2014-02-15	2014-08-16	Placebo	0.0	84.0	>80	3.0	WHITE	1.0	M	Y	Y	Y	Week 24	24.0	WEEK 24	12.0	169.0	2014-08-02	Adas-Cog(11) Subscore	ACTOT	15.0	14.0	19.0	-5.0	-26.3158	missing	Y	missing	>140	168.0	1.0	141.0	missing	DAYS	5060.0
12	CDISCPILOT01	701	701	01-701-1133	2012-10-28	2013-04-28	High Dose	81.0	81.0	>80	3.0	WHITE	1.0	F	Y	Y	Y	Week 24	24.0	WEEK 24	12.0	173.0	2013-04-18	Adas-Cog(11) Subscore	ACTOT	15.0	18.0	13.0	5.0	38.4615	missing	Y	missing	>140	168.0	5.0	141.0	missing	DAYS	5060.0
13	CDISCPILOT01	701	701	01-701-1146	2013-05-20	2013-06-26	High Dose	81.0	75.0	65-80	2.0	WHITE	1.0	F	Y	Y	N	Week 24	24.0	WEEK 6	7.0	42.0	2013-06-30	Adas-Cog(11) Subscore	ACTOT	15.0	10.0	11.0	-1.0	-9.09091	missing	Y	LOCF	>140	168.0	126.0	141.0	missing	DAYS	5030.0
⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮
223	CDISCPILOT01	718	718	01-718-1079	2012-09-19	2012-10-31	Low Dose	54.0	67.0	65-80	2.0	WHITE	1.0	F	Y	Y	N	Week 24	24.0	RETRIEVAL	201.0	168.0	2013-03-05	Adas-Cog(11) Subscore	ACTOT	15.0	36.0	35.0	1.0	2.85714	missing	Y	missing	>140	168.0	0.0	141.0	missing	DAYS	5045.0
224	CDISCPILOT01	718	718	01-718-1101	2013-02-17	2013-07-31	High Dose	81.0	82.0	>80	3.0	BLACK OR AFRICAN AMERICAN	2.0	M	Y	Y	Y	Week 24	24.0	WEEK 24	12.0	167.0	2013-08-02	Adas-Cog(11) Subscore	ACTOT	15.0	44.0	42.0	2.0	4.7619	missing	Y	missing	>140	168.0	1.0	141.0	missing	DAYS	5060.0
225	CDISCPILOT01	718	718	01-718-1139	2013-05-19	2013-11-17	Placebo	0.0	77.0	65-80	2.0	WHITE	1.0	M	Y	Y	Y	Week 24	24.0	WEEK 24	12.0	169.0	2013-11-03	Adas-Cog(11) Subscore	ACTOT	15.0	30.0	40.0	-10.0	-25.0	missing	Y	missing	>140	168.0	1.0	141.0	missing	DAYS	5060.0
226	CDISCPILOT01	718	718	01-718-1150	2013-01-19	2013-07-29	Placebo	0.0	73.0	65-80	2.0	WHITE	1.0	F	Y	Y	Y	Week 24	24.0	WEEK 24	12.0	170.0	2013-07-07	Adas-Cog(11) Subscore	ACTOT	15.0	20.0	14.0	6.0	42.8571	missing	Y	missing	>140	168.0	2.0	141.0	missing	DAYS	5060.0
227	CDISCPILOT01	718	718	01-718-1170	2013-09-16	2013-10-12	Low Dose	54.0	80.0	65-80	2.0	WHITE	1.0	F	Y	Y	N	Week 24	24.0	RETRIEVAL	201.0	181.0	2014-03-15	Adas-Cog(11) Subscore	ACTOT	15.0	25.0	20.0	5.0	25.0	missing	Y	missing	>140	168.0	13.0	141.0	missing	DAYS	5045.0
228	CDISCPILOT01	718	718	01-718-1172	2013-09-21	2013-11-29	Placebo	0.0	74.0	65-80	2.0	WHITE	1.0	M	Y	Y	N	Week 24	24.0	RETRIEVAL	201.0	182.0	2014-03-21	Adas-Cog(11) Subscore	ACTOT	15.0	50.0	49.0	1.0	2.04082	missing	Y	missing	>140	168.0	14.0	141.0	missing	DAYS	5060.0
229	CDISCPILOT01	718	718	01-718-1250	2013-09-21	2014-01-31	Low Dose	54.0	82.0	>80	3.0	WHITE	1.0	F	Y	Y	N	Week 24	24.0	RETRIEVAL	201.0	169.0	2014-03-08	Adas-Cog(11) Subscore	ACTOT	15.0	25.0	20.0	5.0	25.0	missing	Y	missing	>140	168.0	1.0	141.0	missing	DAYS	5075.0
230	CDISCPILOT01	718	718	01-718-1254	2013-07-10	2014-01-09	Low Dose	54.0	78.0	65-80	2.0	WHITE	1.0	M	Y	Y	Y	Week 24	24.0	WEEK 24	12.0	170.0	2013-12-26	Adas-Cog(11) Subscore	ACTOT	15.0	28.0	25.0	3.0	12.0	missing	Y	missing	>140	168.0	2.0	141.0	missing	DAYS	5060.0
231	CDISCPILOT01	718	718	01-718-1328	2013-02-01	2013-04-18	High Dose	81.0	86.0	>80	3.0	WHITE	1.0	M	Y	Y	N	Week 24	24.0	RETRIEVAL	201.0	174.0	2013-07-24	Adas-Cog(11) Subscore	ACTOT	15.0	45.0	40.0	5.0	12.5	missing	Y	missing	>140	168.0	6.0	141.0	missing	DAYS	5045.0
232	CDISCPILOT01	718	718	01-718-1355	2013-02-28	2013-08-29	Placebo	0.0	79.0	65-80	2.0	WHITE	1.0	M	Y	Y	Y	Week 24	24.0	WEEK 24	12.0	169.0	2013-08-15	Adas-Cog(11) Subscore	ACTOT	15.0	32.0	37.0	-5.0	-13.5135	missing	Y	missing	>140	168.0	1.0	141.0	missing	DAYS	5060.0
233	CDISCPILOT01	718	718	01-718-1371	2013-04-26	2013-08-01	High Dose	81.0	69.0	65-80	2.0	WHITE	1.0	F	Y	Y	N	Week 24	24.0	WEEK 12	9.0	105.0	2013-08-08	Adas-Cog(11) Subscore	ACTOT	15.0	24.0	27.0	-3.0	-11.1111	missing	Y	LOCF	>140	168.0	63.0	141.0	missing	DAYS	5045.0
234	CDISCPILOT01	718	718	01-718-1427	2012-12-17	2013-02-11	High Dose	81.0	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	Y	Y	N	Week 24	24.0	RETRIEVAL	201.0	169.0	2013-06-03	Adas-Cog(11) Subscore	ACTOT	15.0	22.0	15.0	7.0	46.6667	missing	Y	missing	>140	168.0	1.0	141.0	missing	DAYS	5045.0

		Treatment Arm
	Overall (n=234)	Placebo (n=79)	Low Dose (n=81)	High Dose (n=74)	P-Value	Test
Baseline					0.213	UnequalVarianceTTest
Mean (SD)	23.3 (12.3)	24.1 (12.2)	24.4 (12.9)	21.3 (11.7)
Median [Min, Max]	20.5 [3, 61]	21 [5, 61]	21 [5, 56.7]	18 [3, 57]
Week 24					0.101	UnequalVarianceTTest
Mean (SD)	25.3 (13.2)	26.7 (13.8)	26.4 (13.2)	22.8 (12.5)
Median [Min, Max]	23.2 [3, 62]	24 [5, 61.6]	25 [6, 62]	20 [3, 61.6]
Change from Baseline					0.437	UnequalVarianceTTest
Mean (SD)	2.01 (5.27)	2.54 (5.8)	2 (5.55)	1.47 (4.26)
Median [Min, Max]	2 [-11.0, 17]	2 [-11.0, 16]	2 [-11.0, 17]	1 [-7.0, 13]

TABLE 06

Data Preparation - Table 6

adqsadas_locf = @chain adqsadas_orig begin
    @rsubset :EFFFL == "Y" && :ITTFL == "Y" && :PARAMCD == "ACTOT" && :ANL01FL == "Y"
    @rsubset :AVISITN in (0, 8, 16, 24)
    @select :USUBJID :TRTP :AVISIT :AVISITN :AVAL :BASE :CHG
    @transform :SET = "LOCF"
end

936×8 DataFrame

911 rows omitted

Row	USUBJID	TRTP	AVISIT	AVISITN	AVAL	BASE	CHG	SET
	String15	String31	String15	Float64	Float64?	Float64?	Float64?	String
1	01-701-1015	Placebo	Baseline	0.0	13.0	13.0	missing	LOCF
2	01-701-1015	Placebo	Week 8	8.0	8.0	13.0	-5.0	LOCF
3	01-701-1015	Placebo	Week 16	16.0	11.0	13.0	-2.0	LOCF
4	01-701-1015	Placebo	Week 24	24.0	8.0	13.0	-5.0	LOCF
5	01-701-1023	Placebo	Baseline	0.0	13.0	13.0	missing	LOCF
6	01-701-1023	Placebo	Week 8	8.0	8.0	13.0	-5.0	LOCF
7	01-701-1023	Placebo	Week 16	16.0	8.0	13.0	-5.0	LOCF
8	01-701-1023	Placebo	Week 24	24.0	12.0	13.0	-1.0	LOCF
9	01-701-1028	Xanomeline High Dose	Baseline	0.0	3.0	3.0	missing	LOCF
10	01-701-1028	Xanomeline High Dose	Week 8	8.0	2.0	3.0	-1.0	LOCF
11	01-701-1028	Xanomeline High Dose	Week 16	16.0	4.0	3.0	1.0	LOCF
12	01-701-1028	Xanomeline High Dose	Week 24	24.0	3.0	3.0	0.0	LOCF
13	01-701-1033	Xanomeline Low Dose	Baseline	0.0	7.0	7.0	missing	LOCF
⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮
925	01-718-1355	Placebo	Baseline	0.0	37.0	37.0	missing	LOCF
926	01-718-1355	Placebo	Week 8	8.0	31.0	37.0	-6.0	LOCF
927	01-718-1355	Placebo	Week 16	16.0	28.0	37.0	-9.0	LOCF
928	01-718-1355	Placebo	Week 24	24.0	32.0	37.0	-5.0	LOCF
929	01-718-1371	Xanomeline High Dose	Baseline	0.0	27.0	27.0	missing	LOCF
930	01-718-1371	Xanomeline High Dose	Week 8	8.0	28.0	27.0	1.0	LOCF
931	01-718-1371	Xanomeline High Dose	Week 16	16.0	24.0	27.0	-3.0	LOCF
932	01-718-1371	Xanomeline High Dose	Week 24	24.0	24.0	27.0	-3.0	LOCF
933	01-718-1427	Xanomeline High Dose	Baseline	0.0	15.0	15.0	missing	LOCF
934	01-718-1427	Xanomeline High Dose	Week 8	8.0	16.0	15.0	1.0	LOCF
935	01-718-1427	Xanomeline High Dose	Week 16	16.0	16.0	15.0	1.0	LOCF
936	01-718-1427	Xanomeline High Dose	Week 24	24.0	22.0	15.0	7.0	LOCF

Data wrangling

adqsadas_win = @chain adqsadas_orig begin
    @rsubset :EFFFL == "Y" && :ITTFL == "Y" && :PARAMCD == "ACTOT" && :ANL01FL == "Y"
    @rsubset :AVISITN in (0, 8, 16, 24)
    @rsubset :AVISITN != 0 && :DTYPE != "LOCF"
    @select :USUBJID :TRTP :AVISIT :AVISITN :AVAL :BASE :CHG
    @transform :SET = "Windowed"
end

0×8 DataFrame

Row	USUBJID	TRTP	AVISIT	AVISITN	AVAL	BASE	CHG	SET
	String15	String31	String15	Float64	Float64?	Float64?	Float64?	String

Data wrangling

adqsadas_l = @chain vcat(adqsadas_locf, adqsadas_win) begin
    @rtransform :AVISIT_SET = if :AVISIT == "Baseline"
        "Baseline"
    else
        string(:AVISIT, " (", :SET, ")")
    end

    @transform :AVISIT_SET = categorical(:AVISIT_SET,
        levels = ["Baseline", 
                  "Week 8 (Windowed)", "Week 16 (Windowed)", "Week 24 (Windowed)",
                  "Week 8 (LOCF)", "Week 16 (LOCF)", "Week 24 (LOCF)"],
        ordered = true)

    @transform :TRTP = categorical(:TRTP,
        levels = ["Placebo", "Xanomeline Low Dose", "Xanomeline High Dose"],
        ordered = true)

    @transform :TRTP = recode(:TRTP,
        "Xanomeline Low Dose" => "Low Dose",
        "Xanomeline High Dose" => "High Dose")
end

936×9 DataFrame

911 rows omitted

Row	USUBJID	TRTP	AVISIT	AVISITN	AVAL	BASE	CHG	SET	AVISIT_SET
	String15	Cat…	String15	Float64	Float64?	Float64?	Float64?	String	Cat…
1	01-701-1015	Placebo	Baseline	0.0	13.0	13.0	missing	LOCF	Baseline
2	01-701-1015	Placebo	Week 8	8.0	8.0	13.0	-5.0	LOCF	Week 8 (LOCF)
3	01-701-1015	Placebo	Week 16	16.0	11.0	13.0	-2.0	LOCF	Week 16 (LOCF)
4	01-701-1015	Placebo	Week 24	24.0	8.0	13.0	-5.0	LOCF	Week 24 (LOCF)
5	01-701-1023	Placebo	Baseline	0.0	13.0	13.0	missing	LOCF	Baseline
6	01-701-1023	Placebo	Week 8	8.0	8.0	13.0	-5.0	LOCF	Week 8 (LOCF)
7	01-701-1023	Placebo	Week 16	16.0	8.0	13.0	-5.0	LOCF	Week 16 (LOCF)
8	01-701-1023	Placebo	Week 24	24.0	12.0	13.0	-1.0	LOCF	Week 24 (LOCF)
9	01-701-1028	High Dose	Baseline	0.0	3.0	3.0	missing	LOCF	Baseline
10	01-701-1028	High Dose	Week 8	8.0	2.0	3.0	-1.0	LOCF	Week 8 (LOCF)
11	01-701-1028	High Dose	Week 16	16.0	4.0	3.0	1.0	LOCF	Week 16 (LOCF)
12	01-701-1028	High Dose	Week 24	24.0	3.0	3.0	0.0	LOCF	Week 24 (LOCF)
13	01-701-1033	Low Dose	Baseline	0.0	7.0	7.0	missing	LOCF	Baseline
⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮
925	01-718-1355	Placebo	Baseline	0.0	37.0	37.0	missing	LOCF	Baseline
926	01-718-1355	Placebo	Week 8	8.0	31.0	37.0	-6.0	LOCF	Week 8 (LOCF)
927	01-718-1355	Placebo	Week 16	16.0	28.0	37.0	-9.0	LOCF	Week 16 (LOCF)
928	01-718-1355	Placebo	Week 24	24.0	32.0	37.0	-5.0	LOCF	Week 24 (LOCF)
929	01-718-1371	High Dose	Baseline	0.0	27.0	27.0	missing	LOCF	Baseline
930	01-718-1371	High Dose	Week 8	8.0	28.0	27.0	1.0	LOCF	Week 8 (LOCF)
931	01-718-1371	High Dose	Week 16	16.0	24.0	27.0	-3.0	LOCF	Week 16 (LOCF)
932	01-718-1371	High Dose	Week 24	24.0	24.0	27.0	-3.0	LOCF	Week 24 (LOCF)
933	01-718-1427	High Dose	Baseline	0.0	15.0	15.0	missing	LOCF	Baseline
934	01-718-1427	High Dose	Week 8	8.0	16.0	15.0	1.0	LOCF	Week 8 (LOCF)
935	01-718-1427	High Dose	Week 16	16.0	16.0	15.0	1.0	LOCF	Week 16 (LOCF)
936	01-718-1427	High Dose	Week 24	24.0	22.0	15.0	7.0	LOCF	Week 24 (LOCF)

Data wrangling

aval_long = stack(adqsadas_l, [:AVAL, :BASE, :CHG], variable_name = :VAR, value_name = :AVAL_VAL)
aval_long = dropmissing(aval_long, :AVAL_VAL)

2574×8 DataFrame

2549 rows omitted

Row	USUBJID	TRTP	AVISIT	AVISITN	SET	AVISIT_SET	VAR	AVAL_VAL
	String15	Cat…	String15	Float64	String	Cat…	String	Float64
1	01-701-1015	Placebo	Baseline	0.0	LOCF	Baseline	AVAL	13.0
2	01-701-1015	Placebo	Week 8	8.0	LOCF	Week 8 (LOCF)	AVAL	8.0
3	01-701-1015	Placebo	Week 16	16.0	LOCF	Week 16 (LOCF)	AVAL	11.0
4	01-701-1015	Placebo	Week 24	24.0	LOCF	Week 24 (LOCF)	AVAL	8.0
5	01-701-1023	Placebo	Baseline	0.0	LOCF	Baseline	AVAL	13.0
6	01-701-1023	Placebo	Week 8	8.0	LOCF	Week 8 (LOCF)	AVAL	8.0
7	01-701-1023	Placebo	Week 16	16.0	LOCF	Week 16 (LOCF)	AVAL	8.0
8	01-701-1023	Placebo	Week 24	24.0	LOCF	Week 24 (LOCF)	AVAL	12.0
9	01-701-1028	High Dose	Baseline	0.0	LOCF	Baseline	AVAL	3.0
10	01-701-1028	High Dose	Week 8	8.0	LOCF	Week 8 (LOCF)	AVAL	2.0
11	01-701-1028	High Dose	Week 16	16.0	LOCF	Week 16 (LOCF)	AVAL	4.0
12	01-701-1028	High Dose	Week 24	24.0	LOCF	Week 24 (LOCF)	AVAL	3.0
13	01-701-1033	Low Dose	Baseline	0.0	LOCF	Baseline	AVAL	7.0
⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮
2563	01-718-1328	High Dose	Week 8	8.0	LOCF	Week 8 (LOCF)	CHG	4.0
2564	01-718-1328	High Dose	Week 16	16.0	LOCF	Week 16 (LOCF)	CHG	4.0
2565	01-718-1328	High Dose	Week 24	24.0	LOCF	Week 24 (LOCF)	CHG	5.0
2566	01-718-1355	Placebo	Week 8	8.0	LOCF	Week 8 (LOCF)	CHG	-6.0
2567	01-718-1355	Placebo	Week 16	16.0	LOCF	Week 16 (LOCF)	CHG	-9.0
2568	01-718-1355	Placebo	Week 24	24.0	LOCF	Week 24 (LOCF)	CHG	-5.0
2569	01-718-1371	High Dose	Week 8	8.0	LOCF	Week 8 (LOCF)	CHG	1.0
2570	01-718-1371	High Dose	Week 16	16.0	LOCF	Week 16 (LOCF)	CHG	-3.0
2571	01-718-1371	High Dose	Week 24	24.0	LOCF	Week 24 (LOCF)	CHG	-3.0
2572	01-718-1427	High Dose	Week 8	8.0	LOCF	Week 8 (LOCF)	CHG	1.0
2573	01-718-1427	High Dose	Week 16	16.0	LOCF	Week 16 (LOCF)	CHG	1.0
2574	01-718-1427	High Dose	Week 24	24.0	LOCF	Week 24 (LOCF)	CHG	7.0

Data wrangling

function stats_summary(x)
    NamedTuple{(:N, :Mean, :SD, :Median, :Min, :Max)}((
        length(x),
        mean(x),
        std(x),
        median(x),
        minimum(x),
        maximum(x)
    ))
end

stats_summary (generic function with 1 method)

Data wrangling

summary_long = @chain aval_long begin
    groupby([:AVISIT_SET, :TRTP, :VAR])
    combine(:AVAL_VAL => stats_summary => AsTable)
end
names(summary_long)

9-element Vector{String}:
 "AVISIT_SET"
 "TRTP"
 "VAR"
 "N"
 "Mean"
 "SD"
 "Median"
 "Min"
 "Max"

Data wrangling

stats = ["N", "Mean", "SD", "Median", "Min", "Max"]
unstacked_stats = Dict()
for stat in stats
    stat_col = Symbol(stat)
    df = select(summary_long, [:AVISIT_SET, :TRTP, :VAR, stat_col])
    wide = unstack(df, [:AVISIT_SET, :TRTP], :VAR, stat_col)
    
    # Create a dictionary for renaming
    old_names = Symbol.(names(wide)[3:end])
    new_names = [Symbol("$(n)_$stat") for n in old_names]
    rename_dict = Dict(zip(old_names, new_names))
    
    rename!(wide, rename_dict)
    unstacked_stats[stat] = wide
end
wide_tbl = reduce((d1, d2) -> outerjoin(d1, d2, on=[:AVISIT_SET, :TRTP]), values(unstacked_stats))

12×20 DataFrame

Row	AVISIT_SET	TRTP	AVAL_Median	BASE_Median	CHG_Median	AVAL_N	BASE_N	CHG_N	AVAL_Min	BASE_Min	CHG_Min	AVAL_SD	BASE_SD	CHG_SD	AVAL_Mean	BASE_Mean	CHG_Mean	AVAL_Max	BASE_Max	CHG_Max
	Cat…	Cat…	Float64?	Float64?	Float64?	Int64?	Int64?	Int64?	Float64?	Float64?	Float64?	Float64?	Float64?	Float64?	Float64?	Float64?	Float64?	Float64?	Float64?	Float64?
1	Baseline	Placebo	21.0	21.0	missing	79	79	missing	5.0	5.0	missing	12.1864	12.1864	missing	24.1218	24.1218	missing	61.0	61.0	missing
2	Baseline	Low Dose	21.0	21.0	missing	81	81	missing	5.0	5.0	missing	12.9224	12.9224	missing	24.4074	24.4074	missing	56.7241	56.7241	missing
3	Baseline	High Dose	18.0	18.0	missing	74	74	missing	3.0	3.0	missing	11.7365	11.7365	missing	21.2973	21.2973	missing	57.0	57.0	missing
4	Week 8 (LOCF)	Placebo	22.0	21.0	1.0	79	79	79	5.0	5.0	-12.0	13.0987	12.1864	4.80856	24.969	24.1218	0.847228	61.5517	61.0	16.0
5	Week 8 (LOCF)	Low Dose	25.0	21.0	2.0	81	81	81	5.0	5.0	-12.0	12.9823	12.9224	4.14218	26.1716	24.4074	1.76415	62.0	56.7241	14.0
6	Week 8 (LOCF)	High Dose	19.0	18.0	1.0	74	74	74	2.0	3.0	-8.0	12.4105	11.7365	3.62493	22.26	21.2973	0.962721	61.5517	57.0	13.0
7	Week 16 (LOCF)	Placebo	23.0	21.0	2.0	79	79	79	5.0	5.0	-17.0	14.155	12.1864	5.89328	26.0839	24.1218	1.96214	63.0	61.0	23.0
8	Week 16 (LOCF)	Low Dose	25.0	21.0	2.0	81	81	81	5.0	5.0	-9.0	13.0469	12.9224	4.10012	26.0175	24.4074	1.61005	62.0	56.7241	14.0
9	Week 16 (LOCF)	High Dose	20.0	18.0	1.0	74	74	74	4.0	3.0	-11.0	12.3283	11.7365	4.33046	22.4902	21.2973	1.19292	61.5517	57.0	13.0
10	Week 24 (LOCF)	Placebo	24.0	21.0	2.0	79	79	79	5.0	5.0	-11.0	13.7943	12.1864	5.8039	26.6665	24.1218	2.54474	61.5517	61.0	16.0
11	Week 24 (LOCF)	Low Dose	25.0	21.0	2.0	81	81	81	6.0	5.0	-11.0	13.1807	12.9224	5.55279	26.4027	24.4074	1.99532	62.0	56.7241	17.0
12	Week 24 (LOCF)	High Dose	20.0	18.0	1.0	74	74	74	3.0	3.0	-7.0	12.4836	11.7365	4.26238	22.7678	21.2973	1.47049	61.5517	57.0	13.0

Treatment

Placebo

Low Dose

High Dose

Visit

Visit

Visit

Total

Baseline

Week 8 (LOCF)

Week 16 (LOCF)

Week 24 (LOCF)

Baseline

Week 8 (LOCF)

Week 16 (LOCF)

Week 24 (LOCF)

Baseline

Week 8 (LOCF)

Week 16 (LOCF)

Week 24 (LOCF)

Mean (SD)

21.9 (2.47)

21 (NaN)

22 (NaN)

23 (NaN)

24 (NaN)

21 (NaN)

25 (NaN)

25 (NaN)

25 (NaN)

18 (NaN)

19 (NaN)

20 (NaN)

20 (NaN)

Median [Min, Max]

21.5 [18, 25]

21 [21, 21]

22 [22, 22]

23 [23, 23]

24 [24, 24]

21 [21, 21]

25 [25, 25]

25 [25, 25]

25 [25, 25]

18 [18, 18]

19 [19, 19]

20 [20, 20]

20 [20, 20]

Mean (SD)

20 (1.48)

21 (NaN)

21 (NaN)

21 (NaN)

21 (NaN)

21 (NaN)

21 (NaN)

21 (NaN)

21 (NaN)

18 (NaN)

18 (NaN)

18 (NaN)

18 (NaN)

Median [Min, Max]

21 [18, 21]

21 [21, 21]

21 [21, 21]

21 [21, 21]

21 [21, 21]

21 [21, 21]

21 [21, 21]

21 [21, 21]

21 [21, 21]

18 [18, 18]

18 [18, 18]

18 [18, 18]

18 [18, 18]

Mean (SD)

1.56 (0.527)

NC

1 (NaN)

2 (NaN)

2 (NaN)

NC

2 (NaN)

2 (NaN)

2 (NaN)

NC

1 (NaN)

1 (NaN)

1 (NaN)

Median [Min, Max]

2 [1, 2]

NC

1 [1, 1]

2 [2, 2]

2 [2, 2]

NC

2 [2, 2]

2 [2, 2]

2 [2, 2]

NC

1 [1, 1]

1 [1, 1]

1 [1, 1]

Missing

3 (25%)

1 (100%)

0 (0%)

0 (0%)

0 (0%)

1 (100%)

0 (0%)

0 (0%)

0 (0%)

1 (100%)

0 (0%)

0 (0%)

0 (0%)

Mean (SD)

78 (3.07)

79 (NaN)

79 (NaN)

79 (NaN)

79 (NaN)

81 (NaN)

81 (NaN)

81 (NaN)

81 (NaN)

74 (NaN)

74 (NaN)

74 (NaN)

74 (NaN)

Median [Min, Max]

79 [74, 81]

79 [79, 79]

79 [79, 79]

79 [79, 79]

79 [79, 79]

81 [81, 81]

81 [81, 81]

81 [81, 81]

81 [81, 81]

74 [74, 74]

74 [74, 74]

74 [74, 74]

74 [74, 74]

Mean (SD)

78 (3.07)

79 (NaN)

79 (NaN)

79 (NaN)

79 (NaN)

81 (NaN)

81 (NaN)

81 (NaN)

81 (NaN)

74 (NaN)

74 (NaN)

74 (NaN)

74 (NaN)

Median [Min, Max]

79 [74, 81]

79 [79, 79]

79 [79, 79]

79 [79, 79]

79 [79, 79]

81 [81, 81]

81 [81, 81]

81 [81, 81]

81 [81, 81]

74 [74, 74]

74 [74, 74]

74 [74, 74]

74 [74, 74]

Mean (SD)

78 (3.12)

NC

79 (NaN)

79 (NaN)

79 (NaN)

NC

81 (NaN)

81 (NaN)

81 (NaN)

NC

74 (NaN)

74 (NaN)

74 (NaN)

Median [Min, Max]

79 [74, 81]

NC

79 [79, 79]

79 [79, 79]

79 [79, 79]

NC

81 [81, 81]

81 [81, 81]

81 [81, 81]

NC

74 [74, 74]

74 [74, 74]

74 [74, 74]

Missing

3 (25%)

1 (100%)

0 (0%)

0 (0%)

0 (0%)

1 (100%)

0 (0%)

0 (0%)

0 (0%)

1 (100%)

0 (0%)

0 (0%)

0 (0%)

Mean (SD)

4.42 (1.16)

5 (NaN)

5 (NaN)

5 (NaN)

5 (NaN)

5 (NaN)

5 (NaN)

5 (NaN)

6 (NaN)

3 (NaN)

2 (NaN)

4 (NaN)

3 (NaN)

Median [Min, Max]

5 [2, 6]

5 [5, 5]

5 [5, 5]

5 [5, 5]

5 [5, 5]

5 [5, 5]

5 [5, 5]

5 [5, 5]

6 [6, 6]

3 [3, 3]

2 [2, 2]

4 [4, 4]

3 [3, 3]

Mean (SD)

4.33 (0.985)

5 (NaN)

5 (NaN)

5 (NaN)

5 (NaN)

5 (NaN)

5 (NaN)

5 (NaN)

5 (NaN)

3 (NaN)

3 (NaN)

3 (NaN)

3 (NaN)

Median [Min, Max]

5 [3, 5]

5 [5, 5]

5 [5, 5]

5 [5, 5]

5 [5, 5]

5 [5, 5]

5 [5, 5]

5 [5, 5]

5 [5, 5]

3 [3, 3]

3 [3, 3]

3 [3, 3]

3 [3, 3]

Mean (SD)

-10.9 (2.89)

NC

-12.0 (NaN)

-17.0 (NaN)

-11.0 (NaN)

NC

-12.0 (NaN)

-9.0 (NaN)

-11.0 (NaN)

NC

-8.0 (NaN)

-11.0 (NaN)

-7.0 (NaN)

Median [Min, Max]

-11.0 [-17.0, -7.0]

NC

-12.0 [-12.0, -12.0]

-17.0 [-17.0, -17.0]

-11.0 [-11.0, -11.0]

NC

-12.0 [-12.0, -12.0]

-9.0 [-9.0, -9.0]

-11.0 [-11.0, -11.0]

NC

-8.0 [-8.0, -8.0]

-11.0 [-11.0, -11.0]

-7.0 [-7.0, -7.0]

Missing

3 (25%)

1 (100%)

0 (0%)

0 (0%)

0 (0%)

1 (100%)

0 (0%)

0 (0%)

0 (0%)

1 (100%)

0 (0%)

0 (0%)

0 (0%)

Mean (SD)

12.9 (0.681)

12.2 (NaN)

13.1 (NaN)

14.2 (NaN)

13.8 (NaN)

12.9 (NaN)

13 (NaN)

13 (NaN)

13.2 (NaN)

11.7 (NaN)

12.4 (NaN)

12.3 (NaN)

12.5 (NaN)

Median [Min, Max]

13 [11.7, 14.2]

12.2 [12.2, 12.2]

13.1 [13.1, 13.1]

14.2 [14.2, 14.2]

13.8 [13.8, 13.8]

12.9 [12.9, 12.9]

13 [13, 13]

13 [13, 13]

13.2 [13.2, 13.2]

11.7 [11.7, 11.7]

12.4 [12.4, 12.4]

12.3 [12.3, 12.3]

12.5 [12.5, 12.5]

Mean (SD)

12.3 (0.511)

12.2 (NaN)

12.2 (NaN)

12.2 (NaN)

12.2 (NaN)

12.9 (NaN)

12.9 (NaN)

12.9 (NaN)

12.9 (NaN)

11.7 (NaN)

11.7 (NaN)

11.7 (NaN)

11.7 (NaN)

Median [Min, Max]

12.2 [11.7, 12.9]

12.2 [12.2, 12.2]

12.2 [12.2, 12.2]

12.2 [12.2, 12.2]

12.2 [12.2, 12.2]

12.9 [12.9, 12.9]

12.9 [12.9, 12.9]

12.9 [12.9, 12.9]

12.9 [12.9, 12.9]

11.7 [11.7, 11.7]

11.7 [11.7, 11.7]

11.7 [11.7, 11.7]

11.7 [11.7, 11.7]

Mean (SD)

4.72 (0.831)

NC

4.81 (NaN)

5.89 (NaN)

5.8 (NaN)

NC

4.14 (NaN)

4.1 (NaN)

5.55 (NaN)

NC

3.62 (NaN)

4.33 (NaN)

4.26 (NaN)

Median [Min, Max]

4.33 [3.62, 5.89]

NC

4.81 [4.81, 4.81]

5.89 [5.89, 5.89]

5.8 [5.8, 5.8]

NC

4.14 [4.14, 4.14]

4.1 [4.1, 4.1]

5.55 [5.55, 5.55]

NC

3.62 [3.62, 3.62]

4.33 [4.33, 4.33]

4.26 [4.26, 4.26]

Missing

3 (25%)

1 (100%)

0 (0%)

0 (0%)

0 (0%)

1 (100%)

0 (0%)

0 (0%)

0 (0%)

1 (100%)

0 (0%)

0 (0%)

0 (0%)

Mean (SD)

24.5 (1.87)

24.1 (NaN)

25 (NaN)

26.1 (NaN)

26.7 (NaN)

24.4 (NaN)

26.2 (NaN)

26 (NaN)

26.4 (NaN)

21.3 (NaN)

22.3 (NaN)

22.5 (NaN)

22.8 (NaN)

Median [Min, Max]

24.7 [21.3, 26.7]

24.1 [24.1, 24.1]

25 [25, 25]

26.1 [26.1, 26.1]

26.7 [26.7, 26.7]

24.4 [24.4, 24.4]

26.2 [26.2, 26.2]

26 [26, 26]

26.4 [26.4, 26.4]

21.3 [21.3, 21.3]

22.3 [22.3, 22.3]

22.5 [22.5, 22.5]

22.8 [22.8, 22.8]

Mean (SD)

23.3 (1.47)

24.1 (NaN)

24.1 (NaN)

24.1 (NaN)

24.1 (NaN)

24.4 (NaN)

24.4 (NaN)

24.4 (NaN)

24.4 (NaN)

21.3 (NaN)

21.3 (NaN)

21.3 (NaN)

21.3 (NaN)

Median [Min, Max]

24.1 [21.3, 24.4]

24.1 [24.1, 24.1]

24.1 [24.1, 24.1]

24.1 [24.1, 24.1]

24.1 [24.1, 24.1]

24.4 [24.4, 24.4]

24.4 [24.4, 24.4]

24.4 [24.4, 24.4]

24.4 [24.4, 24.4]

21.3 [21.3, 21.3]

21.3 [21.3, 21.3]

21.3 [21.3, 21.3]

21.3 [21.3, 21.3]

Mean (SD)

1.59 (0.543)

NC

0.847 (NaN)

1.96 (NaN)

2.54 (NaN)

NC

1.76 (NaN)

1.61 (NaN)

2 (NaN)

NC

0.963 (NaN)

1.19 (NaN)

1.47 (NaN)

Median [Min, Max]

1.61 [0.847, 2.54]

NC

0.847 [0.847, 0.847]

1.96 [1.96, 1.96]

2.54 [2.54, 2.54]

NC

1.76 [1.76, 1.76]

1.61 [1.61, 1.61]

2 [2, 2]

NC

0.963 [0.963, 0.963]

1.19 [1.19, 1.19]

1.47 [1.47, 1.47]

Missing

3 (25%)

1 (100%)

0 (0%)

0 (0%)

0 (0%)

1 (100%)

0 (0%)

0 (0%)

0 (0%)

1 (100%)

0 (0%)

0 (0%)

0 (0%)

Mean (SD)

61 (1.97)

61 (NaN)

61.6 (NaN)

63 (NaN)

61.6 (NaN)

56.7 (NaN)

62 (NaN)

62 (NaN)

62 (NaN)

57 (NaN)

61.6 (NaN)

61.6 (NaN)

61.6 (NaN)

Median [Min, Max]

61.6 [56.7, 63]

61 [61, 61]

61.6 [61.6, 61.6]

63 [63, 63]

61.6 [61.6, 61.6]

56.7 [56.7, 56.7]

62 [62, 62]

62 [62, 62]

62 [62, 62]

57 [57, 57]

61.6 [61.6, 61.6]

61.6 [61.6, 61.6]

61.6 [61.6, 61.6]

Mean (SD)

58.2 (2.04)

61 (NaN)

61 (NaN)

61 (NaN)

61 (NaN)

56.7 (NaN)

56.7 (NaN)

56.7 (NaN)

56.7 (NaN)

57 (NaN)

57 (NaN)

57 (NaN)

57 (NaN)

Median [Min, Max]

57 [56.7, 61]

61 [61, 61]

61 [61, 61]

61 [61, 61]

61 [61, 61]

56.7 [56.7, 56.7]

56.7 [56.7, 56.7]

56.7 [56.7, 56.7]

56.7 [56.7, 56.7]

57 [57, 57]

57 [57, 57]

57 [57, 57]

57 [57, 57]

Mean (SD)

15.4 (3.21)

NC

16 (NaN)

23 (NaN)

16 (NaN)

NC

14 (NaN)

14 (NaN)

17 (NaN)

NC

13 (NaN)

13 (NaN)

13 (NaN)

Median [Min, Max]

14 [13, 23]

NC

16 [16, 16]

23 [23, 23]

16 [16, 16]

NC

14 [14, 14]

14 [14, 14]

17 [17, 17]

NC

13 [13, 13]

13 [13, 13]

13 [13, 13]

Missing

3 (25%)

1 (100%)

0 (0%)

0 (0%)

0 (0%)

1 (100%)

0 (0%)

0 (0%)

0 (0%)

1 (100%)

0 (0%)

0 (0%)

0 (0%)

NC - Not computable

TABLE 7

Data Preparation - Table 7

adqscibc = @chain adqscibc_orig begin
    @rsubset :EFFFL == "Y" && :ITTFL == "Y" && :AVISITN in (8, 16, 24) && :ANL01FL == "Y"
    @select :USUBJID :TRTP :SITEGR1 :AVISIT :AVISITN :AVAL
    @rtransform :AVALC = begin
        val = string(:AVAL)
        if val == "1"
            "Marked improvement"
        elseif val == "2"
            "Moderate improvement"
        elseif val == "3"
            "Minimal improvement"
        elseif val == "4"
            "No Change"
        elseif val == "5"
            "Minimal worsening"
        elseif val == "6"
            "Moderate worsening"
        elseif val == "7"
            "Marked worsening"
        else
            missing
        end
    end
end

699×7 DataFrame

674 rows omitted

Row	USUBJID	TRTP	SITEGR1	AVISIT	AVISITN	AVAL	AVALC
	String15	String31	String3	String7	Float64	Float64	Missing
1	01-701-1015	Placebo	701	Week 8	8.0	4.0	missing
2	01-701-1015	Placebo	701	Week 16	16.0	4.0	missing
3	01-701-1015	Placebo	701	Week 24	24.0	4.0	missing
4	01-701-1023	Placebo	701	Week 8	8.0	3.0	missing
5	01-701-1023	Placebo	701	Week 16	16.0	3.0	missing
6	01-701-1023	Placebo	701	Week 24	24.0	5.0	missing
7	01-701-1028	Xanomeline High Dose	701	Week 8	8.0	4.0	missing
8	01-701-1028	Xanomeline High Dose	701	Week 16	16.0	4.0	missing
9	01-701-1028	Xanomeline High Dose	701	Week 24	24.0	4.0	missing
10	01-701-1033	Xanomeline Low Dose	701	Week 8	8.0	4.0	missing
11	01-701-1033	Xanomeline Low Dose	701	Week 16	16.0	4.0	missing
12	01-701-1033	Xanomeline Low Dose	701	Week 24	24.0	4.0	missing
13	01-701-1034	Xanomeline High Dose	701	Week 8	8.0	4.0	missing
⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮
688	01-718-1254	Xanomeline Low Dose	718	Week 24	24.0	4.0	missing
689	01-718-1328	Xanomeline High Dose	718	Week 8	8.0	5.0	missing
690	01-718-1328	Xanomeline High Dose	718	Week 16	16.0	5.0	missing
691	01-718-1328	Xanomeline High Dose	718	Week 24	24.0	5.0	missing
692	01-718-1355	Placebo	718	Week 8	8.0	5.0	missing
693	01-718-1355	Placebo	718	Week 16	16.0	4.0	missing
694	01-718-1355	Placebo	718	Week 24	24.0	4.0	missing
695	01-718-1371	Xanomeline High Dose	718	Week 16	16.0	4.0	missing
696	01-718-1371	Xanomeline High Dose	718	Week 24	24.0	4.0	missing
697	01-718-1427	Xanomeline High Dose	718	Week 8	8.0	4.0	missing
698	01-718-1427	Xanomeline High Dose	718	Week 16	16.0	4.0	missing
699	01-718-1427	Xanomeline High Dose	718	Week 24	24.0	4.0	missing

Data wrangling

aval_labels = Dict(
    1 => "Marked improvement",
    2 => "Moderate improvement",
    3 => "Minimal improvement",
    4 => "No Change",
    5 => "Minimal worsening",
    6 => "Moderate worsening",
    7 => "Marked worsening"
)

levels_order = [
    "Marked improvement",
    "Moderate improvement",
    "Minimal improvement",
    "No Change",
    "Minimal worsening",
    "Moderate worsening",
    "Marked worsening"
]

adqscibc = @chain adqscibc begin
    @rtransform :AVALC = get(aval_labels, :AVAL, missing)
    @transform :AVALC = categorical(:AVALC, levels = levels_order, ordered = true)
    
    @transform :TRTP = recode(:TRTP,
        "Xanomeline Low Dose" => "Low Dose",
        "Xanomeline High Dose" => "High Dose")
    
    @transform :TRTP = categorical(:TRTP,
        levels = ["Placebo", "Low Dose", "High Dose"])
    
    @transform :AVISIT = categorical(:AVISIT,
        levels = ["Week 8", "Week 16", "Week 24"], ordered = true)
end

699×7 DataFrame

674 rows omitted

Row	USUBJID	TRTP	SITEGR1	AVISIT	AVISITN	AVAL	AVALC
	String15	Cat…	String3	Cat…	Float64	Float64	Cat…
1	01-701-1015	Placebo	701	Week 8	8.0	4.0	No Change
2	01-701-1015	Placebo	701	Week 16	16.0	4.0	No Change
3	01-701-1015	Placebo	701	Week 24	24.0	4.0	No Change
4	01-701-1023	Placebo	701	Week 8	8.0	3.0	Minimal improvement
5	01-701-1023	Placebo	701	Week 16	16.0	3.0	Minimal improvement
6	01-701-1023	Placebo	701	Week 24	24.0	5.0	Minimal worsening
7	01-701-1028	High Dose	701	Week 8	8.0	4.0	No Change
8	01-701-1028	High Dose	701	Week 16	16.0	4.0	No Change
9	01-701-1028	High Dose	701	Week 24	24.0	4.0	No Change
10	01-701-1033	Low Dose	701	Week 8	8.0	4.0	No Change
11	01-701-1033	Low Dose	701	Week 16	16.0	4.0	No Change
12	01-701-1033	Low Dose	701	Week 24	24.0	4.0	No Change
13	01-701-1034	High Dose	701	Week 8	8.0	4.0	No Change
⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮
688	01-718-1254	Low Dose	718	Week 24	24.0	4.0	No Change
689	01-718-1328	High Dose	718	Week 8	8.0	5.0	Minimal worsening
690	01-718-1328	High Dose	718	Week 16	16.0	5.0	Minimal worsening
691	01-718-1328	High Dose	718	Week 24	24.0	5.0	Minimal worsening
692	01-718-1355	Placebo	718	Week 8	8.0	5.0	Minimal worsening
693	01-718-1355	Placebo	718	Week 16	16.0	4.0	No Change
694	01-718-1355	Placebo	718	Week 24	24.0	4.0	No Change
695	01-718-1371	High Dose	718	Week 16	16.0	4.0	No Change
696	01-718-1371	High Dose	718	Week 24	24.0	4.0	No Change
697	01-718-1427	High Dose	718	Week 8	8.0	4.0	No Change
698	01-718-1427	High Dose	718	Week 16	16.0	4.0	No Change
699	01-718-1427	High Dose	718	Week 24	24.0	4.0	No Change

			Xanomeline
			Placebo	Low Dose	High Dose
VisitDay	Assessment		Value
Week 8	Moderate improvement	N	1	2	1
	Minimal improvement	N	19	16	13
	No Change	N	45	48	38
	Minimal worsening	N	10	14	20
	Moderate worsening	N	2	1	1
Week 16	Moderate improvement	N		3	2
	Minimal improvement	N	12	12	13
	No Change	N	41	46	39
	Minimal worsening	N	25	19	20
	Moderate worsening	N	1	1
Week 24	Moderate improvement	N	1	1
	Minimal improvement	N	9	14	11
	No Change	N	38	37	33
	Minimal worsening	N	28	27	25
	Moderate worsening	N	3	2	5

TABLE 8

Data Preparation - Table 8

adsl_l = @chain adsl_orig begin
    @rtransform :POP = if :COMP24FL == "Y" "COMP24FL" else missing end
    @rtransform :POP = if :SAFFL == "Y" "SAFFL" else :POP end

    @rsubset !ismissing(:POP)
    @select :POP :USUBJID :TRT01P :AVGDD :CUMDOSE

    @transform :TRT01P = categorical(:TRT01P,
        levels = ["Placebo", "Xanomeline Low Dose", "Xanomeline High Dose"],
        ordered = true)
    @transform :TRT01P = recode(:TRT01P,
        "Xanomeline Low Dose" => "Xanomeline Low Dose",
        "Xanomeline High Dose" => "Xanomeline High Dose")
    @rtransform :POP = if :POP == "COMP24FL"
    elseif :POP == "SAFFL"
    else
        :POP
    end
end

254×5 DataFrame

229 rows omitted

Row	POP	USUBJID	TRT01P	AVGDD	CUMDOSE
	Nothing	String15	Cat…	Float64	Float64
1		01-701-1015	Placebo	0.0	0.0
2		01-701-1023	Placebo	0.0	0.0
3		01-701-1028	Xanomeline High Dose	77.7	13986.0
4		01-701-1033	Xanomeline Low Dose	54.0	756.0
5		01-701-1034	Xanomeline High Dose	76.9	14067.0
6		01-701-1047	Placebo	0.0	0.0
7		01-701-1097	Xanomeline Low Dose	54.0	10260.0
8		01-701-1111	Xanomeline Low Dose	54.0	540.0
9		01-701-1115	Xanomeline Low Dose	54.0	2970.0
10		01-701-1118	Placebo	0.0	0.0
11		01-701-1130	Placebo	0.0	0.0
12		01-701-1133	Xanomeline High Dose	77.2	14121.0
13		01-701-1146	Xanomeline High Dose	70.3	2673.0
⋮	⋮	⋮	⋮	⋮	⋮
243		01-718-1079	Xanomeline Low Dose	54.0	2322.0
244		01-718-1101	Xanomeline High Dose	78.5	12960.0
245		01-718-1139	Placebo	0.0	0.0
246		01-718-1150	Placebo	0.0	0.0
247		01-718-1170	Xanomeline Low Dose	54.0	1458.0
248		01-718-1172	Placebo	0.0	0.0
249		01-718-1250	Xanomeline Low Dose	54.0	7182.0
250		01-718-1254	Xanomeline Low Dose	54.0	9936.0
251		01-718-1328	Xanomeline High Dose	76.1	5859.0
252		01-718-1355	Placebo	0.0	0.0
253		01-718-1371	Xanomeline High Dose	77.4	7587.0
254		01-718-1427	Xanomeline High Dose	73.9	4212.0

Data wrangling

function summary_stats(col)
    (
        count(!ismissing, col) => "N",
        mean(skipmissing(col)) => "Mean",
        std(skipmissing(col)) => "SD",
        median(skipmissing(col)) => "Median",
        minimum(skipmissing(col)) => "Min",
        maximum(skipmissing(col)) => "Max",
    )
end

summary_stats (generic function with 1 method)

Data wrangling

pop_labels = Dict(
    "COMP24FL" => "**Completers at Week 24**<br>",
    "SAFFL" => "**Safety Population**<br><small>Includes completers and early terminators</small>"
)

Dict{String, String} with 2 entries:
  "COMP24FL" => "**Completers at Week 24**<br>"
  "SAFFL"    => "**Safety Population**<br><small>Includes completers and early …

		Treatment
	Total (n=254)	Placebo (n=86)	Xanomeline Low Dose (n=84)	Xanomeline High Dose (n=84)
Average daily dose (mg)
N	254	86	84	84
Mean	41.5	0	54	71.6
SD	31	0	0	8.11
Median	54	0	54	75.1
Min	0	0	54	54
Max	78.6	0	54	78.6
Cumulative dose at end of study
N	254	86	84	84
Mean	4266	0	5347	7551
SD	4964	0	3680	5531
Median	2322	0	4455	5778
Min	0	0	108	54
Max	15417	0	11448	15417

TABLE 9

Data Preparation - Table 9

adsl = @chain adsl_orig begin
    @rsubset :SAFFL == "Y"
    @rtransform :TRTA = replace(:TRT01A,
        "Xanomeline Low Dose" => "Low Dose",
        "Xanomeline High Dose" => "High Dose",
        "Placebo" => "Placebo")
    @transform :TRTA = categorical(:TRTA, levels=["Placebo", "Low Dose", "High Dose"], ordered=true)
end

254×49 DataFrame

229 rows omitted

Row	STUDYID	USUBJID	SUBJID	SITEID	SITEGR1	ARM	TRT01P	TRT01PN	TRT01A	TRT01AN	TRTSDT	TRTEDT	TRTDUR	AVGDD	CUMDOSE	AGE	AGEGR1	AGEGR1N	AGEU	RACE	RACEN	SEX	ETHNIC	SAFFL	ITTFL	EFFFL	COMP8FL	COMP16FL	COMP24FL	DISCONFL	DSRAEFL	DTHFL	BMIBL	BMIBLGR1	HEIGHTBL	WEIGHTBL	EDUCLVL	DISONSDT	DURDIS	DURDSGR1	VISIT1DT	RFSTDTC	RFENDTC	VISNUMEN	RFENDT	DCDECOD	DCREASCD	MMSETOT	TRTA
	String15	String15	String7	String3	String3	String31	String31	Float64	String31	Float64	Date	Date	Float64	Float64	Float64	Float64	String7	Float64	String7	String	Float64	String3	String31	String3	String3	String3	String3	String3	String3	String3?	String3?	String3?	Float64?	String7	Float64	Float64?	Float64	Date	Float64	String7	Date	String15	String15	Float64	Date	String31	String31	Float64	Cat…
1	CDISCPILOT01	01-701-1015	1015	701	701	Placebo	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	182.0	0.0	0.0	63.0	<65	1.0	YEARS	WHITE	1.0	F	HISPANIC OR LATINO	Y	Y	Y	Y	Y	Y	missing	missing	missing	25.1	25-<30	147.3	54.4	16.0	2010-04-30	43.9	>=12	2013-12-26	2014-01-02	2014-07-02	12.0	2014-07-02	COMPLETED	Completed	23.0	Placebo
2	CDISCPILOT01	01-701-1023	1023	701	701	Placebo	Placebo	0.0	Placebo	0.0	2012-08-05	2012-09-01	28.0	0.0	0.0	64.0	<65	1.0	YEARS	WHITE	1.0	M	HISPANIC OR LATINO	Y	Y	Y	N	N	N	Y	Y	missing	30.4	>=30	162.6	80.3	14.0	2006-03-11	76.4	>=12	2012-07-22	2012-08-05	2012-09-02	5.0	2012-09-02	ADVERSE EVENT	Adverse Event	23.0	Placebo
3	CDISCPILOT01	01-701-1028	1028	701	701	Xanomeline High Dose	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2013-07-19	2014-01-14	180.0	77.7	13986.0	71.0	65-80	2.0	YEARS	WHITE	1.0	M	NOT HISPANIC OR LATINO	Y	Y	Y	Y	Y	Y	missing	missing	missing	31.4	>=30	177.8	99.3	16.0	2009-12-16	42.8	>=12	2013-07-11	2013-07-19	2014-01-14	12.0	2014-01-14	COMPLETED	Completed	23.0	High Dose
4	CDISCPILOT01	01-701-1033	1033	701	701	Xanomeline Low Dose	Xanomeline Low Dose	54.0	Xanomeline Low Dose	54.0	2014-03-18	2014-03-31	14.0	54.0	756.0	74.0	65-80	2.0	YEARS	WHITE	1.0	M	NOT HISPANIC OR LATINO	Y	Y	Y	N	N	N	Y	missing	missing	28.8	25-<30	175.3	88.5	12.0	2009-08-02	55.3	>=12	2014-03-10	2014-03-18	2014-04-14	5.0	2014-04-14	STUDY TERMINATED BY SPONSOR	Sponsor Decision	23.0	Low Dose
5	CDISCPILOT01	01-701-1034	1034	701	701	Xanomeline High Dose	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2014-07-01	2014-12-30	183.0	76.9	14067.0	77.0	65-80	2.0	YEARS	WHITE	1.0	F	NOT HISPANIC OR LATINO	Y	Y	Y	Y	Y	Y	missing	missing	missing	26.1	25-<30	154.9	62.6	9.0	2011-09-29	32.9	>=12	2014-06-24	2014-07-01	2014-12-30	12.0	2014-12-30	COMPLETED	Completed	21.0	High Dose
6	CDISCPILOT01	01-701-1047	1047	701	701	Placebo	Placebo	0.0	Placebo	0.0	2013-02-12	2013-03-09	26.0	0.0	0.0	85.0	>80	3.0	YEARS	WHITE	1.0	F	NOT HISPANIC OR LATINO	Y	Y	Y	N	N	N	Y	Y	missing	30.4	>=30	148.6	67.1	8.0	2009-07-26	42.0	>=12	2013-01-22	2013-02-12	2013-03-29	6.0	2013-03-29	ADVERSE EVENT	Adverse Event	23.0	Placebo
7	CDISCPILOT01	01-701-1097	1097	701	701	Xanomeline Low Dose	Xanomeline Low Dose	54.0	Xanomeline Low Dose	54.0	2014-01-01	2014-07-09	190.0	54.0	10260.0	68.0	65-80	2.0	YEARS	WHITE	1.0	M	NOT HISPANIC OR LATINO	Y	Y	Y	Y	Y	Y	missing	missing	missing	27.3	25-<30	168.9	78.0	18.0	2005-09-22	99.1	>=12	2013-12-23	2014-01-01	2014-07-09	12.0	2014-07-09	COMPLETED	Completed	10.0	Low Dose
8	CDISCPILOT01	01-701-1111	1111	701	701	Xanomeline Low Dose	Xanomeline Low Dose	54.0	Xanomeline Low Dose	54.0	2012-09-07	2012-09-16	10.0	54.0	540.0	81.0	>80	3.0	YEARS	WHITE	1.0	F	NOT HISPANIC OR LATINO	Y	Y	Y	N	N	N	Y	Y	missing	23.9	<25	158.2	59.9	22.0	2009-04-04	40.7	>=12	2012-08-25	2012-09-07	2012-09-17	4.0	2012-09-17	ADVERSE EVENT	Adverse Event	23.0	Low Dose
9	CDISCPILOT01	01-701-1115	1115	701	701	Xanomeline Low Dose	Xanomeline Low Dose	54.0	Xanomeline Low Dose	54.0	2012-11-30	2013-01-23	55.0	54.0	2970.0	84.0	>80	3.0	YEARS	WHITE	1.0	M	NOT HISPANIC OR LATINO	Y	Y	Y	Y	N	N	Y	Y	missing	23.9	<25	181.6	78.9	12.0	2004-05-28	101.9	>=12	2012-11-23	2012-11-30	2013-01-23	8.0	2013-01-23	ADVERSE EVENT	Adverse Event	20.0	Low Dose
10	CDISCPILOT01	01-701-1118	1118	701	701	Placebo	Placebo	0.0	Placebo	0.0	2014-03-12	2014-09-09	182.0	0.0	0.0	52.0	<65	1.0	YEARS	WHITE	1.0	M	NOT HISPANIC OR LATINO	Y	Y	Y	Y	Y	Y	missing	missing	missing	21.9	<25	180.3	71.2	14.0	2010-06-24	44.2	>=12	2014-02-27	2014-03-12	2014-09-09	12.0	2014-09-09	COMPLETED	Completed	20.0	Placebo
11	CDISCPILOT01	01-701-1130	1130	701	701	Placebo	Placebo	0.0	Placebo	0.0	2014-02-15	2014-08-16	183.0	0.0	0.0	84.0	>80	3.0	YEARS	WHITE	1.0	M	NOT HISPANIC OR LATINO	Y	Y	Y	Y	Y	Y	missing	missing	missing	27.6	25-<30	169.7	79.4	12.0	2010-05-22	44.7	>=12	2014-02-09	2014-02-15	2014-08-16	12.0	2014-08-16	COMPLETED	Completed	19.0	Placebo
12	CDISCPILOT01	01-701-1133	1133	701	701	Xanomeline High Dose	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2012-10-28	2013-04-28	183.0	77.2	14121.0	81.0	>80	3.0	YEARS	WHITE	1.0	F	NOT HISPANIC OR LATINO	Y	Y	Y	Y	Y	Y	missing	missing	missing	28.1	25-<30	162.6	74.4	10.0	2010-03-11	31.5	>=12	2012-10-23	2012-10-28	2013-04-29	12.0	2013-04-29	COMPLETED	Completed	21.0	High Dose
13	CDISCPILOT01	01-701-1146	1146	701	701	Xanomeline High Dose	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2013-05-20	2013-06-26	38.0	70.3	2673.0	75.0	65-80	2.0	YEARS	WHITE	1.0	F	NOT HISPANIC OR LATINO	Y	Y	Y	N	N	N	Y	Y	missing	24.9	<25	147.3	54.0	16.0	2009-11-17	41.7	>=12	2013-05-07	2013-05-20	2013-06-30	7.0	2013-06-30	ADVERSE EVENT	Adverse Event	22.0	High Dose
⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮
243	CDISCPILOT01	01-718-1079	1079	718	718	Xanomeline Low Dose	Xanomeline Low Dose	54.0	Xanomeline Low Dose	54.0	2012-09-19	2012-10-31	43.0	54.0	2322.0	67.0	65-80	2.0	YEARS	WHITE	1.0	F	NOT HISPANIC OR LATINO	Y	Y	Y	N	N	N	Y	Y	missing	20.0	<25	158.8	50.4	16.0	2005-06-27	86.5	>=12	2012-09-11	2012-09-19	2012-11-06	7.0	2012-11-06	ADVERSE EVENT	Adverse Event	17.0	Low Dose
244	CDISCPILOT01	01-718-1101	1101	718	718	Xanomeline High Dose	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2013-02-17	2013-07-31	165.0	78.5	12960.0	82.0	>80	3.0	YEARS	BLACK OR AFRICAN AMERICAN	2.0	M	NOT HISPANIC OR LATINO	Y	Y	Y	Y	Y	Y	Y	missing	missing	23.2	<25	186.2	80.3	12.0	2008-04-14	57.7	>=12	2013-02-01	2013-02-17	2013-08-02	12.0	2013-08-02	STUDY TERMINATED BY SPONSOR	Sponsor Decision	13.0	High Dose
245	CDISCPILOT01	01-718-1139	1139	718	718	Placebo	Placebo	0.0	Placebo	0.0	2013-05-19	2013-11-17	183.0	0.0	0.0	77.0	65-80	2.0	YEARS	WHITE	1.0	M	NOT HISPANIC OR LATINO	Y	Y	Y	Y	Y	Y	missing	missing	missing	22.4	<25	171.5	65.8	14.0	2008-03-29	61.2	>=12	2013-05-03	2013-05-19	2013-11-17	12.0	2013-11-17	COMPLETED	Completed	16.0	Placebo
246	CDISCPILOT01	01-718-1150	1150	718	718	Placebo	Placebo	0.0	Placebo	0.0	2013-01-19	2013-07-29	192.0	0.0	0.0	73.0	65-80	2.0	YEARS	WHITE	1.0	F	NOT HISPANIC OR LATINO	Y	Y	Y	Y	Y	Y	missing	missing	missing	22.5	<25	156.2	54.9	16.0	2012-03-11	10.1	<12	2013-01-12	2013-01-19	2013-07-31	12.0	2013-07-31	COMPLETED	Completed	22.0	Placebo
247	CDISCPILOT01	01-718-1170	1170	718	718	Xanomeline Low Dose	Xanomeline Low Dose	54.0	Xanomeline Low Dose	54.0	2013-09-16	2013-10-12	27.0	54.0	1458.0	80.0	65-80	2.0	YEARS	WHITE	1.0	F	NOT HISPANIC OR LATINO	Y	Y	Y	N	N	N	Y	Y	missing	21.8	<25	162.6	57.6	12.0	2012-08-25	12.0	>=12	2013-08-25	2013-09-16	2013-11-03	5.0	2013-11-03	ADVERSE EVENT	Adverse Event	19.0	Low Dose
248	CDISCPILOT01	01-718-1172	1172	718	718	Placebo	Placebo	0.0	Placebo	0.0	2013-09-21	2013-11-29	70.0	0.0	0.0	74.0	65-80	2.0	YEARS	WHITE	1.0	M	NOT HISPANIC OR LATINO	Y	Y	Y	Y	N	N	Y	missing	missing	21.9	<25	174.0	66.2	21.0	2011-10-01	23.5	>=12	2013-09-15	2013-09-21	2013-11-29	9.0	2013-11-29	WITHDRAWAL BY SUBJECT	Withdrew Consent	10.0	Placebo
249	CDISCPILOT01	01-718-1250	1250	718	718	Xanomeline Low Dose	Xanomeline Low Dose	54.0	Xanomeline Low Dose	54.0	2013-09-21	2014-01-31	133.0	54.0	7182.0	82.0	>80	3.0	YEARS	WHITE	1.0	F	HISPANIC OR LATINO	Y	Y	Y	Y	Y	N	Y	Y	missing	23.6	<25	157.5	58.5	21.0	2008-08-20	60.1	>=12	2013-08-21	2013-09-21	2014-02-08	11.0	2014-02-08	ADVERSE EVENT	Adverse Event	18.0	Low Dose
250	CDISCPILOT01	01-718-1254	1254	718	718	Xanomeline Low Dose	Xanomeline Low Dose	54.0	Xanomeline Low Dose	54.0	2013-07-10	2014-01-09	184.0	54.0	9936.0	78.0	65-80	2.0	YEARS	WHITE	1.0	M	HISPANIC OR LATINO	Y	Y	Y	Y	Y	Y	missing	missing	missing	28.3	25-<30	170.2	82.1	18.0	2011-09-12	21.6	>=12	2013-06-28	2013-07-10	2014-01-09	12.0	2014-01-09	COMPLETED	Completed	16.0	Low Dose
251	CDISCPILOT01	01-718-1328	1328	718	718	Xanomeline High Dose	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2013-02-01	2013-04-18	77.0	76.1	5859.0	86.0	>80	3.0	YEARS	WHITE	1.0	M	NOT HISPANIC OR LATINO	Y	Y	Y	Y	N	N	Y	missing	missing	21.9	<25	170.2	63.5	12.0	2010-01-11	36.6	>=12	2013-01-28	2013-02-01	2013-05-01	9.0	2013-05-01	WITHDRAWAL BY SUBJECT	Withdrew Consent	13.0	High Dose
252	CDISCPILOT01	01-718-1355	1355	718	718	Placebo	Placebo	0.0	Placebo	0.0	2013-02-28	2013-08-29	183.0	0.0	0.0	79.0	65-80	2.0	YEARS	WHITE	1.0	M	NOT HISPANIC OR LATINO	Y	Y	Y	Y	Y	Y	missing	missing	missing	20.8	<25	167.6	58.5	15.0	2008-12-05	50.3	>=12	2013-02-12	2013-02-28	2013-08-29	12.0	2013-08-29	COMPLETED	Completed	16.0	Placebo
253	CDISCPILOT01	01-718-1371	1371	718	718	Xanomeline High Dose	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2013-04-26	2013-08-01	98.0	77.4	7587.0	69.0	65-80	2.0	YEARS	WHITE	1.0	F	NOT HISPANIC OR LATINO	Y	Y	Y	Y	N	N	Y	Y	missing	27.8	25-<30	154.9	66.7	10.0	2013-02-04	2.2	<12	2013-04-11	2013-04-26	2013-08-08	9.0	2013-08-08	ADVERSE EVENT	Adverse Event	16.0	High Dose
254	CDISCPILOT01	01-718-1427	1427	718	718	Xanomeline High Dose	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	57.0	73.9	4212.0	74.0	65-80	2.0	YEARS	BLACK OR AFRICAN AMERICAN	2.0	F	NOT HISPANIC OR LATINO	Y	Y	Y	Y	N	N	Y	missing	missing	20.5	<25	158.8	51.7	16.0	2010-05-03	31.4	>=12	2012-12-13	2012-12-17	2013-02-18	8.0	2013-02-18	LACK OF EFFICACY	Lack of Efficacy	19.0	High Dose

Data wrangling

adae = @chain adae_orig begin
    @rsubset :SAFFL == "Y" && :TRTEMFL == "Y"
    @rtransform :TRTA = replace(:TRTA,
        "Xanomeline Low Dose" => "Low Dose",
        "Xanomeline High Dose" => "High Dose",
        "Placebo" => "Placebo")
    @transform :TRTA = categorical(:TRTA, levels=["Placebo", "Low Dose", "High Dose"], ordered=true)
    @rtransform :AETERM = titlecase(strip(:AETERM))
    @rtransform :AEBODSYS = titlecase(strip(:AEBODSYS))
end

1126×55 DataFrame

1101 rows omitted

Row	STUDYID	SITEID	USUBJID	TRTA	TRTAN	AGE	AGEGR1	AGEGR1N	RACE	RACEN	SEX	SAFFL	TRTSDT	TRTEDT	ASTDT	ASTDTF	ASTDY	AENDT	AENDY	ADURN	ADURU	AETERM	AELLT	AELLTCD	AEDECOD	AEPTCD	AEHLT	AEHLTCD	AEHLGT	AEHLGTCD	AEBODSYS	AESOC	AESOCCD	AESEV	AESER	AESCAN	AESCONG	AESDISAB	AESDTH	AESHOSP	AESLIFE	AESOD	AEREL	AEACN	AEOUT	AESEQ	TRTEMFL	AOCCFL	AOCCSFL	AOCCPFL	AOCC02FL	AOCC03FL	AOCC04FL	CQ01NAM	AOCC01FL
	String15	String3	String15	Cat…	Float64	Float64	String7	Float64	String	Float64	String3	String3	Date	Date	Date?	String3?	Float64?	Date?	Float64?	Float64?	String3?	String	String	Float64?	String	Float64?	String15	Float64?	String15	Float64?	String	String	Float64?	String15	String3	String3	String3	String3	String3	String3	String3	String3	String15?	Missing	String31	Float64	String3	String3?	String3?	String3?	String3?	String3?	String3?	String31?	String3?
1	CDISCPILOT01	701	01-701-1015	Placebo	0.0	63.0	<65	1.0	WHITE	1.0	F	Y	2014-01-02	2014-07-02	2014-01-03	missing	2.0	missing	missing	missing	missing	Application Site Erythema	APPLICATION SITE REDNESS	missing	APPLICATION SITE ERYTHEMA	missing	HLT_0617	missing	HLGT_0152	missing	General Disorders And Administration Site Conditions	GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS	missing	MILD	N	N	N	N	N	N	N	N	PROBABLE	missing	NOT RECOVERED/NOT RESOLVED	1.0	Y	Y	Y	Y	missing	missing	missing	DERMATOLOGIC EVENTS	Y
2	CDISCPILOT01	701	01-701-1015	Placebo	0.0	63.0	<65	1.0	WHITE	1.0	F	Y	2014-01-02	2014-07-02	2014-01-03	missing	2.0	missing	missing	missing	missing	Application Site Pruritus	APPLICATION SITE ITCHING	missing	APPLICATION SITE PRURITUS	missing	HLT_0317	missing	HLGT_0338	missing	General Disorders And Administration Site Conditions	GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS	missing	MILD	N	N	N	N	N	N	N	N	PROBABLE	missing	NOT RECOVERED/NOT RESOLVED	2.0	Y	missing	missing	Y	missing	missing	missing	DERMATOLOGIC EVENTS	missing
3	CDISCPILOT01	701	01-701-1015	Placebo	0.0	63.0	<65	1.0	WHITE	1.0	F	Y	2014-01-02	2014-07-02	2014-01-09	missing	8.0	2014-01-11	10.0	3.0	DAY	Diarrhoea	DIARRHEA	missing	DIARRHOEA	missing	HLT_0148	missing	HLGT_0588	missing	Gastrointestinal Disorders	GASTROINTESTINAL DISORDERS	missing	MILD	N	N	N	N	N	N	N	N	REMOTE	missing	RECOVERED/RESOLVED	3.0	Y	missing	Y	Y	missing	missing	missing	missing	missing
4	CDISCPILOT01	701	01-701-1023	Placebo	0.0	64.0	<65	1.0	WHITE	1.0	M	Y	2012-08-05	2012-09-01	2012-08-07	missing	3.0	2012-08-30	26.0	24.0	DAY	Erythema	ERYTHEMA	missing	ERYTHEMA	missing	HLT_0284	missing	HLGT_0192	missing	Skin And Subcutaneous Tissue Disorders	SKIN AND SUBCUTANEOUS TISSUE DISORDERS	missing	MILD	N	N	N	N	N	N	N	N	POSSIBLE	missing	NOT RECOVERED/NOT RESOLVED	1.0	Y	Y	Y	Y	missing	missing	missing	DERMATOLOGIC EVENTS	Y
5	CDISCPILOT01	701	01-701-1023	Placebo	0.0	64.0	<65	1.0	WHITE	1.0	M	Y	2012-08-05	2012-09-01	2012-08-07	missing	3.0	missing	missing	missing	missing	Erythema	LOCALIZED ERYTHEMA	missing	ERYTHEMA	missing	HLT_0284	missing	HLGT_0192	missing	Skin And Subcutaneous Tissue Disorders	SKIN AND SUBCUTANEOUS TISSUE DISORDERS	missing	MODERATE	N	N	N	N	N	N	N	N	PROBABLE	missing	NOT RECOVERED/NOT RESOLVED	2.0	Y	missing	missing	missing	missing	missing	missing	DERMATOLOGIC EVENTS	missing
6	CDISCPILOT01	701	01-701-1023	Placebo	0.0	64.0	<65	1.0	WHITE	1.0	M	Y	2012-08-05	2012-09-01	2012-08-26	missing	22.0	missing	missing	missing	missing	Atrioventricular Block Second Degree	AV BLOCK SECOND DEGREE	missing	ATRIOVENTRICULAR BLOCK SECOND DEGREE	missing	HLT_0415	missing	HLGT_0086	missing	Cardiac Disorders	CARDIAC DISORDERS	missing	MILD	N	N	N	N	N	N	N	N	POSSIBLE	missing	NOT RECOVERED/NOT RESOLVED	3.0	Y	missing	Y	Y	missing	missing	missing	missing	missing
7	CDISCPILOT01	701	01-701-1023	Placebo	0.0	64.0	<65	1.0	WHITE	1.0	M	Y	2012-08-05	2012-09-01	2012-08-07	missing	3.0	2012-08-30	26.0	24.0	DAY	Erythema	ERYTHEMA	missing	ERYTHEMA	missing	HLT_0284	missing	HLGT_0192	missing	Skin And Subcutaneous Tissue Disorders	SKIN AND SUBCUTANEOUS TISSUE DISORDERS	missing	MILD	N	N	N	N	N	N	N	N	POSSIBLE	missing	RECOVERED/RESOLVED	4.0	Y	missing	missing	missing	missing	missing	missing	DERMATOLOGIC EVENTS	missing
8	CDISCPILOT01	701	01-701-1028	High Dose	81.0	71.0	65-80	2.0	WHITE	1.0	M	Y	2013-07-19	2014-01-14	2013-07-21	missing	3.0	missing	missing	missing	missing	Application Site Erythema	APPLICATION SITE ERYTHEMA	missing	APPLICATION SITE ERYTHEMA	missing	HLT_0617	missing	HLGT_0152	missing	General Disorders And Administration Site Conditions	GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS	missing	MILD	N	N	N	N	N	N	N	N	POSSIBLE	missing	NOT RECOVERED/NOT RESOLVED	1.0	Y	Y	Y	Y	missing	missing	missing	DERMATOLOGIC EVENTS	Y
9	CDISCPILOT01	701	01-701-1028	High Dose	81.0	71.0	65-80	2.0	WHITE	1.0	M	Y	2013-07-19	2014-01-14	2013-08-08	missing	21.0	missing	missing	missing	missing	Application Site Pruritus	APPLICATION SITE ITCHING	missing	APPLICATION SITE PRURITUS	missing	HLT_0317	missing	HLGT_0338	missing	General Disorders And Administration Site Conditions	GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS	missing	MILD	N	N	N	N	N	N	N	N	PROBABLE	missing	NOT RECOVERED/NOT RESOLVED	2.0	Y	missing	missing	Y	missing	missing	missing	DERMATOLOGIC EVENTS	missing
10	CDISCPILOT01	701	01-701-1034	High Dose	81.0	77.0	65-80	2.0	WHITE	1.0	F	Y	2014-07-01	2014-12-30	2014-08-27	missing	58.0	missing	missing	missing	missing	Application Site Pruritus	APPLICATION SITE ITCHING	missing	APPLICATION SITE PRURITUS	missing	HLT_0317	missing	HLGT_0338	missing	General Disorders And Administration Site Conditions	GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS	missing	MILD	N	N	N	N	N	N	N	N	PROBABLE	missing	NOT RECOVERED/NOT RESOLVED	1.0	Y	Y	Y	Y	missing	missing	missing	DERMATOLOGIC EVENTS	Y
11	CDISCPILOT01	701	01-701-1034	High Dose	81.0	77.0	65-80	2.0	WHITE	1.0	F	Y	2014-07-01	2014-12-30	2014-11-02	missing	125.0	missing	missing	missing	missing	Fatigue	FATIGUE	missing	FATIGUE	missing	HLT_0043	missing	HLGT_0181	missing	General Disorders And Administration Site Conditions	GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS	missing	MILD	N	N	N	N	N	N	N	N	POSSIBLE	missing	NOT RECOVERED/NOT RESOLVED	2.0	Y	missing	missing	Y	missing	missing	missing	missing	missing
12	CDISCPILOT01	701	01-701-1047	Placebo	0.0	85.0	>80	3.0	WHITE	1.0	F	Y	2013-02-12	2013-03-09	2013-02-12	missing	1.0	2013-02-12	1.0	1.0	DAY	Hiatus Hernia	HERNIA HIATAL	missing	HIATUS HERNIA	missing	HLT_0159	missing	HLGT_0109	missing	Gastrointestinal Disorders	GASTROINTESTINAL DISORDERS	missing	MODERATE	N	N	N	N	N	N	N	N	NONE	missing	NOT RECOVERED/NOT RESOLVED	1.0	Y	Y	Y	Y	missing	missing	missing	missing	missing
13	CDISCPILOT01	701	01-701-1047	Placebo	0.0	85.0	>80	3.0	WHITE	1.0	F	Y	2013-02-12	2013-03-09	2013-02-12	missing	1.0	2013-02-12	1.0	1.0	DAY	Hiatus Hernia	HERNIA HIATAL	missing	HIATUS HERNIA	missing	HLT_0159	missing	HLGT_0109	missing	Gastrointestinal Disorders	GASTROINTESTINAL DISORDERS	missing	MODERATE	N	N	N	N	N	N	N	N	NONE	missing	RECOVERED/RESOLVED	2.0	Y	missing	missing	missing	missing	missing	missing	missing	missing
⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮
1115	CDISCPILOT01	718	01-718-1427	High Dose	81.0	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	Y	2012-12-17	2013-02-11	2013-01-05	missing	20.0	2013-01-05	20.0	1.0	DAY	Lethargy	LETHARGY	missing	LETHARGY	missing	HLT_0027	missing	HLGT_0448	missing	Nervous System Disorders	NERVOUS SYSTEM DISORDERS	missing	MODERATE	N	N	N	N	N	N	N	N	POSSIBLE	missing	RECOVERED/RESOLVED	5.0	Y	missing	missing	Y	missing	missing	missing	missing	missing
1116	CDISCPILOT01	718	01-718-1427	High Dose	81.0	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	Y	2012-12-17	2013-02-11	2013-01-16	missing	31.0	2013-01-16	31.0	1.0	DAY	Nausea	NAUSEA	missing	NAUSEA	missing	HLT_0742	missing	HLGT_0326	missing	Gastrointestinal Disorders	GASTROINTESTINAL DISORDERS	missing	MODERATE	N	N	N	N	N	N	N	N	POSSIBLE	missing	RECOVERED/RESOLVED	6.0	Y	missing	missing	missing	missing	missing	missing	missing	missing
1117	CDISCPILOT01	718	01-718-1427	High Dose	81.0	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	Y	2012-12-17	2013-02-11	2013-01-01	missing	16.0	2013-01-19	34.0	19.0	DAY	Amnesia	SHORT-TERM MEMORY LOSS	missing	AMNESIA	missing	HLT_0501	missing	HLGT_0641	missing	Nervous System Disorders	NERVOUS SYSTEM DISORDERS	missing	MILD	N	N	N	N	N	N	N	N	NONE	missing	RECOVERED/RESOLVED	7.0	Y	missing	missing	missing	missing	missing	missing	missing	missing
1118	CDISCPILOT01	718	01-718-1427	High Dose	81.0	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	Y	2012-12-17	2013-02-11	2013-01-21	missing	36.0	2013-01-24	39.0	4.0	DAY	Nausea	NAUSEA	missing	NAUSEA	missing	HLT_0742	missing	HLGT_0326	missing	Gastrointestinal Disorders	GASTROINTESTINAL DISORDERS	missing	SEVERE	N	N	N	N	N	N	N	N	PROBABLE	missing	RECOVERED/RESOLVED	8.0	Y	missing	missing	missing	missing	missing	missing	missing	missing
1119	CDISCPILOT01	718	01-718-1427	High Dose	81.0	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	Y	2012-12-17	2013-02-11	2013-01-27	missing	42.0	2013-01-28	43.0	2.0	DAY	Application Site Pruritus	APPLICATION SITE ITCHING	missing	APPLICATION SITE PRURITUS	missing	HLT_0317	missing	HLGT_0338	missing	General Disorders And Administration Site Conditions	GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS	missing	MODERATE	N	N	N	N	N	N	N	N	PROBABLE	missing	NOT RECOVERED/NOT RESOLVED	9.0	Y	missing	Y	Y	missing	missing	missing	DERMATOLOGIC EVENTS	Y
1120	CDISCPILOT01	718	01-718-1427	High Dose	81.0	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	Y	2012-12-17	2013-02-11	2013-01-27	missing	42.0	2013-01-27	42.0	1.0	DAY	Application Site Dermatitis	APPLICATION SITE RASH	missing	APPLICATION SITE DERMATITIS	missing	HLT_0343	missing	HLGT_0241	missing	General Disorders And Administration Site Conditions	GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS	missing	MODERATE	N	N	N	N	N	N	N	N	PROBABLE	missing	RECOVERED/RESOLVED	10.0	Y	missing	missing	Y	missing	missing	missing	DERMATOLOGIC EVENTS	missing
1121	CDISCPILOT01	718	01-718-1427	High Dose	81.0	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	Y	2012-12-17	2013-02-11	2013-01-27	missing	42.0	2013-01-28	43.0	2.0	DAY	Application Site Pruritus	APPLICATION SITE ITCHING	missing	APPLICATION SITE PRURITUS	missing	HLT_0317	missing	HLGT_0338	missing	General Disorders And Administration Site Conditions	GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS	missing	MODERATE	N	N	N	N	N	N	N	N	PROBABLE	missing	RECOVERED/RESOLVED	11.0	Y	missing	missing	missing	missing	missing	missing	DERMATOLOGIC EVENTS	missing
1122	CDISCPILOT01	718	01-718-1427	High Dose	81.0	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	Y	2012-12-17	2013-02-11	2013-01-29	missing	44.0	missing	missing	missing	missing	Application Site Dermatitis	APPLICATION SITE RASH	missing	APPLICATION SITE DERMATITIS	missing	HLT_0343	missing	HLGT_0241	missing	General Disorders And Administration Site Conditions	GENERAL DISORDERS AND ADMINISTRATION SITE CONDITIONS	missing	MILD	N	N	N	N	N	N	N	N	PROBABLE	missing	NOT RECOVERED/NOT RESOLVED	12.0	Y	missing	missing	missing	missing	missing	missing	DERMATOLOGIC EVENTS	missing
1123	CDISCPILOT01	718	01-718-1427	High Dose	81.0	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	Y	2012-12-17	2013-02-11	2013-02-04	missing	50.0	2013-02-25	71.0	22.0	DAY	Decreased Appetite	DECREASED APPETITE	missing	DECREASED APPETITE	missing	HLT_0574	missing	HLGT_0231	missing	Metabolism And Nutrition Disorders	METABOLISM AND NUTRITION DISORDERS	missing	MODERATE	N	N	N	N	N	N	N	N	POSSIBLE	missing	NOT RECOVERED/NOT RESOLVED	13.0	Y	missing	Y	Y	missing	missing	missing	missing	missing
1124	CDISCPILOT01	718	01-718-1427	High Dose	81.0	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	Y	2012-12-17	2013-02-11	2013-02-04	missing	50.0	2013-02-25	71.0	22.0	DAY	Nausea	NAUSEA	missing	NAUSEA	missing	HLT_0742	missing	HLGT_0326	missing	Gastrointestinal Disorders	GASTROINTESTINAL DISORDERS	missing	MODERATE	N	N	N	N	N	N	N	N	POSSIBLE	missing	NOT RECOVERED/NOT RESOLVED	14.0	Y	missing	missing	missing	missing	missing	missing	missing	missing
1125	CDISCPILOT01	718	01-718-1427	High Dose	81.0	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	Y	2012-12-17	2013-02-11	2013-02-04	missing	50.0	2013-02-25	71.0	22.0	DAY	Decreased Appetite	DECREASED APPETITE	missing	DECREASED APPETITE	missing	HLT_0574	missing	HLGT_0231	missing	Metabolism And Nutrition Disorders	METABOLISM AND NUTRITION DISORDERS	missing	MODERATE	N	N	N	N	N	N	N	N	POSSIBLE	missing	RECOVERED/RESOLVED	15.0	Y	missing	missing	missing	missing	missing	missing	missing	missing
1126	CDISCPILOT01	718	01-718-1427	High Dose	81.0	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	Y	2012-12-17	2013-02-11	2013-02-04	missing	50.0	2013-02-25	71.0	22.0	DAY	Nausea	NAUSEA	missing	NAUSEA	missing	HLT_0742	missing	HLGT_0326	missing	Gastrointestinal Disorders	GASTROINTESTINAL DISORDERS	missing	MODERATE	N	N	N	N	N	N	N	N	POSSIBLE	missing	RECOVERED/RESOLVED	16.0	Y	missing	missing	missing	missing	missing	missing	missing	missing

Data wrangling

function complete_ae_data(df_adae, df_adsl; id_col=:USUBJID, soc_col=:AEBODSYS, ae_col=:AETERM, strata_col=:TRTA)
    all_ids = unique(df_adsl[:, id_col])
    levels_strata = levels(df_adsl[:, strata_col])
    levels_soc = unique(df_adae[:, soc_col])
    levels_ae = unique(df_adae[:, ae_col])

    # Generate dummy combinations
    rows = DataFrame()
    for id in all_ids, soc in levels_soc, ae in levels_ae, trt in levels_strata
        push!(rows, (USUBJID=id, AEBODSYS=soc, AETERM=ae, TRTA=trt))
    end

    # Mark those that are present in real ADAE
    real_ids = select(df_adae, id_col, soc_col, ae_col, strata_col)
    real_ids = unique(real_ids)
    rename!(real_ids, Dict(id_col => :USUBJID, soc_col => :AEBODSYS, ae_col => :AETERM, strata_col => :TRTA))

    merged = leftjoin(rows, real_ids, on=[:USUBJID, :AEBODSYS, :AETERM, :TRTA], indicator=:present)
    merged.present = coalesce.(merged.present .== "both", false)
    return merged
end

ae_cmpl = complete_ae_data(adae, adsl)

4030980×5 DataFrame

4030955 rows omitted

Row	USUBJID	AEBODSYS	AETERM	TRTA	present
	String15	String	String	String	Bool
1	01-701-1015	General Disorders And Administration Site Conditions	Application Site Erythema	Placebo	true
2	01-701-1015	General Disorders And Administration Site Conditions	Application Site Pruritus	Placebo	true
3	01-701-1015	Gastrointestinal Disorders	Diarrhoea	Placebo	true
4	01-701-1023	Skin And Subcutaneous Tissue Disorders	Erythema	Placebo	true
5	01-701-1023	Cardiac Disorders	Atrioventricular Block Second Degree	Placebo	true
6	01-701-1028	General Disorders And Administration Site Conditions	Application Site Erythema	High Dose	true
7	01-701-1028	General Disorders And Administration Site Conditions	Application Site Pruritus	High Dose	true
8	01-701-1034	General Disorders And Administration Site Conditions	Application Site Pruritus	High Dose	true
9	01-701-1034	General Disorders And Administration Site Conditions	Fatigue	High Dose	true
10	01-701-1047	Gastrointestinal Disorders	Hiatus Hernia	Placebo	true
11	01-701-1047	Cardiac Disorders	Bundle Branch Block Left	Placebo	true
12	01-701-1047	Infections And Infestations	Upper Respiratory Tract Infection	Placebo	true
13	01-701-1097	General Disorders And Administration Site Conditions	Application Site Pruritus	Low Dose	true
⋮	⋮	⋮	⋮	⋮	⋮
4030969	01-718-1427	Immune System Disorders	Skin Ulcer	Placebo	false
4030970	01-718-1427	Immune System Disorders	Skin Ulcer	Low Dose	false
4030971	01-718-1427	Immune System Disorders	Skin Ulcer	High Dose	false
4030972	01-718-1427	Immune System Disorders	Partial Seizures With Secondary Generalisation	Placebo	false
4030973	01-718-1427	Immune System Disorders	Partial Seizures With Secondary Generalisation	Low Dose	false
4030974	01-718-1427	Immune System Disorders	Partial Seizures With Secondary Generalisation	High Dose	false
4030975	01-718-1427	Immune System Disorders	Hallucination, Visual	Placebo	false
4030976	01-718-1427	Immune System Disorders	Hallucination, Visual	Low Dose	false
4030977	01-718-1427	Immune System Disorders	Hallucination, Visual	High Dose	false
4030978	01-718-1427	Immune System Disorders	Amnesia	Placebo	false
4030979	01-718-1427	Immune System Disorders	Amnesia	Low Dose	false
4030980	01-718-1427	Immune System Disorders	Amnesia	High Dose	false

Data wrangling

ae_any = @chain adae begin
    @rtransform :AEBODSYS = "Any Body System"
    @rtransform :AETERM = "Any Body System"
end

ae_cmpl_any = complete_ae_data(ae_any, adsl)
ae_all = vcat(ae_cmpl, ae_cmpl_any)

4031742×5 DataFrame

4031717 rows omitted

Row	USUBJID	AEBODSYS	AETERM	TRTA	present
	String15	String	String	String	Bool
1	01-701-1015	General Disorders And Administration Site Conditions	Application Site Erythema	Placebo	true
2	01-701-1015	General Disorders And Administration Site Conditions	Application Site Pruritus	Placebo	true
3	01-701-1015	Gastrointestinal Disorders	Diarrhoea	Placebo	true
4	01-701-1023	Skin And Subcutaneous Tissue Disorders	Erythema	Placebo	true
5	01-701-1023	Cardiac Disorders	Atrioventricular Block Second Degree	Placebo	true
6	01-701-1028	General Disorders And Administration Site Conditions	Application Site Erythema	High Dose	true
7	01-701-1028	General Disorders And Administration Site Conditions	Application Site Pruritus	High Dose	true
8	01-701-1034	General Disorders And Administration Site Conditions	Application Site Pruritus	High Dose	true
9	01-701-1034	General Disorders And Administration Site Conditions	Fatigue	High Dose	true
10	01-701-1047	Gastrointestinal Disorders	Hiatus Hernia	Placebo	true
11	01-701-1047	Cardiac Disorders	Bundle Branch Block Left	Placebo	true
12	01-701-1047	Infections And Infestations	Upper Respiratory Tract Infection	Placebo	true
13	01-701-1097	General Disorders And Administration Site Conditions	Application Site Pruritus	Low Dose	true
⋮	⋮	⋮	⋮	⋮	⋮
4031731	01-718-1250	Any Body System	Any Body System	Placebo	false
4031732	01-718-1250	Any Body System	Any Body System	High Dose	false
4031733	01-718-1254	Any Body System	Any Body System	Placebo	false
4031734	01-718-1254	Any Body System	Any Body System	High Dose	false
4031735	01-718-1328	Any Body System	Any Body System	Placebo	false
4031736	01-718-1328	Any Body System	Any Body System	Low Dose	false
4031737	01-718-1355	Any Body System	Any Body System	Low Dose	false
4031738	01-718-1355	Any Body System	Any Body System	High Dose	false
4031739	01-718-1371	Any Body System	Any Body System	Placebo	false
4031740	01-718-1371	Any Body System	Any Body System	Low Dose	false
4031741	01-718-1427	Any Body System	Any Body System	Placebo	false
4031742	01-718-1427	Any Body System	Any Body System	Low Dose	false

Data wrangling

ae_long = @chain ae_all begin
    @rtransform :SOC = :AEBODSYS
    @rtransform :AE = :AETERM
    @rtransform :AE_Label = ifelse(:AEBODSYS == "Any Body System", "All " * :SOC, :AE)
    @rtransform :PRESENT = :present
    unique(:USUBJID)

end

254×9 DataFrame

229 rows omitted

Row	USUBJID	AEBODSYS	AETERM	TRTA	present	SOC	AE	AE_Label	PRESENT
	String15	String	String	String	Bool	String	String	String	Bool
1	01-701-1015	General Disorders And Administration Site Conditions	Application Site Erythema	Placebo	true	General Disorders And Administration Site Conditions	Application Site Erythema	Application Site Erythema	true
2	01-701-1023	Skin And Subcutaneous Tissue Disorders	Erythema	Placebo	true	Skin And Subcutaneous Tissue Disorders	Erythema	Erythema	true
3	01-701-1028	General Disorders And Administration Site Conditions	Application Site Erythema	High Dose	true	General Disorders And Administration Site Conditions	Application Site Erythema	Application Site Erythema	true
4	01-701-1034	General Disorders And Administration Site Conditions	Application Site Pruritus	High Dose	true	General Disorders And Administration Site Conditions	Application Site Pruritus	Application Site Pruritus	true
5	01-701-1047	Gastrointestinal Disorders	Hiatus Hernia	Placebo	true	Gastrointestinal Disorders	Hiatus Hernia	Hiatus Hernia	true
6	01-701-1097	General Disorders And Administration Site Conditions	Application Site Pruritus	Low Dose	true	General Disorders And Administration Site Conditions	Application Site Pruritus	Application Site Pruritus	true
7	01-701-1111	Infections And Infestations	Cellulitis	Low Dose	true	Infections And Infestations	Cellulitis	Cellulitis	true
8	01-701-1115	General Disorders And Administration Site Conditions	Application Site Erythema	Low Dose	true	General Disorders And Administration Site Conditions	Application Site Erythema	Application Site Erythema	true
9	01-701-1130	General Disorders And Administration Site Conditions	Pyrexia	Placebo	true	General Disorders And Administration Site Conditions	Pyrexia	Pyrexia	true
10	01-701-1133	General Disorders And Administration Site Conditions	Application Site Erythema	High Dose	true	General Disorders And Administration Site Conditions	Application Site Erythema	Application Site Erythema	true
11	01-701-1146	General Disorders And Administration Site Conditions	Application Site Erythema	High Dose	true	General Disorders And Administration Site Conditions	Application Site Erythema	Application Site Erythema	true
12	01-701-1148	General Disorders And Administration Site Conditions	Application Site Erythema	High Dose	true	General Disorders And Administration Site Conditions	Application Site Erythema	Application Site Erythema	true
13	01-701-1153	Metabolism And Nutrition Disorders	Increased Appetite	Placebo	true	Metabolism And Nutrition Disorders	Increased Appetite	Increased Appetite	true
⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮
243	01-708-1372	General Disorders And Administration Site Conditions	Application Site Erythema	Placebo	false	General Disorders And Administration Site Conditions	Application Site Erythema	Application Site Erythema	false
244	01-708-1378	General Disorders And Administration Site Conditions	Application Site Erythema	Placebo	false	General Disorders And Administration Site Conditions	Application Site Erythema	Application Site Erythema	false
245	01-709-1001	General Disorders And Administration Site Conditions	Application Site Erythema	Placebo	false	General Disorders And Administration Site Conditions	Application Site Erythema	Application Site Erythema	false
246	01-710-1078	General Disorders And Administration Site Conditions	Application Site Erythema	Placebo	false	General Disorders And Administration Site Conditions	Application Site Erythema	Application Site Erythema	false
247	01-713-1106	General Disorders And Administration Site Conditions	Application Site Erythema	Placebo	false	General Disorders And Administration Site Conditions	Application Site Erythema	Application Site Erythema	false
248	01-714-1425	General Disorders And Administration Site Conditions	Application Site Erythema	Placebo	false	General Disorders And Administration Site Conditions	Application Site Erythema	Application Site Erythema	false
249	01-715-1085	General Disorders And Administration Site Conditions	Application Site Erythema	Placebo	false	General Disorders And Administration Site Conditions	Application Site Erythema	Application Site Erythema	false
250	01-715-1155	General Disorders And Administration Site Conditions	Application Site Erythema	Placebo	false	General Disorders And Administration Site Conditions	Application Site Erythema	Application Site Erythema	false
251	01-715-1397	General Disorders And Administration Site Conditions	Application Site Erythema	Placebo	false	General Disorders And Administration Site Conditions	Application Site Erythema	Application Site Erythema	false
252	01-716-1030	General Disorders And Administration Site Conditions	Application Site Erythema	Placebo	false	General Disorders And Administration Site Conditions	Application Site Erythema	Application Site Erythema	false
253	01-716-1177	General Disorders And Administration Site Conditions	Application Site Erythema	Placebo	false	General Disorders And Administration Site Conditions	Application Site Erythema	Application Site Erythema	false
254	01-718-1172	General Disorders And Administration Site Conditions	Application Site Erythema	Placebo	false	General Disorders And Administration Site Conditions	Application Site Erythema	Application Site Erythema	false

		Xanomeline
		High Dose (n=76)																												Low Dose (n=77)																																	Placebo (n=101)
	Total (n=254)	Agitation (n=1)	Application Site Dermatitis (n=1)	Application Site Erythema (n=15)	Application Site Irritation (n=3)	Application Site Perspiration (n=1)	Application Site Pruritus (n=10)	Application Site Reaction (n=1)	Arthritis (n=1)	Asthenia (n=1)	Atrial Fibrillation (n=1)	Chest Discomfort (n=1)	Chest Pain (n=2)	Diarrhoea (n=1)	Dyspnoea (n=1)	Erythema (n=8)	Fatigue (n=3)	Gastrointestinal Haemorrhage (n=1)	Hyperhidrosis (n=1)	Nausea (n=1)	Oedema Peripheral (n=1)	Pruritus (n=11)	Pruritus Generalised (n=1)	Pyrexia (n=1)	Rash Pruritic (n=2)	Salivary Hypersecretion (n=1)	Sinus Bradycardia (n=1)	Syncope (n=2)	Vomiting (n=2)	Abdominal Pain (n=1)	Anxiety (n=1)	Application Site Dermatitis (n=4)	Application Site Desquamation (n=1)	Application Site Erythema (n=12)	Application Site Irritation (n=6)	Application Site Pruritus (n=12)	Application Site Urticaria (n=1)	Application Site Vesicles (n=1)	Atrial Flutter (n=1)	Blood Glucose Increased (n=1)	Cellulitis (n=1)	Dermatitis Contact (n=1)	Dizziness (n=1)	Dyspepsia (n=1)	Erythema (n=7)	Fatigue (n=3)	Hyperhidrosis (n=2)	Inflammation (n=1)	Myocardial Infarction (n=1)	Oedema (n=2)	Oedema Peripheral (n=1)	Pain (n=1)	Palpitations (n=1)	Pruritus (n=4)	Rash (n=2)	Skin Irritation (n=1)	Skin Laceration (n=1)	Swelling (n=1)	Transient Ischaemic Attack (n=1)	Ulcer (n=1)	Vision Blurred (n=1)	Vomiting (n=1)	Application Site Dermatitis (n=5)	Application Site Erythema (n=39)	Application Site Irritation (n=2)	Application Site Pruritus (n=5)	Asthenia (n=1)	Blood Alkaline Phosphatase Increased (n=1)	Chills (n=1)	Completed Suicide (n=1)	Decreased Appetite (n=1)	Delusion (n=1)	Diabetes Mellitus (n=1)	Diarrhoea (n=7)	Erythema (n=8)	Eye Laser Surgery (n=1)	Fatigue (n=1)	Flatulence (n=1)	Glossitis (n=1)	Haemoptysis (n=1)	Heart Rate Increased (n=1)	Heart Rate Irregular (n=1)	Hiatus Hernia (n=1)	Hyperbilirubinaemia (n=1)	Increased Appetite (n=1)	Myocardial Infarction (n=2)	Nasopharyngitis (n=2)	Nephrolithiasis (n=1)	Oedema Peripheral (n=1)	Parkinson'S Disease (n=1)	Pruritus (n=2)	Pyrexia (n=2)	Sinus Arrhythmia (n=1)	Sinus Bradycardia (n=1)	Skin Irritation (n=1)	Supraventricular Extrasystoles (n=1)	Tachycardia (n=1)	Upper Respiratory Tract Infection (n=1)	Vomiting (n=1)	P-Value	Test
All any body system
Cardiac Disorders	11 (4.33%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	1 (100%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	1 (100%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	1 (100%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	1 (100%)	0 (0%)	0 (0%)	0 (0%)	1 (100%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	2 (100%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	1 (100%)	1 (100%)	0 (0%)	1 (100%)	1 (100%)	0 (0%)	0 (0%)
Eye Disorders	1 (0.394%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	1 (100%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)
Gastrointestinal Disorders	20 (7.87%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	1 (100%)	0 (0%)	0 (0%)	0 (0%)	1 (100%)	0 (0%)	1 (100%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	1 (100%)	0 (0%)	0 (0%)	2 (100%)	1 (100%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	1 (100%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	1 (100%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	7 (100%)	0 (0%)	0 (0%)	0 (0%)	1 (100%)	1 (100%)	0 (0%)	0 (0%)	0 (0%)	1 (100%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	1 (100%)
General Disorders And Administration Site Conditions	144 (56.7%)	0 (0%)	1 (100%)	15 (100%)	3 (100%)	1 (100%)	10 (100%)	1 (100%)	0 (0%)	1 (100%)	0 (0%)	1 (100%)	2 (100%)	0 (0%)	0 (0%)	0 (0%)	3 (100%)	0 (0%)	0 (0%)	0 (0%)	1 (100%)	0 (0%)	0 (0%)	1 (100%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	4 (100%)	1 (100%)	12 (100%)	6 (100%)	12 (100%)	1 (100%)	1 (100%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	3 (100%)	0 (0%)	1 (100%)	0 (0%)	2 (100%)	1 (100%)	1 (100%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	1 (100%)	0 (0%)	1 (100%)	0 (0%)	0 (0%)	5 (100%)	39 (100%)	2 (100%)	5 (100%)	1 (100%)	0 (0%)	1 (100%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	1 (100%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	1 (100%)	0 (0%)	0 (0%)	2 (100%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)
Hepatobiliary Disorders	1 (0.394%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	1 (100%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)
Infections And Infestations	4 (1.57%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	1 (100%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	2 (100%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	1 (100%)	0 (0%)
Injury, Poisoning And Procedural Complications	1 (0.394%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	1 (100%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)
Investigations	4 (1.57%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	1 (100%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	1 (100%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	1 (100%)	1 (100%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)
Metabolism And Nutrition Disorders	3 (1.18%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	1 (100%)	0 (0%)	1 (100%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	1 (100%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)
Musculoskeletal And Connective Tissue Disorders	1 (0.394%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	1 (100%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)
Nervous System Disorders	5 (1.97%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	2 (100%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	1 (100%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	1 (100%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	1 (100%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)
Psychiatric Disorders	4 (1.57%)	1 (100%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	1 (100%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	1 (100%)	0 (0%)	1 (100%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)
Renal And Urinary Disorders	1 (0.394%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	1 (100%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)
Respiratory, Thoracic And Mediastinal Disorders	2 (0.787%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	1 (100%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	1 (100%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)
Skin And Subcutaneous Tissue Disorders	51 (20.1%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	8 (100%)	0 (0%)	0 (0%)	1 (100%)	0 (0%)	0 (0%)	11 (100%)	1 (100%)	0 (0%)	2 (100%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	1 (100%)	0 (0%)	0 (0%)	7 (100%)	0 (0%)	2 (100%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	4 (100%)	2 (100%)	1 (100%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	8 (100%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	2 (100%)	0 (0%)	0 (0%)	0 (0%)	1 (100%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)
Surgical And Medical Procedures	1 (0.394%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	1 (100%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)	0 (0%)

TABLE 10

Data Preparation - Table 10

adlbc = @chain readstat(joinpath(path, "adlbc.xpt")) DataFrame begin
    @rsubset :SAFFL == "Y" && (:AVISITN != 99 || (:AVISITN == 99 && :AENTMTFL == "Y"))
end

adlbh = @chain readstat(joinpath(path, "adlbh.xpt")) DataFrame begin
    @rsubset :SAFFL == "Y" && (:AVISITN != 99 || (:AVISITN == 99 && :AENTMTFL == "Y"))
    @rsubset !in(:PARAM, ["Anisocytes", "Poikilocytes", "Microcytes", "Macrocytes", "Polychromasia"])
end

48403×46 DataFrame

48378 rows omitted

Row	STUDYID	SUBJID	USUBJID	TRTP	TRTPN	TRTA	TRTAN	TRTSDT	TRTEDT	AGE	AGEGR1	AGEGR1N	RACE	RACEN	SEX	COMP24FL	DSRAEFL	SAFFL	AVISIT	AVISITN	ADY	ADT	VISIT	VISITNUM	PARAM	PARAMCD	PARAMN	PARCAT1	AVAL	BASE	CHG	A1LO	A1HI	R2A1LO	R2A1HI	BR2A1LO	BR2A1HI	ANL01FL	ALBTRVAL	ANRIND	BNRIND	ABLFL	AENTMTFL	LBSEQ	LBNRIND	LBSTRESN
	String15	String7	String15	String31	Float64	String31	Float64	Date	Date	Float64	String7	Float64	String	Float64	String3	String3	String3	String3	String31	Float64	Float64	Date	String15	Float64	String	String15	Float64	String3	Float64?	Float64?	Float64?	Float64?	Float64?	Float64?	Float64?	Float64?	Float64?	String3	Float64?	String3	String3	String3	String3	Float64	String15	Float64
1	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y		Y	Baseline	0.0	-7.0	2013-12-26	SCREENING 1	1.0	Hemoglobin (mmol/L)	HGB	1.0	HEM	8.87458	8.87458	missing	7.14	9.81	1.24294	0.904646	1.24294	0.904646		5.84042	N	N	Y		19.0	NORMAL	8.87458
2	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y		Y	Baseline	0.0	-7.0	2013-12-26	SCREENING 1	1.0	Hematocrit	HCT	2.0	HEM	0.42	0.42	missing	0.34	0.48	1.23529	0.875	1.23529	0.875		0.3	N	N	Y		18.0	NORMAL	0.42
3	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y		Y	Baseline	0.0	-7.0	2013-12-26	SCREENING 1	1.0	Ery. Mean Corpuscular Volume (fL)	MCV	3.0	HEM	80.0	80.0	missing	80.0	100.0	1.0	0.8	1.0	0.8		70.0	N	N	Y		25.0	NORMAL	80.0
4	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y		Y	Baseline	0.0	-7.0	2013-12-26	SCREENING 1	1.0	Ery. Mean Corpuscular Hemoglobin (fmol(Fe))	MCH	4.0	HEM	1.67562	1.67562	missing	1.6	2.1	1.04726	0.797914	1.04726	0.797914		1.47438	N	N	Y		23.0	NORMAL	1.67562
5	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y		Y	Baseline	0.0	-7.0	2013-12-26	SCREENING 1	1.0	Ery. Mean Corpuscular HGB Concentration (mmol/L)	MCHC	5.0	HEM	21.1004	21.1004	missing	19.0	24.0	1.11055	0.879183	1.11055	0.879183		14.8996	N	N	Y		24.0	NORMAL	21.1004
6	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y		Y	Baseline	0.0	-7.0	2013-12-26	SCREENING 1	1.0	Leukocytes (GI/L)	WBC	6.0	HEM	5.78	5.78	missing	3.8	10.7	1.52105	0.540187	1.52105	0.540187		10.27	N	N	Y		38.0	NORMAL	5.78
7	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y		Y	Baseline	0.0	-7.0	2013-12-26	SCREENING 1	1.0	Lymphocytes (GI/L)	LYM	7.0	HEM	2.11	2.11	missing	0.8	3.0	2.6375	0.703333	2.6375	0.703333		2.39	N	N	Y		22.0	NORMAL	2.11
8	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y		Y	Baseline	0.0	-7.0	2013-12-26	SCREENING 1	1.0	Monocytes (GI/L)	MONO	8.0	HEM	0.22	0.22	missing	0.12	0.92	1.83333	0.23913	1.83333	0.23913		1.16	N	N	Y		26.0	NORMAL	0.22
9	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y		Y	Baseline	0.0	-7.0	2013-12-26	SCREENING 1	1.0	Eosinophils (GI/L)	EOS	9.0	HEM	0.13	0.13	missing	missing	0.57	missing	0.22807	missing	0.22807		0.725	N	N	Y		15.0	NORMAL	0.13
10	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y		Y	Baseline	0.0	-7.0	2013-12-26	SCREENING 1	1.0	Basophils (GI/L)	BASO	10.0	HEM	0.05	0.05	missing	missing	0.2	missing	0.25	missing	0.25		0.25	N	N	Y		6.0	NORMAL	0.05
11	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y		Y	Baseline	0.0	-7.0	2013-12-26	SCREENING 1	1.0	Platelet (GI/L)	PLAT	11.0	HEM	266.0	266.0	missing	130.0	394.0	2.04615	0.675127	2.04615	0.675127		325.0	N	N	Y		30.0	NORMAL	266.0
12	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y		Y	Baseline	0.0	-7.0	2013-12-26	SCREENING 1	1.0	Erythrocytes (TI/L)	RBC	12.0	HEM	5.3	5.3	missing	3.9	5.5	1.35897	0.963636	1.35897	0.963636		3.35	N	N	Y		32.0	NORMAL	5.3
13	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y		Y	Baseline	0.0	-7.0	2013-12-26	SCREENING 1	1.0	Hemoglobin (mmol/L) change from previous visit, relative to normal range	_HGB	101.0	HEM	missing	missing	missing	missing	missing	missing	missing	missing	missing		5.84042					19.0	NORMAL	8.87458
⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮
48392	CDISCPILOT01	1427	01-718-1427	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	N		Y	Week 8	8.0	57.0	2013-02-11	WEEK 8	8.0	Lymphocytes (GI/L) change from previous visit, relative to normal range	_LYM	107.0	HEM	-0.4	missing	missing	missing	missing	missing	missing	missing	missing		3.62	N			Y	151.0	NORMAL	0.88
48393	CDISCPILOT01	1427	01-718-1427	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	N		Y	End of Treatment	99.0	57.0	2013-02-11	WEEK 8	8.0	Lymphocytes (GI/L) change from previous visit, relative to normal range	_LYM	107.0	HEM	-0.4	missing	missing	missing	missing	missing	missing	missing	missing		3.62	N			Y	151.0	NORMAL	0.88
48394	CDISCPILOT01	1427	01-718-1427	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	N		Y	Week 8	8.0	57.0	2013-02-11	WEEK 8	8.0	Monocytes (GI/L) change from previous visit, relative to normal range	_MONO	108.0	HEM	-0.1	missing	missing	missing	missing	missing	missing	missing	missing		1.03	N			Y	155.0	NORMAL	0.35
48395	CDISCPILOT01	1427	01-718-1427	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	N		Y	End of Treatment	99.0	57.0	2013-02-11	WEEK 8	8.0	Monocytes (GI/L) change from previous visit, relative to normal range	_MONO	108.0	HEM	-0.1	missing	missing	missing	missing	missing	missing	missing	missing		1.03	N			Y	155.0	NORMAL	0.35
48396	CDISCPILOT01	1427	01-718-1427	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	N		Y	Week 8	8.0	57.0	2013-02-11	WEEK 8	8.0	Eosinophils (GI/L) change from previous visit, relative to normal range	_EOS	109.0	HEM	-0.2	missing	missing	missing	missing	missing	missing	missing	missing		0.705	N			Y	145.0	NORMAL	0.15
48397	CDISCPILOT01	1427	01-718-1427	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	N		Y	End of Treatment	99.0	57.0	2013-02-11	WEEK 8	8.0	Eosinophils (GI/L) change from previous visit, relative to normal range	_EOS	109.0	HEM	-0.2	missing	missing	missing	missing	missing	missing	missing	missing		0.705	N			Y	145.0	NORMAL	0.15
48398	CDISCPILOT01	1427	01-718-1427	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	N		Y	Week 8	8.0	57.0	2013-02-11	WEEK 8	8.0	Basophils (GI/L) change from previous visit, relative to normal range	_BASO	110.0	HEM	-0.1	missing	missing	missing	missing	missing	missing	missing	missing		0.28	N			Y	137.0	NORMAL	0.02
48399	CDISCPILOT01	1427	01-718-1427	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	N		Y	End of Treatment	99.0	57.0	2013-02-11	WEEK 8	8.0	Basophils (GI/L) change from previous visit, relative to normal range	_BASO	110.0	HEM	-0.1	missing	missing	missing	missing	missing	missing	missing	missing		0.28	N			Y	137.0	NORMAL	0.02
48400	CDISCPILOT01	1427	01-718-1427	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	N		Y	Week 8	8.0	57.0	2013-02-11	WEEK 8	8.0	Platelet (GI/L) change from previous visit, relative to normal range	_PLAT	111.0	HEM	-0.1	missing	missing	missing	missing	missing	missing	missing	missing		384.0	N			Y	158.0	NORMAL	207.0
48401	CDISCPILOT01	1427	01-718-1427	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	N		Y	End of Treatment	99.0	57.0	2013-02-11	WEEK 8	8.0	Platelet (GI/L) change from previous visit, relative to normal range	_PLAT	111.0	HEM	-0.1	missing	missing	missing	missing	missing	missing	missing	missing		384.0	N			Y	158.0	NORMAL	207.0
48402	CDISCPILOT01	1427	01-718-1427	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	N		Y	Week 8	8.0	57.0	2013-02-11	WEEK 8	8.0	Erythrocytes (TI/L) change from previous visit, relative to normal range	_RBC	112.0	HEM	0.1	missing	missing	missing	missing	missing	missing	missing	missing		4.25	N			Y	160.0	NORMAL	4.0
48403	CDISCPILOT01	1427	01-718-1427	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	N		Y	End of Treatment	99.0	57.0	2013-02-11	WEEK 8	8.0	Erythrocytes (TI/L) change from previous visit, relative to normal range	_RBC	112.0	HEM	0.1	missing	missing	missing	missing	missing	missing	missing	missing		4.25	N			Y	160.0	NORMAL	4.0

Data wrangling

adlbc2 = insertcols(copy(adlbc), :ORIG => fill("CHEMISTRY", nrow(adlbc)))
adlbh2 = insertcols(copy(adlbh), :ORIG => fill("HEMATOLOGY", nrow(adlbh)))

adlb = vcat(adlbc2, adlbh2)

adlb = @chain adlb begin
    @select :ORIG :PARCAT1 :PARAM :PARAMCD :USUBJID :TRTA :AVISIT :AVISITN :AVAL :CHG
    @transform :TRTA = recode(categorical(:TRTA),
        "Xanomeline Low Dose" => "Low Dose",
        "Xanomeline High Dose" => "High Dose"
    )
    @transform :TRTA = categorical(:TRTA, levels = ["Placebo", "Low Dose", "High Dose"], ordered = true)
    @transform :AVISIT = strip.(String.(:AVISIT))  
end

121185×10 DataFrame

121160 rows omitted

Row	ORIG	PARCAT1	PARAM	PARAMCD	USUBJID	TRTA	AVISIT	AVISITN	AVAL	CHG
	String	String7	String	String15	String15	Cat…	SubStrin…	Float64	Float64?	Float64?
1	CHEMISTRY	CHEM	Sodium (mmol/L)	SODIUM	01-701-1015	Placebo	Baseline	0.0	140.0	missing
2	CHEMISTRY	CHEM	Potassium (mmol/L)	K	01-701-1015	Placebo	Baseline	0.0	4.5	missing
3	CHEMISTRY	CHEM	Chloride (mmol/L)	CL	01-701-1015	Placebo	Baseline	0.0	106.0	missing
4	CHEMISTRY	CHEM	Bilirubin (umol/L)	BILI	01-701-1015	Placebo	Baseline	0.0	10.26	missing
5	CHEMISTRY	CHEM	Alkaline Phosphatase (U/L)	ALP	01-701-1015	Placebo	Baseline	0.0	34.0	missing
6	CHEMISTRY	CHEM	Gamma Glutamyl Transferase (U/L)	GGT	01-701-1015	Placebo	Baseline	0.0	15.0	missing
7	CHEMISTRY	CHEM	Alanine Aminotransferase (U/L)	ALT	01-701-1015	Placebo	Baseline	0.0	27.0	missing
8	CHEMISTRY	CHEM	Aspartate Aminotransferase (U/L)	AST	01-701-1015	Placebo	Baseline	0.0	40.0	missing
9	CHEMISTRY	CHEM	Blood Urea Nitrogen (mmol/L)	BUN	01-701-1015	Placebo	Baseline	0.0	3.57	missing
10	CHEMISTRY	CHEM	Creatinine (umol/L)	CREAT	01-701-1015	Placebo	Baseline	0.0	79.56	missing
11	CHEMISTRY	CHEM	Urate (umol/L)	URATE	01-701-1015	Placebo	Baseline	0.0	267.66	missing
12	CHEMISTRY	CHEM	Phosphate (mmol/L)	PHOS	01-701-1015	Placebo	Baseline	0.0	1.22702	missing
13	CHEMISTRY	CHEM	Calcium (mmol/L)	CA	01-701-1015	Placebo	Baseline	0.0	2.1956	missing
⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮
121174	HEMATOLOGY	HEM	Lymphocytes (GI/L) change from previous visit, relative to normal range	_LYM	01-718-1427	High Dose	Week 8	8.0	-0.4	missing
121175	HEMATOLOGY	HEM	Lymphocytes (GI/L) change from previous visit, relative to normal range	_LYM	01-718-1427	High Dose	End of Treatment	99.0	-0.4	missing
121176	HEMATOLOGY	HEM	Monocytes (GI/L) change from previous visit, relative to normal range	_MONO	01-718-1427	High Dose	Week 8	8.0	-0.1	missing
121177	HEMATOLOGY	HEM	Monocytes (GI/L) change from previous visit, relative to normal range	_MONO	01-718-1427	High Dose	End of Treatment	99.0	-0.1	missing
121178	HEMATOLOGY	HEM	Eosinophils (GI/L) change from previous visit, relative to normal range	_EOS	01-718-1427	High Dose	Week 8	8.0	-0.2	missing
121179	HEMATOLOGY	HEM	Eosinophils (GI/L) change from previous visit, relative to normal range	_EOS	01-718-1427	High Dose	End of Treatment	99.0	-0.2	missing
121180	HEMATOLOGY	HEM	Basophils (GI/L) change from previous visit, relative to normal range	_BASO	01-718-1427	High Dose	Week 8	8.0	-0.1	missing
121181	HEMATOLOGY	HEM	Basophils (GI/L) change from previous visit, relative to normal range	_BASO	01-718-1427	High Dose	End of Treatment	99.0	-0.1	missing
121182	HEMATOLOGY	HEM	Platelet (GI/L) change from previous visit, relative to normal range	_PLAT	01-718-1427	High Dose	Week 8	8.0	-0.1	missing
121183	HEMATOLOGY	HEM	Platelet (GI/L) change from previous visit, relative to normal range	_PLAT	01-718-1427	High Dose	End of Treatment	99.0	-0.1	missing
121184	HEMATOLOGY	HEM	Erythrocytes (TI/L) change from previous visit, relative to normal range	_RBC	01-718-1427	High Dose	Week 8	8.0	0.1	missing
121185	HEMATOLOGY	HEM	Erythrocytes (TI/L) change from previous visit, relative to normal range	_RBC	01-718-1427	High Dose	End of Treatment	99.0	0.1	missing

Data wrangling

adlb_l = stack(adlb, [:AVAL, :CHG], variable_name = :VARIABLE, value_name = :VALUE)

242370×10 DataFrame

242345 rows omitted

Row	ORIG	PARCAT1	PARAM	PARAMCD	USUBJID	TRTA	AVISIT	AVISITN	VARIABLE	VALUE
	String	String7	String	String15	String15	Cat…	SubStrin…	Float64	String	Float64?
1	CHEMISTRY	CHEM	Sodium (mmol/L)	SODIUM	01-701-1015	Placebo	Baseline	0.0	AVAL	140.0
2	CHEMISTRY	CHEM	Potassium (mmol/L)	K	01-701-1015	Placebo	Baseline	0.0	AVAL	4.5
3	CHEMISTRY	CHEM	Chloride (mmol/L)	CL	01-701-1015	Placebo	Baseline	0.0	AVAL	106.0
4	CHEMISTRY	CHEM	Bilirubin (umol/L)	BILI	01-701-1015	Placebo	Baseline	0.0	AVAL	10.26
5	CHEMISTRY	CHEM	Alkaline Phosphatase (U/L)	ALP	01-701-1015	Placebo	Baseline	0.0	AVAL	34.0
6	CHEMISTRY	CHEM	Gamma Glutamyl Transferase (U/L)	GGT	01-701-1015	Placebo	Baseline	0.0	AVAL	15.0
7	CHEMISTRY	CHEM	Alanine Aminotransferase (U/L)	ALT	01-701-1015	Placebo	Baseline	0.0	AVAL	27.0
8	CHEMISTRY	CHEM	Aspartate Aminotransferase (U/L)	AST	01-701-1015	Placebo	Baseline	0.0	AVAL	40.0
9	CHEMISTRY	CHEM	Blood Urea Nitrogen (mmol/L)	BUN	01-701-1015	Placebo	Baseline	0.0	AVAL	3.57
10	CHEMISTRY	CHEM	Creatinine (umol/L)	CREAT	01-701-1015	Placebo	Baseline	0.0	AVAL	79.56
11	CHEMISTRY	CHEM	Urate (umol/L)	URATE	01-701-1015	Placebo	Baseline	0.0	AVAL	267.66
12	CHEMISTRY	CHEM	Phosphate (mmol/L)	PHOS	01-701-1015	Placebo	Baseline	0.0	AVAL	1.22702
13	CHEMISTRY	CHEM	Calcium (mmol/L)	CA	01-701-1015	Placebo	Baseline	0.0	AVAL	2.1956
⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮
242359	HEMATOLOGY	HEM	Lymphocytes (GI/L) change from previous visit, relative to normal range	_LYM	01-718-1427	High Dose	Week 8	8.0	CHG	missing
242360	HEMATOLOGY	HEM	Lymphocytes (GI/L) change from previous visit, relative to normal range	_LYM	01-718-1427	High Dose	End of Treatment	99.0	CHG	missing
242361	HEMATOLOGY	HEM	Monocytes (GI/L) change from previous visit, relative to normal range	_MONO	01-718-1427	High Dose	Week 8	8.0	CHG	missing
242362	HEMATOLOGY	HEM	Monocytes (GI/L) change from previous visit, relative to normal range	_MONO	01-718-1427	High Dose	End of Treatment	99.0	CHG	missing
242363	HEMATOLOGY	HEM	Eosinophils (GI/L) change from previous visit, relative to normal range	_EOS	01-718-1427	High Dose	Week 8	8.0	CHG	missing
242364	HEMATOLOGY	HEM	Eosinophils (GI/L) change from previous visit, relative to normal range	_EOS	01-718-1427	High Dose	End of Treatment	99.0	CHG	missing
242365	HEMATOLOGY	HEM	Basophils (GI/L) change from previous visit, relative to normal range	_BASO	01-718-1427	High Dose	Week 8	8.0	CHG	missing
242366	HEMATOLOGY	HEM	Basophils (GI/L) change from previous visit, relative to normal range	_BASO	01-718-1427	High Dose	End of Treatment	99.0	CHG	missing
242367	HEMATOLOGY	HEM	Platelet (GI/L) change from previous visit, relative to normal range	_PLAT	01-718-1427	High Dose	Week 8	8.0	CHG	missing
242368	HEMATOLOGY	HEM	Platelet (GI/L) change from previous visit, relative to normal range	_PLAT	01-718-1427	High Dose	End of Treatment	99.0	CHG	missing
242369	HEMATOLOGY	HEM	Erythrocytes (TI/L) change from previous visit, relative to normal range	_RBC	01-718-1427	High Dose	Week 8	8.0	CHG	missing
242370	HEMATOLOGY	HEM	Erythrocytes (TI/L) change from previous visit, relative to normal range	_RBC	01-718-1427	High Dose	End of Treatment	99.0	CHG	missing

Data wrangling

group_vars = [:ORIG, :PARCAT1, :PARAM, :PARAMCD, :AVISIT, :AVISITN, :VARIABLE]
adlb_n = groupby(adlb_l, group_vars)

GroupedDataFrame with 1396 groups based on keys: ORIG, PARCAT1, PARAM, PARAMCD, AVISIT, AVISITN, VARIABLE

First Group (251 rows): ORIG = "CHEMISTRY", PARCAT1 = "CHEM", PARAM = "Sodium (mmol/L)", PARAMCD = "SODIUM", AVISIT = "Baseline", AVISITN = 0.0, VARIABLE = "AVAL"

226 rows omitted

Row	ORIG	PARCAT1	PARAM	PARAMCD	USUBJID	TRTA	AVISIT	AVISITN	VARIABLE	VALUE
	String	String7	String	String15	String15	Cat…	SubStrin…	Float64	String	Float64?
1	CHEMISTRY	CHEM	Sodium (mmol/L)	SODIUM	01-701-1015	Placebo	Baseline	0.0	AVAL	140.0
2	CHEMISTRY	CHEM	Sodium (mmol/L)	SODIUM	01-701-1023	Placebo	Baseline	0.0	AVAL	142.0
3	CHEMISTRY	CHEM	Sodium (mmol/L)	SODIUM	01-701-1028	High Dose	Baseline	0.0	AVAL	139.0
4	CHEMISTRY	CHEM	Sodium (mmol/L)	SODIUM	01-701-1033	Low Dose	Baseline	0.0	AVAL	145.0
5	CHEMISTRY	CHEM	Sodium (mmol/L)	SODIUM	01-701-1034	High Dose	Baseline	0.0	AVAL	138.0
6	CHEMISTRY	CHEM	Sodium (mmol/L)	SODIUM	01-701-1047	Placebo	Baseline	0.0	AVAL	144.0
7	CHEMISTRY	CHEM	Sodium (mmol/L)	SODIUM	01-701-1097	Low Dose	Baseline	0.0	AVAL	134.0
8	CHEMISTRY	CHEM	Sodium (mmol/L)	SODIUM	01-701-1111	Low Dose	Baseline	0.0	AVAL	137.0
9	CHEMISTRY	CHEM	Sodium (mmol/L)	SODIUM	01-701-1115	Low Dose	Baseline	0.0	AVAL	139.0
10	CHEMISTRY	CHEM	Sodium (mmol/L)	SODIUM	01-701-1118	Placebo	Baseline	0.0	AVAL	141.0
11	CHEMISTRY	CHEM	Sodium (mmol/L)	SODIUM	01-701-1130	Placebo	Baseline	0.0	AVAL	140.0
12	CHEMISTRY	CHEM	Sodium (mmol/L)	SODIUM	01-701-1133	High Dose	Baseline	0.0	AVAL	142.0
13	CHEMISTRY	CHEM	Sodium (mmol/L)	SODIUM	01-701-1146	High Dose	Baseline	0.0	AVAL	136.0
⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮
240	CHEMISTRY	CHEM	Sodium (mmol/L)	SODIUM	01-718-1079	Low Dose	Baseline	0.0	AVAL	141.0
241	CHEMISTRY	CHEM	Sodium (mmol/L)	SODIUM	01-718-1101	High Dose	Baseline	0.0	AVAL	141.0
242	CHEMISTRY	CHEM	Sodium (mmol/L)	SODIUM	01-718-1139	Placebo	Baseline	0.0	AVAL	140.0
243	CHEMISTRY	CHEM	Sodium (mmol/L)	SODIUM	01-718-1150	Placebo	Baseline	0.0	AVAL	138.0
244	CHEMISTRY	CHEM	Sodium (mmol/L)	SODIUM	01-718-1170	Low Dose	Baseline	0.0	AVAL	137.0
245	CHEMISTRY	CHEM	Sodium (mmol/L)	SODIUM	01-718-1172	Placebo	Baseline	0.0	AVAL	145.0
246	CHEMISTRY	CHEM	Sodium (mmol/L)	SODIUM	01-718-1250	Low Dose	Baseline	0.0	AVAL	139.0
247	CHEMISTRY	CHEM	Sodium (mmol/L)	SODIUM	01-718-1254	Low Dose	Baseline	0.0	AVAL	138.0
248	CHEMISTRY	CHEM	Sodium (mmol/L)	SODIUM	01-718-1328	High Dose	Baseline	0.0	AVAL	141.0
249	CHEMISTRY	CHEM	Sodium (mmol/L)	SODIUM	01-718-1355	Placebo	Baseline	0.0	AVAL	141.0
250	CHEMISTRY	CHEM	Sodium (mmol/L)	SODIUM	01-718-1371	High Dose	Baseline	0.0	AVAL	139.0
251	CHEMISTRY	CHEM	Sodium (mmol/L)	SODIUM	01-718-1427	High Dose	Baseline	0.0	AVAL	138.0

⋮

Last Group (2 rows): ORIG = "HEMATOLOGY", PARCAT1 = "HEM", PARAM = "Polychromasia change from previous visit, relative to normal range", PARAMCD = "_POLYCHR", AVISIT = "Week 26", AVISITN = 26.0, VARIABLE = "CHG"

Row	ORIG	PARCAT1	PARAM	PARAMCD	USUBJID	TRTA	AVISIT	AVISITN	VARIABLE	VALUE
	String	String7	String	String15	String15	Cat…	SubStrin…	Float64	String	Float64?
1	HEMATOLOGY	HEM	Polychromasia change from previous visit, relative to normal range	_POLYCHR	01-716-1024	Placebo	Week 26	26.0	CHG	missing
2	HEMATOLOGY	HEM	Polychromasia change from previous visit, relative to normal range	_POLYCHR	01-716-1044	Placebo	Week 26	26.0	CHG	missing

Data wrangling

function custom_lab_summary(x)
    data = collect(skipmissing(x))
    if isempty(data)
        return (
            0 => "n",
            missing => "Mean",
            missing => "SD",
            missing => "Median",
            missing => "Min",
            missing => "Max"
        )
    else
        return (
            length(data) => "n",
            mean(data) => "Mean",
            std(data) => "SD",
            median(data) => "Median",
            minimum(data) => "Min",
            maximum(data) => "Max"
        )
    end
end

custom_lab_summary (generic function with 1 method)

Data wrangling

group_vars = [:PARAM, :AVISIT, :TRTA, :VARIABLE]

adlb_summary = @chain adlb_l begin
    groupby(group_vars)
    @combine begin
        :N = count(!ismissing, :VALUE)
        :Mean = mean(skipmissing(:VALUE))
        :SD = std(skipmissing(:VALUE))
    end
end

4152×7 DataFrame

4127 rows omitted

Row	PARAM	AVISIT	TRTA	VARIABLE	N	Mean	SD
	String	SubStrin…	Cat…	String	Int64	Float64	Float64
1	Sodium (mmol/L)	Baseline	Placebo	AVAL	86	140.326	2.73729
2	Potassium (mmol/L)	Baseline	Placebo	AVAL	86	4.25233	0.42502
3	Chloride (mmol/L)	Baseline	Placebo	AVAL	86	105.709	3.19141
4	Bilirubin (umol/L)	Baseline	Placebo	AVAL	86	9.70326	3.96451
5	Alkaline Phosphatase (U/L)	Baseline	Placebo	AVAL	86	77.6977	58.106
6	Gamma Glutamyl Transferase (U/L)	Baseline	Placebo	AVAL	86	24.8837	49.7465
7	Alanine Aminotransferase (U/L)	Baseline	Placebo	AVAL	86	17.5698	9.21577
8	Aspartate Aminotransferase (U/L)	Baseline	Placebo	AVAL	86	23.2442	7.50206
9	Blood Urea Nitrogen (mmol/L)	Baseline	Placebo	AVAL	86	5.53765	1.38509
10	Creatinine (umol/L)	Baseline	Placebo	AVAL	86	97.6512	17.7789
11	Urate (umol/L)	Baseline	Placebo	AVAL	86	285.02	74.4484
12	Phosphate (mmol/L)	Baseline	Placebo	AVAL	86	1.15118	0.147495
13	Calcium (mmol/L)	Baseline	Placebo	AVAL	86	2.31223	0.0949445
⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮
4141	Polychromasia change from previous visit, relative to normal range	Week 4	Placebo	CHG	0	NaN	NaN
4142	Anisocytes change from previous visit, relative to normal range	Week 20	Low Dose	CHG	0	NaN	NaN
4143	Macrocytes change from previous visit, relative to normal range	Week 24	Low Dose	CHG	0	NaN	NaN
4144	Polychromasia change from previous visit, relative to normal range	Week 26	Placebo	CHG	0	NaN	NaN
4145	Polychromasia change from previous visit, relative to normal range	Baseline	Placebo	CHG	0	NaN	NaN
4146	Polychromasia change from previous visit, relative to normal range	Week 20	Placebo	CHG	0	NaN	NaN
4147	Polychromasia change from previous visit, relative to normal range	Week 24	Placebo	CHG	0	NaN	NaN
4148	Polychromasia change from previous visit, relative to normal range	Baseline	Low Dose	CHG	0	NaN	NaN
4149	Macrocytes change from previous visit, relative to normal range	Week 16	Low Dose	CHG	0	NaN	NaN
4150	Macrocytes change from previous visit, relative to normal range	Week 6	Placebo	CHG	0	NaN	NaN
4151	Macrocytes change from previous visit, relative to normal range	Week 12	Low Dose	CHG	0	NaN	NaN
4152	Anisocytes change from previous visit, relative to normal range	Week 12	High Dose	CHG	0	NaN	NaN

Data wrangling

adlb_summary_long = stack(
    adlb_summary,
    [:N, :Mean, :SD],
    variable_name = :SummaryType,
    value_name = :VALUE
)

12456×6 DataFrame

12431 rows omitted

Row	PARAM	AVISIT	TRTA	VARIABLE	SummaryType	VALUE
	String	SubStrin…	Cat…	String	String	Float64
1	Sodium (mmol/L)	Baseline	Placebo	AVAL	N	86.0
2	Potassium (mmol/L)	Baseline	Placebo	AVAL	N	86.0
3	Chloride (mmol/L)	Baseline	Placebo	AVAL	N	86.0
4	Bilirubin (umol/L)	Baseline	Placebo	AVAL	N	86.0
5	Alkaline Phosphatase (U/L)	Baseline	Placebo	AVAL	N	86.0
6	Gamma Glutamyl Transferase (U/L)	Baseline	Placebo	AVAL	N	86.0
7	Alanine Aminotransferase (U/L)	Baseline	Placebo	AVAL	N	86.0
8	Aspartate Aminotransferase (U/L)	Baseline	Placebo	AVAL	N	86.0
9	Blood Urea Nitrogen (mmol/L)	Baseline	Placebo	AVAL	N	86.0
10	Creatinine (umol/L)	Baseline	Placebo	AVAL	N	86.0
11	Urate (umol/L)	Baseline	Placebo	AVAL	N	86.0
12	Phosphate (mmol/L)	Baseline	Placebo	AVAL	N	86.0
13	Calcium (mmol/L)	Baseline	Placebo	AVAL	N	86.0
⋮	⋮	⋮	⋮	⋮	⋮	⋮
12445	Polychromasia change from previous visit, relative to normal range	Week 4	Placebo	CHG	SD	NaN
12446	Anisocytes change from previous visit, relative to normal range	Week 20	Low Dose	CHG	SD	NaN
12447	Macrocytes change from previous visit, relative to normal range	Week 24	Low Dose	CHG	SD	NaN
12448	Polychromasia change from previous visit, relative to normal range	Week 26	Placebo	CHG	SD	NaN
12449	Polychromasia change from previous visit, relative to normal range	Baseline	Placebo	CHG	SD	NaN
12450	Polychromasia change from previous visit, relative to normal range	Week 20	Placebo	CHG	SD	NaN
12451	Polychromasia change from previous visit, relative to normal range	Week 24	Placebo	CHG	SD	NaN
12452	Polychromasia change from previous visit, relative to normal range	Baseline	Low Dose	CHG	SD	NaN
12453	Macrocytes change from previous visit, relative to normal range	Week 16	Low Dose	CHG	SD	NaN
12454	Macrocytes change from previous visit, relative to normal range	Week 6	Placebo	CHG	SD	NaN
12455	Macrocytes change from previous visit, relative to normal range	Week 12	Low Dose	CHG	SD	NaN
12456	Anisocytes change from previous visit, relative to normal range	Week 12	High Dose	CHG	SD	NaN

Data wrangling

adlb_summary_long1 = @chain adlb_summary_long begin
    @transform :VALUE = replace(:VALUE, NaN=>missing)
    dropmissing
end

9732×6 DataFrame

9707 rows omitted

Row	PARAM	AVISIT	TRTA	VARIABLE	SummaryType	VALUE
	String	SubStrin…	Cat…	String	String	Float64
1	Sodium (mmol/L)	Baseline	Placebo	AVAL	N	86.0
2	Potassium (mmol/L)	Baseline	Placebo	AVAL	N	86.0
3	Chloride (mmol/L)	Baseline	Placebo	AVAL	N	86.0
4	Bilirubin (umol/L)	Baseline	Placebo	AVAL	N	86.0
5	Alkaline Phosphatase (U/L)	Baseline	Placebo	AVAL	N	86.0
6	Gamma Glutamyl Transferase (U/L)	Baseline	Placebo	AVAL	N	86.0
7	Alanine Aminotransferase (U/L)	Baseline	Placebo	AVAL	N	86.0
8	Aspartate Aminotransferase (U/L)	Baseline	Placebo	AVAL	N	86.0
9	Blood Urea Nitrogen (mmol/L)	Baseline	Placebo	AVAL	N	86.0
10	Creatinine (umol/L)	Baseline	Placebo	AVAL	N	86.0
11	Urate (umol/L)	Baseline	Placebo	AVAL	N	86.0
12	Phosphate (mmol/L)	Baseline	Placebo	AVAL	N	86.0
13	Calcium (mmol/L)	Baseline	Placebo	AVAL	N	86.0
⋮	⋮	⋮	⋮	⋮	⋮	⋮
9721	Hemoglobin (mmol/L)	Week 26	Low Dose	CHG	SD	0.394408
9722	Hematocrit	Week 26	Low Dose	CHG	SD	0.0275016
9723	Ery. Mean Corpuscular Volume (fL)	Week 26	Low Dose	CHG	SD	3.70443
9724	Ery. Mean Corpuscular Hemoglobin (fmol(Fe))	Week 26	Low Dose	CHG	SD	0.0754086
9725	Ery. Mean Corpuscular HGB Concentration (mmol/L)	Week 26	Low Dose	CHG	SD	1.09006
9726	Leukocytes (GI/L)	Week 26	Low Dose	CHG	SD	1.14577
9727	Lymphocytes (GI/L)	Week 26	Low Dose	CHG	SD	0.392125
9728	Monocytes (GI/L)	Week 26	Low Dose	CHG	SD	0.119903
9729	Eosinophils (GI/L)	Week 26	Low Dose	CHG	SD	0.13227
9730	Basophils (GI/L)	Week 26	Low Dose	CHG	SD	0.01711
9731	Platelet (GI/L)	Week 26	Low Dose	CHG	SD	38.8411
9732	Erythrocytes (TI/L)	Week 26	Low Dose	CHG	SD	0.204124

Data wrangling

adlb_summary_long2 = combine(groupby(adlb_summary_long1,[:VARIABLE])) do df
    if all(x -> x == "CHG", df.VARIABLE)
        df = @rsubset df :SummaryType == "Mean"
    else 
        df = df
    end
end

6756×6 DataFrame

6731 rows omitted

Row	VARIABLE	PARAM	AVISIT	TRTA	SummaryType	VALUE
	String	String	SubStrin…	Cat…	String	Float64
1	AVAL	Sodium (mmol/L)	Baseline	Placebo	N	86.0
2	AVAL	Potassium (mmol/L)	Baseline	Placebo	N	86.0
3	AVAL	Chloride (mmol/L)	Baseline	Placebo	N	86.0
4	AVAL	Bilirubin (umol/L)	Baseline	Placebo	N	86.0
5	AVAL	Alkaline Phosphatase (U/L)	Baseline	Placebo	N	86.0
6	AVAL	Gamma Glutamyl Transferase (U/L)	Baseline	Placebo	N	86.0
7	AVAL	Alanine Aminotransferase (U/L)	Baseline	Placebo	N	86.0
8	AVAL	Aspartate Aminotransferase (U/L)	Baseline	Placebo	N	86.0
9	AVAL	Blood Urea Nitrogen (mmol/L)	Baseline	Placebo	N	86.0
10	AVAL	Creatinine (umol/L)	Baseline	Placebo	N	86.0
11	AVAL	Urate (umol/L)	Baseline	Placebo	N	86.0
12	AVAL	Phosphate (mmol/L)	Baseline	Placebo	N	86.0
13	AVAL	Calcium (mmol/L)	Baseline	Placebo	N	86.0
⋮	⋮	⋮	⋮	⋮	⋮	⋮
6745	CHG	Hemoglobin (mmol/L)	Week 26	Low Dose	Mean	-0.307714
6746	CHG	Hematocrit	Week 26	Low Dose	Mean	-0.00208333
6747	CHG	Ery. Mean Corpuscular Volume (fL)	Week 26	Low Dose	Mean	2.625
6748	CHG	Ery. Mean Corpuscular Hemoglobin (fmol(Fe))	Week 26	Low Dose	Mean	-0.0129292
6749	CHG	Ery. Mean Corpuscular HGB Concentration (mmol/L)	Week 26	Low Dose	Mean	-0.594742
6750	CHG	Leukocytes (GI/L)	Week 26	Low Dose	Mean	-0.324167
6751	CHG	Lymphocytes (GI/L)	Week 26	Low Dose	Mean	-0.141667
6752	CHG	Monocytes (GI/L)	Week 26	Low Dose	Mean	-0.02125
6753	CHG	Eosinophils (GI/L)	Week 26	Low Dose	Mean	0.0245833
6754	CHG	Basophils (GI/L)	Week 26	Low Dose	Mean	-0.00833333
6755	CHG	Platelet (GI/L)	Week 26	Low Dose	Mean	-1.91304
6756	CHG	Erythrocytes (TI/L)	Week 26	Low Dose	Mean	-0.141667

Data wrangling

adlb_summary_long3 = @chain adlb_summary_long2 begin
   @rtransform :SummaryType = (:VARIABLE == "CHG") ? "CHG" : :SummaryType
   @rtransform :VARIABLE = (:VARIABLE == "CHG") ? "AVAL" : :VARIABLE
end

6756×6 DataFrame

6731 rows omitted

Row	VARIABLE	PARAM	AVISIT	TRTA	SummaryType	VALUE
	String	String	SubStrin…	Cat…	String	Float64
1	AVAL	Sodium (mmol/L)	Baseline	Placebo	N	86.0
2	AVAL	Potassium (mmol/L)	Baseline	Placebo	N	86.0
3	AVAL	Chloride (mmol/L)	Baseline	Placebo	N	86.0
4	AVAL	Bilirubin (umol/L)	Baseline	Placebo	N	86.0
5	AVAL	Alkaline Phosphatase (U/L)	Baseline	Placebo	N	86.0
6	AVAL	Gamma Glutamyl Transferase (U/L)	Baseline	Placebo	N	86.0
7	AVAL	Alanine Aminotransferase (U/L)	Baseline	Placebo	N	86.0
8	AVAL	Aspartate Aminotransferase (U/L)	Baseline	Placebo	N	86.0
9	AVAL	Blood Urea Nitrogen (mmol/L)	Baseline	Placebo	N	86.0
10	AVAL	Creatinine (umol/L)	Baseline	Placebo	N	86.0
11	AVAL	Urate (umol/L)	Baseline	Placebo	N	86.0
12	AVAL	Phosphate (mmol/L)	Baseline	Placebo	N	86.0
13	AVAL	Calcium (mmol/L)	Baseline	Placebo	N	86.0
⋮	⋮	⋮	⋮	⋮	⋮	⋮
6745	AVAL	Hemoglobin (mmol/L)	Week 26	Low Dose	CHG	-0.307714
6746	AVAL	Hematocrit	Week 26	Low Dose	CHG	-0.00208333
6747	AVAL	Ery. Mean Corpuscular Volume (fL)	Week 26	Low Dose	CHG	2.625
6748	AVAL	Ery. Mean Corpuscular Hemoglobin (fmol(Fe))	Week 26	Low Dose	CHG	-0.0129292
6749	AVAL	Ery. Mean Corpuscular HGB Concentration (mmol/L)	Week 26	Low Dose	CHG	-0.594742
6750	AVAL	Leukocytes (GI/L)	Week 26	Low Dose	CHG	-0.324167
6751	AVAL	Lymphocytes (GI/L)	Week 26	Low Dose	CHG	-0.141667
6752	AVAL	Monocytes (GI/L)	Week 26	Low Dose	CHG	-0.02125
6753	AVAL	Eosinophils (GI/L)	Week 26	Low Dose	CHG	0.0245833
6754	AVAL	Basophils (GI/L)	Week 26	Low Dose	CHG	-0.00833333
6755	AVAL	Platelet (GI/L)	Week 26	Low Dose	CHG	-1.91304
6756	AVAL	Erythrocytes (TI/L)	Week 26	Low Dose	CHG	-0.141667

		Treatment
		Placebo				Low Dose				High Dose
		CHG	Mean	N	SD	CHG	Mean	N	SD	CHG	Mean	N	SD
		VALUE
Alanine Aminotransferase (U/L)	Baseline		17.6	86	9.22		18	82	8.72		19.2	84	10
	End of Treatment	0.417	18.1	84	16.7	0.262	18.3	82	8.26	0.075	19.5	80	7.44
	Week 2	0.217	18	83	12.5	2.78	20.9	80	10.5	1.62	21	78	8.87
	Week 4	0.709	18.7	79	12.9	-0.686	17.5	72	7.66	2.14	21.3	72	9.51
	Week 6	-0.315	17	73	9.92	-0.8	17	62	7.98	1.61	21.2	66	9.49
	Week 8	-1.1	16.7	72	9.34	0.155	17.6	60	7.86	3.18	22.8	56	17.5
	Week 12	0.0149	18	67	9.16	0.14	18.5	51	12.7	0.72	21	50	10.2
	Week 16	-0.794	17.1	68	7.39	0.675	17.3	42	7.51	-0.27	19.6	37	7.61
	Week 20	-1.91	16.1	65	6.56	0.931	16.7	30	6.33	-0.29	19.6	31	6.82
	Week 24	-0.316	17.9	57	15.6	1.6	18.2	26	9.17	0.167	21	30	8.7
	Week 26	-2.09	16	57	5.98	1.46	17.8	25	9.51	-2.04	18.9	27	7.02
Alanine Aminotransferase (U/L) change from previous visit, relative to normal range	Baseline			0				0				0
	End of Treatment		0.0798	84	1		-0.028	82	0.491		-0.136	80	1.09
	Week 2		0.0229	83	0.597		0.201	78	0.527		0.129	78	0.433
	Week 4		0.0253	79	0.391		-0.235	72	0.482		0.0167	72	0.387
	Week 6		9.89e-18	73	0.562		-0.0403	62	0.368		-0.053	66	0.447
	Week 8		-0.0625	72	0.42		0.0583	60	0.382		0.143	56	1.18
	Week 12		0.0612	67	0.431		0.0196	51	0.743		-0.196	50	1.38
	Week 16		-0.0544	68	0.482		-0.0619	42	0.744		-0.1	37	0.448
	Week 20		-0.0492	65	0.378		0.1	30	0.357		-0.0323	31	0.338
	Week 24		0.112	57	1.19		0.0154	26	0.262		0.0367	30	0.315
	Week 26		-0.125	57	1.07		-0.04	25	0.258		-0.167	27	0.277
Albumin (g/L)	Baseline		39.8	86	2.81		39.8	82	2.56		40.3	84	2.84
	End of Treatment	-0.226	39.6	84	3.32	-0.538	39.2	82	2.97	-0.55	39.8	80	2.48
	Week 2	-1.0	38.9	83	3.11	-1.09	38.7	80	3.17	-1.37	38.9	78	2.76
	Week 4	-1.01	38.8	79	3.29	-1.19	38.6	72	2.8	-1.31	39.1	72	3.05
	Week 6	-0.973	39.1	73	2.56	-1.2	38.4	62	2.6	-0.97	39.5	66	2.76
	Week 8	-0.403	39.8	72	3.51	-0.5	39.1	60	2.93	-0.929	39.8	56	2.33
	Week 12	-0.537	39.5	67	3.49	-0.92	38.9	51	2.18	-0.64	39.8	50	2.45
	Week 16	0.353	40.4	68	3.02	-0.375	39.1	42	2.98	-0.703	39.9	37	1.92
	Week 20	-0.538	39.6	65	3.47	-1.21	38.6	30	2.66	-1.35	39.6	31	1.85
	Week 24	-0.228	39.7	57	3.34	0.4	40.4	26	2.52	-0.533	40.5	30	2.1
	Week 26	0	39.8	57	3.02	-0.958	39.2	25	2.39	-1.22	40	27	2.26
Albumin (g/L) change from previous visit, relative to normal range	Baseline			0				0				0
	End of Treatment		0.0881	84	0.479		0.0232	82	0.44		0.0412	80	0.429
	Week 2		-0.175	83	0.41		-0.19	78	0.485		-0.229	78	0.438
	Week 4		-0.0038	79	0.389		-0.0125	72	0.435		0.00972	72	0.453
	Week 6		0.00548	73	0.422		-0.00645	62	0.373		0.053	66	0.475
	Week 8		0.108	72	0.39		0.148	60	0.481		0.0429	56	0.439
	Week 12		-0.0463	67	0.404		-0.11	51	0.472		0.032	50	0.38
	Week 16		0.181	68	0.461		0.081	42	0.403		-0.0108	37	0.464
	Week 20		-0.148	65	0.513		-0.14	30	0.438		-0.0871	31	0.328
	Week 24		0.0719	57	0.522		0.235	26	0.371		0.16	30	0.309
	Week 26		0.0386	57	0.419		-0.192	25	0.358		-0.115	27	0.452
Alkaline Phosphatase (U/L)	Baseline		77.7	86	58.1		73.3	81	20.7		71	83	38.8
	End of Treatment	7.07	84.6	84	84.9	-1.08	71.6	82	23.8	-1.6	70.2	80	37.9
	Week 2	0.0952	77.7	84	69.5	0.346	73	80	21.9	-0.115	72.2	78	40.2
	Week 4	0.39	78	82	69.4	-0.333	73.2	72	23.2	-0.681	71.3	72	40.7
	Week 6	-0.4	68.4	75	21.5	-1.02	72.7	64	23.2	-0.179	71.5	67	43.4
	Week 8	-0.0274	70	73	27.1	0.517	72.9	60	23.8	0.786	74	56	45.6
	Week 12	1.82	72.1	67	32.7	-1.54	69.5	52	20.5	-1.72	71.9	50	46.7
	Week 16	0.324	70.6	68	29.5	-1.68	69.5	42	19.4	-1.41	74.7	37	54.8
	Week 20	1.94	72.6	65	37.4	-2.23	70.6	31	22.2	-2.74	73.5	31	55.2
	Week 24	10.1	80.6	56	68.1	-0.423	72	27	21.8	-2.4	64.4	30	17.6
	Week 26	10.1	81	57	79.3	-4.08	68.6	25	21.1	-3.85	61.9	27	16.6
Alkaline Phosphatase (U/L) change from previous visit, relative to normal range	Baseline			0				0				0
	End of Treatment		0.115	84	0.703		-0.00741	81	0.297		-0.0438	80	0.319
	Week 2		-0.00119	84	0.397		0.00641	78	0.27		-0.00513	78	0.216
	Week 4		0.00122	82	0.213		-0.0211	71	0.247		-0.0153	72	0.177
	Week 6		0.008	75	0.235		-0.0156	64	0.203		0.00746	67	0.325
	Week 8		0.0123	73	0.198		0.0167	60	0.242		0.0304	56	0.304
	Week 12		0.0433	67	0.366		-0.0192	52	0.214		-0.062	50	0.274
	Week 16		-0.0368	68	0.339		-0.019	42	0.25		-0.0135	37	0.21
	Week 20		0.0308	65	0.405		-9.85e-18	31	0.237		0.00323	31	0.178
	Week 24		0.188	56	0.844		0.0593	27	0.185		-0.0333	30	0.212
	Week 26		0.014	57	0.514		-0.1	25	0.166		-0.0296	27	0.19
Anisocytes change from previous visit, relative to normal range	Baseline			0				0				0
	End of Treatment			0				0				0
	Week 2			0				0				0
	Week 4			0				0				0
	Week 6			0				0				0
	Week 8			0				0				0
	Week 12			0				0				0
	Week 16			0				0				0
	Week 20			0				0				0
	Week 24			0				0				0
	Week 26			0				0				0
Aspartate Aminotransferase (U/L)	Baseline		23.2	86	7.5		23.4	82	8.24		23.1	84	6.61
	End of Treatment	1.82	25.1	84	21.3	-0.3	23.2	82	8.21	-0.4	22.7	80	6.13
	Week 2	0.229	23.6	83	12.3	1.6	24.7	80	8.06	0.385	23.4	78	5.2
	Week 4	0.481	23.9	79	14.9	-1.39	22.3	72	6.75	0.583	23.8	72	5.85
	Week 6	-0.932	22	73	6.4	-0.4	22.1	62	6.11	0.424	24.1	66	7.84
	Week 8	-1.1	22.3	72	7.05	0.276	22.7	60	5.95	1.57	25.7	56	13.3
	Week 12	-0.597	22.8	67	7.64	1.5	24.2	51	15.9	-1.18	23.3	50	6.11
	Week 16	-0.618	22.8	68	6.42	0.575	22.4	42	10.3	-0.73	23.1	37	5.78
	Week 20	-1.63	21.9	65	5.9	0.448	20.7	30	5.74	-0.323	24	31	6.9
	Week 24	1.19	25.2	57	21	2.12	22.4	26	10.8	-0.2	24.4	30	7.29
	Week 26	-2.46	21.5	57	6.99	1.38	22.1	25	11.8	-3.11	21.6	27	5.71
Aspartate Aminotransferase (U/L) change from previous visit, relative to normal range	Baseline			0				0				0
	End of Treatment		0.186	84	1.3		-0.0646	82	0.573		-0.139	80	0.946
	Week 2		0.0157	83	0.715		0.129	78	0.526		0.0231	78	0.456
	Week 4		0.0241	79	0.499		-0.231	72	0.544		0.0194	72	0.361
	Week 6		7.22e-18	73	0.515		-0.0113	62	0.335		-0.0167	66	0.595
	Week 8		-0.0361	72	0.372		0.05	60	0.315		0.0964	56	1.1
	Week 12		0.0403	67	0.366		0.106	51	1.04		-0.21	50	1.14
	Week 16		0.00294	68	0.4		-0.155	42	0.775		-0.0432	37	0.369
	Week 20		-0.0692	65	0.316		0.0667	30	0.352		0.0323	31	0.321
	Week 24		0.237	57	1.56		0.0346	26	0.276		0.00333	30	0.34
	Week 26		-0.254	57	1.47		-0.032	25	0.3		-0.278	27	0.349
Basophils (GI/L)	Baseline		0.0545	85	0.0364		0.0541	81	0.0308		0.0521	81	0.0204
	End of Treatment	-0.00723	0.0477	84	0.0258	-0.0062	0.0488	82	0.0269	-0.000769	0.0507	81	0.0244
	Week 2	-0.00817	0.0461	83	0.0238	-0.00169	0.0535	80	0.0254	-0.0039	0.049	80	0.0252
	Week 4	-0.0138	0.041	79	0.0233	-0.00652	0.0497	71	0.0276	-0.00435	0.0476	71	0.0234
	Week 6	-0.00972	0.0448	73	0.027	-0.00525	0.0495	62	0.0254	0.00194	0.055	64	0.031
	Week 8	-0.00986	0.0435	72	0.0244	-0.00321	0.0529	59	0.025	0.00527	0.0579	56	0.0274
	Week 12	-0.0135	0.0424	66	0.0235	-0.00583	0.0466	50	0.0242	-0.000204	0.0532	50	0.0296
	Week 16	-0.0121	0.0434	68	0.0274	-0.00564	0.0462	42	0.0221	-0.00333	0.0535	37	0.0334
	Week 20	-0.00906	0.0469	65	0.0279	-0.00517	0.0433	30	0.0231	-0.0106	0.0465	31	0.0227
	Week 24	-0.00825	0.0471	58	0.0252	-0.000833	0.0488	25	0.0306	-0.00586	0.0523	30	0.024
	Week 26	-0.0105	0.0437	57	0.0238	-0.00833	0.0428	25	0.0253	-0.00269	0.0567	27	0.0317
Basophils (GI/L) change from previous visit, relative to normal range	Baseline			0				0				0
	End of Treatment		0.0333	84	0.253		0.00976	82	0.208		0.0175	80	0.227
	Week 2		-0.0817	82	0.299		-0.0169	77	0.3		-0.039	77	0.224
	Week 4		-0.0595	79	0.223		-0.0479	71	0.237		-0.0155	71	0.178
	Week 6		0.0411	73	0.23		0.00161	62	0.208		0.0594	64	0.211
	Week 8		-0.0208	72	0.225		0.0305	59	0.219		0.0411	56	0.214
	Week 12		-0.0167	66	0.232		-0.066	50	0.205		-0.042	50	0.179
	Week 16		0.0162	68	0.233		-0.00238	42	0.165		-0.0405	37	0.223
	Week 20		0.0446	65	0.274		-0.03	30	0.214		-0.0484	31	0.342
	Week 24		0.0207	58	0.194		0.072	25	0.207		0.0567	30	0.254
	Week 26		-0.0175	57	0.205		-0.044	25	0.171		0.0296	27	0.232
Bilirubin (umol/L)	Baseline		9.7	86	3.96		9.45	82	4.01		11	84	5.35
	End of Treatment	1.42	11.2	82	13.4	0.46	9.83	80	4.29	-0.0214	11.1	80	5.36
	Week 2	1.07	10.8	83	12.3	-0.0222	9.37	79	4.16	-0.614	10.4	78	3.94
	Week 4	1.43	11.1	79	13.6	-0.347	9.2	71	3.84	-0.332	10.9	72	5.62
	Week 6	0.0937	9.58	73	3.78	-0.0285	9.46	62	4.03	-0.596	10.9	66	4.89
	Week 8	-0.38	9.36	72	3.89	0.501	9.58	60	4.72	-0.733	10.8	56	5.21
	Week 12	-0.128	9.55	67	3.56	0.103	8.78	51	4.15	-0.274	11.5	50	6.16
	Week 16	0.201	9.96	68	3.63	0.385	8.75	42	3.91	-0.739	11.6	37	4.89
	Week 20	0.289	10.1	65	5.19	0.295	8.84	30	4.51	-0.221	11.8	31	8.69
	Week 24	0.124	9.39	55	3.39	1.14	10.1	25	4.44	-0.627	12.3	30	6.52
	Week 26	0.36	9.96	57	4.73	1.42	10.2	25	6.21	-0.633	12.2	27	6.82
Bilirubin (umol/L) change from previous visit, relative to normal range	Baseline			0				0				0
	End of Treatment		0.028	82	0.363		0.0525	80	0.369		0.0413	80	0.49
	Week 2		0.119	83	1.15		-0.0039	77	0.356		-0.0705	78	0.417
	Week 4		0.019	79	0.366		-0.0214	70	0.304		0.0319	72	0.353
	Week 6		-0.00137	73	0.333		0.0452	62	0.252		-0.00606	66	0.344
	Week 8		-0.0472	72	0.326		0.0467	60	0.286		-0.0179	56	0.344
	Week 12		0.00448	67	0.364		-0.0275	51	0.339		0.056	50	0.359
	Week 16		0.05	68	0.292		-0.0333	42	0.253		-0.0108	37	0.521
	Week 20		0.0123	65	0.39		0.02	30	0.285		0.0516	31	0.607
	Week 24		0.00364	55	0.355		0.12	25	0.289		0.00333	30	0.669
	Week 26		0.00909	55	0.385		0.028	25	0.341		0.0037	27	0.449
Blood Urea Nitrogen (mmol/L)	Baseline		5.54	86	1.39		6.37	82	1.97		5.75	84	1.88
	End of Treatment	0.344	5.9	84	1.38	0.187	6.57	82	1.95	-0.0134	5.7	80	1.97
	Week 2	0.255	5.81	84	1.51	0.261	6.63	80	1.82	0.316	6.03	78	2.06
	Week 4	0.283	5.86	82	1.47	0.0459	6.43	72	1.63	0.258	5.95	72	1.87
	Week 6	0.49	6.08	75	1.42	-0.0749	6.36	64	1.76	0.25	5.98	67	2.06
	Week 8	-0.0147	5.63	73	1.58	-0.0308	6.32	60	1.92	0.0637	5.85	56	1.93
	Week 12	0.208	5.88	67	1.61	-0.0214	6.16	52	1.49	0.114	5.9	50	1.76
	Week 16	0.158	5.84	68	1.6	-0.205	5.98	42	1.62	0.183	5.73	37	1.92
	Week 20	0.135	5.79	66	1.53	-0.595	5.62	31	1.57	0.219	5.86	31	2.25
	Week 24	0.269	5.92	57	1.32	-0.0137	6.02	27	2.07	-0.262	5.28	30	1.92
	Week 26	0.382	6.05	57	1.62	-0.268	5.74	25	1.93	0.304	5.86	27	2.47
Blood Urea Nitrogen (mmol/L) change from previous visit, relative to normal range	Baseline			0				0				0
	End of Treatment		0.0369	84	0.309		0.0707	82	0.372		-0.0825	80	0.402
	Week 2		0.0714	84	0.327		0.0731	78	0.427		0.0885	78	0.38
	Week 4		0.0134	82	0.296		-0.0361	72	0.349		-0.0111	72	0.348
	Week 6		0.0587	75	0.284		-0.00469	64	0.364		0.0179	67	0.331
	Week 8		-0.129	73	0.332		0.00333	60	0.312		-0.0768	56	0.311
	Week 12		0.0582	67	0.293		0.0135	52	0.265		0.038	50	0.296
	Week 16		-0.0103	68	0.326		-0.0262	42	0.38		-0.0405	37	0.415
	Week 20		0.00152	66	0.305		-0.0581	31	0.361		0.00968	31	0.413
	Week 24		0.0474	57	0.302		0.107	27	0.39		-0.133	30	0.365
	Week 26		0.0123	57	0.342		-0.024	25	0.295		0.122	27	0.332
Calcium (mmol/L)	Baseline		2.31	86	0.0949		2.3	82	0.113		2.3	84	0.0954
	End of Treatment	-0.0428	2.27	84	0.0919	-0.0187	2.28	82	0.102	-0.0281	2.27	80	0.102
	Week 2	-0.0306	2.28	84	0.0929	-0.00384	2.3	80	0.118	-0.0141	2.29	78	0.113
	Week 4	-0.0313	2.28	82	0.088	-0.0146	2.29	72	0.104	-0.0201	2.28	72	0.0983
	Week 6	-0.0163	2.3	75	0.0927	-0.0173	2.28	64	0.105	-0.025	2.28	67	0.0924
	Week 8	-0.026	2.29	73	0.0866	-0.0146	2.29	60	0.116	-0.0209	2.29	56	0.116
	Week 12	-0.019	2.3	67	0.0852	-0.0354	2.28	52	0.101	-0.0314	2.28	50	0.0851
	Week 16	-0.0235	2.29	68	0.0995	-0.0356	2.28	42	0.111	-0.0223	2.28	37	0.107
	Week 20	-0.0461	2.27	66	0.0912	-0.0316	2.27	31	0.104	-0.0483	2.25	31	0.0798
	Week 24	-0.0543	2.26	57	0.0889	-0.0125	2.29	27	0.114	-0.0507	2.26	30	0.0984
	Week 26	-0.0403	2.27	57	0.105	-0.0426	2.26	25	0.103	-0.0471	2.26	27	0.0885
Calcium (mmol/L) change from previous visit, relative to normal range	Baseline			0				0				0
	End of Treatment		-0.00357	84	0.359		0.00366	82	0.389		-0.02	80	0.38
	Week 2		-0.126	84	0.391		-0.0192	78	0.427		-0.0577	78	0.441
	Week 4		-0.00122	82	0.343		-0.0611	72	0.397		-0.0292	72	0.44
	Week 6		0.0653	75	0.362		0.00937	64	0.381		-0.00597	67	0.39
	Week 8		-0.026	73	0.402		0.00333	60	0.374		0.0357	56	0.454
	Week 12		0.0164	67	0.392		-0.0519	52	0.31		-0.02	50	0.329
	Week 16		-0.0103	68	0.415		-0.00238	42	0.336		0.0432	37	0.39
	Week 20		-0.097	66	0.43		-0.0194	31	0.351		-0.106	31	0.377
	Week 24		-0.0228	57	0.34		0.0852	27	0.394		-0.0333	30	0.361
	Week 26		0.0351	57	0.379		-0.148	25	0.417		0.0444	27	0.382
Chloride (mmol/L)	Baseline		106	86	3.19		106	82	3.25		105	83	3.33
	End of Treatment	-0.0833	106	84	3.42	-0.075	106	82	3.37	-0.481	105	80	3.2
	Week 2	0.286	106	84	3.12	-0.0385	106	80	3.12	-0.829	104	77	3.49
	Week 4	-0.134	106	82	3.53	-0.314	105	72	2.88	-0.423	105	72	3.46
	Week 6	-0.133	105	75	3.14	0.581	106	64	3.07	-0.348	105	67	3.09
	Week 8	0.315	106	73	3.34	-0.172	106	60	3.01	-0.107	105	56	3.57
	Week 12	-0.313	105	67	2.93	-0.44	106	52	3.21	-0.102	105	49	2.4
	Week 16	-0.0441	106	68	3.16	0.2	106	42	2.93	0.595	106	37	2.66
	Week 20	0.569	106	65	3.68	-0.0667	106	31	2.75	-0.161	105	31	3.03
	Week 24	-0.0526	105	57	3.14	-1.19	105	27	2.52	-0.1	105	30	3.21
	Week 26	0.754	106	57	2.58	-0.542	106	25	2.35	0.37	106	27	3.44
Chloride (mmol/L) change from previous visit, relative to normal range	Baseline			0				0				0
	End of Treatment		-0.0179	84	0.443		-0.0171	82	0.404		-0.025	80	0.329
	Week 2		0.0321	84	0.374		4.98e-18	78	0.379		-0.0908	76	0.428
	Week 4		-0.0439	82	0.387		-0.0194	72	0.377		0.0361	72	0.396
	Week 6		-0.0173	75	0.407		0.0703	64	0.37		0.0194	67	0.396
	Week 8		0.0466	73	0.397		-0.0783	60	0.361		-0.00536	56	0.449
	Week 12		-0.0642	67	0.378		0.00192	52	0.408		0.0143	49	0.348
	Week 16		0.00882	68	0.374		0.069	42	0.438		0.0838	37	0.307
	Week 20		0.0708	65	0.383		-0.00968	31	0.299		-0.0968	31	0.382
	Week 24		-0.0561	57	0.412		-0.0889	27	0.368		-0.02	30	0.314
	Week 26		0.0702	57	0.363		0.068	25	0.377		0.0519	27	0.311
Cholesterol (mmol/L)	Baseline		5.76	86	1.07		5.65	82	0.996		5.79	84	1.02
	End of Treatment	-0.256	5.48	84	1.02	-0.263	5.42	82	0.962	-0.36	5.41	80	0.892
	Week 2	-0.123	5.61	84	1.02	-0.0975	5.57	80	0.915	-0.223	5.56	78	0.927
	Week 4	-0.241	5.52	82	0.939	-0.206	5.49	72	0.97	-0.26	5.49	72	1
	Week 6	-0.127	5.59	75	0.953	-0.205	5.43	64	0.949	-0.269	5.51	67	0.915
	Week 8	-0.238	5.49	73	1.02	-0.218	5.47	60	0.963	-0.271	5.48	56	0.942
	Week 12	-0.221	5.51	67	0.924	-0.315	5.34	52	0.898	-0.324	5.45	50	0.908
	Week 16	-0.114	5.64	68	0.984	-0.267	5.35	42	0.996	-0.238	5.42	37	0.937
	Week 20	-0.248	5.52	66	0.944	-0.412	5.16	31	0.864	-0.279	5.32	31	0.851
	Week 24	-0.343	5.49	57	1.01	-0.215	5.37	27	0.941	-0.259	5.32	30	0.886
	Week 26	-0.275	5.53	57	0.938	-0.394	5.24	25	0.761	-0.18	5.35	27	0.902
Cholesterol (mmol/L) change from previous visit, relative to normal range	Baseline			0				0				0
	End of Treatment		-0.0167	84	0.314		-0.00732	82	0.298		-0.0362	80	0.247
	Week 2		-0.0679	84	0.294		-0.0564	78	0.273		-0.119	78	0.296
	Week 4		-0.0659	82	0.247		-0.0722	72	0.273		-0.0306	72	0.27
	Week 6		0.0493	75	0.255		-0.00938	64	0.263		-0.00896	67	0.33
	Week 8		-0.0274	73	0.297		-0.00833	60	0.257		-0.00536	56	0.286
	Week 12		-0.00149	67	0.316		-0.0385	52	0.213		-0.022	50	0.257
	Week 16		0.0691	68	0.255		0.0119	42	0.248		-0.0297	37	0.258
	Week 20		-0.0742	66	0.319		-0.0935	31	0.213		-0.029	31	0.273
	Week 24		-0.0421	57	0.309		0.107	27	0.293		0.00667	30	0.193
	Week 26		0.0351	57	0.262		-0.088	25	0.264		0.0259	27	0.277
Creatine Kinase (U/L)	Baseline		86.9	86	43.7		101	82	68.9		104	84	71.8
	End of Treatment	24.6	113	84	173	-1.91	98.2	82	61.1	-9.91	95.1	80	56.3
	Week 2	2.43	90.3	83	66.1	6.03	106	80	83.9	-12.0	93.8	78	53.2
	Week 4	8.33	96.9	79	124	-7.83	93.2	72	51.7	-4.78	101	72	58.4
	Week 6	-0.274	88	73	42.4	-13.7	89	62	44.3	17.8	124	66	227
	Week 8	1.24	93.8	72	45.8	-8.26	90	60	39.2	-9.29	91.8	56	52.3
	Week 12	8.85	102	67	78.7	-7.18	94.7	51	53.6	-2.78	96.6	50	60.6
	Week 16	12.7	105	68	66.4	-6.88	97.5	42	56.4	-1.62	86.1	37	47.7
	Week 20	1.05	93.8	65	46.6	21.5	112	30	137	5.97	97.5	31	68.6
	Week 24	32.6	127	57	208	0.76	83.6	26	38.6	-1.07	90.9	30	54
	Week 26	1.96	94.1	57	51	-15.0	69.9	25	23.7	1.41	93	27	59.9
Creatine Kinase (U/L) change from previous visit, relative to normal range	Baseline			0				0				0
	End of Treatment		0.292	84	2.17		-0.0598	82	1.06		-0.0562	80	0.72
	Week 2		0.0325	83	0.752		0.0859	78	1.09		-0.142	78	0.622
	Week 4		0.0481	79	1.46		-0.197	72	0.934		0.0917	72	0.464
	Week 6		-0.107	73	1.4		-0.0629	62	0.353		0.241	66	2.55
	Week 8		0.0417	72	0.482		0.0617	60	0.293		-0.332	56	2.7
	Week 12		0.0955	67	0.845		0.0176	51	0.44		0.094	50	0.698
	Week 16		0.0485	68	0.804		0.0738	42	0.322		-0.176	37	0.643
	Week 20		-0.103	65	0.519		0.3	30	1.8		0.113	31	0.39
	Week 24		0.412	57	2.63		-0.285	26	1.66		-0.103	30	0.348
	Week 26		-0.104	57	0.705		-0.176	25	0.254		0.0111	27	0.524
Creatinine (umol/L)	Baseline		97.7	86	17.8		103	82	20		104	84	19.4
	End of Treatment	0.842	98.5	84	16.1	1.77	106	82	19.8	1.44	105	80	20.5
	Week 2	1.37	99	84	17.5	2.27	106	80	21.3	2.83	106	78	21.2
	Week 4	1.08	98.6	82	18.6	2.02	105	72	19.8	2.58	106	72	20.7
	Week 6	3.3	102	75	18.5	1.71	104	64	19.9	3.17	106	67	20.9
	Week 8	-1.95e-16	99.1	73	16.1	1.83	104	60	21.3	3.16	106	56	22.2
	Week 12	2.37	101	67	16.5	1.77	102	52	17.7	5.83	108	50	20.5
	Week 16	1.17	100	68	16.4	-1.33	98.5	42	16.6	2.15	102	37	17.9
	Week 20	1.34	100	66	17.9	-1.77	97.2	31	17.2	3.14	104	31	19.7
	Week 24	0.775	99.3	57	15.9	1.7	99.2	27	16.1	-0.589	100	30	19.6
	Week 26	2.02	100	57	18.5	2.95	99.7	25	18.8	0.327	102	27	18.7
Creatinine (umol/L) change from previous visit, relative to normal range	Baseline			0				0				0
	End of Treatment		-0.0202	84	0.312		0.0524	82	0.317		-0.05	80	0.305
	Week 2		0.0476	84	0.266		0.0744	78	0.337		0.0949	78	0.304
	Week 4		-0.011	82	0.338		-1.54e-18	72	0.287		-7.71e-18	72	0.304
	Week 6		0.0573	75	0.4		-0.0172	64	0.283		0.0179	67	0.332
	Week 8		-0.103	73	0.31		-9.25e-19	60	0.304		-0.0357	56	0.296
	Week 12		0.0701	67	0.298		0.0173	52	0.26		0.102	50	0.338
	Week 16		-0.0279	68	0.288		-0.117	42	0.29		-0.143	37	0.324
	Week 20		-0.00152	66	0.293		0.0581	31	0.225		0.0484	31	0.351
	Week 24		-0.00702	57	0.335		0.1	27	0.3		-0.117	30	0.29
	Week 26		0.0105	57	0.303		0.008	25	0.298		0.0926	27	0.312
Eosinophils (GI/L)	Baseline		0.144	85	0.124		0.146	81	0.119		0.144	81	0.105
	End of Treatment	-0.0336	0.112	84	0.0761	0.0428	0.19	82	0.17	0.0701	0.206	81	0.196
	Week 2	-0.0178	0.129	83	0.1	0.0227	0.164	80	0.173	-0.00494	0.133	80	0.105
	Week 4	-0.0195	0.129	79	0.126	0.0246	0.171	71	0.137	0.0271	0.159	71	0.152
	Week 6	-0.0185	0.131	73	0.13	0.0785	0.24	62	0.211	0.106	0.247	64	0.281
	Week 8	-0.0158	0.129	72	0.104	0.167	0.321	59	0.258	0.0929	0.241	56	0.245
	Week 12	-0.0272	0.122	66	0.0886	0.11	0.261	50	0.212	0.0988	0.229	50	0.174
	Week 16	-0.0351	0.112	68	0.0752	0.0644	0.214	42	0.16	0.0647	0.206	37	0.208
	Week 20	-0.0369	0.109	65	0.0752	0.0593	0.205	30	0.186	0.0177	0.145	31	0.107
	Week 24	-0.0263	0.122	58	0.0828	0.0242	0.176	25	0.138	0.0383	0.165	30	0.154
	Week 26	-0.0375	0.111	57	0.0986	0.0246	0.173	25	0.153	0.0165	0.13	27	0.0994
Eosinophils (GI/L) change from previous visit, relative to normal range	Baseline			0				0				0
	End of Treatment		1.98e-18	84	0.224		-0.168	82	0.519		0.0425	80	0.58
	Week 2		-0.0622	82	0.301		0.0792	77	0.487		-0.013	77	0.248
	Week 4		-0.00633	79	0.252		0.0197	71	0.429		0.117	71	0.454
	Week 6		0.00548	73	0.342		0.224	62	0.44		0.262	64	0.584
	Week 8		-0.0194	72	0.267		0.249	59	0.615		-0.00893	56	0.747
	Week 12		-0.0288	66	0.33		-0.214	50	0.604		7.22e-18	50	0.42
	Week 16		-0.0353	68	0.265		-0.255	42	0.442		-0.0676	37	0.384
	Week 20		-0.00308	65	0.239		-0.0233	30	0.424		-0.0645	31	0.441
	Week 24		0.019	58	0.245		-0.04	25	0.334		0.02	30	0.505
	Week 26		-0.0263	57	0.246		-0.02	25	0.235		-0.119	27	0.41
Ery. Mean Corpuscular HGB Concentration (mmol/L)	Baseline		20.6	85	0.87		20.2	80	0.976		20.5	80	0.875
	End of Treatment	-0.439	20.2	83	0.847	-0.0239	20.2	82	0.809	-0.0645	20.4	81	0.784
	Week 2	-0.341	20.3	83	0.775	0.0408	20.3	80	0.853	-0.0408	20.4	80	0.738
	Week 4	-0.4	20.2	77	0.777	-0.00926	20.2	69	0.716	-0.0556	20.5	70	0.713
	Week 6	-0.166	20.5	72	0.765	-0.174	20.1	60	0.835	-0.167	20.4	65	0.886
	Week 8	-0.231	20.3	71	0.681	-0.0117	20.2	56	0.834	-0.0564	20.5	56	0.757
	Week 12	-0.291	20.3	65	0.735	-0.0132	20.3	49	0.68	-0.127	20.5	50	0.762
	Week 16	-0.435	20.2	68	0.746	-0.239	20	42	0.82	-0.19	20.4	37	0.832
	Week 20	-0.276	20.3	64	0.797	-0.428	20	30	0.848	-0.34	20.3	31	0.88
	Week 24	-0.49	20.1	58	0.892	-0.31	20.3	25	0.909	-0.321	20.4	30	0.848
	Week 26	-0.372	20.3	56	0.993	-0.595	19.9	25	0.939	-0.573	20.2	27	0.917
Ery. Mean Corpuscular HGB Concentration (mmol/L) change from previous visit, relative to normal rang	Baseline			0				0				0
	End of Treatment		-0.00843	83	0.326		0.0432	81	0.351		0.035	80	0.348
	Week 2		-0.129	82	0.39		0.0184	76	0.398		-0.0171	76	0.379
	Week 4		-0.0312	77	0.297		-0.00725	69	0.35		0.0129	70	0.333
	Week 6		0.121	72	0.353		-0.0333	60	0.321		-0.0431	65	0.314
	Week 8		-0.0746	71	0.29		0.0232	56	0.301		0.0304	56	0.314
	Week 12		-0.04	65	0.341		0.0265	49	0.303		-0.016	50	0.273
	Week 16		-0.025	68	0.372		-0.121	42	0.282		0.00541	37	0.289
	Week 20		0.0391	64	0.307		0.00333	30	0.378		-0.0452	31	0.374
	Week 24		-0.0534	58	0.304		0.124	25	0.309		0.03	30	0.365
	Week 26		0.0554	56	0.368		-0.148	25	0.378		-0.0704	27	0.371
Ery. Mean Corpuscular Hemoglobin (fmol(Fe))	Baseline		1.91	85	0.116		1.91	81	0.0921		1.92	81	0.126
	End of Treatment	-0.0105	1.9	84	0.125	0.011	1.92	82	0.086	0.00159	1.92	81	0.127
	Week 2	-0.00984	1.91	83	0.109	0.0113	1.92	80	0.0922	-0.00564	1.91	80	0.128
	Week 4	-0.00239	1.9	79	0.118	0.0144	1.92	71	0.089	-0.0036	1.91	71	0.126
	Week 6	0.00517	1.92	73	0.125	0.0021	1.91	62	0.0847	-0.0108	1.91	65	0.128
	Week 8	0.00524	1.91	72	0.118	0.0166	1.92	59	0.0947	-0.00113	1.93	56	0.0996
	Week 12	0.00191	1.91	66	0.123	0.0116	1.92	50	0.0925	-0.00127	1.94	50	0.093
	Week 16	-0.00463	1.9	68	0.12	-0.00159	1.91	42	0.104	-0.00862	1.93	37	0.113
	Week 20	-0.00582	1.89	65	0.107	0.00214	1.91	30	0.081	-0.014	1.93	31	0.117
	Week 24	-0.0131	1.89	58	0.123	-0.0207	1.91	25	0.0887	-0.0171	1.93	30	0.129
	Week 26	-0.00887	1.9	57	0.122	-0.0129	1.9	25	0.0796	-0.0286	1.93	27	0.122
Ery. Mean Corpuscular Hemoglobin (fmol(Fe)) change from previous visit, relative to normal range	Baseline			0				0				0
	End of Treatment		-0.00833	84	0.186		0.00976	82	0.203		0.03	80	0.224
	Week 2		-0.039	82	0.253		0.0455	77	0.259		-0.026	77	0.256
	Week 4		0.019	79	0.208		0.0141	71	0.252		0.0239	71	0.231
	Week 6		0.0438	73	0.217		-0.0323	62	0.158		-0.0185	65	0.208
	Week 8		-0.0333	72	0.202		0.0458	59	0.207		0.0393	56	0.209
	Week 12		-0.00758	66	0.228		-0.008	50	0.165		2.22e-18	50	0.18
	Week 16		-0.00588	68	0.224		-0.031	42	0.204		-0.0108	37	0.187
	Week 20		-0.0154	65	0.173		0.04	30	0.194		3.58e-18	31	0.188
	Week 24		-0.0155	58	0.161		-0.032	25	0.199		0.00667	30	0.266
	Week 26		0.0211	57	0.199		0.004	25	0.179		-0.0407	27	0.224
Ery. Mean Corpuscular Volume (fL)	Baseline		92.9	85	5.69		94.6	80	4.9		93.3	80	5.91
	End of Treatment	1.43	94.4	83	5.93	0.564	95	82	3.98	0.688	93.8	81	6.14
	Week 2	1.2	94.1	83	5.31	0.158	94.6	80	4.12	0.237	93.4	80	5.93
	Week 4	1.74	94.6	77	5.87	0.597	95.1	69	4.22	0.0149	93	70	5.52
	Week 6	1.34	94.2	72	6.21	0.702	95.2	60	4.51	0.571	94	65	6.61
	Week 8	1.46	94.3	71	5.51	0.642	94.9	56	3.97	0.382	94.4	56	4.77
	Week 12	1.59	94.2	65	5.66	0.851	95.1	49	4.17	0.816	94.9	50	4.9
	Week 16	1.72	94.1	68	6.01	1.15	95.8	42	5.17	0.556	94.7	37	6.27
	Week 20	1.27	93.3	64	5.58	1.97	95.4	30	5.43	0.871	95.1	31	5.91
	Week 24	1.6	93.9	58	5.9	0.833	94.3	25	3.85	0.69	95	30	5.99
	Week 26	1.69	93.9	56	6.4	2.62	95.8	25	4.33	1.15	95.4	27	6.19
Ery. Mean Corpuscular Volume (fL) change from previous visit, relative to normal range	Baseline			0				0				0
	End of Treatment		0.00602	83	0.341		-0.0296	81	0.33		0.02	80	0.331
	Week 2		0.118	82	0.395		0.0132	76	0.363		0.0237	76	0.394
	Week 4		0.0506	77	0.295		0.0348	69	0.306		-0.0243	70	0.25
	Week 6		-0.0625	72	0.322		0.0167	60	0.305		0.0646	65	0.33
	Week 8		0.0338	71	0.32		-0.0107	56	0.317		5.95e-18	56	0.308
	Week 12		0.00769	65	0.316		0.00408	49	0.295		0.028	50	0.276
	Week 16		0.0147	68	0.38		0.0833	42	0.249		-0.0297	37	0.386
	Week 20		-0.0297	64	0.321		-0.00667	30	0.393		0.0419	31	0.431
	Week 24		0.0172	58	0.353		-0.116	25	0.346		-0.0133	30	0.345
	Week 26		-0.0107	56	0.328		0.18	25	0.364		0.0111	27	0.352
Erythrocytes (TI/L)	Baseline		4.53	85	0.448		4.55	81	0.419		4.67	81	0.469
	End of Treatment	-0.0795	4.44	84	0.427	-0.162	4.37	82	0.381	-0.133	4.55	81	0.495
	Week 2	-0.0622	4.44	83	0.395	-0.11	4.43	80	0.428	-0.0974	4.59	80	0.474
	Week 4	-0.108	4.42	79	0.447	-0.193	4.37	71	0.383	-0.103	4.54	71	0.492
	Week 6	-0.117	4.4	73	0.374	-0.186	4.34	62	0.376	-0.114	4.54	65	0.498
	Week 8	-0.0944	4.44	72	0.41	-0.191	4.36	59	0.337	-0.125	4.54	56	0.451
	Week 12	-0.126	4.4	66	0.44	-0.192	4.35	50	0.318	-0.139	4.55	50	0.466
	Week 16	-0.0418	4.48	68	0.407	-0.121	4.35	42	0.36	-0.156	4.55	37	0.444
	Week 20	-0.0844	4.45	65	0.413	-0.11	4.33	30	0.324	-0.165	4.53	31	0.504
	Week 24	-0.0702	4.42	58	0.449	-0.0708	4.41	25	0.377	-0.0966	4.63	30	0.577
	Week 26	-0.0482	4.44	57	0.421	-0.142	4.36	25	0.346	-0.181	4.54	27	0.465
Erythrocytes (TI/L) change from previous visit, relative to normal range	Baseline			0				0				0
	End of Treatment		0.00357	84	0.322		-0.0427	82	0.311		-0.0238	80	0.316
	Week 2		-0.0768	82	0.266		-0.132	77	0.327		-0.114	77	0.253
	Week 4		-0.0557	79	0.274		-0.104	71	0.347		-0.0225	71	0.279
	Week 6		-0.0178	73	0.216		0.00645	62	0.29		-0.0185	65	0.32
	Week 8		0.0444	72	0.256		0.0322	59	0.265		0.00536	56	0.238
	Week 12		-0.0667	66	0.284		-0.016	50	0.302		-0.006	50	0.249
	Week 16		0.101	68	0.33		0.0452	42	0.276		-0.0514	37	0.245
	Week 20		-0.0538	65	0.276		-0.04	30	0.286		-0.0161	31	0.185
	Week 24		0.0103	58	0.312		0.024	25	0.276		0.0733	30	0.317
	Week 26		0.0351	57	0.253		-0.048	25	0.224		-0.063	27	0.286
Gamma Glutamyl Transferase (U/L)	Baseline		24.9	86	49.7		22.2	82	15.6		22.8	84	17.7
	End of Treatment	0.667	25.7	84	48.8	0.338	22.4	82	14	-0.575	22.3	80	15.7
	Week 2	-0.845	24.2	84	47	0.167	22.6	80	15.5	0.615	23.7	78	18.2
	Week 4	-0.768	24.5	82	48.7	-1.11	21.8	72	13.8	0.0972	23.3	72	16.1
	Week 6	0.253	19.9	75	15.6	-0.597	21.9	64	13.7	-0.537	21.6	67	13.5
	Week 8	0.11	20.6	73	16.4	1.09	23.6	60	15.6	4.04	26.8	56	30
	Week 12	0.478	21.4	67	15	-0.7	21.9	52	14	1.22	24.7	50	21.3
	Week 16	-0.103	20.8	68	13	-0.1	22.8	42	14.9	-1.32	23.9	37	17.8
	Week 20	-0.485	20.4	66	13.9	-0.367	24.1	31	17.5	-0.484	22.2	31	11.3
	Week 24	0.544	22	57	16.7	0.538	23.7	27	14.7	-0.933	25.5	30	22.6
	Week 26	-0.421	21.4	57	13.9	-1.0	22	25	15.3	-3.37	23.4	27	18.7
Gamma Glutamyl Transferase (U/L) change from previous visit, relative to normal range	Baseline			0				0				0
	End of Treatment		0.0571	84	0.405		0.0244	82	0.374		-0.08	80	0.801
	Week 2		-0.0417	84	0.253		0.0115	78	0.416		0.0359	78	0.426
	Week 4		0.00854	82	0.144		-0.0583	72	0.274		-0.0139	72	0.313
	Week 6		0.052	75	0.391		-0.00625	64	0.299		-0.0716	67	0.267
	Week 8		-0.011	73	0.142		0.07	60	0.396		0.198	56	1.08
	Week 12		0.0209	67	0.267		-0.0519	52	0.368		-0.158	50	0.978
	Week 16		-0.0206	68	0.278		0.0286	42	0.285		-0.0973	37	0.402
	Week 20		-0.0121	66	0.219		0.029	31	0.192		0.0548	31	0.173
	Week 24		0.0614	57	0.472		0.0481	27	0.217		-0.00333	30	0.257
	Week 26		-0.0544	57	0.332		-0.084	25	0.165		-0.13	27	0.3
Glucose (mmol/L)	Baseline		5.63	86	2.14		5.41	82	0.945		5.41	84	1.34
	End of Treatment	0.0106	5.65	84	1.61	-0.0777	5.39	82	1.07	0.484	5.86	80	2.15
	Week 2	-0.0468	5.6	83	1.87	0.132	5.58	80	1.75	0.717	6.1	78	2.92
	Week 4	-0.0401	5.61	79	1.87	-0.0612	5.39	70	1.41	0.425	5.87	72	1.84
	Week 6	0.089	5.73	73	2.22	-0.104	5.34	62	1.34	0.505	5.96	66	2.8
	Week 8	-0.136	5.53	72	1.35	0.122	5.54	59	1.76	0.248	5.76	56	2.15
	Week 12	0.353	6.07	67	1.97	0.427	5.9	51	3.18	0.418	6.04	49	2.28
	Week 16	-0.249	5.48	68	1.42	-0.216	5.3	42	0.835	0.195	5.9	37	2.3
	Week 20	0.0589	5.81	65	1.5	0.0919	5.67	30	1.73	0.233	5.81	31	1.61
	Week 24	-0.0623	5.74	57	1.83	0.182	5.7	26	1.26	0.466	6.05	30	1.92
	Week 26	-0.00682	5.76	57	1.85	0.146	5.54	25	1.72	0.0863	5.63	27	1.01
Glucose (mmol/L) change from previous visit, relative to normal range	Baseline			0				0				0
	End of Treatment		-0.0226	84	0.277		-0.00488	82	0.256		0.0238	80	0.256
	Week 2		-0.00602	83	0.253		0.0269	78	0.277		0.127	78	0.376
	Week 4		7.03e-19	79	0.238		-0.0486	70	0.245		-0.05	72	0.399
	Week 6		0.0192	73	0.249		-0.0131	61	0.2		0.0227	66	0.448
	Week 8		-0.0333	72	0.341		0.0271	59	0.236		-0.0625	56	0.366
	Week 12		0.094	67	0.31		0.0529	51	0.385		0.0163	49	0.246
	Week 16		-0.104	68	0.275		-0.126	42	0.526		-0.0216	37	0.274
	Week 20		0.0477	65	0.219		0.0633	30	0.236		0.071	31	0.251
	Week 24		-0.0175	57	0.308		0.0269	26	0.272		0.0267	30	0.308
	Week 26		0.00175	57	0.39		-0.036	25	0.245		-0.0704	27	0.309
Hematocrit	Baseline		0.42	85	0.0406		0.429	80	0.0372		0.434	80	0.0383
	End of Treatment	-0.000854	0.418	83	0.0373	-0.0119	0.415	82	0.0355	-0.00948	0.426	81	0.0377
	Week 2	-0.00134	0.417	83	0.0356	-0.00868	0.418	80	0.0388	-0.00855	0.427	80	0.0388
	Week 4	-0.00237	0.417	77	0.0413	-0.0158	0.415	69	0.035	-0.0103	0.422	70	0.0379
	Week 6	-0.00521	0.413	72	0.0381	-0.0132	0.414	60	0.0366	-0.0081	0.424	65	0.0374
	Week 8	-0.00329	0.417	71	0.0383	-0.014	0.413	56	0.03	-0.01	0.427	56	0.0336
	Week 12	-0.00453	0.413	65	0.0393	-0.0134	0.413	49	0.0332	-0.00918	0.43	50	0.0352
	Week 16	0.00299	0.42	68	0.0353	-0.00564	0.416	42	0.0325	-0.0119	0.429	37	0.0334
	Week 20	-0.00222	0.415	64	0.0394	-0.000345	0.414	30	0.035	-0.011	0.429	31	0.037
	Week 24	0.00158	0.415	58	0.0373	-0.00375	0.415	25	0.0365	-0.00517	0.438	30	0.0409
	Week 26	0.00164	0.414	56	0.0382	-0.00208	0.417	25	0.0359	-0.0115	0.431	27	0.0398
Hematocrit change from previous visit, relative to normal range	Baseline			0				0				0
	End of Treatment		0.0217	83	0.415		-0.079	81	0.379		-0.00625	80	0.408
	Week 2		-0.0171	82	0.398		-0.122	76	0.42		-0.12	76	0.438
	Week 4		-0.00779	77	0.347		-0.103	69	0.423		-0.0443	70	0.353
	Week 6		-0.0681	72	0.351		0.02	60	0.419		0.0262	65	0.422
	Week 8		0.0662	71	0.351		0.0232	56	0.356		0.00179	56	0.334
	Week 12		-0.0385	65	0.392		-0.00816	49	0.33		0.016	50	0.279
	Week 16		0.0853	68	0.434		0.1	42	0.376		-0.0973	37	0.409
	Week 20		-0.0594	64	0.388		-0.02	30	0.398		0.00323	31	0.354
	Week 24		0.0328	58	0.429		-0.088	25	0.349		0.09	30	0.413
	Week 26		0.00536	56	0.337		0.06	25	0.337		-0.1	27	0.379
Hemoglobin (mmol/L)	Baseline		8.62	85	0.828		8.62	81	0.768		8.87	81	0.783
	End of Treatment	-0.206	8.39	84	0.779	-0.25	8.36	82	0.689	-0.243	8.68	81	0.793
	Week 2	-0.156	8.44	83	0.765	-0.159	8.45	80	0.763	-0.207	8.72	80	0.829
	Week 4	-0.233	8.37	79	0.815	-0.295	8.35	71	0.78	-0.215	8.62	71	0.78
	Week 6	-0.193	8.44	73	0.772	-0.322	8.3	62	0.763	-0.265	8.6	65	0.748
	Week 8	-0.165	8.47	72	0.756	-0.281	8.34	59	0.713	-0.26	8.72	56	0.734
	Week 12	-0.223	8.36	66	0.833	-0.287	8.34	50	0.692	-0.262	8.78	50	0.791
	Week 16	-0.118	8.47	68	0.728	-0.231	8.28	42	0.69	-0.336	8.74	37	0.698
	Week 20	-0.167	8.42	65	0.801	-0.21	8.24	30	0.632	-0.378	8.68	31	0.792
	Week 24	-0.188	8.32	58	0.825	-0.217	8.38	25	0.689	-0.265	8.88	30	0.845
	Week 26	-0.151	8.37	57	0.802	-0.308	8.27	25	0.669	-0.499	8.69	27	0.736
Hemoglobin (mmol/L) change from previous visit, relative to normal range	Baseline			0				0				0
	End of Treatment		-0.0143	84	0.32		-0.0512	82	0.342		0.00125	80	0.303
	Week 2		-0.107	82	0.308		-0.118	77	0.339		-0.151	77	0.306
	Week 4		-0.0544	79	0.287		-0.103	71	0.341		-0.00423	71	0.298
	Week 6		0.0384	73	0.264		-0.00645	62	0.311		-0.0338	65	0.341
	Week 8		0.00833	72	0.266		0.0508	59	0.286		0.0304	56	0.28
	Week 12		-0.0727	66	0.3		-0.016	50	0.313		0.008	50	0.302
	Week 16		0.0868	68	0.334		0.0119	42	0.326		-0.0784	37	0.271
	Week 20		-0.0431	65	0.312		0.00667	30	0.273		-0.0258	31	0.213
	Week 24		-0.0224	58	0.33		1.11e-17	25	0.268		0.1	30	0.285
	Week 26		0.0386	57	0.27		-0.06	25	0.227		-0.141	27	0.266
Leukocytes (GI/L)	Baseline		6.87	85	1.76		6.62	81	1.95		6.55	81	1.54
	End of Treatment	-0.188	6.65	84	1.8	0.102	6.78	82	2.17	0.201	6.74	81	1.76
	Week 2	-0.389	6.48	83	1.55	0.204	6.92	80	1.99	-0.0783	6.51	80	1.59
	Week 4	-0.377	6.38	79	1.63	0.0626	6.81	71	2.12	0.0794	6.59	71	1.42
	Week 6	-0.431	6.46	73	1.57	0.144	6.88	62	1.99	0.425	7.01	65	1.84
	Week 8	-0.341	6.47	72	1.7	0.335	7.05	59	1.88	0.44	6.94	56	1.95
	Week 12	-0.469	6.33	66	1.28	0.165	6.8	50	2.03	-0.0459	6.59	50	1.51
	Week 16	-0.457	6.39	68	1.5	0.172	6.56	42	2.11	-0.0897	6.76	37	1.72
	Week 20	-0.46	6.45	65	1.77	0.102	6.47	30	1.94	-0.231	6.65	31	1.67
	Week 24	-0.227	6.67	58	1.77	0.00333	6.29	25	1.84	-0.0521	6.74	30	1.8
	Week 26	-0.431	6.45	57	1.47	-0.324	6.11	25	1.93	-0.196	6.68	27	1.78
Leukocytes (GI/L) change from previous visit, relative to normal range	Baseline			0				0				0
	End of Treatment		0.0988	84	0.356		0.0244	82	0.354		-1.11e-17	80	0.398
	Week 2		-0.116	82	0.405		0.061	77	0.395		-0.0234	77	0.348
	Week 4		-0.0241	79	0.335		-0.0352	71	0.394		0.0451	71	0.328
	Week 6		0.00822	73	0.343		0.00161	62	0.451		0.0754	65	0.403
	Week 8		0.00972	72	0.319		0.0559	59	0.341		0.0357	56	0.394
	Week 12		-0.0409	66	0.359		-0.088	50	0.307		-0.108	50	0.39
	Week 16		0.0162	68	0.299		-0.019	42	0.353		-0.00541	37	0.378
	Week 20		0.0123	65	0.38		-0.02	30	0.309		-0.0129	31	0.27
	Week 24		0.0914	58	0.318		0.064	25	0.26		0.03	30	0.332
	Week 26		-0.0456	57	0.332		-0.12	25	0.296		-0.0222	27	0.361
Lymphocytes (GI/L)	Baseline		1.8	85	0.574		1.77	81	0.574		1.68	81	0.52
	End of Treatment	-0.0218	1.76	84	0.587	-0.0165	1.77	82	0.619	-0.0463	1.64	81	0.536
	Week 2	-0.107	1.68	83	0.505	0.0331	1.82	80	0.664	0.0387	1.74	80	0.495
	Week 4	-0.00577	1.74	79	0.558	0.0159	1.83	71	0.666	-0.0149	1.68	71	0.5
	Week 6	-0.00847	1.78	73	0.579	0.0622	1.87	62	0.636	-0.0131	1.71	64	0.485
	Week 8	-0.00169	1.76	72	0.665	0.0638	1.88	59	0.652	-0.0189	1.66	56	0.499
	Week 12	-0.0734	1.69	66	0.585	-0.0642	1.79	50	0.581	-0.0465	1.65	50	0.467
	Week 16	-0.0596	1.74	68	0.582	-0.1	1.78	42	0.626	0.0236	1.73	37	0.618
	Week 20	-0.104	1.72	65	0.501	-0.114	1.73	30	0.59	-0.0332	1.74	31	0.586
	Week 24	-0.0474	1.78	58	0.651	-0.05	1.84	25	0.557	-0.049	1.67	30	0.556
	Week 26	-0.0175	1.81	57	0.593	-0.142	1.72	25	0.623	0.113	1.79	27	0.614
Lymphocytes (GI/L) change from previous visit, relative to normal range	Baseline			0				0				0
	End of Treatment		0.0619	84	0.431		-0.0317	82	0.444		-0.0688	80	0.315
	Week 2		-0.0927	82	0.33		0.026	77	0.398		0.0377	77	0.341
	Week 4		0.0722	79	0.338		-0.0169	71	0.437		-0.0352	71	0.31
	Week 6		0.00959	73	0.419		0.0306	62	0.439		-0.00781	64	0.416
	Week 8		0.00972	72	0.355		0.0102	59	0.344		-0.0304	56	0.336
	Week 12		-0.0742	66	0.386		-0.084	50	0.329		-0.032	50	0.263
	Week 16		0.0338	68	0.374		-0.031	42	0.347		0.0459	37	0.348
	Week 20		-0.0231	65	0.396		-0.07	30	0.334		-0.0387	31	0.371
	Week 24		0.0569	58	0.449		0.108	25	0.333		-0.00667	30	0.333
	Week 26		0.0421	57	0.482		-0.144	25	0.349		0.1	27	0.382
Macrocytes change from previous visit, relative to normal range	Baseline			0				0
	End of Treatment			0				0				0
	Week 2			0				0				0
	Week 4			0				0				0
	Week 6			0				0				0
	Week 8			0				0				0
	Week 12			0				0				0
	Week 16			0				0				0
	Week 20			0				0				0
	Week 24			0				0				0
	Week 26			0				0				0
Microcytes change from previous visit, relative to normal range	End of Treatment											0
	Week 2											0
	Week 6											0
Monocytes (GI/L)	Baseline		0.435	85	0.151		0.458	81	0.162		0.429	81	0.118
	End of Treatment	0.0386	0.469	84	0.17	0.0119	0.474	82	0.168	0.0129	0.452	81	0.153
	Week 2	-0.0141	0.418	83	0.147	0.00416	0.466	80	0.163	0.00351	0.443	80	0.149
	Week 4	0.00667	0.428	79	0.12	-0.000435	0.474	71	0.17	0.00652	0.439	71	0.125
	Week 6	-0.00611	0.43	73	0.15	0.0061	0.477	62	0.187	0.0229	0.462	64	0.15
	Week 8	0.00718	0.438	72	0.143	0.0166	0.48	59	0.142	0.0218	0.47	56	0.152
	Week 12	0.0146	0.44	66	0.134	0.0121	0.468	50	0.149	-0.0224	0.437	50	0.145
	Week 16	0.0318	0.465	68	0.153	0.0303	0.468	42	0.162	0.00778	0.485	37	0.16
	Week 20	0.035	0.475	65	0.162	0.00931	0.454	30	0.132	0.00484	0.488	31	0.169
	Week 24	0.0423	0.473	58	0.166	0.0162	0.452	25	0.188	-0.0128	0.484	30	0.178
	Week 26	0.0164	0.442	57	0.142	-0.0212	0.421	25	0.17	-0.0115	0.477	27	0.143
Monocytes (GI/L) change from previous visit, relative to normal range	Baseline			0				0				0
	End of Treatment		0.0321	84	0.437		0.0244	82	0.302		-0.00375	80	0.345
	Week 2		-0.039	82	0.36		0.00909	77	0.328		0.0039	77	0.319
	Week 4		0.0291	79	0.308		0.00845	71	0.31		0.0225	71	0.298
	Week 6		0.00137	73	0.356		1.07e-17	62	0.408		0.0156	64	0.309
	Week 8		0.0236	72	0.366		0.0169	59	0.335		0.0411	56	0.322
	Week 12		0.0121	66	0.406		-0.016	50	0.334		-0.098	50	0.287
	Week 16		0.0574	68	0.451		0.0262	42	0.36		0.0919	37	0.358
	Week 20		0.0246	65	0.462		-0.0533	30	0.35		-0.00968	31	0.27
	Week 24		0.0172	58	0.412		0.056	25	0.349		-0.0133	30	0.373
	Week 26		-0.0825	57	0.361		-0.1	25	0.243		-0.0259	27	0.317
Phosphate (mmol/L)	Baseline		1.15	86	0.147		1.15	81	0.111		1.16	83	0.148
	End of Treatment	0.0142	1.17	84	0.17	0.00245	1.16	82	0.167	0.0182	1.18	80	0.157
	Week 2	0.000384	1.15	84	0.153	-0.00538	1.15	80	0.154	0.00911	1.18	78	0.176
	Week 4	-0.0118	1.14	82	0.162	-0.0328	1.13	71	0.14	-0.00269	1.17	72	0.18
	Week 6	0.0418	1.18	75	0.147	0.00365	1.16	64	0.171	-0.00723	1.17	67	0.154
	Week 8	0.00398	1.14	73	0.142	-0.00612	1.15	60	0.162	-0.0138	1.15	56	0.161
	Week 12	0.0217	1.17	67	0.164	-0.0342	1.12	52	0.143	-0.0207	1.15	50	0.154
	Week 16	-0.00285	1.14	68	0.135	-0.025	1.11	42	0.171	0.00611	1.17	37	0.171
	Week 20	0.0129	1.16	65	0.168	0.0194	1.14	31	0.131	-0.024	1.16	31	0.15
	Week 24	0.03	1.17	56	0.153	0.0534	1.17	27	0.192	-0.0226	1.15	30	0.169
	Week 26	0.0147	1.15	57	0.148	0.0121	1.13	25	0.167	0.0299	1.21	27	0.193
Phosphate (mmol/L) change from previous visit, relative to normal range	Baseline			0				0				0
	End of Treatment		0.0369	84	0.391		0.0346	81	0.307		0.0463	80	0.37
	Week 2		0.00238	84	0.346		-0.0115	78	0.338		0.0167	78	0.387
	Week 4		-0.0171	82	0.332		-0.0514	70	0.323		-0.00139	72	0.34
	Week 6		0.0733	75	0.286		0.0625	64	0.293		-0.00896	67	0.36
	Week 8		-0.0671	73	0.337		-0.0117	60	0.401		0.0143	56	0.368
	Week 12		0.0358	67	0.31		-0.0481	52	0.352		0.022	50	0.367
	Week 16		-0.0382	68	0.335		0.019	42	0.344		0.0595	37	0.318
	Week 20		0.0308	65	0.391		0.0129	31	0.253		-0.0581	31	0.41
	Week 24		0.025	56	0.396		0.0667	27	0.294		0.01	30	0.351
	Week 26		-0.0281	57	0.339		-0.112	25	0.257		0.0815	27	0.447
Platelet (GI/L)	Baseline		250	84	65.5		234	79	58.6		228	81	54.7
	End of Treatment	-8.48	242	84	59.5	1.09	237	82	63.6	4.05	234	81	60.8
	Week 2	-4.38	246	83	57.5	9.11	247	78	59.4	8.44	238	80	59.8
	Week 4	-7.35	244	78	54.3	5.69	239	70	57.8	9.79	238	70	49.6
	Week 6	-3.35	251	73	59	3.54	238	62	55.7	9.21	239	63	56.8
	Week 8	-6.15	246	72	66.6	5.11	245	59	60.2	11	237	55	70.9
	Week 12	-12.8	242	65	53.7	1.94	239	50	49.5	9.08	236	49	53
	Week 16	-13.7	242	68	55.6	2.78	244	41	57.6	5.28	231	37	58
	Week 20	-8.36	248	65	60.7	7.29	241	30	64.1	2.33	235	30	65.5
	Week 24	-11.3	239	57	51.9	1.82	250	24	63.4	4.5	238	29	67.5
	Week 26	-2.73	248	56	60.1	-1.91	241	25	57.2	0.308	237	27	67.1
Platelet (GI/L) change from previous visit, relative to normal range	Baseline			0				0				0
	End of Treatment		-0.019	84	0.215		0.00122	82	0.283		-0.0313	80	0.259
	Week 2		-0.0329	82	0.279		0.0716	74	0.353		0.0636	77	0.242
	Week 4		-0.0231	78	0.243		-0.0493	69	0.269		-2.78e-18	70	0.191
	Week 6		0.0466	73	0.263		-0.0274	62	0.214		-0.0143	63	0.221
	Week 8		-0.0125	72	0.271		0.0407	59	0.245		-0.00545	55	0.382
	Week 12		-0.0523	65	0.265		-0.064	50	0.221		-0.0388	49	0.313
	Week 16		-0.00441	68	0.228		0.0317	41	0.239		-0.0135	37	0.18
	Week 20		0.0354	65	0.271		-0.0367	30	0.343		-0.0233	30	0.199
	Week 24		-0.0368	57	0.19		0.0333	24	0.214		0.0069	29	0.207
	Week 26		0.0643	56	0.245		-0.028	25	0.256		0.00741	27	0.234
Poikilocytes change from previous visit, relative to normal range	End of Treatment			0								0
	Week 2			0								0
Polychromasia change from previous visit, relative to normal range	Baseline			0				0				0
	End of Treatment			0				0				0
	Week 2							0				0
	Week 4			0				0				0
	Week 6			0				0				0
	Week 8			0								0
	Week 12			0
	Week 16							0
	Week 20			0				0				0
	Week 24			0								0
	Week 26			0
Potassium (mmol/L)	Baseline		4.25	86	0.425		4.33	81	0.34		4.31	82	0.406
	End of Treatment	0.0262	4.28	84	0.428	-0.0544	4.28	82	0.432	-0.0911	4.21	80	0.364
	Week 2	-0.0131	4.24	84	0.411	-0.0167	4.31	80	0.407	-0.0461	4.26	77	0.401
	Week 4	-0.0573	4.19	82	0.372	-0.0824	4.27	71	0.403	-0.0507	4.21	72	0.374
	Week 6	0.0453	4.29	75	0.33	-0.0758	4.29	64	0.388	-0.0879	4.19	67	0.316
	Week 8	-0.0521	4.18	73	0.372	-0.0397	4.33	60	0.394	-0.0268	4.25	56	0.388
	Week 12	-0.0134	4.23	67	0.405	-0.186	4.18	52	0.42	-0.0735	4.21	49	0.256
	Week 16	-0.0103	4.24	68	0.408	-0.0775	4.28	42	0.327	0.0135	4.28	37	0.273
	Week 20	0.0344	4.28	64	0.462	-0.02	4.27	31	0.362	0.0355	4.31	31	0.37
	Week 24	0.0661	4.29	56	0.442	-0.0231	4.29	27	0.412	-0.0233	4.24	30	0.424
	Week 26	0.0474	4.24	57	0.376	-0.0417	4.28	25	0.399	0.0148	4.29	27	0.389
Potassium (mmol/L) change from previous visit, relative to normal range	Baseline			0				0				0
	End of Treatment		0.0214	84	0.397		0.0111	81	0.428		-0.0775	80	0.413
	Week 2		-0.0131	84	0.368		-0.0167	78	0.382		-0.0461	76	0.462
	Week 4		-0.0439	82	0.293		-0.0543	70	0.375		-0.0569	72	0.404
	Week 6		0.0893	75	0.378		0.0219	64	0.405		-0.0284	67	0.32
	Week 8		-0.0986	73	0.372		0.0483	60	0.413		0.05	56	0.421
	Week 12		0.0358	67	0.362		-0.152	52	0.406		-0.0286	49	0.412
	Week 16		0.0103	68	0.477		0.126	42	0.325		0.0811	37	0.337
	Week 20		0.0391	64	0.401		-0.0355	31	0.334		0.00645	31	0.381
	Week 24		0.0321	56	0.395		0.0111	27	0.425		-0.08	30	0.451
	Week 26		-0.00526	57	0.34		-0.028	25	0.395		0.0296	27	0.452
Protein (g/L)	Baseline		70.5	86	4.72		70.4	82	4.29		71	84	4.24
	End of Treatment	-0.345	70.2	84	4.26	-0.412	70.1	82	4.95	-0.675	70.4	80	3.91
	Week 2	-1.29	69.2	84	4.93	-0.885	69.5	80	4.48	-1.58	69.5	78	4.31
	Week 4	-1.57	69	82	4.18	-1.46	68.8	72	4.3	-1.42	69.8	72	4.54
	Week 6	-1.16	69.6	75	3.95	-1.27	68.8	64	4.33	-1.13	70.2	67	4.28
	Week 8	-0.356	70.5	73	5.2	-0.862	69.2	60	3.95	-1.0	70.6	56	3.78
	Week 12	-0.612	70	67	4.28	-0.78	69.3	52	4.98	-1.04	70.4	50	3.83
	Week 16	0.382	71.2	68	4.57	-0.5	69.3	42	4.79	-0.973	70.5	37	4.93
	Week 20	-1.06	70	66	4.92	-1.33	68.7	31	4.82	-1.81	69.5	31	4.15
	Week 24	-0.754	70.1	57	4.33	0.692	70.9	27	6.11	-0.733	70.7	30	3.47
	Week 26	-0.491	70.4	57	4.48	-1.12	69.4	25	5.29	-2.52	69.4	27	4.89
Protein (g/L) change from previous visit, relative to normal range	Baseline			0				0				0
	End of Treatment		0.0845	84	0.407		0.0463	82	0.4		0.0162	80	0.389
	Week 2		-0.127	84	0.453		-0.0872	78	0.362		-0.154	78	0.389
	Week 4		-0.0232	82	0.377		-0.0764	72	0.364		0.0125	72	0.424
	Week 6		0.0453	75	0.386		0.0203	64	0.334		0.0343	67	0.477
	Week 8		0.0986	73	0.398		0.0583	60	0.323		0.0375	56	0.385
	Week 12		-0.0418	67	0.42		0.0154	52	0.321		0.008	50	0.35
	Week 16		0.119	68	0.437		0.0167	42	0.366		-0.00541	37	0.458
	Week 20		-0.142	66	0.417		-0.0903	31	0.352		-0.0742	31	0.305
	Week 24		0.0596	57	0.452		0.23	27	0.379		0.117	30	0.277
	Week 26		0.0316	57	0.398		-0.168	25	0.403		-0.133	27	0.389
Sodium (mmol/L)	Baseline		140	86	2.74		140	82	2.61		140	83	3.11
	End of Treatment	1.13	142	84	2.74	1.29	141	82	2.65	0.544	140	80	3.22
	Week 2	-0.0238	140	84	2.62	-0.308	140	80	2.47	-0.579	139	77	2.74
	Week 4	-0.39	140	82	2.74	0.243	140	72	2.4	-0.324	140	72	2.75
	Week 6	0.04	140	75	2.58	0.823	141	64	2.69	-0.152	140	67	2.61
	Week 8	0.425	141	73	2.48	0.569	140	60	2.58	0.286	140	56	3.15
	Week 12	0.179	140	67	2.39	1.06	141	52	2.77	-0.0612	140	49	2.39
	Week 16	0.897	141	68	2.37	1.23	141	42	2.62	1.43	142	37	2.96
	Week 20	1.08	141	65	2.53	1.6	141	31	2.53	1.23	142	31	3.87
	Week 24	1.61	142	57	2.23	1.19	142	27	2.12	0.967	142	30	2.99
	Week 26	2.53	143	57	2.25	1.88	142	25	2.08	1.85	142	27	3.07
Sodium (mmol/L) change from previous visit, relative to normal range	Baseline			0				0				0
	End of Treatment		0.0845	84	0.592		0.145	82	0.564		0.0512	80	0.709
	Week 2		-0.00714	84	0.669		-0.0654	78	0.565		-0.114	76	0.558
	Week 4		-0.0585	82	0.524		0.114	72	0.587		0.0611	72	0.633
	Week 6		0.0653	75	0.561		0.0812	64	0.572		0.0746	67	0.682
	Week 8		0.0781	73	0.555		-0.0383	60	0.573		0.05	56	0.606
	Week 12		-0.0463	67	0.534		0.175	52	0.548		0.0143	49	0.534
	Week 16		0.126	68	0.538		0.0595	42	0.562		0.214	37	0.497
	Week 20		0.0338	65	0.49		0.0484	31	0.523		0.00323	31	0.72
	Week 24		0.1	57	0.599		0.0259	27	0.47		-0.0933	30	0.772
	Week 26		0.186	57	0.573		0.124	25	0.604		0.167	27	0.454
Urate (umol/L)	Baseline		285	86	74.4		301	82	77.8		302	84	78
	End of Treatment	4.74	291	84	73.9	-3.12	298	82	80.5	-10.5	292	80	80.8
	Week 2	-1.77	284	84	68.7	0.991	306	80	74.2	-2.67	302	78	82
	Week 4	-0.58	286	82	69.2	-3.74	300	72	79.4	-9.5	291	72	79.3
	Week 6	-1.11	288	75	68.7	-6.24	298	64	74.5	-9.77	292	67	74.8
	Week 8	-5.05	286	73	65.6	-15.6	291	60	71.2	-11.2	292	56	76.8
	Week 12	3.2	291	67	70.1	-11.5	290	52	63.2	-9.04	294	50	78.8
	Week 16	-3.59	286	68	68.7	-12.9	289	42	58.8	-19.9	284	37	80.5
	Week 20	12.1	302	66	73.4	-16.5	280	31	58.7	-9.59	295	31	85.9
	Week 24	4.59	294	57	73.5	-19.2	275	27	57.7	-19.4	288	30	88.4
	Week 26	5.11	292	57	74.4	-13.6	279	25	60	-12.6	301	27	86.3
Urate (umol/L) change from previous visit, relative to normal range	Baseline			0				0				0
	End of Treatment		0.00476	84	0.254		0.0293	82	0.257		-0.0275	80	0.244
	Week 2		-0.0107	84	0.333		0.00256	78	0.274		-0.0205	78	0.231
	Week 4		0.011	82	0.265		-0.0167	72	0.259		-0.0431	72	0.25
	Week 6		-0.00133	75	0.216		-0.0141	64	0.24		0.00597	67	0.226
	Week 8		-0.0452	73	0.217		-0.0567	60	0.211		-0.00714	56	0.193
	Week 12		0.0433	67	0.23		0.0365	52	0.169		0.022	50	0.183
	Week 16		-0.05	68	0.222		-0.00476	42	0.236		-0.0595	37	0.185
	Week 20		0.114	66	0.281		0.0419	31	0.236		0.0581	31	0.209
	Week 24		-0.0298	57	0.252		-2.06e-18	27	0.217		-0.05	30	0.235
	Week 26		-0.0263	57	0.256		0.064	25	0.191		0.0593	27	0.231

TABLE 11

Data Preparation - Table 11

adlbc2 = insertcols(copy(adlbc), :ORIG => fill("CHEMISTRY", nrow(adlbc)))
adlbh2 = insertcols(copy(adlbh), :ORIG => fill("HEMATOLOGY", nrow(adlbh)))
adlb = vcat(adlbc2, adlbh2)

adlb = @chain adlb begin
    @rsubset coalesce(:SAFFL == "Y", false) &&
             coalesce(:ANL01FL == "Y", false) &&
             coalesce(:AVISITN != 99, false) &&
             !ismissing(:PARAM) &&
             !ismissing(:TRTA) &&
             !ismissing(:LBNRIND) &&
             :LBNRIND in ["LOW", "NORMAL", "HIGH"] &&
             (!ismissing(:PARAMCD) && !coalesce(startswith(:PARAMCD, "_"), false))
    @select :ORIG :PARCAT1 :PARAM :PARAMCD :USUBJID :TRTA :AVISIT :AVISITN :AVAL :CHG :LBNRIND
    @transform :TRTA = recode(categorical(:TRTA),
        "Xanomeline Low Dose" => "Low Dose",
        "Xanomeline High Dose" => "High Dose"
    )
    @transform :TRTA = categorical(:TRTA, levels = ["Placebo", "Low Dose", "High Dose"], ordered = true)
    @transform :LBNRIND = recode(categorical(:LBNRIND),
                    "LOW" => "Low",
                    "NORMAL" => "Normal",
                    "HIGH" => "High")
    @rtransform :PARAM = replace(:PARAM, r"\(.*?\)" => "") |> strip
end

7388×11 DataFrame

7363 rows omitted

Row	ORIG	PARCAT1	PARAM	PARAMCD	USUBJID	TRTA	AVISIT	AVISITN	AVAL	CHG	LBNRIND
	String	String7	SubStrin…	String15	String15	Cat…	String31	Float64	Float64?	Float64?	Cat…
1	CHEMISTRY	CHEM	Alanine Aminotransferase	ALT	01-701-1015	Placebo	Week 2	2.0	41.0	14.0	High
2	CHEMISTRY	CHEM	Alkaline Phosphatase	ALP	01-701-1015	Placebo	Week 4	4.0	41.0	7.0	Normal
3	CHEMISTRY	CHEM	Blood Urea Nitrogen	BUN	01-701-1015	Placebo	Week 4	4.0	2.856	-0.714	Normal
4	CHEMISTRY	CHEM	Creatinine	CREAT	01-701-1015	Placebo	Week 4	4.0	70.72	-8.84	Normal
5	CHEMISTRY	CHEM	Glucose	GLUC	01-701-1015	Placebo	Week 4	4.0	4.38529	-0.33306	Normal
6	CHEMISTRY	CHEM	Cholesterol	CHOL	01-701-1015	Placebo	Week 4	4.0	4.99098	-0.95682	Normal
7	CHEMISTRY	CHEM	Bilirubin	BILI	01-701-1015	Placebo	Week 6	6.0	5.13	-5.13	Normal
8	CHEMISTRY	CHEM	Gamma Glutamyl Transferase	GGT	01-701-1015	Placebo	Week 6	6.0	14.0	-1.0	Normal
9	CHEMISTRY	CHEM	Albumin	ALB	01-701-1015	Placebo	Week 6	6.0	37.0	-1.0	Normal
10	CHEMISTRY	CHEM	Sodium	SODIUM	01-701-1015	Placebo	Week 12	12.0	139.0	-1.0	Normal
11	CHEMISTRY	CHEM	Potassium	K	01-701-1015	Placebo	Week 12	12.0	3.6	-0.9	Normal
12	CHEMISTRY	CHEM	Chloride	CL	01-701-1015	Placebo	Week 12	12.0	99.0	-7.0	Normal
13	CHEMISTRY	CHEM	Urate	URATE	01-701-1015	Placebo	Week 16	16.0	255.764	-11.896	Normal
⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮
7377	HEMATOLOGY	HEM	Hematocrit	HCT	01-718-1427	High Dose	Week 2	2.0	0.36	-0.05	Normal
7378	HEMATOLOGY	HEM	Leukocytes	WBC	01-718-1427	High Dose	Week 2	2.0	2.8	-0.81	Low
7379	HEMATOLOGY	HEM	Monocytes	MONO	01-718-1427	High Dose	Week 2	2.0	0.34	0.2	Normal
7380	HEMATOLOGY	HEM	Eosinophils	EOS	01-718-1427	High Dose	Week 2	2.0	0.08	-0.21	Normal
7381	HEMATOLOGY	HEM	Ery. Mean Corpuscular HGB Concentration	MCHC	01-718-1427	High Dose	Week 4	4.0	19.8592	1.2412	Normal
7382	HEMATOLOGY	HEM	Lymphocytes	LYM	01-718-1427	High Dose	Week 4	4.0	0.6	-0.74	Low
7383	HEMATOLOGY	HEM	Basophils	BASO	01-718-1427	High Dose	Week 4	4.0	0.01	0.01	Normal
7384	HEMATOLOGY	HEM	Platelet	PLAT	01-718-1427	High Dose	Week 4	4.0	192.0	-21.0	Normal
7385	HEMATOLOGY	HEM	Hemoglobin	HGB	01-718-1427	High Dose	Week 6	6.0	7.4472	-0.06206	Normal
7386	HEMATOLOGY	HEM	Erythrocytes	RBC	01-718-1427	High Dose	Week 6	6.0	3.9	-0.2	Normal
7387	HEMATOLOGY	HEM	Ery. Mean Corpuscular Volume	MCV	01-718-1427	High Dose	Week 8	8.0	89.0	-10.0	Normal
7388	HEMATOLOGY	HEM	Ery. Mean Corpuscular Hemoglobin )	MCH	01-718-1427	High Dose	Week 8	8.0	1.8618	0.0	Normal

Data wrangling

adlb_cross = @chain adlb begin
    groupby([:ORIG, :PARAM, :TRTA, :LBNRIND])
    @combine :N = length(:LBNRIND)
    unstack(:LBNRIND, :N, fill=0)
    @rtransform :Total = coalesce(:Low, 0) + coalesce(:Normal, 0) + coalesce(:High, 0)
    @rtransform :LowP = round(100 * coalesce(:Low, 0) / :Total, digits=1)
    @rtransform :NormalP = round(100 * coalesce(:Normal, 0) / :Total, digits=1)
    @rtransform :HighP = round(100 * coalesce(:High, 0) / :Total, digits=1)
end

90×10 DataFrame

65 rows omitted

Row	ORIG	PARAM	TRTA	High	Normal	Low	Total	LowP	NormalP	HighP
	String	SubStrin…	Cat…	Int64	Int64	Int64	Int64	Float64	Float64	Float64
1	CHEMISTRY	Alanine Aminotransferase	Placebo	9	74	1	84	1.2	88.1	10.7
2	CHEMISTRY	Alkaline Phosphatase	Placebo	8	72	4	84	4.8	85.7	9.5
3	CHEMISTRY	Blood Urea Nitrogen	Placebo	9	75	0	84	0.0	89.3	10.7
4	CHEMISTRY	Creatinine	Placebo	4	80	0	84	0.0	95.2	4.8
5	CHEMISTRY	Glucose	Placebo	2	82	0	84	0.0	97.6	2.4
6	CHEMISTRY	Cholesterol	Placebo	6	73	5	84	6.0	86.9	7.1
7	CHEMISTRY	Bilirubin	Placebo	6	78	0	84	0.0	92.9	7.1
8	CHEMISTRY	Gamma Glutamyl Transferase	Placebo	7	73	4	84	4.8	86.9	8.3
9	CHEMISTRY	Albumin	Placebo	3	65	16	84	19.0	77.4	3.6
10	CHEMISTRY	Sodium	Placebo	5	75	4	84	4.8	89.3	6.0
11	CHEMISTRY	Potassium	Placebo	1	80	3	84	3.6	95.2	1.2
12	CHEMISTRY	Chloride	Placebo	10	74	0	84	0.0	88.1	11.9
13	CHEMISTRY	Urate	Placebo	4	77	3	84	3.6	91.7	4.8
⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮
79	HEMATOLOGY	Hemoglobin	Low Dose	0	72	10	82	12.2	87.8	0.0
80	HEMATOLOGY	Hematocrit	Low Dose	1	72	9	82	11.0	87.8	1.2
81	HEMATOLOGY	Ery. Mean Corpuscular HGB Concentration	Low Dose	0	65	17	82	20.7	79.3	0.0
82	HEMATOLOGY	Leukocytes	Low Dose	8	68	6	82	7.3	82.9	9.8
83	HEMATOLOGY	Eosinophils	Low Dose	11	71	0	82	0.0	86.6	13.4
84	HEMATOLOGY	Erythrocytes	Low Dose	0	64	18	82	22.0	78.0	0.0
85	HEMATOLOGY	Ery. Mean Corpuscular Volume	Low Dose	18	64	0	82	0.0	78.0	22.0
86	HEMATOLOGY	Ery. Mean Corpuscular Hemoglobin )	Low Dose	1	81	0	82	0.0	98.8	1.2
87	HEMATOLOGY	Lymphocytes	Low Dose	9	69	4	82	4.9	84.1	11.0
88	HEMATOLOGY	Monocytes	Low Dose	4	77	1	82	1.2	93.9	4.9
89	HEMATOLOGY	Basophils	Low Dose	0	82	0	82	0.0	100.0	0.0
90	HEMATOLOGY	Platelet	Low Dose	3	77	2	82	2.4	93.9	3.7

Data wrangling

adlb_summary = @chain adlb begin
    groupby([:ORIG, :TRTA, :LBNRIND, :PARAM])
    @combine :N = length(:LBNRIND)
    unstack(:LBNRIND, :N, fill=0)
    @rtransform :Total = coalesce(:Low, 0) + coalesce(:Normal, 0) + coalesce(:High, 0)
end

90×7 DataFrame

65 rows omitted

Row	ORIG	TRTA	PARAM	High	Normal	Low	Total
	String	Cat…	SubStrin…	Int64	Int64	Int64	Int64
1	CHEMISTRY	Placebo	Alanine Aminotransferase	9	74	1	84
2	CHEMISTRY	Placebo	Alkaline Phosphatase	8	72	4	84
3	CHEMISTRY	Placebo	Blood Urea Nitrogen	9	75	0	84
4	CHEMISTRY	Placebo	Creatinine	4	80	0	84
5	CHEMISTRY	Placebo	Glucose	2	82	0	84
6	CHEMISTRY	Placebo	Cholesterol	6	73	5	84
7	CHEMISTRY	Placebo	Bilirubin	6	78	0	84
8	CHEMISTRY	Placebo	Gamma Glutamyl Transferase	7	73	4	84
9	CHEMISTRY	Placebo	Albumin	3	65	16	84
10	CHEMISTRY	Placebo	Sodium	5	75	4	84
11	CHEMISTRY	Placebo	Potassium	1	80	3	84
12	CHEMISTRY	Placebo	Chloride	10	74	0	84
13	CHEMISTRY	Placebo	Urate	4	77	3	84
⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮
79	HEMATOLOGY	Low Dose	Hemoglobin	0	72	10	82
80	HEMATOLOGY	Low Dose	Hematocrit	1	72	9	82
81	HEMATOLOGY	Low Dose	Ery. Mean Corpuscular HGB Concentration	0	65	17	82
82	HEMATOLOGY	Low Dose	Leukocytes	8	68	6	82
83	HEMATOLOGY	Low Dose	Eosinophils	11	71	0	82
84	HEMATOLOGY	Low Dose	Erythrocytes	0	64	18	82
85	HEMATOLOGY	Low Dose	Ery. Mean Corpuscular Volume	18	64	0	82
86	HEMATOLOGY	Low Dose	Ery. Mean Corpuscular Hemoglobin )	1	81	0	82
87	HEMATOLOGY	Low Dose	Lymphocytes	9	69	4	82
88	HEMATOLOGY	Low Dose	Monocytes	4	77	1	82
89	HEMATOLOGY	Low Dose	Basophils	0	82	0	82
90	HEMATOLOGY	Low Dose	Platelet	3	77	2	82

Data wrangling

tbl_final = @chain adlb_summary begin
    select(:ORIG, :TRTA, :PARAM, :Low, :Normal, :High, :Total)
    stack([:Low, :Normal, :High], variable_name = :Category, value_name = :Count)
    @rtransform :Percent = if :Total > 0
        string(:Count, " (", round(100 * :Count / :Total, digits=1), "%)")
    else
        "0 (0%)"
    end
end

270×7 DataFrame

245 rows omitted

Row	ORIG	TRTA	PARAM	Total	Category	Count	Percent
	String	Cat…	SubStrin…	Int64	String	Int64	String
1	CHEMISTRY	Placebo	Alanine Aminotransferase	84	Low	1	1 (1.2%)
2	CHEMISTRY	Placebo	Alkaline Phosphatase	84	Low	4	4 (4.8%)
3	CHEMISTRY	Placebo	Blood Urea Nitrogen	84	Low	0	0 (0.0%)
4	CHEMISTRY	Placebo	Creatinine	84	Low	0	0 (0.0%)
5	CHEMISTRY	Placebo	Glucose	84	Low	0	0 (0.0%)
6	CHEMISTRY	Placebo	Cholesterol	84	Low	5	5 (6.0%)
7	CHEMISTRY	Placebo	Bilirubin	84	Low	0	0 (0.0%)
8	CHEMISTRY	Placebo	Gamma Glutamyl Transferase	84	Low	4	4 (4.8%)
9	CHEMISTRY	Placebo	Albumin	84	Low	16	16 (19.0%)
10	CHEMISTRY	Placebo	Sodium	84	Low	4	4 (4.8%)
11	CHEMISTRY	Placebo	Potassium	84	Low	3	3 (3.6%)
12	CHEMISTRY	Placebo	Chloride	84	Low	0	0 (0.0%)
13	CHEMISTRY	Placebo	Urate	84	Low	3	3 (3.6%)
⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮
259	HEMATOLOGY	Low Dose	Hemoglobin	82	High	0	0 (0.0%)
260	HEMATOLOGY	Low Dose	Hematocrit	82	High	1	1 (1.2%)
261	HEMATOLOGY	Low Dose	Ery. Mean Corpuscular HGB Concentration	82	High	0	0 (0.0%)
262	HEMATOLOGY	Low Dose	Leukocytes	82	High	8	8 (9.8%)
263	HEMATOLOGY	Low Dose	Eosinophils	82	High	11	11 (13.4%)
264	HEMATOLOGY	Low Dose	Erythrocytes	82	High	0	0 (0.0%)
265	HEMATOLOGY	Low Dose	Ery. Mean Corpuscular Volume	82	High	18	18 (22.0%)
266	HEMATOLOGY	Low Dose	Ery. Mean Corpuscular Hemoglobin )	82	High	1	1 (1.2%)
267	HEMATOLOGY	Low Dose	Lymphocytes	82	High	9	9 (11.0%)
268	HEMATOLOGY	Low Dose	Monocytes	82	High	4	4 (4.9%)
269	HEMATOLOGY	Low Dose	Basophils	82	High	0	0 (0.0%)
270	HEMATOLOGY	Low Dose	Platelet	82	High	3	3 (3.7%)

		Treatment
		Placebo			Low Dose			High Dose
		Lab Status			Lab Status			Lab Status
		High	Low	Normal	High	Low	Normal	High	Low	Normal
		Percent
CHEMISTRY	Alanine Aminotransferase	9 (10.7%)	1 (1.2%)	74 (88.1%)	9 (11.0%)	5 (6.1%)	68 (82.9%)	10 (12.5%)	0 (0.0%)	70 (87.5%)
	Albumin	3 (3.6%)	16 (19.0%)	65 (77.4%)	1 (1.2%)	15 (18.3%)	66 (80.5%)	1 (1.2%)	5 (6.2%)	74 (92.5%)
	Alkaline Phosphatase	8 (9.5%)	4 (4.8%)	72 (85.7%)	6 (7.3%)	2 (2.4%)	74 (90.2%)	4 (5.0%)	3 (3.8%)	73 (91.2%)
	Aspartate Aminotransferase	10 (11.9%)	0 (0.0%)	74 (88.1%)	10 (12.2%)	0 (0.0%)	72 (87.8%)	8 (10.0%)	0 (0.0%)	72 (90.0%)
	Bilirubin	6 (7.1%)	0 (0.0%)	78 (92.9%)	2 (2.5%)	0 (0.0%)	79 (97.5%)	5 (6.2%)	0 (0.0%)	75 (93.8%)
	Blood Urea Nitrogen	9 (10.7%)	0 (0.0%)	75 (89.3%)	22 (26.8%)	0 (0.0%)	60 (73.2%)	12 (15.0%)	0 (0.0%)	68 (85.0%)
	Calcium	1 (1.2%)	5 (6.0%)	78 (92.9%)	3 (3.7%)	7 (8.5%)	72 (87.8%)	2 (2.5%)	7 (8.8%)	71 (88.8%)
	Chloride	10 (11.9%)	0 (0.0%)	74 (88.1%)	8 (9.8%)	0 (0.0%)	74 (90.2%)	2 (2.5%)	0 (0.0%)	78 (97.5%)
	Cholesterol	6 (7.1%)	5 (6.0%)	73 (86.9%)	4 (4.9%)	6 (7.3%)	72 (87.8%)	4 (5.0%)	6 (7.5%)	70 (87.5%)
	Creatine Kinase	17 (20.2%)	1 (1.2%)	66 (78.6%)	13 (15.9%)	1 (1.2%)	68 (82.9%)	13 (16.2%)	0 (0.0%)	67 (83.8%)
	Creatinine	4 (4.8%)	0 (0.0%)	80 (95.2%)	6 (7.3%)	0 (0.0%)	76 (92.7%)	7 (8.8%)	0 (0.0%)	73 (91.2%)
	Gamma Glutamyl Transferase	7 (8.3%)	4 (4.8%)	73 (86.9%)	9 (11.0%)	4 (4.9%)	69 (84.1%)	8 (10.0%)	1 (1.2%)	71 (88.8%)
	Glucose	2 (2.4%)	0 (0.0%)	82 (97.6%)	1 (1.2%)	0 (0.0%)	81 (98.8%)	3 (3.8%)	0 (0.0%)	77 (96.2%)
	Phosphate	0 (0.0%)	1 (1.2%)	83 (98.8%)	2 (2.4%)	0 (0.0%)	80 (97.6%)	1 (1.2%)	1 (1.2%)	78 (97.5%)
	Potassium	1 (1.2%)	3 (3.6%)	80 (95.2%)	0 (0.0%)	3 (3.7%)	79 (96.3%)	0 (0.0%)	2 (2.5%)	78 (97.5%)
	Protein	7 (8.3%)	1 (1.2%)	76 (90.5%)	5 (6.1%)	2 (2.4%)	75 (91.5%)	2 (2.5%)	1 (1.2%)	77 (96.2%)
	Sodium	5 (6.0%)	4 (4.8%)	75 (89.3%)	5 (6.1%)	3 (3.7%)	74 (90.2%)	11 (13.8%)	7 (8.8%)	62 (77.5%)
	Urate	4 (4.8%)	3 (3.6%)	77 (91.7%)	6 (7.3%)	1 (1.2%)	75 (91.5%)	7 (8.8%)	4 (5.0%)	69 (86.2%)
HEMATOLOGY	Basophils	0 (0.0%)	0 (0.0%)	84 (100.0%)	0 (0.0%)	0 (0.0%)	82 (100.0%)	0 (0.0%)	0 (0.0%)	81 (100.0%)
	Eosinophils	0 (0.0%)	0 (0.0%)	84 (100.0%)	11 (13.4%)	0 (0.0%)	71 (86.6%)	7 (8.6%)	0 (0.0%)	74 (91.4%)
	Ery. Mean Corpuscular HGB Concentration	0 (0.0%)	15 (18.1%)	68 (81.9%)	0 (0.0%)	17 (20.7%)	65 (79.3%)	0 (0.0%)	9 (11.1%)	72 (88.9%)
	Ery. Mean Corpuscular Hemoglobin )	3 (3.6%)	0 (0.0%)	81 (96.4%)	1 (1.2%)	0 (0.0%)	81 (98.8%)	5 (6.2%)	1 (1.2%)	75 (92.6%)
	Ery. Mean Corpuscular Volume	29 (34.9%)	1 (1.2%)	53 (63.9%)	18 (22.0%)	0 (0.0%)	64 (78.0%)	16 (19.8%)	1 (1.2%)	64 (79.0%)
	Erythrocytes	0 (0.0%)	13 (15.5%)	71 (84.5%)	0 (0.0%)	18 (22.0%)	64 (78.0%)	2 (2.5%)	11 (13.6%)	68 (84.0%)
	Hematocrit	4 (4.8%)	5 (6.0%)	74 (89.2%)	1 (1.2%)	9 (11.0%)	72 (87.8%)	2 (2.5%)	1 (1.2%)	78 (96.3%)
	Hemoglobin	2 (2.4%)	14 (16.7%)	68 (81.0%)	0 (0.0%)	10 (12.2%)	72 (87.8%)	3 (3.7%)	5 (6.2%)	73 (90.1%)
	Leukocytes	4 (4.8%)	7 (8.3%)	73 (86.9%)	8 (9.8%)	6 (7.3%)	68 (82.9%)	3 (3.7%)	4 (4.9%)	74 (91.4%)
	Lymphocytes	5 (6.0%)	6 (7.1%)	73 (86.9%)	9 (11.0%)	4 (4.9%)	69 (84.1%)	1 (1.2%)	4 (4.9%)	76 (93.8%)
	Monocytes	2 (2.4%)	2 (2.4%)	80 (95.2%)	4 (4.9%)	1 (1.2%)	77 (93.9%)	2 (2.5%)	0 (0.0%)	79 (97.5%)
	Platelet	3 (3.6%)	0 (0.0%)	81 (96.4%)	3 (3.7%)	2 (2.4%)	77 (93.9%)	2 (2.5%)	2 (2.5%)	77 (95.1%)

TABLE 12

Data Preparation - Table 12

adlbc2 = insertcols(copy(adlbc), :ORIG => fill("CHEMISTRY", nrow(adlbc)))
adlbh2 = insertcols(copy(adlbh), :ORIG => fill("HEMATOLOGY", nrow(adlbh)))
adlb = vcat(adlbc2, adlbh2)

121185×47 DataFrame

121160 rows omitted

Row	STUDYID	SUBJID	USUBJID	TRTP	TRTPN	TRTA	TRTAN	TRTSDT	TRTEDT	AGE	AGEGR1	AGEGR1N	RACE	RACEN	SEX	COMP24FL	DSRAEFL	SAFFL	AVISIT	AVISITN	ADY	ADT	VISIT	VISITNUM	PARAM	PARAMCD	PARAMN	PARCAT1	AVAL	BASE	CHG	A1LO	A1HI	R2A1LO	R2A1HI	BR2A1LO	BR2A1HI	ANL01FL	ALBTRVAL	ANRIND	BNRIND	ABLFL	AENTMTFL	LBSEQ	LBNRIND	LBSTRESN	ORIG
	String15	String7	String15	String31	Float64	String31	Float64	Date	Date	Float64	String7	Float64	String	Float64	String3	String3	String3	String3	String31	Float64	Float64	Date	String15	Float64	String	String15	Float64	String7	Float64?	Float64?	Float64?	Float64?	Float64?	Float64?	Float64?	Float64?	Float64?	String3	Float64?	String3	String3	String3	String3	Float64	String15	Float64?	String
1	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y		Y	Baseline	0.0	-7.0	2013-12-26	SCREENING 1	1.0	Sodium (mmol/L)	SODIUM	18.0	CHEM	140.0	140.0	missing	135.0	145.0	1.03704	0.965517	1.03704	0.965517		77.5	N	N	Y		27.0	NORMAL	140.0	CHEMISTRY
2	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y		Y	Baseline	0.0	-7.0	2013-12-26	SCREENING 1	1.0	Potassium (mmol/L)	K	19.0	CHEM	4.5	4.5	missing	3.4	5.4	1.32353	0.833333	1.32353	0.833333		3.6	N	N	Y		20.0	NORMAL	4.5	CHEMISTRY
3	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y		Y	Baseline	0.0	-7.0	2013-12-26	SCREENING 1	1.0	Chloride (mmol/L)	CL	20.0	CHEM	106.0	106.0	missing	94.0	112.0	1.12766	0.946429	1.12766	0.946429		62.0	N	N	Y		12.0	NORMAL	106.0	CHEMISTRY
4	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y		Y	Baseline	0.0	-7.0	2013-12-26	SCREENING 1	1.0	Bilirubin (umol/L)	BILI	21.0	CHEM	10.26	10.26	missing	3.0	21.0	3.42	0.488571	3.42	0.488571		21.24	N	N	Y		7.0	NORMAL	10.26	CHEMISTRY
5	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y		Y	Baseline	0.0	-7.0	2013-12-26	SCREENING 1	1.0	Alkaline Phosphatase (U/L)	ALP	22.0	CHEM	34.0	34.0	missing	35.0	115.0	0.971429	0.295652	0.971429	0.295652		138.5	N	N	Y		2.0	LOW	34.0	CHEMISTRY
6	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y		Y	Baseline	0.0	-7.0	2013-12-26	SCREENING 1	1.0	Gamma Glutamyl Transferase (U/L)	GGT	23.0	CHEM	15.0	15.0	missing	5.0	50.0	3.0	0.3	3.0	0.3		60.0	N	N	Y		16.0	NORMAL	15.0	CHEMISTRY
7	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y		Y	Baseline	0.0	-7.0	2013-12-26	SCREENING 1	1.0	Alanine Aminotransferase (U/L)	ALT	24.0	CHEM	27.0	27.0	missing	6.0	34.0	4.5	0.794118	4.5	0.794118		24.0	N	N	Y		3.0	NORMAL	27.0	CHEMISTRY
8	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y		Y	Baseline	0.0	-7.0	2013-12-26	SCREENING 1	1.0	Aspartate Aminotransferase (U/L)	AST	25.0	CHEM	40.0	40.0	missing	9.0	34.0	4.44444	1.17647	4.44444	1.17647		35.5	N	N	Y		5.0	HIGH	40.0	CHEMISTRY
9	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y		Y	Baseline	0.0	-7.0	2013-12-26	SCREENING 1	1.0	Blood Urea Nitrogen (mmol/L)	BUN	26.0	CHEM	3.57	3.57	missing	1.4	8.6	2.55	0.415116	2.55	0.415116		9.33	N	N	Y		8.0	NORMAL	3.57	CHEMISTRY
10	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y		Y	Baseline	0.0	-7.0	2013-12-26	SCREENING 1	1.0	Creatinine (umol/L)	CREAT	27.0	CHEM	79.56	79.56	missing	62.0	124.0	1.28323	0.641613	1.28323	0.641613		106.44	N	N	Y		14.0	NORMAL	79.56	CHEMISTRY
11	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y		Y	Baseline	0.0	-7.0	2013-12-26	SCREENING 1	1.0	Urate (umol/L)	URATE	28.0	CHEM	267.66	267.66	missing	149.0	446.0	1.79638	0.600135	1.79638	0.600135		401.34	N	N	Y		35.0	NORMAL	267.66	CHEMISTRY
12	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y		Y	Baseline	0.0	-7.0	2013-12-26	SCREENING 1	1.0	Phosphate (mmol/L)	PHOS	29.0	CHEM	1.22702	1.22702	missing	0.71	1.65	1.7282	0.743648	1.7282	0.743648		1.24798	N	N	Y		29.0	NORMAL	1.22702	CHEMISTRY
13	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y		Y	Baseline	0.0	-7.0	2013-12-26	SCREENING 1	1.0	Calcium (mmol/L)	CA	30.0	CHEM	2.1956	2.1956	missing	2.1	2.57	1.04552	0.854319	1.04552	0.854319		1.6594	N	N	Y		9.0	NORMAL	2.1956	CHEMISTRY
⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮
121174	CDISCPILOT01	1427	01-718-1427	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	N		Y	Week 8	8.0	57.0	2013-02-11	WEEK 8	8.0	Lymphocytes (GI/L) change from previous visit, relative to normal range	_LYM	107.0	HEM	-0.4	missing	missing	missing	missing	missing	missing	missing	missing		3.62	N			Y	151.0	NORMAL	0.88	HEMATOLOGY
121175	CDISCPILOT01	1427	01-718-1427	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	N		Y	End of Treatment	99.0	57.0	2013-02-11	WEEK 8	8.0	Lymphocytes (GI/L) change from previous visit, relative to normal range	_LYM	107.0	HEM	-0.4	missing	missing	missing	missing	missing	missing	missing	missing		3.62	N			Y	151.0	NORMAL	0.88	HEMATOLOGY
121176	CDISCPILOT01	1427	01-718-1427	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	N		Y	Week 8	8.0	57.0	2013-02-11	WEEK 8	8.0	Monocytes (GI/L) change from previous visit, relative to normal range	_MONO	108.0	HEM	-0.1	missing	missing	missing	missing	missing	missing	missing	missing		1.03	N			Y	155.0	NORMAL	0.35	HEMATOLOGY
121177	CDISCPILOT01	1427	01-718-1427	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	N		Y	End of Treatment	99.0	57.0	2013-02-11	WEEK 8	8.0	Monocytes (GI/L) change from previous visit, relative to normal range	_MONO	108.0	HEM	-0.1	missing	missing	missing	missing	missing	missing	missing	missing		1.03	N			Y	155.0	NORMAL	0.35	HEMATOLOGY
121178	CDISCPILOT01	1427	01-718-1427	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	N		Y	Week 8	8.0	57.0	2013-02-11	WEEK 8	8.0	Eosinophils (GI/L) change from previous visit, relative to normal range	_EOS	109.0	HEM	-0.2	missing	missing	missing	missing	missing	missing	missing	missing		0.705	N			Y	145.0	NORMAL	0.15	HEMATOLOGY
121179	CDISCPILOT01	1427	01-718-1427	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	N		Y	End of Treatment	99.0	57.0	2013-02-11	WEEK 8	8.0	Eosinophils (GI/L) change from previous visit, relative to normal range	_EOS	109.0	HEM	-0.2	missing	missing	missing	missing	missing	missing	missing	missing		0.705	N			Y	145.0	NORMAL	0.15	HEMATOLOGY
121180	CDISCPILOT01	1427	01-718-1427	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	N		Y	Week 8	8.0	57.0	2013-02-11	WEEK 8	8.0	Basophils (GI/L) change from previous visit, relative to normal range	_BASO	110.0	HEM	-0.1	missing	missing	missing	missing	missing	missing	missing	missing		0.28	N			Y	137.0	NORMAL	0.02	HEMATOLOGY
121181	CDISCPILOT01	1427	01-718-1427	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	N		Y	End of Treatment	99.0	57.0	2013-02-11	WEEK 8	8.0	Basophils (GI/L) change from previous visit, relative to normal range	_BASO	110.0	HEM	-0.1	missing	missing	missing	missing	missing	missing	missing	missing		0.28	N			Y	137.0	NORMAL	0.02	HEMATOLOGY
121182	CDISCPILOT01	1427	01-718-1427	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	N		Y	Week 8	8.0	57.0	2013-02-11	WEEK 8	8.0	Platelet (GI/L) change from previous visit, relative to normal range	_PLAT	111.0	HEM	-0.1	missing	missing	missing	missing	missing	missing	missing	missing		384.0	N			Y	158.0	NORMAL	207.0	HEMATOLOGY
121183	CDISCPILOT01	1427	01-718-1427	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	N		Y	End of Treatment	99.0	57.0	2013-02-11	WEEK 8	8.0	Platelet (GI/L) change from previous visit, relative to normal range	_PLAT	111.0	HEM	-0.1	missing	missing	missing	missing	missing	missing	missing	missing		384.0	N			Y	158.0	NORMAL	207.0	HEMATOLOGY
121184	CDISCPILOT01	1427	01-718-1427	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	N		Y	Week 8	8.0	57.0	2013-02-11	WEEK 8	8.0	Erythrocytes (TI/L) change from previous visit, relative to normal range	_RBC	112.0	HEM	0.1	missing	missing	missing	missing	missing	missing	missing	missing		4.25	N			Y	160.0	NORMAL	4.0	HEMATOLOGY
121185	CDISCPILOT01	1427	01-718-1427	Xanomeline High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	N		Y	End of Treatment	99.0	57.0	2013-02-11	WEEK 8	8.0	Erythrocytes (TI/L) change from previous visit, relative to normal range	_RBC	112.0	HEM	0.1	missing	missing	missing	missing	missing	missing	missing	missing		4.25	N			Y	160.0	NORMAL	4.0	HEMATOLOGY

Data wrangling

lab_keep = ["Alanine Aminotransferase", "Albumin", "Basophils", "Eosinophils"]

adlb1 = @chain adlb begin
    @transform :PARAM = strip.(replace.(string.(:PARAM), r"\(.*?\)" => ""))
    @rsubset :SAFFL == "Y" &&
             :AVISITN != 99 &&
             strip(:VISIT) != "SCREENING 1" &&
             !ismissing(:VISIT) && !ismissing(:TRTA) &&
             !ismissing(:BNRIND) && !ismissing(:ANRIND) &&
             !ismissing(:PARAM) && !startswith(:PARAMCD, "_") &&
             :PARAM in lab_keep


    @transform :TRTP = recode(categorical(:TRTP),
        "Placebo" => "Placebo",
        "Xanomeline Low Dose" => "Low Dose",
        "Xanomeline High Dose" => "High Dose"
    )
    @transform :TRTP = categorical(:TRTP, levels=["Placebo", "Low Dose", "High Dose"], ordered=true)
    @transform :ANRIND = recode(categorical(:ANRIND),
        "N" => "Normal", "H" => "High")
    @transform :BNRIND = recode(categorical(:BNRIND),
        "N" => "Normal", "H" => "High")
    @rtransform :PARAM = replace(:PARAM, r"\(.*?\)" => "") |> strip
end

6054×47 DataFrame

6029 rows omitted

Row	STUDYID	SUBJID	USUBJID	TRTP	TRTPN	TRTA	TRTAN	TRTSDT	TRTEDT	AGE	AGEGR1	AGEGR1N	RACE	RACEN	SEX	COMP24FL	DSRAEFL	SAFFL	AVISIT	AVISITN	ADY	ADT	VISIT	VISITNUM	PARAM	PARAMCD	PARAMN	PARCAT1	AVAL	BASE	CHG	A1LO	A1HI	R2A1LO	R2A1HI	BR2A1LO	BR2A1HI	ANL01FL	ALBTRVAL	ANRIND	BNRIND	ABLFL	AENTMTFL	LBSEQ	LBNRIND	LBSTRESN	ORIG
	String15	String7	String15	Cat…	Float64	String31	Float64	Date	Date	Float64	String7	Float64	String	Float64	String3	String3	String3	String3	String31	Float64	Float64	Date	String15	Float64	SubStrin…	String15	Float64	String7	Float64?	Float64?	Float64?	Float64?	Float64?	Float64?	Float64?	Float64?	Float64?	String3	Float64?	Cat…	Cat…	String3	String3	Float64	String15	Float64?	String
1	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y		Y	Week 2	2.0	15.0	2014-01-16	WEEK 2	4.0	Alanine Aminotransferase	ALT	24.0	CHEM	41.0	27.0	14.0	6.0	34.0	6.83333	1.20588	4.5	0.794118	Y	38.0	Normal	Normal			41.0	HIGH	41.0	CHEMISTRY
2	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y		Y	Week 2	2.0	15.0	2014-01-16	WEEK 2	4.0	Albumin	ALB	33.0	CHEM	39.0	38.0	1.0	33.0	49.0	1.18182	0.795918	1.15152	0.77551		34.5	Normal	Normal			39.0	NORMAL	39.0	CHEMISTRY
3	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y		Y	Week 4	4.0	29.0	2014-01-30	WEEK 4	5.0	Alanine Aminotransferase	ALT	24.0	CHEM	18.0	27.0	-9.0	6.0	34.0	3.0	0.529412	4.5	0.794118		33.0	Normal	Normal			76.0	NORMAL	18.0	CHEMISTRY
4	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y		Y	Week 4	4.0	29.0	2014-01-30	WEEK 4	5.0	Albumin	ALB	33.0	CHEM	38.0	38.0	0.0	33.0	49.0	1.15152	0.77551	1.15152	0.77551		35.5	Normal	Normal			74.0	NORMAL	38.0	CHEMISTRY
5	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y		Y	Week 6	6.0	42.0	2014-02-12	WEEK 6	7.0	Alanine Aminotransferase	ALT	24.0	CHEM	26.0	27.0	-1.0	6.0	34.0	4.33333	0.764706	4.5	0.794118		25.0	Normal	Normal			106.0	NORMAL	26.0	CHEMISTRY
6	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y		Y	Week 6	6.0	42.0	2014-02-12	WEEK 6	7.0	Albumin	ALB	33.0	CHEM	37.0	38.0	-1.0	33.0	49.0	1.12121	0.755102	1.15152	0.77551	Y	36.5	Normal	Normal			104.0	NORMAL	37.0	CHEMISTRY
7	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y		Y	Week 8	8.0	63.0	2014-03-05	WEEK 8	8.0	Alanine Aminotransferase	ALT	24.0	CHEM	22.0	27.0	-5.0	6.0	34.0	3.66667	0.647059	4.5	0.794118		29.0	Normal	Normal			136.0	NORMAL	22.0	CHEMISTRY
8	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y		Y	Week 8	8.0	63.0	2014-03-05	WEEK 8	8.0	Albumin	ALB	33.0	CHEM	38.0	38.0	0.0	33.0	49.0	1.15152	0.77551	1.15152	0.77551		35.5	Normal	Normal			134.0	NORMAL	38.0	CHEMISTRY
9	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y		Y	Week 12	12.0	84.0	2014-03-26	WEEK 12	9.0	Alanine Aminotransferase	ALT	24.0	CHEM	27.0	27.0	0.0	6.0	34.0	4.5	0.794118	4.5	0.794118		24.0	Normal	Normal			166.0	NORMAL	27.0	CHEMISTRY
10	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y		Y	Week 12	12.0	84.0	2014-03-26	WEEK 12	9.0	Albumin	ALB	33.0	CHEM	38.0	38.0	0.0	33.0	49.0	1.15152	0.77551	1.15152	0.77551		35.5	Normal	Normal			164.0	NORMAL	38.0	CHEMISTRY
11	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y		Y	Week 16	16.0	126.0	2014-05-07	WEEK 16	10.0	Alanine Aminotransferase	ALT	24.0	CHEM	17.0	27.0	-10.0	6.0	34.0	2.83333	0.5	4.5	0.794118		34.0	Normal	Normal			201.0	NORMAL	17.0	CHEMISTRY
12	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y		Y	Week 16	16.0	126.0	2014-05-07	WEEK 16	10.0	Albumin	ALB	33.0	CHEM	37.0	38.0	-1.0	33.0	49.0	1.12121	0.755102	1.15152	0.77551		36.5	Normal	Normal			199.0	NORMAL	37.0	CHEMISTRY
13	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y		Y	Week 20	20.0	140.0	2014-05-21	WEEK 20	11.0	Alanine Aminotransferase	ALT	24.0	CHEM	21.0	27.0	-6.0	6.0	34.0	3.5	0.617647	4.5	0.794118		30.0	Normal	Normal			231.0	NORMAL	21.0	CHEMISTRY
⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮
6043	CDISCPILOT01	1371	01-718-1371	High Dose	81.0	Xanomeline High Dose	81.0	2013-04-26	2013-08-01	69.0	65-80	2.0	WHITE	1.0	F	N	Y	Y	Week 8	8.0	70.0	2013-07-04	WEEK 8	8.0	Eosinophils	EOS	9.0	HEM	0.3	0.2	0.1	missing	0.57	missing	0.526316	missing	0.350877		0.555	Normal	Normal			145.0	NORMAL	0.3	HEMATOLOGY
6044	CDISCPILOT01	1371	01-718-1371	High Dose	81.0	Xanomeline High Dose	81.0	2013-04-26	2013-08-01	69.0	65-80	2.0	WHITE	1.0	F	N	Y	Y	Week 8	8.0	70.0	2013-07-04	WEEK 8	8.0	Basophils	BASO	10.0	HEM	0.06	0.05	0.01	missing	0.2	missing	0.3	missing	0.25		0.24	Normal	Normal			137.0	NORMAL	0.06	HEMATOLOGY
6045	CDISCPILOT01	1371	01-718-1371	High Dose	81.0	Xanomeline High Dose	81.0	2013-04-26	2013-08-01	69.0	65-80	2.0	WHITE	1.0	F	N	Y	Y	Week 12	12.0	98.0	2013-08-01	WEEK 12	9.0	Eosinophils	EOS	9.0	HEM	0.31	0.2	0.11	missing	0.57	missing	0.54386	missing	0.350877		0.545	Normal	Normal		Y	176.0	NORMAL	0.31	HEMATOLOGY
6046	CDISCPILOT01	1371	01-718-1371	High Dose	81.0	Xanomeline High Dose	81.0	2013-04-26	2013-08-01	69.0	65-80	2.0	WHITE	1.0	F	N	Y	Y	Week 12	12.0	98.0	2013-08-01	WEEK 12	9.0	Basophils	BASO	10.0	HEM	0.04	0.05	-0.01	missing	0.2	missing	0.2	missing	0.25		0.26	Normal	Normal		Y	167.0	NORMAL	0.04	HEMATOLOGY
6047	CDISCPILOT01	1427	01-718-1427	High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	N		Y	Week 2	2.0	15.0	2012-12-31	WEEK 2	4.0	Eosinophils	EOS	9.0	HEM	0.08	0.29	-0.21	missing	0.57	missing	0.140351	missing	0.508772	Y	0.775	Normal	Normal			51.0	NORMAL	0.08	HEMATOLOGY
6048	CDISCPILOT01	1427	01-718-1427	High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	N		Y	Week 2	2.0	15.0	2012-12-31	WEEK 2	4.0	Basophils	BASO	10.0	HEM	0.03	0.0	0.03	missing	0.2	missing	0.15	missing	0.0		0.27	Normal	Normal			42.0	NORMAL	0.03	HEMATOLOGY
6049	CDISCPILOT01	1427	01-718-1427	High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	N		Y	Week 4	4.0	32.0	2013-01-17	WEEK 4	5.0	Eosinophils	EOS	9.0	HEM	0.08	0.29	-0.21	missing	0.57	missing	0.140351	missing	0.508772		0.775	Normal	Normal			85.0	NORMAL	0.08	HEMATOLOGY
6050	CDISCPILOT01	1427	01-718-1427	High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	N		Y	Week 4	4.0	32.0	2013-01-17	WEEK 4	5.0	Basophils	BASO	10.0	HEM	0.01	0.0	0.01	missing	0.2	missing	0.05	missing	0.0	Y	0.29	Normal	Normal			77.0	NORMAL	0.01	HEMATOLOGY
6051	CDISCPILOT01	1427	01-718-1427	High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	N		Y	Week 6	6.0	43.0	2013-01-28	WEEK 6	7.0	Eosinophils	EOS	9.0	HEM	0.22	0.29	-0.07	missing	0.57	missing	0.385965	missing	0.508772		0.635	Normal	Normal			115.0	NORMAL	0.22	HEMATOLOGY
6052	CDISCPILOT01	1427	01-718-1427	High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	N		Y	Week 6	6.0	43.0	2013-01-28	WEEK 6	7.0	Basophils	BASO	10.0	HEM	0.03	0.0	0.03	missing	0.2	missing	0.15	missing	0.0		0.27	Normal	Normal			107.0	NORMAL	0.03	HEMATOLOGY
6053	CDISCPILOT01	1427	01-718-1427	High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	N		Y	Week 8	8.0	57.0	2013-02-11	WEEK 8	8.0	Eosinophils	EOS	9.0	HEM	0.15	0.29	-0.14	missing	0.57	missing	0.263158	missing	0.508772		0.705	Normal	Normal		Y	145.0	NORMAL	0.15	HEMATOLOGY
6054	CDISCPILOT01	1427	01-718-1427	High Dose	81.0	Xanomeline High Dose	81.0	2012-12-17	2013-02-11	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	N		Y	Week 8	8.0	57.0	2013-02-11	WEEK 8	8.0	Basophils	BASO	10.0	HEM	0.02	0.0	0.02	missing	0.2	missing	0.1	missing	0.0		0.28	Normal	Normal		Y	137.0	NORMAL	0.02	HEMATOLOGY

Data wrangling

group_vars = [:ORIG, :PARAM, :PARAMCD, :TRTP, :VISIT]
adlb_groups = groupby(adlb1, group_vars)

GroupedDataFrame with 108 groups based on keys: ORIG, PARAM, PARAMCD, TRTP, VISIT

First Group (83 rows): ORIG = "CHEMISTRY", PARAM = "Alanine Aminotransferase", PARAMCD = "ALT", TRTP = CategoricalArrays.CategoricalValue{String, UInt32} "Placebo" (1/3), VISIT = "WEEK 2"

58 rows omitted

Row	STUDYID	SUBJID	USUBJID	TRTP	TRTPN	TRTA	TRTAN	TRTSDT	TRTEDT	AGE	AGEGR1	AGEGR1N	RACE	RACEN	SEX	COMP24FL	DSRAEFL	SAFFL	AVISIT	AVISITN	ADY	ADT	VISIT	VISITNUM	PARAM	PARAMCD	PARAMN	PARCAT1	AVAL	BASE	CHG	A1LO	A1HI	R2A1LO	R2A1HI	BR2A1LO	BR2A1HI	ANL01FL	ALBTRVAL	ANRIND	BNRIND	ABLFL	AENTMTFL	LBSEQ	LBNRIND	LBSTRESN	ORIG
	String15	String7	String15	Cat…	Float64	String31	Float64	Date	Date	Float64	String7	Float64	String	Float64	String3	String3	String3	String3	String31	Float64	Float64	Date	String15	Float64	SubStrin…	String15	Float64	String7	Float64?	Float64?	Float64?	Float64?	Float64?	Float64?	Float64?	Float64?	Float64?	String3	Float64?	Cat…	Cat…	String3	String3	Float64	String15	Float64?	String
1	CDISCPILOT01	1015	01-701-1015	Placebo	0.0	Placebo	0.0	2014-01-02	2014-07-02	63.0	<65	1.0	WHITE	1.0	F	Y		Y	Week 2	2.0	15.0	2014-01-16	WEEK 2	4.0	Alanine Aminotransferase	ALT	24.0	CHEM	41.0	27.0	14.0	6.0	34.0	6.83333	1.20588	4.5	0.794118	Y	38.0	Normal	Normal			41.0	HIGH	41.0	CHEMISTRY
2	CDISCPILOT01	1023	01-701-1023	Placebo	0.0	Placebo	0.0	2012-08-05	2012-09-01	64.0	<65	1.0	WHITE	1.0	M	N	Y	Y	Week 2	2.0	23.0	2012-08-27	WEEK 2	4.0	Alanine Aminotransferase	ALT	24.0	CHEM	30.0	23.0	7.0	6.0	43.0	5.0	0.697674	3.83333	0.534884		34.5	Normal	Normal			40.0	NORMAL	30.0	CHEMISTRY
3	CDISCPILOT01	1047	01-701-1047	Placebo	0.0	Placebo	0.0	2013-02-12	2013-03-09	85.0	>80	3.0	WHITE	1.0	F	N	Y	Y	Week 2	2.0	14.0	2013-02-25	WEEK 2	4.0	Alanine Aminotransferase	ALT	24.0	CHEM	16.0	22.0	-6.0	6.0	32.0	2.66667	0.5	3.66667	0.6875	Y	32.0	Normal	Normal			40.0	NORMAL	16.0	CHEMISTRY
4	CDISCPILOT01	1118	01-701-1118	Placebo	0.0	Placebo	0.0	2014-03-12	2014-09-09	52.0	<65	1.0	WHITE	1.0	M	Y		Y	Week 2	2.0	15.0	2014-03-26	WEEK 2	4.0	Alanine Aminotransferase	ALT	24.0	CHEM	7.0	15.0	-8.0	6.0	43.0	1.16667	0.162791	2.5	0.348837	Y	57.5	Normal	Normal			40.0	NORMAL	7.0	CHEMISTRY
5	CDISCPILOT01	1130	01-701-1130	Placebo	0.0	Placebo	0.0	2014-02-15	2014-08-16	84.0	>80	3.0	WHITE	1.0	M	Y		Y	Week 2	2.0	15.0	2014-03-01	WEEK 2	4.0	Alanine Aminotransferase	ALT	24.0	CHEM	14.0	15.0	-1.0	6.0	35.0	2.33333	0.4	2.5	0.428571		38.5	Normal	Normal			40.0	NORMAL	14.0	CHEMISTRY
6	CDISCPILOT01	1153	01-701-1153	Placebo	0.0	Placebo	0.0	2013-09-23	2014-03-16	79.0	65-80	2.0	WHITE	1.0	F	Y		Y	Week 2	2.0	16.0	2013-10-08	WEEK 2	4.0	Alanine Aminotransferase	ALT	24.0	CHEM	14.0	13.0	1.0	6.0	32.0	2.33333	0.4375	2.16667	0.40625		34.0	Normal	Normal			40.0	NORMAL	14.0	CHEMISTRY
7	CDISCPILOT01	1203	01-701-1203	Placebo	0.0	Placebo	0.0	2013-02-02	2013-08-03	81.0	>80	3.0	BLACK OR AFRICAN AMERICAN	2.0	F	Y		Y	Week 2	2.0	22.0	2013-02-23	WEEK 2	4.0	Alanine Aminotransferase	ALT	24.0	CHEM	14.0	13.0	1.0	6.0	32.0	2.33333	0.4375	2.16667	0.40625		34.0	Normal	Normal			40.0	NORMAL	14.0	CHEMISTRY
8	CDISCPILOT01	1234	01-701-1234	Placebo	0.0	Placebo	0.0	2013-03-30	2013-09-22	69.0	65-80	2.0	WHITE	1.0	M	Y		Y	Week 2	2.0	23.0	2013-04-21	WEEK 2	4.0	Alanine Aminotransferase	ALT	24.0	CHEM	30.0	18.0	12.0	6.0	35.0	5.0	0.857143	3.0	0.514286		27.0	Normal	Normal			41.0	NORMAL	30.0	CHEMISTRY
9	CDISCPILOT01	1345	01-701-1345	Placebo	0.0	Placebo	0.0	2013-10-08	2014-03-18	63.0	<65	1.0	WHITE	1.0	F	Y		Y	Week 2	2.0	17.0	2013-10-24	WEEK 2	4.0	Alanine Aminotransferase	ALT	24.0	CHEM	9.0	13.0	-4.0	6.0	34.0	1.5	0.264706	2.16667	0.382353		42.0	Normal	Normal			40.0	NORMAL	9.0	CHEMISTRY
10	CDISCPILOT01	1363	01-701-1363	Placebo	0.0	Placebo	0.0	2013-05-30	2013-11-27	81.0	>80	3.0	BLACK OR AFRICAN AMERICAN	2.0	F	Y		Y	Week 2	2.0	14.0	2013-06-12	WEEK 2	4.0	Alanine Aminotransferase	ALT	24.0	CHEM	11.0	9.0	2.0	6.0	32.0	1.83333	0.34375	1.5	0.28125		37.0	Normal	Normal			40.0	NORMAL	11.0	CHEMISTRY
11	CDISCPILOT01	1387	01-701-1387	Placebo	0.0	Placebo	0.0	2014-03-12	2014-03-25	87.0	>80	3.0	WHITE	1.0	F	N		Y	Week 2	2.0	14.0	2014-03-25	WEEK 2	4.0	Alanine Aminotransferase	ALT	24.0	CHEM	12.0	12.0	0.0	6.0	32.0	2.0	0.375	2.0	0.375	Y	36.0	Normal	Normal		Y	40.0	NORMAL	12.0	CHEMISTRY
12	CDISCPILOT01	1392	01-701-1392	Placebo	0.0	Placebo	0.0	2012-10-28	2013-04-28	78.0	65-80	2.0	WHITE	1.0	M	Y		Y	Week 2	2.0	15.0	2012-11-11	WEEK 2	4.0	Alanine Aminotransferase	ALT	24.0	CHEM	20.0	23.0	-3.0	6.0	35.0	3.33333	0.571429	3.83333	0.657143		32.5	Normal	Normal			40.0	NORMAL	20.0	CHEMISTRY
13	CDISCPILOT01	1415	01-701-1415	Placebo	0.0	Placebo	0.0	2013-09-23	2014-03-24	85.0	>80	3.0	WHITE	1.0	M	Y		Y	Week 2	2.0	15.0	2013-10-07	WEEK 2	4.0	Alanine Aminotransferase	ALT	24.0	CHEM	16.0	13.0	3.0	6.0	35.0	2.66667	0.457143	2.16667	0.371429		36.5	Normal	Normal			45.0	NORMAL	16.0	CHEMISTRY
⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮
72	CDISCPILOT01	1044	01-716-1044	Placebo	0.0	Placebo	0.0	2013-04-27	2013-11-03	74.0	65-80	2.0	WHITE	1.0	M	Y		Y	Week 2	2.0	14.0	2013-05-10	WEEK 2	4.0	Alanine Aminotransferase	ALT	24.0	CHEM	13.0	12.0	1.0	6.0	35.0	2.16667	0.371429	2.0	0.342857		39.5	Normal	Normal			42.0	NORMAL	13.0	CHEMISTRY
73	CDISCPILOT01	1108	01-716-1108	Placebo	0.0	Placebo	0.0	2013-02-12	2013-08-10	86.0	>80	3.0	WHITE	1.0	F	Y		Y	Week 2	2.0	15.0	2013-02-26	WEEK 2	4.0	Alanine Aminotransferase	ALT	24.0	CHEM	15.0	16.0	-1.0	6.0	32.0	2.5	0.46875	2.66667	0.5		33.0	Normal	Normal			41.0	NORMAL	15.0	CHEMISTRY
74	CDISCPILOT01	1160	01-716-1160	Placebo	0.0	Placebo	0.0	2013-04-05	2013-10-11	83.0	>80	3.0	WHITE	1.0	F	Y		Y	Week 2	2.0	15.0	2013-04-19	WEEK 2	4.0	Alanine Aminotransferase	ALT	24.0	CHEM	18.0	13.0	5.0	6.0	32.0	3.0	0.5625	2.16667	0.40625		30.0	Normal	Normal			40.0	NORMAL	18.0	CHEMISTRY
75	CDISCPILOT01	1177	01-716-1177	Placebo	0.0	Placebo	0.0	2014-09-02	2015-03-05	72.0	65-80	2.0	WHITE	1.0	M	Y		Y	Week 2	2.0	15.0	2014-09-16	WEEK 2	4.0	Alanine Aminotransferase	ALT	24.0	CHEM	14.0	17.0	-3.0	6.0	35.0	2.33333	0.4	2.83333	0.485714		38.5	Normal	Normal			40.0	NORMAL	14.0	CHEMISTRY
76	CDISCPILOT01	1308	01-716-1308	Placebo	0.0	Placebo	0.0	2013-08-28	2013-10-07	76.0	65-80	2.0	WHITE	1.0	F	N		Y	Week 2	2.0	16.0	2013-09-12	WEEK 2	4.0	Alanine Aminotransferase	ALT	24.0	CHEM	8.0	7.0	1.0	6.0	32.0	1.33333	0.25	1.16667	0.21875	Y	40.0	Normal	Normal			45.0	NORMAL	8.0	CHEMISTRY
77	CDISCPILOT01	1441	01-716-1441	Placebo	0.0	Placebo	0.0	2014-01-22	2014-07-22	85.0	>80	3.0	WHITE	1.0	M	Y		Y	Week 2	2.0	16.0	2014-02-06	WEEK 2	4.0	Alanine Aminotransferase	ALT	24.0	CHEM	12.0	15.0	-3.0	6.0	35.0	2.0	0.342857	2.5	0.428571	Y	40.5	Normal	Normal			40.0	NORMAL	12.0	CHEMISTRY
78	CDISCPILOT01	1201	01-717-1201	Placebo	0.0	Placebo	0.0	2013-12-19	2014-02-21	85.0	>80	3.0	WHITE	1.0	F	N		Y	Week 2	2.0	16.0	2014-01-03	WEEK 2	4.0	Alanine Aminotransferase	ALT	24.0	CHEM	14.0	23.0	-9.0	6.0	32.0	2.33333	0.4375	3.83333	0.71875		34.0	Normal	Normal			40.0	NORMAL	14.0	CHEMISTRY
79	CDISCPILOT01	1344	01-717-1344	Placebo	0.0	Placebo	0.0	2014-01-11	2014-03-14	64.0	<65	1.0	WHITE	1.0	F	N		Y	Week 2	2.0	14.0	2014-01-24	WEEK 2	4.0	Alanine Aminotransferase	ALT	24.0	CHEM	11.0	12.0	-1.0	6.0	34.0	1.83333	0.323529	2.0	0.352941		40.0	Normal	Normal			45.0	NORMAL	11.0	CHEMISTRY
80	CDISCPILOT01	1139	01-718-1139	Placebo	0.0	Placebo	0.0	2013-05-19	2013-11-17	77.0	65-80	2.0	WHITE	1.0	M	Y		Y	Week 2	2.0	15.0	2013-06-02	WEEK 2	4.0	Alanine Aminotransferase	ALT	24.0	CHEM	14.0	17.0	-3.0	6.0	35.0	2.33333	0.4	2.83333	0.485714	Y	38.5	Normal	Normal			40.0	NORMAL	14.0	CHEMISTRY
81	CDISCPILOT01	1150	01-718-1150	Placebo	0.0	Placebo	0.0	2013-01-19	2013-07-29	73.0	65-80	2.0	WHITE	1.0	F	Y		Y	Week 2	2.0	15.0	2013-02-02	WEEK 2	4.0	Alanine Aminotransferase	ALT	24.0	CHEM	26.0	30.0	-4.0	6.0	32.0	4.33333	0.8125	5.0	0.9375		23.0	Normal	Normal			40.0	NORMAL	26.0	CHEMISTRY
82	CDISCPILOT01	1172	01-718-1172	Placebo	0.0	Placebo	0.0	2013-09-21	2013-11-29	74.0	65-80	2.0	WHITE	1.0	M	N		Y	Week 2	2.0	15.0	2013-10-05	WEEK 2	4.0	Alanine Aminotransferase	ALT	24.0	CHEM	12.0	13.0	-1.0	6.0	35.0	2.0	0.342857	2.16667	0.371429	Y	40.5	Normal	Normal			41.0	NORMAL	12.0	CHEMISTRY
83	CDISCPILOT01	1355	01-718-1355	Placebo	0.0	Placebo	0.0	2013-02-28	2013-08-29	79.0	65-80	2.0	WHITE	1.0	M	Y		Y	Week 2	2.0	17.0	2013-03-16	WEEK 2	4.0	Alanine Aminotransferase	ALT	24.0	CHEM	13.0	12.0	1.0	6.0	35.0	2.16667	0.371429	2.0	0.342857		39.5	Normal	Normal			40.0	NORMAL	13.0	CHEMISTRY

⋮

Last Group (25 rows): ORIG = "HEMATOLOGY", PARAM = "Basophils", PARAMCD = "BASO", TRTP = CategoricalArrays.CategoricalValue{String, UInt32} "Low Dose" (2/3), VISIT = "WEEK 26"

Row	STUDYID	SUBJID	USUBJID	TRTP	TRTPN	TRTA	TRTAN	TRTSDT	TRTEDT	AGE	AGEGR1	AGEGR1N	RACE	RACEN	SEX	COMP24FL	DSRAEFL	SAFFL	AVISIT	AVISITN	ADY	ADT	VISIT	VISITNUM	PARAM	PARAMCD	PARAMN	PARCAT1	AVAL	BASE	CHG	A1LO	A1HI	R2A1LO	R2A1HI	BR2A1LO	BR2A1HI	ANL01FL	ALBTRVAL	ANRIND	BNRIND	ABLFL	AENTMTFL	LBSEQ	LBNRIND	LBSTRESN	ORIG
	String15	String7	String15	Cat…	Float64	String31	Float64	Date	Date	Float64	String7	Float64	String	Float64	String3	String3	String3	String3	String31	Float64	Float64	Date	String15	Float64	SubStrin…	String15	Float64	String7	Float64?	Float64?	Float64?	Float64?	Float64?	Float64?	Float64?	Float64?	Float64?	String3	Float64?	Cat…	Cat…	String3	String3	Float64	String15	Float64?	String
1	CDISCPILOT01	1097	01-701-1097	Low Dose	54.0	Xanomeline Low Dose	54.0	2014-01-01	2014-07-09	68.0	65-80	2.0	WHITE	1.0	M	Y		Y	Week 26	26.0	190.0	2014-07-09	WEEK 26	13.0	Basophils	BASO	10.0	HEM	0.06	0.06	0.0	missing	0.2	missing	0.3	missing	0.3		0.24	Normal	Normal			297.0	NORMAL	0.06	HEMATOLOGY
2	CDISCPILOT01	1192	01-701-1192	Low Dose	54.0	Xanomeline Low Dose	54.0	2012-07-22	2013-01-20	80.0	65-80	2.0	WHITE	1.0	F	Y		Y	Week 26	26.0	183.0	2013-01-20	WEEK 26	13.0	Basophils	BASO	10.0	HEM	0.04	0.07	-0.03	missing	0.2	missing	0.2	missing	0.35		0.26	Normal	Normal			302.0	NORMAL	0.04	HEMATOLOGY
3	CDISCPILOT01	1317	01-701-1317	Low Dose	54.0	Xanomeline Low Dose	54.0	2014-05-22	2014-11-20	68.0	65-80	2.0	WHITE	1.0	M	Y		Y	Week 26	26.0	183.0	2014-11-20	WEEK 26	13.0	Basophils	BASO	10.0	HEM	0.03	0.05	-0.02	missing	0.2	missing	0.15	missing	0.25		0.27	Normal	Normal			328.0	NORMAL	0.03	HEMATOLOGY
4	CDISCPILOT01	1324	01-701-1324	Low Dose	54.0	Xanomeline Low Dose	54.0	2012-10-02	2013-04-02	79.0	65-80	2.0	WHITE	1.0	M	Y		Y	Week 26	26.0	183.0	2013-04-02	WEEK 26	13.0	Basophils	BASO	10.0	HEM	0.02	0.03	-0.01	missing	0.2	missing	0.1	missing	0.15		0.28	Normal	Normal			306.0	NORMAL	0.02	HEMATOLOGY
5	CDISCPILOT01	1442	01-701-1442	Low Dose	54.0	Xanomeline Low Dose	54.0	2013-10-26	2014-04-26	57.0	<65	1.0	BLACK OR AFRICAN AMERICAN	2.0	F	Y		Y	Week 26	26.0	183.0	2014-04-26	WEEK 26	13.0	Basophils	BASO	10.0	HEM	0.06	0.03	0.03	missing	0.2	missing	0.3	missing	0.15		0.24	Normal	Normal			297.0	NORMAL	0.06	HEMATOLOGY
6	CDISCPILOT01	1379	01-703-1379	Low Dose	54.0	Xanomeline Low Dose	54.0	2013-09-22	2014-03-21	81.0	>80	3.0	BLACK OR AFRICAN AMERICAN	2.0	F	Y		Y	Week 26	26.0	181.0	2014-03-21	WEEK 26	13.0	Basophils	BASO	10.0	HEM	0.02	0.04	-0.02	missing	0.2	missing	0.1	missing	0.2		0.28	Normal	Normal			293.0	NORMAL	0.02	HEMATOLOGY
7	CDISCPILOT01	1135	01-704-1135	Low Dose	54.0	Xanomeline Low Dose	54.0	2013-10-31	2014-05-16	74.0	65-80	2.0	WHITE	1.0	F	Y		Y	Week 26	26.0	198.0	2014-05-16	WEEK 26	13.0	Basophils	BASO	10.0	HEM	0.04	0.04	0.0	missing	0.2	missing	0.2	missing	0.2		0.26	Normal	Normal			305.0	NORMAL	0.04	HEMATOLOGY
8	CDISCPILOT01	1218	01-704-1218	Low Dose	54.0	Xanomeline Low Dose	54.0	2012-11-19	2013-05-27	81.0	>80	3.0	WHITE	1.0	F	Y		Y	Week 26	26.0	190.0	2013-05-27	WEEK 26	13.0	Basophils	BASO	10.0	HEM	0.03	0.03	0.0	missing	0.2	missing	0.15	missing	0.15		0.27	Normal	Normal			355.0	NORMAL	0.03	HEMATOLOGY
9	CDISCPILOT01	1292	01-705-1292	Low Dose	54.0	Xanomeline Low Dose	54.0	2013-10-14	2014-05-13	60.0	<65	1.0	BLACK OR AFRICAN AMERICAN	2.0	F	Y		Y	Week 26	26.0	213.0	2014-05-14	WEEK 26	13.0	Basophils	BASO	10.0	HEM	0.03	0.03	0.0	missing	0.2	missing	0.15	missing	0.15		0.27	Normal	Normal			294.0	NORMAL	0.03	HEMATOLOGY
10	CDISCPILOT01	1431	01-705-1431	Low Dose	54.0	Xanomeline Low Dose	54.0	2013-06-23	2013-12-19	68.0	65-80	2.0	WHITE	1.0	F	Y		Y	Week 26	26.0	180.0	2013-12-19	WEEK 26	13.0	Basophils	BASO	10.0	HEM	0.04	0.03	0.01	missing	0.2	missing	0.2	missing	0.15		0.26	Normal	Normal			299.0	NORMAL	0.04	HEMATOLOGY
11	CDISCPILOT01	1084	01-708-1084	Low Dose	54.0	Xanomeline Low Dose	54.0	2013-05-09	2013-11-11	73.0	65-80	2.0	WHITE	1.0	F	Y		Y	Week 26	26.0	187.0	2013-11-11	WEEK 26	13.0	Basophils	BASO	10.0	HEM	0.02	0.06	-0.04	missing	0.2	missing	0.1	missing	0.3		0.28	Normal	Normal			297.0	NORMAL	0.02	HEMATOLOGY
12	CDISCPILOT01	1348	01-708-1348	Low Dose	54.0	Xanomeline Low Dose	54.0	2013-08-05	2014-02-13	79.0	65-80	2.0	WHITE	1.0	F	Y		Y	Week 26	26.0	193.0	2014-02-13	WEEK 26	13.0	Basophils	BASO	10.0	HEM	0.05	missing	missing	missing	0.2	missing	0.25	missing	missing		0.25	Normal				279.0	NORMAL	0.05	HEMATOLOGY
13	CDISCPILOT01	1020	01-709-1020	Low Dose	54.0	Xanomeline Low Dose	54.0	2012-12-01	2013-06-01	72.0	65-80	2.0	WHITE	1.0	F	Y		Y	Week 26	26.0	183.0	2013-06-01	WEEK 26	13.0	Basophils	BASO	10.0	HEM	0.02	0.04	-0.02	missing	0.2	missing	0.1	missing	0.2		0.28	Normal	Normal			299.0	NORMAL	0.02	HEMATOLOGY
14	CDISCPILOT01	1326	01-709-1326	Low Dose	54.0	Xanomeline Low Dose	54.0	2013-04-05	2013-10-02	75.0	65-80	2.0	WHITE	1.0	F	Y		Y	Week 26	26.0	181.0	2013-10-02	WEEK 26	13.0	Basophils	BASO	10.0	HEM	0.05	0.05	0.0	missing	0.2	missing	0.25	missing	0.25		0.25	Normal	Normal			285.0	NORMAL	0.05	HEMATOLOGY
15	CDISCPILOT01	1235	01-710-1235	Low Dose	54.0	Xanomeline Low Dose	54.0	2012-09-26	2013-03-27	56.0	<65	1.0	WHITE	1.0	F	Y		Y	Week 26	26.0	183.0	2013-03-27	WEEK 26	13.0	Basophils	BASO	10.0	HEM	0.04	0.05	-0.01	missing	0.2	missing	0.2	missing	0.25		0.26	Normal	Normal			297.0	NORMAL	0.04	HEMATOLOGY
16	CDISCPILOT01	1043	01-713-1043	Low Dose	54.0	Xanomeline Low Dose	54.0	2013-09-15	2014-03-24	78.0	65-80	2.0	WHITE	1.0	F	Y		Y	Week 26	26.0	191.0	2014-03-24	WEEK 26	13.0	Basophils	BASO	10.0	HEM	0.05	0.08	-0.03	missing	0.2	missing	0.25	missing	0.4		0.25	Normal	Normal			297.0	NORMAL	0.05	HEMATOLOGY
17	CDISCPILOT01	1073	01-713-1073	Low Dose	54.0	Xanomeline Low Dose	54.0	2014-03-30	2014-10-05	74.0	65-80	2.0	BLACK OR AFRICAN AMERICAN	2.0	F	Y		Y	Week 26	26.0	190.0	2014-10-05	WEEK 26	13.0	Basophils	BASO	10.0	HEM	0.02	0.01	0.01	missing	0.2	missing	0.1	missing	0.05		0.28	Normal	Normal			301.0	NORMAL	0.02	HEMATOLOGY
18	CDISCPILOT01	1195	01-714-1195	Low Dose	54.0	Xanomeline Low Dose	54.0	2013-04-26	2013-10-23	75.0	65-80	2.0	WHITE	1.0	M	Y		Y	Week 26	26.0	181.0	2013-10-23	WEEK 26	13.0	Basophils	BASO	10.0	HEM	0.06	0.06	0.0	missing	0.2	missing	0.3	missing	0.3		0.24	Normal	Normal			303.0	NORMAL	0.06	HEMATOLOGY
19	CDISCPILOT01	1085	01-715-1085	Low Dose	54.0	Xanomeline Low Dose	54.0	2013-02-16	2013-08-18	77.0	65-80	2.0	WHITE	1.0	F	Y		Y	Week 26	26.0	184.0	2013-08-18	WEEK 26	13.0	Basophils	BASO	10.0	HEM	0.01	0.03	-0.02	missing	0.2	missing	0.05	missing	0.15		0.29	Normal	Normal			297.0	NORMAL	0.01	HEMATOLOGY
20	CDISCPILOT01	1103	01-716-1103	Low Dose	54.0	Xanomeline Low Dose	54.0	2014-03-20	2014-09-20	79.0	65-80	2.0	WHITE	1.0	M	Y		Y	Week 26	26.0	185.0	2014-09-20	WEEK 26	13.0	Basophils	BASO	10.0	HEM	0.03	0.05	-0.02	missing	0.2	missing	0.15	missing	0.25		0.27	Normal	Normal			309.0	NORMAL	0.03	HEMATOLOGY
21	CDISCPILOT01	1157	01-716-1157	Low Dose	54.0	Xanomeline Low Dose	54.0	2013-10-02	2014-04-04	85.0	>80	3.0	WHITE	1.0	M	Y		Y	Week 26	26.0	186.0	2014-04-05	WEEK 26	13.0	Basophils	BASO	10.0	HEM	0.07	0.07	0.0	missing	0.2	missing	0.35	missing	0.35		0.23	Normal	Normal			287.0	NORMAL	0.07	HEMATOLOGY
22	CDISCPILOT01	1167	01-716-1167	Low Dose	54.0	Xanomeline Low Dose	54.0	2012-10-08	2013-04-12	68.0	65-80	2.0	WHITE	1.0	M	Y		Y	Week 26	26.0	188.0	2013-04-13	WEEK 26	13.0	Basophils	BASO	10.0	HEM	0.04	0.06	-0.02	missing	0.2	missing	0.2	missing	0.3		0.26	Normal	Normal			297.0	NORMAL	0.04	HEMATOLOGY
23	CDISCPILOT01	1004	01-717-1004	Low Dose	54.0	Xanomeline Low Dose	54.0	2014-01-14	2014-07-16	80.0	65-80	2.0	WHITE	1.0	F	Y		Y	Week 26	26.0	184.0	2014-07-16	WEEK 26	13.0	Basophils	BASO	10.0	HEM	0.08	0.08	0.0	missing	0.2	missing	0.4	missing	0.4		0.22	Normal	Normal			298.0	NORMAL	0.08	HEMATOLOGY
24	CDISCPILOT01	1446	01-717-1446	Low Dose	54.0	Xanomeline Low Dose	54.0	2013-09-01	2014-03-03	75.0	65-80	2.0	WHITE	1.0	F	Y		Y	Week 26	26.0	184.0	2014-03-03	WEEK 26	13.0	Basophils	BASO	10.0	HEM	0.03	0.06	-0.03	missing	0.2	missing	0.15	missing	0.3		0.27	Normal	Normal			299.0	NORMAL	0.03	HEMATOLOGY
25	CDISCPILOT01	1254	01-718-1254	Low Dose	54.0	Xanomeline Low Dose	54.0	2013-07-10	2014-01-09	78.0	65-80	2.0	WHITE	1.0	M	Y		Y	Week 26	26.0	184.0	2014-01-09	WEEK 26	13.0	Basophils	BASO	10.0	HEM	0.13	0.11	0.02	missing	0.2	missing	0.65	missing	0.55		0.17	Normal	Normal			297.0	NORMAL	0.13	HEMATOLOGY

Data wrangling

function shift_table(df)
    tbl = @chain df begin
        groupby([:BNRIND, :ANRIND])
        @combine :Count = length(:BNRIND)
        unstack(:ANRIND, :Count, fill=0, allowmissing=true)
        @transform :RowLabel = string(:BNRIND)
    end
    return select(tbl, :RowLabel, Not(:BNRIND))
end

shift_table (generic function with 1 method)

Data wrangling

using Tables

shifts_df = combine(adlb_groups) do sdf
    tbl = shift_table(sdf)
    (; ORIG = [first(sdf.ORIG)],
       PARAM = [first(sdf.PARAM)],
       PARAMCD = [first(sdf.PARAMCD)],
       TRTP = [first(sdf.TRTP)],
       VISIT = [first(sdf.VISIT)],
       table = [tbl]) 
end

108×6 DataFrame

83 rows omitted

Row	ORIG	PARAM	PARAMCD	TRTP	VISIT	table
	String	SubStrin…	String15	Cat…	String15	DataFrame
1	CHEMISTRY	Alanine Aminotransferase	ALT	Placebo	WEEK 2	2×3 DataFrame
2	CHEMISTRY	Albumin	ALB	Placebo	WEEK 2	1×2 DataFrame
3	CHEMISTRY	Alanine Aminotransferase	ALT	Placebo	WEEK 4	2×3 DataFrame
4	CHEMISTRY	Albumin	ALB	Placebo	WEEK 4	1×2 DataFrame
5	CHEMISTRY	Alanine Aminotransferase	ALT	Placebo	WEEK 6	2×3 DataFrame
6	CHEMISTRY	Albumin	ALB	Placebo	WEEK 6	1×2 DataFrame
7	CHEMISTRY	Alanine Aminotransferase	ALT	Placebo	WEEK 8	2×3 DataFrame
8	CHEMISTRY	Albumin	ALB	Placebo	WEEK 8	1×2 DataFrame
9	CHEMISTRY	Alanine Aminotransferase	ALT	Placebo	WEEK 12	2×3 DataFrame
10	CHEMISTRY	Albumin	ALB	Placebo	WEEK 12	1×2 DataFrame
11	CHEMISTRY	Alanine Aminotransferase	ALT	Placebo	WEEK 16	2×2 DataFrame
12	CHEMISTRY	Albumin	ALB	Placebo	WEEK 16	1×2 DataFrame
13	CHEMISTRY	Alanine Aminotransferase	ALT	Placebo	WEEK 20	2×2 DataFrame
⋮	⋮	⋮	⋮	⋮	⋮	⋮
97	HEMATOLOGY	Eosinophils	EOS	Low Dose	WEEK 8	2×3 DataFrame
98	HEMATOLOGY	Basophils	BASO	Low Dose	WEEK 8	2×2 DataFrame
99	HEMATOLOGY	Eosinophils	EOS	Low Dose	WEEK 12	2×3 DataFrame
100	HEMATOLOGY	Basophils	BASO	Low Dose	WEEK 12	2×2 DataFrame
101	HEMATOLOGY	Eosinophils	EOS	Low Dose	WEEK 16	2×2 DataFrame
102	HEMATOLOGY	Basophils	BASO	Low Dose	WEEK 16	2×2 DataFrame
103	HEMATOLOGY	Eosinophils	EOS	Low Dose	WEEK 20	2×2 DataFrame
104	HEMATOLOGY	Basophils	BASO	Low Dose	WEEK 20	2×2 DataFrame
105	HEMATOLOGY	Eosinophils	EOS	Low Dose	WEEK 24	2×2 DataFrame
106	HEMATOLOGY	Basophils	BASO	Low Dose	WEEK 24	2×2 DataFrame
107	HEMATOLOGY	Eosinophils	EOS	Low Dose	WEEK 26	2×2 DataFrame
108	HEMATOLOGY	Basophils	BASO	Low Dose	WEEK 26	2×2 DataFrame

Data wrangling

rows = eachrow(shifts_df)
tables_list = map(rows) do row
    inner_tbl = deepcopy(row.table)
    insertcols!(inner_tbl, 1,
        :ORIG => row.ORIG,
        :PARAM => row.PARAM,
        :PARAMCD => row.PARAMCD,
        :TRTP => row.TRTP,
        :VISIT => row.VISIT
    )
    inner_tbl
end
shifts_long = vcat(tables_list...; cols = :union)

193×8 DataFrame

168 rows omitted

Row	ORIG	PARAM	PARAMCD	TRTP	VISIT	RowLabel	Normal	High
	String	SubStrin…	String15	Cat…	String15	String	Int64	Int64?
1	CHEMISTRY	Alanine Aminotransferase	ALT	Placebo	WEEK 2	CategoricalArrays.CategoricalValue{String, UInt32}["Normal", "High"]	81	0
2	CHEMISTRY	Alanine Aminotransferase	ALT	Placebo	WEEK 2	CategoricalArrays.CategoricalValue{String, UInt32}["Normal", "High"]	0	2
3	CHEMISTRY	Albumin	ALB	Placebo	WEEK 2	CategoricalArrays.CategoricalValue{String, UInt32}["Normal"]	83	missing
4	CHEMISTRY	Alanine Aminotransferase	ALT	Placebo	WEEK 4	CategoricalArrays.CategoricalValue{String, UInt32}["Normal", "High"]	77	0
5	CHEMISTRY	Alanine Aminotransferase	ALT	Placebo	WEEK 4	CategoricalArrays.CategoricalValue{String, UInt32}["Normal", "High"]	1	1
6	CHEMISTRY	Albumin	ALB	Placebo	WEEK 4	CategoricalArrays.CategoricalValue{String, UInt32}["Normal"]	79	missing
7	CHEMISTRY	Alanine Aminotransferase	ALT	Placebo	WEEK 6	CategoricalArrays.CategoricalValue{String, UInt32}["Normal", "High"]	71	1
8	CHEMISTRY	Alanine Aminotransferase	ALT	Placebo	WEEK 6	CategoricalArrays.CategoricalValue{String, UInt32}["Normal", "High"]	1	0
9	CHEMISTRY	Albumin	ALB	Placebo	WEEK 6	CategoricalArrays.CategoricalValue{String, UInt32}["Normal"]	73	missing
10	CHEMISTRY	Alanine Aminotransferase	ALT	Placebo	WEEK 8	CategoricalArrays.CategoricalValue{String, UInt32}["Normal", "High"]	71	0
11	CHEMISTRY	Alanine Aminotransferase	ALT	Placebo	WEEK 8	CategoricalArrays.CategoricalValue{String, UInt32}["Normal", "High"]	0	1
12	CHEMISTRY	Albumin	ALB	Placebo	WEEK 8	CategoricalArrays.CategoricalValue{String, UInt32}["Normal"]	72	missing
13	CHEMISTRY	Alanine Aminotransferase	ALT	Placebo	WEEK 12	CategoricalArrays.CategoricalValue{String, UInt32}["Normal", "High"]	65	1
⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮
182	HEMATOLOGY	Eosinophils	EOS	Low Dose	WEEK 20	CategoricalArrays.CategoricalValue{String, UInt32}["", "Normal"]	1	missing
183	HEMATOLOGY	Eosinophils	EOS	Low Dose	WEEK 20	CategoricalArrays.CategoricalValue{String, UInt32}["", "Normal"]	29	missing
184	HEMATOLOGY	Basophils	BASO	Low Dose	WEEK 20	CategoricalArrays.CategoricalValue{String, UInt32}["", "Normal"]	1	missing
185	HEMATOLOGY	Basophils	BASO	Low Dose	WEEK 20	CategoricalArrays.CategoricalValue{String, UInt32}["", "Normal"]	29	missing
186	HEMATOLOGY	Eosinophils	EOS	Low Dose	WEEK 24	CategoricalArrays.CategoricalValue{String, UInt32}["", "Normal"]	1	missing
187	HEMATOLOGY	Eosinophils	EOS	Low Dose	WEEK 24	CategoricalArrays.CategoricalValue{String, UInt32}["", "Normal"]	24	missing
188	HEMATOLOGY	Basophils	BASO	Low Dose	WEEK 24	CategoricalArrays.CategoricalValue{String, UInt32}["", "Normal"]	1	missing
189	HEMATOLOGY	Basophils	BASO	Low Dose	WEEK 24	CategoricalArrays.CategoricalValue{String, UInt32}["", "Normal"]	24	missing
190	HEMATOLOGY	Eosinophils	EOS	Low Dose	WEEK 26	CategoricalArrays.CategoricalValue{String, UInt32}["", "Normal"]	1	missing
191	HEMATOLOGY	Eosinophils	EOS	Low Dose	WEEK 26	CategoricalArrays.CategoricalValue{String, UInt32}["", "Normal"]	24	missing
192	HEMATOLOGY	Basophils	BASO	Low Dose	WEEK 26	CategoricalArrays.CategoricalValue{String, UInt32}["", "Normal"]	1	missing
193	HEMATOLOGY	Basophils	BASO	Low Dose	WEEK 26	CategoricalArrays.CategoricalValue{String, UInt32}["", "Normal"]	24	missing

Data wrangling

tbl_final = @chain shifts_long begin
    stack(Not([:ORIG, :PARAM, :PARAMCD, :TRTP, :VISIT, :RowLabel]),
          variable_name=:ShiftTo, value_name=:Count)
    @rtransform :Percent = ismissing(:Count) ? "0 (0%)" :
                        (:Count == 0 ? "0 (0%)" :
                        string(:Count, " (", round(100 * :Count / sum(skipmissing(:Count)), digits=1), "%)"))
    select(:ORIG, :PARAM, :TRTP, :VISIT, :RowLabel, :ShiftTo, :Percent)
end

386×7 DataFrame

361 rows omitted

Row	ORIG	PARAM	TRTP	VISIT	RowLabel	ShiftTo	Percent
	String	SubStrin…	Cat…	String15	String	String	String
1	CHEMISTRY	Alanine Aminotransferase	Placebo	WEEK 2	CategoricalArrays.CategoricalValue{String, UInt32}["Normal", "High"]	Normal	81 (100.0%)
2	CHEMISTRY	Alanine Aminotransferase	Placebo	WEEK 2	CategoricalArrays.CategoricalValue{String, UInt32}["Normal", "High"]	Normal	0 (0%)
3	CHEMISTRY	Albumin	Placebo	WEEK 2	CategoricalArrays.CategoricalValue{String, UInt32}["Normal"]	Normal	83 (100.0%)
4	CHEMISTRY	Alanine Aminotransferase	Placebo	WEEK 4	CategoricalArrays.CategoricalValue{String, UInt32}["Normal", "High"]	Normal	77 (100.0%)
5	CHEMISTRY	Alanine Aminotransferase	Placebo	WEEK 4	CategoricalArrays.CategoricalValue{String, UInt32}["Normal", "High"]	Normal	1 (100.0%)
6	CHEMISTRY	Albumin	Placebo	WEEK 4	CategoricalArrays.CategoricalValue{String, UInt32}["Normal"]	Normal	79 (100.0%)
7	CHEMISTRY	Alanine Aminotransferase	Placebo	WEEK 6	CategoricalArrays.CategoricalValue{String, UInt32}["Normal", "High"]	Normal	71 (100.0%)
8	CHEMISTRY	Alanine Aminotransferase	Placebo	WEEK 6	CategoricalArrays.CategoricalValue{String, UInt32}["Normal", "High"]	Normal	1 (100.0%)
9	CHEMISTRY	Albumin	Placebo	WEEK 6	CategoricalArrays.CategoricalValue{String, UInt32}["Normal"]	Normal	73 (100.0%)
10	CHEMISTRY	Alanine Aminotransferase	Placebo	WEEK 8	CategoricalArrays.CategoricalValue{String, UInt32}["Normal", "High"]	Normal	71 (100.0%)
11	CHEMISTRY	Alanine Aminotransferase	Placebo	WEEK 8	CategoricalArrays.CategoricalValue{String, UInt32}["Normal", "High"]	Normal	0 (0%)
12	CHEMISTRY	Albumin	Placebo	WEEK 8	CategoricalArrays.CategoricalValue{String, UInt32}["Normal"]	Normal	72 (100.0%)
13	CHEMISTRY	Alanine Aminotransferase	Placebo	WEEK 12	CategoricalArrays.CategoricalValue{String, UInt32}["Normal", "High"]	Normal	65 (100.0%)
⋮	⋮	⋮	⋮	⋮	⋮	⋮	⋮
375	HEMATOLOGY	Eosinophils	Low Dose	WEEK 20	CategoricalArrays.CategoricalValue{String, UInt32}["", "Normal"]	High	0 (0%)
376	HEMATOLOGY	Eosinophils	Low Dose	WEEK 20	CategoricalArrays.CategoricalValue{String, UInt32}["", "Normal"]	High	0 (0%)
377	HEMATOLOGY	Basophils	Low Dose	WEEK 20	CategoricalArrays.CategoricalValue{String, UInt32}["", "Normal"]	High	0 (0%)
378	HEMATOLOGY	Basophils	Low Dose	WEEK 20	CategoricalArrays.CategoricalValue{String, UInt32}["", "Normal"]	High	0 (0%)
379	HEMATOLOGY	Eosinophils	Low Dose	WEEK 24	CategoricalArrays.CategoricalValue{String, UInt32}["", "Normal"]	High	0 (0%)
380	HEMATOLOGY	Eosinophils	Low Dose	WEEK 24	CategoricalArrays.CategoricalValue{String, UInt32}["", "Normal"]	High	0 (0%)
381	HEMATOLOGY	Basophils	Low Dose	WEEK 24	CategoricalArrays.CategoricalValue{String, UInt32}["", "Normal"]	High	0 (0%)
382	HEMATOLOGY	Basophils	Low Dose	WEEK 24	CategoricalArrays.CategoricalValue{String, UInt32}["", "Normal"]	High	0 (0%)
383	HEMATOLOGY	Eosinophils	Low Dose	WEEK 26	CategoricalArrays.CategoricalValue{String, UInt32}["", "Normal"]	High	0 (0%)
384	HEMATOLOGY	Eosinophils	Low Dose	WEEK 26	CategoricalArrays.CategoricalValue{String, UInt32}["", "Normal"]	High	0 (0%)
385	HEMATOLOGY	Basophils	Low Dose	WEEK 26	CategoricalArrays.CategoricalValue{String, UInt32}["", "Normal"]	High	0 (0%)
386	HEMATOLOGY	Basophils	Low Dose	WEEK 26	CategoricalArrays.CategoricalValue{String, UInt32}["", "Normal"]	High	0 (0%)

Data wrangling

tbl_final_cleaned = @chain shifts_long begin
    stack(Not([:ORIG, :PARAM, :PARAMCD, :TRTP, :VISIT, :RowLabel]),
          variable_name = :ShiftTo, value_name = :Count)
    @rsubset(:ShiftTo in ["High", "Normal"])
    @rtransform :Percent = ismissing(:Count) ? "0 (0%)" :
        (:Count == 0 ? "0 (0%)" :
        string(:Count, " (", round(100 * :Count / sum(skipmissing(:Count)), digits = 1), "%)"))
    @select :ORIG :PARAM :TRTP :VISIT :ShiftTo :Percent
end

386×6 DataFrame

361 rows omitted

Row	ORIG	PARAM	TRTP	VISIT	ShiftTo	Percent
	String	SubStrin…	Cat…	String15	String	String
1	CHEMISTRY	Alanine Aminotransferase	Placebo	WEEK 2	Normal	81 (100.0%)
2	CHEMISTRY	Alanine Aminotransferase	Placebo	WEEK 2	Normal	0 (0%)
3	CHEMISTRY	Albumin	Placebo	WEEK 2	Normal	83 (100.0%)
4	CHEMISTRY	Alanine Aminotransferase	Placebo	WEEK 4	Normal	77 (100.0%)
5	CHEMISTRY	Alanine Aminotransferase	Placebo	WEEK 4	Normal	1 (100.0%)
6	CHEMISTRY	Albumin	Placebo	WEEK 4	Normal	79 (100.0%)
7	CHEMISTRY	Alanine Aminotransferase	Placebo	WEEK 6	Normal	71 (100.0%)
8	CHEMISTRY	Alanine Aminotransferase	Placebo	WEEK 6	Normal	1 (100.0%)
9	CHEMISTRY	Albumin	Placebo	WEEK 6	Normal	73 (100.0%)
10	CHEMISTRY	Alanine Aminotransferase	Placebo	WEEK 8	Normal	71 (100.0%)
11	CHEMISTRY	Alanine Aminotransferase	Placebo	WEEK 8	Normal	0 (0%)
12	CHEMISTRY	Albumin	Placebo	WEEK 8	Normal	72 (100.0%)
13	CHEMISTRY	Alanine Aminotransferase	Placebo	WEEK 12	Normal	65 (100.0%)
⋮	⋮	⋮	⋮	⋮	⋮	⋮
375	HEMATOLOGY	Eosinophils	Low Dose	WEEK 20	High	0 (0%)
376	HEMATOLOGY	Eosinophils	Low Dose	WEEK 20	High	0 (0%)
377	HEMATOLOGY	Basophils	Low Dose	WEEK 20	High	0 (0%)
378	HEMATOLOGY	Basophils	Low Dose	WEEK 20	High	0 (0%)
379	HEMATOLOGY	Eosinophils	Low Dose	WEEK 24	High	0 (0%)
380	HEMATOLOGY	Eosinophils	Low Dose	WEEK 24	High	0 (0%)
381	HEMATOLOGY	Basophils	Low Dose	WEEK 24	High	0 (0%)
382	HEMATOLOGY	Basophils	Low Dose	WEEK 24	High	0 (0%)
383	HEMATOLOGY	Eosinophils	Low Dose	WEEK 26	High	0 (0%)
384	HEMATOLOGY	Eosinophils	Low Dose	WEEK 26	High	0 (0%)
385	HEMATOLOGY	Basophils	Low Dose	WEEK 26	High	0 (0%)
386	HEMATOLOGY	Basophils	Low Dose	WEEK 26	High	0 (0%)

Data wrangling

tbl_f = @chain tbl_final_cleaned begin
    groupby([:ORIG, :PARAM, :TRTP, :VISIT, :ShiftTo])
    combine(_) do sdf
        sdf[1, :] 
    end
end

216×6 DataFrame

191 rows omitted

Row	ORIG	PARAM	TRTP	VISIT	ShiftTo	Percent
	String	SubStrin…	Cat…	String15	String	String
1	CHEMISTRY	Alanine Aminotransferase	Placebo	WEEK 2	Normal	81 (100.0%)
2	CHEMISTRY	Albumin	Placebo	WEEK 2	Normal	83 (100.0%)
3	CHEMISTRY	Alanine Aminotransferase	Placebo	WEEK 4	Normal	77 (100.0%)
4	CHEMISTRY	Albumin	Placebo	WEEK 4	Normal	79 (100.0%)
5	CHEMISTRY	Alanine Aminotransferase	Placebo	WEEK 6	Normal	71 (100.0%)
6	CHEMISTRY	Albumin	Placebo	WEEK 6	Normal	73 (100.0%)
7	CHEMISTRY	Alanine Aminotransferase	Placebo	WEEK 8	Normal	71 (100.0%)
8	CHEMISTRY	Albumin	Placebo	WEEK 8	Normal	72 (100.0%)
9	CHEMISTRY	Alanine Aminotransferase	Placebo	WEEK 12	Normal	65 (100.0%)
10	CHEMISTRY	Albumin	Placebo	WEEK 12	Normal	67 (100.0%)
11	CHEMISTRY	Alanine Aminotransferase	Placebo	WEEK 16	Normal	67 (100.0%)
12	CHEMISTRY	Albumin	Placebo	WEEK 16	Normal	68 (100.0%)
13	CHEMISTRY	Alanine Aminotransferase	Placebo	WEEK 20	Normal	64 (100.0%)
⋮	⋮	⋮	⋮	⋮	⋮	⋮
205	HEMATOLOGY	Eosinophils	Low Dose	WEEK 8	High	0 (0%)
206	HEMATOLOGY	Basophils	Low Dose	WEEK 8	High	0 (0%)
207	HEMATOLOGY	Eosinophils	Low Dose	WEEK 12	High	0 (0%)
208	HEMATOLOGY	Basophils	Low Dose	WEEK 12	High	0 (0%)
209	HEMATOLOGY	Eosinophils	Low Dose	WEEK 16	High	0 (0%)
210	HEMATOLOGY	Basophils	Low Dose	WEEK 16	High	0 (0%)
211	HEMATOLOGY	Eosinophils	Low Dose	WEEK 20	High	0 (0%)
212	HEMATOLOGY	Basophils	Low Dose	WEEK 20	High	0 (0%)
213	HEMATOLOGY	Eosinophils	Low Dose	WEEK 24	High	0 (0%)
214	HEMATOLOGY	Basophils	Low Dose	WEEK 24	High	0 (0%)
215	HEMATOLOGY	Eosinophils	Low Dose	WEEK 26	High	0 (0%)
216	HEMATOLOGY	Basophils	Low Dose	WEEK 26	High	0 (0%)

			Treatment
			Placebo		Low Dose		High Dose
			High	Normal	High	Normal	High	Normal
			Percent
CHEMISTRY	Alanine Aminotransferase	WEEK 2	0 (0%)	81 (100.0%)	0 (0%)	2 (100.0%)	0 (0%)	78 (100.0%)
		WEEK 4	0 (0%)	77 (100.0%)	0 (0%)	2 (100.0%)	0 (0%)	72 (100.0%)
		WEEK 6	1 (100.0%)	71 (100.0%)	0 (0%)	2 (100.0%)	0 (0%)	66 (100.0%)
		WEEK 8	0 (0%)	71 (100.0%)	0 (0%)	2 (100.0%)	2 (100.0%)	54 (100.0%)
		WEEK 12	1 (100.0%)	65 (100.0%)	0 (0%)	1 (100.0%)	1 (100.0%)	49 (100.0%)
		WEEK 16	0 (0%)	67 (100.0%)	0 (0%)	2 (100.0%)	0 (0%)	37 (100.0%)
		WEEK 20	0 (0%)	64 (100.0%)	0 (0%)	1 (100.0%)	0 (0%)	31 (100.0%)
		WEEK 24	1 (100.0%)	55 (100.0%)	0 (0%)	1 (100.0%)	0 (0%)	30 (100.0%)
		WEEK 26	0 (0%)	56 (100.0%)	0 (0%)	1 (100.0%)	0 (0%)	27 (100.0%)
	Albumin	WEEK 2	0 (0%)	83 (100.0%)	0 (0%)	2 (100.0%)	0 (0%)	78 (100.0%)
		WEEK 4	0 (0%)	79 (100.0%)	0 (0%)	2 (100.0%)	0 (0%)	72 (100.0%)
		WEEK 6	0 (0%)	73 (100.0%)	0 (0%)	2 (100.0%)	0 (0%)	66 (100.0%)
		WEEK 8	0 (0%)	72 (100.0%)	0 (0%)	2 (100.0%)	0 (0%)	56 (100.0%)
		WEEK 12	0 (0%)	67 (100.0%)	0 (0%)	1 (100.0%)	0 (0%)	50 (100.0%)
		WEEK 16	0 (0%)	68 (100.0%)	0 (0%)	2 (100.0%)	0 (0%)	37 (100.0%)
		WEEK 20	0 (0%)	65 (100.0%)	0 (0%)	1 (100.0%)	0 (0%)	31 (100.0%)
		WEEK 24	0 (0%)	57 (100.0%)	0 (0%)	1 (100.0%)	0 (0%)	30 (100.0%)
		WEEK 26	0 (0%)	57 (100.0%)	0 (0%)	1 (100.0%)	0 (0%)	27 (100.0%)
HEMATOLOGY	Basophils	WEEK 2	0 (0%)	1 (100.0%)	0 (0%)	3 (100.0%)	0 (0%)	3 (100.0%)
		WEEK 4	0 (0%)	1 (100.0%)	0 (0%)	2 (100.0%)	0 (0%)	2 (100.0%)
		WEEK 6	0 (0%)	1 (100.0%)	0 (0%)	3 (100.0%)	0 (0%)	2 (100.0%)
		WEEK 8	0 (0%)	1 (100.0%)	0 (0%)	3 (100.0%)	0 (0%)	1 (100.0%)
		WEEK 12	0 (0%)	1 (100.0%)	0 (0%)	2 (100.0%)	0 (0%)	1 (100.0%)
		WEEK 16	0 (0%)	1 (100.0%)	0 (0%)	3 (100.0%)	0 (0%)	1 (100.0%)
		WEEK 20	0 (0%)	1 (100.0%)	0 (0%)	1 (100.0%)	0 (0%)	31 (100.0%)
		WEEK 24	0 (0%)	1 (100.0%)	0 (0%)	1 (100.0%)	0 (0%)	1 (100.0%)
		WEEK 26	0 (0%)	1 (100.0%)	0 (0%)	1 (100.0%)	0 (0%)	1 (100.0%)
	Eosinophils	WEEK 2	0 (0%)	1 (100.0%)	0 (0%)	3 (100.0%)	0 (0%)	3 (100.0%)
		WEEK 4	0 (0%)	1 (100.0%)	0 (0%)	2 (100.0%)	0 (0%)	2 (100.0%)
		WEEK 6	0 (0%)	1 (100.0%)	1 (100.0%)	2 (100.0%)	0 (0%)	2 (100.0%)
		WEEK 8	0 (0%)	1 (100.0%)	0 (0%)	3 (100.0%)	0 (0%)	1 (100.0%)
		WEEK 12	0 (0%)	1 (100.0%)	0 (0%)	2 (100.0%)	0 (0%)	1 (100.0%)
		WEEK 16	0 (0%)	1 (100.0%)	0 (0%)	3 (100.0%)	0 (0%)	1 (100.0%)
		WEEK 20	0 (0%)	1 (100.0%)	0 (0%)	1 (100.0%)	0 (0%)	31 (100.0%)
		WEEK 24	0 (0%)	1 (100.0%)	0 (0%)	1 (100.0%)	0 (0%)	1 (100.0%)
		WEEK 26	0 (0%)	1 (100.0%)	0 (0%)	1 (100.0%)	0 (0%)	1 (100.0%)